Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain
- Xiaoyan LiuXiaoyan LiuShenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of ChinaCAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, University of Chinese Academy of Sciences, No. 11 Zhongguancun Beiyitiao, Beijing 100190, People’s Republic of ChinaAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, People’s Republic of ChinaMore by Xiaoyan Liu,
- Yingcan ZhaoYingcan ZhaoShenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of ChinaMore by Yingcan Zhao,
- Jiabin DouJiabin DouShenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of ChinaCAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, University of Chinese Academy of Sciences, No. 11 Zhongguancun Beiyitiao, Beijing 100190, People’s Republic of ChinaMore by Jiabin Dou,
- Qinghong HouQinghong HouShenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of ChinaMore by Qinghong Hou,
- Jinxiong ChengJinxiong ChengShenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of ChinaMore by Jinxiong Cheng, and
- Xingyu Jiang*Xingyu Jiang*Email for X.J.: [email protected]Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, People’s Republic of ChinaCAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, University of Chinese Academy of Sciences, No. 11 Zhongguancun Beiyitiao, Beijing 100190, People’s Republic of ChinaMore by Xingyu Jiang
Abstract
The potential toxicity of nanoplastics on plants has previously been illustrated, but whether nanoplastics could cause neurotoxicity, especially to higher animals, remains unclear. We now demonstrate that nanoplastics can be deposited in the brain via nasal inhalation, triggering neuron toxicity and altering the animal behavior. Polystyrene nanoparticles (PS-NPs) of PS-COOH and PS-NH2 are used as models for nanoplastics. We designed a microfluidic chip to evaluate the PS-NPs with different concentrations, surface ligands, and sizes to interact with neurons. Smaller PS-NPs can induce more cellular uptake than larger PS-NPs. PS-NPs with a size of 80 nm can reach and deposit in the brain of mice via aerosol inhalation. Mice inhaling PS-NPs exhibit fewer activities in comparison to those inhaling water droplets. An obvious neurotoxicity of the nanoplastics could be observed from the results of the inhibition of AChE activities. Our results show the potential significance of the physiochemical properties of organic nanoplastics on depositing in mammalian brains by nasal inhalation.
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