Christina Applegate left feeling 'trapped' in heartbreaking health update as she fights MS

Christina Applegate was diagnosed with Multiple Sclerosis back in 2021 at the age of 49, and has now opened up about the toll the condition has taken on her mentally.

The actress, now 52, revealed she has suffered from "real depression" after she was forced to come to terms with her tragic diagnosis. The star bravely spoke out during the latest episode of her podcast MeSsy, which she co-hosts with her friend Jamie-Lynn Sigler, 43.

"I'm in a depression right now, which I don't think I've felt that for years," the Days Of Our Lives star admitted.

"Like a real, f*** it all depression where it's kind of scaring me to a little bit because it feels really fatalistic. I'm trapped in like this darkness right now that I haven't felt like... I don't even know how long, probably 20-something years," the actress went on to share.

The new episode was recorded not long after Christina made a surprise appearance at the Emmy Awards in January, which Applegate referred to as "the hardest day of my life," saying that she slept for "two days" afterwards.

Speaking of the effects MS has taken on her body, Christina added: "This is being really honest...I don't enjoy living. I don't enjoy it. I don't enjoy things anymore."

Jamie-Lynn, who has been living with MS for more than 20 years since she was diagnosed while starring on The Sopranos, shared her empathy with Christina.

"It's so hard to live in a disabled body. It is so hard. I will not take that away from you and I am right there with you," Jamie-Lynn said.

She then explained: "But what makes it harder is when you compare it to how it used to be....Once we get you to this place where we're accepting that this is how it's going to be, maybe forever...[coping with MS] is not a reason enough for you to stop living because I sit here across from you and you still make me laugh like nobody else can. You still make me smile. You make me feel loved."

The Big Sky star has made her adoration for Christina no secret, as in March 2024 she told PEOPLE how important their friendship has become to each other.

Jamie-Lynn gushed over how "incredibly strong," Christina is, as she expressed: "I'm hoping that this podcast will also show you even more of your value and show you how incredibly strong you are and how much you deserve to give yourself a chance."

Christina revealed she's been reluctant to seek out therapy since she learned of her MS diagnosis, while filming the final episode of Dead To Me.

"I have avoided therapy since I've been diagnosed because I'm so afraid to start crying and that I'm not going to be able to end crying," she said.

"I just am so I'm so afraid for those floodgates to open and that I won't be able to stop."