J Biomed Sci. 2019 May 8;26(1):32. doi: 10.1186/s12929-019-0528-7.

Green tea extract catechin improves cardiac function in pediatric cardiomyopathy patients with diastolic dysfunction.

Quan J^1,^2,^3,⁴, Jia Z^1,^2,^3,⁴, Lv T^1,^2,^3,⁴, Zhang L^1,^2,^3,⁴, Liu L^1,^2,^3,⁴, Pan B^1,^2,^3,⁴, Zhu J^2,^3,⁴, Gelb IJ⁵, Huang X⁶, Tian J^7,^8,^9,¹⁰.

Author information

1: Department of Cardiology, Children's Hospital of Chongqing Medical University, 136 Zhongshan Er Road, Yu Zhong District, Chongqing, 400014, China.
2: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.
3: China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China.
4: Chongqing Key Laboratory of Pediatrics, Chongqing, China.
5: Charlie E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
6: Charlie E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA. [email protected].
7: Department of Cardiology, Children's Hospital of Chongqing Medical University, 136 Zhongshan Er Road, Yu Zhong District, Chongqing, 400014, China. [email protected].
8: Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China. [email protected].
9: China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China. [email protected].
10: Chongqing Key Laboratory of Pediatrics, Chongqing, China. [email protected].

Abstract

BACKGROUND:

Our previous studies have demonstrated that Ca²⁺ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies.

METHODS:

Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study. Echocardiography, ECG, and laboratory tests were performed before and after the catechin administration for 12 months. Comparison has been made in these patients before and after the treatment with catechin. Next Generation Sequencing was conducted to find out the potential causative gene variants in all patients.

RESULTS:

A significant decrease of isovolumetric relaxation time (115 ± 46 vs 100 ± 42 ms, P = 0.047 at 6 months; 115 ± 46 vs 94 ± 30 ms, P = 0.033 at 12 months), an increase of left ventricle end diastolic volume (40 ± 28 vs 53 ± 28 ml, P = 0.028 at 6 months; 40 ± 28 vs 48 ± 33 ml, P = 0.011 at 12 months) and stroke volume (25 ± 16 vs 32 ± 17 ml, P = 0.022 at 6 months; 25 ± 16 vs 30 ± 17 ml, P = 0.021 at 12 months) were observed with echocardiography in these patients 6-month after the treatment with catechin. Ejection fraction, left ventricular wall thickness, biatrial dimension remained unchanged. No significant side effects were observed in the patients tested.

CONCLUSIONS:

This study indicates that Ca²⁺ desensitizing green tea extract catechin, is helpful in correcting the impaired relaxation in pediatric cardiomyopathy patients with diastolic dysfunction.