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2020 5
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CRISPR-CasΦ from huge phages is a hypercompact genome editor.
Pausch P, Al-Shayeb B, Bisom-Rapp E, Tsuchida CA, Li Z, Cress BF, Knott GJ, Jacobsen SE, Banfield JF, Doudna JA. Pausch P, et al. Science. 2020 Jul 17;369(6501):333-337. doi: 10.1126/science.abb1400. Science. 2020. PMID: 32675376 Free PMC article.
Precise transcript targeting by CRISPR-Csm complexes.
Colognori D, Trinidad M, Doudna JA. Colognori D, et al. Nat Biotechnol. 2023 Sep;41(9):1256-1264. doi: 10.1038/s41587-022-01649-9. Epub 2023 Jan 23. Nat Biotechnol. 2023. PMID: 36690762 Free PMC article.
Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors.
Al-Shayeb B, Skopintsev P, Soczek KM, Stahl EC, Li Z, Groover E, Smock D, Eggers AR, Pausch P, Cress BF, Huang CJ, Staskawicz B, Savage DF, Jacobsen SE, Banfield JF, Doudna JA. Al-Shayeb B, et al. Cell. 2022 Nov 23;185(24):4574-4586.e16. doi: 10.1016/j.cell.2022.10.020. Cell. 2022. PMID: 36423580 Free article.
DNA interference states of the hypercompact CRISPR-CasΦ effector.
Pausch P, Soczek KM, Herbst DA, Tsuchida CA, Al-Shayeb B, Banfield JF, Nogales E, Doudna JA. Pausch P, et al. Nat Struct Mol Biol. 2021 Aug;28(8):652-661. doi: 10.1038/s41594-021-00632-3. Epub 2021 Aug 11. Nat Struct Mol Biol. 2021. PMID: 34381246 Free PMC article.
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells.
Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Hofman L, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. Tsuchida CA, et al. Cell. 2023 Oct 12;186(21):4567-4582.e20. doi: 10.1016/j.cell.2023.08.041. Epub 2023 Oct 3. Cell. 2023. PMID: 37794590 Free PMC article.
In vivo human T cell engineering with enveloped delivery vehicles.
Hamilton JR, Chen E, Perez BS, Sandoval Espinoza CR, Kang MH, Trinidad M, Ngo W, Doudna JA. Hamilton JR, et al. Nat Biotechnol. 2024 Nov;42(11):1684-1692. doi: 10.1038/s41587-023-02085-z. Epub 2024 Jan 11. Nat Biotechnol. 2024. PMID: 38212493 Free PMC article.
Targeted nonviral delivery of genome editors in vivo.
Tsuchida CA, Wasko KM, Hamilton JR, Doudna JA. Tsuchida CA, et al. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307796121. doi: 10.1073/pnas.2307796121. Epub 2024 Mar 4. Proc Natl Acad Sci U S A. 2024. PMID: 38437567 Free PMC article. Review.
23 results