Cia;
Arsenic is one of those environmental trigger pullers too.
Is it really just taking the right kind of genes to resist? Or are those other 36 just on borrowed time?

Grace Green made a good point, the whole of us are dumbing down. .

It may seem to you looking at others from afar that they are well. Those 36 have no problems.

This is even harder to spot in areas of larger populations, but in smaller populations, such problems are obvious so much sooner.

Those other 36, that are competent, are rare in my community. Rare is some one you can hire to put a new roof on your home, rare is a competent plumber, Rare is a competent person.

And then Cia you used that word "accumulative"

How soon did the generations in your family start taking the pertussis shot? For that matter the typhoid vaccine, or something that you never dreamed about them taking. Things that would surprise and shock you?

I would never have known that my mother born in 1929 in the back woods walked a long way to meet the nurse to get a series of the pertussis vaccine. Not the D or the T in it, just the P. She already had the D, the T, the small pox, and every fall she took a typhoid shot. I now know she always had a mood disorder and so did the rest of her brothers and sisters. How on earth did the Europeans come to this country and procreate as well as they did, with mood disorders?

Without her telling me about Dr. Pinkleton and his nurse showing up every year to give out Typhoid shots, I would never have realized just how many typhoid shots her community received.

Their little world, their community of a school, post office, a couple of stores, lumber mill, a grain mill, all of farmers and timber are all gone now. Their community of many people living along the tributaries that emptied into their creek, is for me a community frozen in time.

Buried on a wooded hill that is so steep that I have to grab trees and branches to pull myself up is a grave yard is full of strange stories. Not just babies born to early, or women that died in childbirth, and from hard work, but a few stories of young women that had periods that would not stop. A few young people that just died after some fainting spells. Dad's 25 year old cousin is buried there. He watched him die from what he did not know. Mother said it was leukemia since his brother died 20 years later with the same symptoms.
Mother's best friend had fits (seizures) . IT just goes on and on. The Great Depression years when life up there had no changed much for decades. Then suddenly the birth rate plummeted. In two generations going from 12 kids, to two, or even none.

Benedetta,

You’re assuming that it’s off/on, you have the gene, you react, you don’t have the gene, you don’t. But you said that since it’s environmental, everyone gets zapped sooner or later.

It’s more that child A has a very sensitive genetic profile: he gets one vaccine, or one hep-B or one DTaP, and he reacts with a disability. Child B can get ten and seems to be fine, but the eleventh disables him. Child C seems to do fine with fifteen shots, but the sixteenth disables him. In 1980, children got five DPTs, sometimes six; four polios; one or two MMRs. Some were disabled by vaccines, but not that many. As they gave more and more and more shots, more and more children reached the genetic set point beyond which they reacted. Most children can take even fifteen shots, but fewer and fewer are able to keep going indefinitely without overt disabling reactions. Why would it just be off/on, you do or you don’t? It’s cumulative, and each person has a different genetically- set tolerance level.

Cia;

Philosophically you can look at it that way.

But when the bare truth is looked at; some people react sooner, get sick sooner and die sooner to an environmental insult than others do, but in the end it is still an environmental insult, which makes it just a matter of when, and not if for everyone else.

Once again; if it was just a genetic problem with the trigger pulling environment then we would not have gone from 1 out of 11,000 in 1960s to today's 1 out of 39.

Does that sound genetic to you? Are you saying to yourself yeah it does, cause it ain't 100 percent? Really?

Remember they have to make the vaccines till at least they don't kill and maimed for a while after the event. People that worked with Aluminum dust, or talcum powder takes years to succumb to their little genetic weakness. Does that really make it genetic, or just a slow poison?

Just a couple of points to add to this discussion:

1. Unavoidably unsafe-- “The Committee has set forth Comment K in this bill because it intends that the principle in Comment K regarding ‘unavoidably unsafe’ products, i.e., those products which in the present state of human skill and knowledge cannot be made safe, apply to the vaccines covered in the bill and that such products not be the subject of liability in the tort system.”
2. "Cannot be made safe," why? Because of the individual genetics; because of the ingredients; because of manufacturing? (Because Merck, Glaxo Smith Kline, Sanofi, Pfizer are felons?) Because of the FDA. All of the above?
3. More than 20+ years ago when the DPT was the issue, before Wakefield, I remember a pro-vaccine doctor saying, "if we screen all the people who could react to the DPT, there could be no mass vaccination program." There could be no mass vaccination program.
4. I remember the media would love to interview some old geezer who was having his 90th birthday and would ask him what was the secret to a long life. He was a smoker, a drinker, and chased women. I would say he had some outstanding genetics and good fortune. Where as some 40 or 50 year old would die of smoking related lung cancer. I guess he forgot to drink and chase women.

