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Epithelial-derived interleukin-23 promotes oral mucosal immunopathology.
Kim TS, Ikeuchi T, Theofilou VI, Williams DW, Greenwell-Wild T, June A, Adade EE, Li L, Abusleme L, Dutzan N, Yuan Y, Brenchley L, Bouladoux N, Sakamachi Y; NIDCD/NIDCR Genomics and Computational Biology Core; Palmer RJ Jr, Iglesias-Bartolome R, Trinchieri G, Garantziotis S, Belkaid Y, Valm AM, Diaz PI, Holland SM, Moutsopoulos NM. Kim TS, et al. Immunity. 2024 Apr 9;57(4):859-875.e11. doi: 10.1016/j.immuni.2024.02.020. Epub 2024 Mar 20. Immunity. 2024. PMID: 38513665
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity.
Williams DW, Greenwell-Wild T, Brenchley L, Dutzan N, Overmiller A, Sawaya AP, Webb S, Martin D; NIDCD/NIDCR Genomics and Computational Biology Core; Hajishengallis G, Divaris K, Morasso M, Haniffa M, Moutsopoulos NM. Williams DW, et al. Cell. 2021 Jul 22;184(15):4090-4104.e15. doi: 10.1016/j.cell.2021.05.013. Epub 2021 Jun 14. Cell. 2021. PMID: 34129837 Free PMC article.
Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis.
Kim TS, Silva LM, Theofilou VI, Greenwell-Wild T, Li L, Williams DW, Ikeuchi T, Brenchley L; NIDCD/NIDCR Genomics and Computational Biology Core; Bugge TH, Diaz PI, Kaplan MJ, Carmona-Rivera C, Moutsopoulos NM. Kim TS, et al. J Exp Med. 2023 Sep 4;220(9):e20221751. doi: 10.1084/jem.20221751. Epub 2023 Jun 1. J Exp Med. 2023. PMID: 37261457 Free PMC article.
Sp6/Epiprofin is a master regulator in the developing tooth.
Rhodes CS, Yoshitomi Y, Burbelo PD, Freese NH, Nakamura T; NIDCD/NIDCR Genomics and Computational Biology Core; Chiba Y, Yamada Y. Rhodes CS, et al. Biochem Biophys Res Commun. 2021 Dec 3;581:89-95. doi: 10.1016/j.bbrc.2021.10.017. Epub 2021 Oct 9. Biochem Biophys Res Commun. 2021. PMID: 34662808 Free PMC article.
Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy.
Gadomski SJ, Mui BWH, Gorodetsky R, Paravastu SS, Featherall J, Li L, Haffey A, Kim JC, Kuznetsov SA, Futrega K, Lazmi-Hailu A, Merling RK; NIDCD/NIDCR Genomics and Computational Biology Core,; Martin D, McCaskie AW, Robey PG. Gadomski SJ, et al. iScience. 2024 Jul 18;27(8):110537. doi: 10.1016/j.isci.2024.110537. eCollection 2024 Aug 16. iScience. 2024. PMID: 39193188 Free PMC article.
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells.
Chibly AM, Patel VN, Aure MH, Pasquale MC; NIDCD/NIDCR Genomics and Computational Biology Core; Martin GE, Ghannam M, Andrade J, Denegre NG, Simpson C, Goldstein DP, Liu FF, Lombaert IMA, Hoffman MP. Chibly AM, et al. NPJ Regen Med. 2023 Mar 25;8(1):17. doi: 10.1038/s41536-023-00290-7. NPJ Regen Med. 2023. PMID: 36966175 Free PMC article.
Loss of 3-O-sulfotransferase enzymes, Hs3st3a1 and Hs3st3b1, reduces kidney and glomerular size and disrupts glomerular architecture.
Patel VN, Ball JR, Choi SH, Lane ED, Wang Z, Aure MH, Villapudua CU, Zheng C; NIDCD/NIDCR Genomics and Computational Biology Core; Bleck C, Mohammed H, Syed Z, Liu J, Hoffman MP. Patel VN, et al. Matrix Biol. 2024 Nov;133:134-149. doi: 10.1016/j.matbio.2024.06.006. Epub 2024 Jun 27. Matrix Biol. 2024. PMID: 38944161 Free article.