Vítor Espírito Santo

Vítor Espírito Santo

London, England, United Kingdom
2K followers 500+ connections

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With a PhD in Stem Cells, Regenerative Medicine & Tissue Engineering and 15 years of…

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  • Hoxton Farms Graphic

    Hoxton Farms

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    San Francisco Bay Area

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    San Francisco Bay Area

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    San Francisco, Kalifornien

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    San Francisco Bay Area

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    Oxford, United Kingdom

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    Lisbon Area, Portugal

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    Oeiras

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    Greater Chicago Area

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    Greater Chicago Area

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    Guimarães Area, Portugal

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    Guimarães Area, Portugal

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    Kyoto, Japan

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    Braga Area, Portugal

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    Valladolid Area, Spain

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    Braga Area, Portugal

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  • Universidade do Minho Graphic

    Universidade do Minho

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    Activities and Societies: - Co-founder and Head of Pedagogical Department of "Gabinete de alunos de Engenharia Biomedica" (GAEB) at University of Minho. - Responsible for negotiations between students and department leaders during implementation of Bologna Process. - Activation of ERASMUS program for Biomedical Engineering students. Part of the first group (of 3) students that embarked for international exchange program in 2006. - Member of CAUM, the university Choir, for approximately 3 years.

    - First class of students of Biomedical Engineering at University of Minho, Portugal.
    - Major in Biomaterials, Rehabilitation and Biomechanics.

Publications

  • Layer-by-Layer Assembled Cell Instructive Nanocoatings containing Platelet Lysate

    Biomaterials

    Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in
    order to control cell behavior. Platelet Lysate (PL) presents itself as a cost-effective source of multiple
    GFs and other proteins. The instruction given by a construct-PL combination will depend on how its
    instructive cues are presented to the cells. The content, stability and conformation of the GFs affect
    their instruction. Strategies for a controlled incorporation of PL are needed. Herein, PL…

    Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in
    order to control cell behavior. Platelet Lysate (PL) presents itself as a cost-effective source of multiple
    GFs and other proteins. The instruction given by a construct-PL combination will depend on how its
    instructive cues are presented to the cells. The content, stability and conformation of the GFs affect
    their instruction. Strategies for a controlled incorporation of PL are needed. Herein, PL was
    incorporated into nanocoatings by layer-by-layer assembling with polysaccharides presenting
    different sulfation degrees (SD) and charges. Heparin and several marine polysaccharides were tested
    to evaluate their PL and GF incorporation capability. The consequent effects of those multilayers on
    human adipose derived stem cells (hASCs) were assessed in short-term cultures. Both nature of the
    polysaccharide and SD were important properties that influenced the adsorption of PL, vascular
    endothelial growth factor (VEGF), fibroblast growth factor b (FGFb) and platelet derived growth factor
    (PDGF). The sulfated polysaccharides-PL multilayers showed to be efficient in the promotion of
    morphological changes, serum-free adhesion and proliferation of high passage hASCs (P>5). These
    biomimetic multilayers promise to be versatile platforms to fabricate instructive devices allowing a
    tunable incorporation of PL.

    Other authors
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Languages

  • Englisch

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  • Spanish

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  • Portuguese

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