John,

Blame is probably not the best word to use as it makes people defensive. Maybe it would be better to say "taking responsibility for the outcomes of one's decisions in the knowledge of frequent outcomes." While some smokers can smoke ten packs a day for sixty years and never get lung disease, most cannot. Good genes. A few people get lung cancer despite never having smoked a cigarette in their lives. Problematic genes. But large numbers of people in the middle eventually get lung cancer as the result of having smoked. I don't know what else you can say.

While sometimes there are bad vaccine lots, as in the Cutter incident in which the polio vaccine was not properly prepared and many children got polio as a result, in most cases the same vaccine from the same lot is given to many vaccine recipients, but only a few have disabling or fatal reactions. The reason that it was they and not others is usually for genetic reason.

Dr. Moskowitz on 126 of Vaccination, said: "With autoimmunity as possibly the underlying mechanism by which vaccines do everything they do, good and bad alike, why not screen children for evidence of it in the form of C-reactive protein, erythrocyte sedimentation rate (ESR), antinuclear antibodies (ANA), and perhaps other typical markers at suitable intervals after their vaccinations? Although by no means infallible, and possibly subject to both false positives and negatives, just as in clinical medicine, it would nevertheless be a simple, interesting, and inexpensive test of that hypothesis, whether or not those testing positive actually develop symptoms at the time."

The factors resulting in elevated levels of these markers in some children but not in others would be for mainly genetic reasons. But it is a more indirect and more accurate way to identify those at greatly increased risk for vaccine reaction. Don't look for GENE X, look for genetically-designed factors which increase the chances of a hyperinflammatory and disabling reaction to vaccines.

It is a mistake to assume that the cause of vaccine reaction is usually idiopathic, of unknown and random origin. People will always say, Well, I went with my neighbor to get our identically-aged infants vaccinated, same age, same sex, same vaccines, same vials, and hers did fine, no reaction, but mine had ...... reaction. Why? It's NOT going to be Hers had Cheerios for breakfast while mine had Frosted Flakes. The cause in nearly all cases is genetic in origin, NOT faulty genes, but genes programmed to react swiftly and vigorously to an invading pathogen.

"Genes loads the gun, and the vaccines (environment) pulls the trigger."

We all have heard that.
Looking at it another way: When I was going to school, the biology professors loved to ask again, and again:
"Which is more important; genes or the environment?"

I was a baby back then, and it took a while to have the final answer to their question, and it really is not that hard.

. The environment is every thing. With out the environment there would be no genes. If they say it is genetic; then there was an environmental insult that acted on the genes; generations ago. What was that environmental insult?

it is as Mark Blaxill says: "There is no such thing as a genetic epidemic."

As autism, autoimmune numbers rise, and SAT scores plummet, and as mental health collapses as people seek treatment in a cocktails of illegal drugs from poppy fields, to Coco groves on mountain sides, to meth labs, to the distilling alcohol factories, all the way to fluoride riddled serotonin reuptake pharma drugs.

Nothing to do with the genes, and all about the environment. That is why my friend, Cia that they don't bother to look at your family's genes.

Cia

No, I think that would be a very poor way to proceed, and it is not the purpose - after three decades of smoke and mirrors they have made zero progress with identifying who should not have vaccines, and there may be plenty of other environmental and health issues that lead to bad outcomes (or for that matter variations in manufacturing standards, storage, random molecular action etc). Genes are pretty much a red-herring - research originally started by the tobacco industry on the basis that you could deflect attention from tobacco if you could show that those who got lung cancer were at fault through their genes.

http://markcrispinmiller.com/2013/08/the-cigarette-industry-spent-millions-on-genomics-research-and-somebody-just-sabotaged-a-new-report-about-it/

Cia

But I don’t think the licensing and recommending agencies should be playing roulette with our children, and denying harm.

