MCL1 is essential for the survival of stem and progenitor cells of multiple lineages 1 , 2 , and
is unique among pro-survival BCL2 family members in that it is rapidly turned over through …

… For further information, please visit http://www.wiley.com/go/huang The bulk of the material
presented in this book is the result of the authors and their coworkers, mainly since 2004. The …

This paper presents an improved algorithm for the bi-directional evolutionary structural
optimization (BESO) method for topology optimization problems. The elemental sensitivity …

There are several well-established techniques for the generation of solid-void optimal
topologies such as solid isotropic material with penalization (SIMP) method and evolutionary …

Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood
glucose (BG) control on the degree of required medical interventions and on mortality in …

Evolutionary Structural Optimization (ESO) and its later version bi-directional ESO (BESO)
have gained widespread popularity among researchers in structural optimization and …

Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin
II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (…

The evolutionary structural optimization (ESO) method developed by Xie and Steven (Comput
Struct 49(5):885–896, 162 ), an important branch of topology optimization, has undergone …

This paper introduces a topology optimization algorithm for the optimal design of cellular
materials and composites with periodic microstructures so that the resulting macrostructure has …

Dynamic modulation of protein levels is tightly controlled in response to physiological cues.
In mammalian cells, much of the protein degradation is carried out by the ubiquitin-…