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The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia.
Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, Zhou K, Li W, Hu J, Fu C, Aziz T, Li H, Li J, Yang Y, Han L, Zhang S, Ma Y, Sun M, Wu H, Zhang Z, Wunderlich M, Robinson S, Braas D, Hoeve JT, Zhang B, Marcucci G, Mulloy JC, Zhou K, Tao HF, Deng X, Horne D, Wei M, Huang H, Chen J. Weng H, et al. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. doi: 10.1016/j.ccell.2022.10.004. Epub 2022 Oct 27. Cancer Cell. 2022. PMID: 36306790 Free PMC article.
Incidence of Pediatric Celiac Disease Varies by Region.
Stahl M, Li Q, Lynch K, Koletzko S, Mehta P, Gragert L, Norris JM, Andrén Aronsson C, Lindfors K, Kurppa K, Ilonen J, Krischer J, Alkolkar B, Ziegler AG, Toppari J, Rewers MJ, Agardh D, Hagopian W, Liu E; TEDDY Study Group. Stahl M, et al. Am J Gastroenterol. 2023 Mar 1;118(3):539-545. doi: 10.14309/ajg.0000000000002056. Epub 2022 Oct 11. Am J Gastroenterol. 2023. PMID: 36219178 Free PMC article.
Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection.
Lin J, Moradi E, Salenius K, Lehtipuro S, Häkkinen T, Laiho JE, Oikarinen S, Randelin S, Parikh HM, Krischer JP, Toppari J, Lernmark Å, Petrosino JF, Ajami NJ, She JX, Hagopian WA, Rewers MJ, Lloyd RE, Rautajoki KJ, Hyöty H, Nykter M; TEDDY Study Group. Lin J, et al. Nat Commun. 2023 Nov 22;14(1):7630. doi: 10.1038/s41467-023-42763-9. Nat Commun. 2023. PMID: 37993433 Free PMC article.
SARS-CoV-2 - No Increased Islet Autoimmunity or Type 1 Diabetes in Teens.
Krischer JP, Lernmark Å, Hagopian WA, Rewers MJ, McIndoe R, Toppari J, Ziegler AG, Akolkar B; TEDDY Study Group. Krischer JP, et al. N Engl J Med. 2023 Aug 3;389(5):474-475. doi: 10.1056/NEJMc2216477. N Engl J Med. 2023. PMID: 37530831 Free PMC article. No abstract available.
Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity.
Nakayasu ES, Bramer LM, Ansong C, Schepmoes AA, Fillmore TL, Gritsenko MA, Clauss TR, Gao Y, Piehowski PD, Stanfill BA, Engel DW, Orton DJ, Moore RJ, Qian WJ, Sechi S, Frohnert BI, Toppari J, Ziegler AG, Lernmark Å, Hagopian W, Akolkar B, Smith RD, Rewers MJ, Webb-Robertson BM, Metz TO; TEDDY Study Group. Nakayasu ES, et al. Cell Rep Med. 2023 Jul 18;4(7):101093. doi: 10.1016/j.xcrm.2023.101093. Epub 2023 Jun 29. Cell Rep Med. 2023. PMID: 37390828 Free PMC article.
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