I agree that blaming diet and lack of exercise are just excuses. I have repeatedly been accused of neglecting both of these issues when it was known that I was growing my own organic food! (Exercise and good food.) They have also said that not all autistic people are the same, and I've been pondering that. Other genetic conditions, such as Down's syndrome or Rett's, cause a characteristic appearance which is unmistakable, but autism doesn't result in any such features, another sign if any were needed that it's not in our genes!

Kate C

Yes, of course, even in 2006 Collins was not going to mention vaccination but the presence of toxic chemicals in the food chain is an evident problem and naturally he failed to do anything about that either.

https://www.ageofautism.com/2011/05/an-open-letter-to-francis-collins-54-of-american-children-suffer-f.html

What does it matter provided he strums a guitar before the Union and NIH flags?

@ go Trump...yup, AS looks as if they are just rebranding the idea from years ago. Any way AS can rake in more money the better. Look closely at the people who work for that organization. Always traveling and living it up despite some of them having autistic kids at home (who watches them all the time? Nannies no doubt...more money), wearing top of the line clothes, perfect hair at all times, living in the most expensive towns, vacationing (wth is that? must be nice!), constantly showcasing their money. Anyone who donates to them should really have their heads examined. While most people with kids on the spectrum sit home struggling to make ends meet, these people are living the high life on donations from people who believe their hype.

@Frederic Chopin,

Please let us know your age and any pertinent experience/professional credentials.

Thank you, David Burd

(now 77 years old, the healthiest generation ever - without any vaccines except some getting the DTP at age 4 years, and sailing through all the other "childhood diseases" barely noticed, AND, no such thing as "special education classrooms") - and NO autism among countless relatives neighbors, community.

Francis Crick reflected on the early days in Cambridge. . .

when it was SO easy to steal research from someone else !!

Never, never give Crick and Watson full credit. They absolutely do not deserve it. Disgusting.

Paul Shattock marvelous man very helpful when we were starting out kind words of wisdom.

I wonder if the gene science have a vaccinated and non vaccinated gene pool study or is it not needed beause our genes mutate better with heavy metals and chlorine and all the toxic vaccine contents as it would be unfair to us unvaccinated.

Chops gene pool like lots of chlorine in the pool plus mercury,big al, yup!

Pharma For Prison

MMR RIP

Soooo, did Francis Collins also have to sit down with Kennedy, Bigtree and the team of lawyers that got to interview our bunch of criminals heads of the health federal agencies?

Will justice come?
Will he end up in at least disgrace?
I suppose hoping for a long prison sentence is unlikely? The death penalty for all the children maimed and killed over the past 30 or 40 years is out of the question for sure?

Darn shame.

Many genetic variants have been linked to autism, but only a handful are potent enough to induce the disorder on their own. Among these variants, mutations in a gene called Shank3 are among the most common which accounts for 1–2% of all ASD cases. While mutations in these genes are generally rare, Zinc deficiency is not, and via interactions with the proteins encoded by these genes also leads to the development of autism and links many environmental to genetic causes. A loss of synaptic Shank3 comparable to that observed in Shank3 knock-out mice was detected in immunohistochemical and biochemical analyses of zinc deficient animals. So someone with a zinc deficiency would experience the same problems as someone with the rarer Shank3 mutation problems. Zinc shapes the properties of developing synapses via Shank proteins.

During the acute phase of an inflammatory response such as from infection, inflammation and vaccination the cytokine interleukin 6 (IL-6) is released which induces the expression of α2-macroglobulin (A2M) and Metallothionein which sequesters zinc and consequently reduces zinc availability. In pregnancy it induces both maternal and fetal hypozincemia. Interleukin-6 regulates the zinc transporter Zip14 in the liver and contributes to the hypozincemia of the acute-phase response.

Propionic acid, a short chain fatty acid, is used as an autism model in mice and rats. Increased propionic acid production and a corresponding reduction in butyric acid were also associated with zinc deficiency in young lambs https://academic.oup.com/jn/article-abstract/82/1/41/4779372 Its now been shown that treatment with a selective PPAR-α agonist (activator), fenofibrate significantly attenuated the propionic acid induced-social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity. Even better, Palmitoylethanolamide (PEA), a substance that is naturally produced in the body, not to be confused with another supplement phenylethlamine, which is also abbreviated as PEA also has shown to reverse autism in mice via PPARa activation and available over the counter. Upon PEA treatment the overall microbial community of BTBR mice was restructured and resulted significantly different from that of untreated BTBR mice. It was able to restore hippocampal BDNF signalling pathway, and improve mitochondrial dysfunction, both pathological aspects, known to be consistently associated with ASDs. Furthermore, it reduced the overall inflammatory state of BTBR mice, reducing the expression of pro-inflammatory cytokines at hippocampal, serum, and colonic level. Significant reductions of all cytokines TNFα, IL-1β, and IL-6 were found in BTBR PEA mice compared to BTBR group (It reduced cytokines both in the brain and the gut). A significant increase in gut permeability was shown in vivo in BTBR mice. The analysis of gut permeability and the expression of colonic tight junctions showed a reduction of leaky gut in PEA-treated BTBR mice. https://www.sciencedirect.com/science/article/pii/S0889159118305488

Zinc increases the gene expression of A20 and PPAR-α, the two zinc finger proteins with anti-inflammatory properties and a key finding is that all PPAR agonists (activators) tested lost their potency to downregulate the TNF-α–induced inflammatory response in zinc-deficient cells. However, if zinc was added back, all PPAR agonists significantly downregulated the TNF-α–mediated induction of inflammatory transcription factors NF-κB and AP-1 and significantly reduced the expression of their target genes, VCAM-1 and IL-6. In regards to Autism, I have compiled my ongoing research here so far I was doing occasionally on the side, take a look at the zinc/shank3 - butyrate/propionate section to start. https://tgl.ink/v0VrgZ

A quick review just now of my own research so far shows the development of autism and its rise is impacted most by nutritional status with an added emphasis on Zinc, along with Vitamin A and Magnesium. Some of the many other Influential contributors I found contributing to the rise in autism include intake of the food additive calcium propionate (E282) in processed foods (propionic acid source), glyphosate exposure, heavy metal exposure especially of mercury, cadmium and lead (all lower zinc among many effects), aluminum, vaccination, EMF exposure, pesticide exposure, higher fluoride exposure, air pollution, use of acetaminophen, dental amalgams in pregnant mother (emf including wifi increases mercury release), sugar intake, Polybrominated diphenyl ethers (PBDEs) (fire retardants), excessive synthetic folic acid intake during pregnancy, excessive iron intake (these lower zinc absorption), nanosized titanium dioxide (TiO2), thickeners and emulsifiers, factors that modify gut flora composition, infections, immune activation events and oxidative stress from the second trimester of pregnancy through early childhood.

Excellent, John.

I'd have to quibble with your wording on just one sentence: "but in terms of government approved science we are not an inch nearer discovering what is driving the autism epidemic,"

But we do have government approved science that shows what is driving the autism epidemic. It's just that the government fiddled with the results (while Rome burns). Maybe that should be the instrument Collins plays.

Posted by: Frederic Chopin | February 13, 2020 at 09:20 AM

I don't like any of your rude snarly comments. Makes food want to come back up.
Your music isn't too bad. Have to give you that. But you are certainly no scientist !

Fred

I imagine even he knew better.

John

Thank you John, well put as usual!

Not only is Dr. Collins, the NIH and most ASD researchers way off the mark, they are digging a deeper hole. What a joke that is not funny yet still laughable.

I found the article communicated little information except numbers of old genes confirmed, new genes, rare genes, genes for proteins (exomes, 1.5% if our DNA), genes that regulate other genes and genes that overlap with genes of kids with motor and other developmental delays.

Below is the concluding paragraph of Dr. Collins articles.

“Overall, these findings underscore that ASD truly does exist on a spectrum. Indeed, there are many molecular paths to this disorder. The ASC researchers continue to collect samples, so we can expect this list of 102 genes will continue to expand in the future.“

Wow, profound research findings! Digging a deeper hole to nowhere, wasting everyone’s time, careers and still not helping those suffering from ASD.

Thus all this research just confirms his opening statement in the article:

”The wide variability seen among individuals with [ASD]... has also posed a huge challenge for researchers trying to identify underlying genetic and environmental factors.”