Cytotherapy

Here are our top 8 most cited articles in 2024! What have you read in Cytotherapy that you expect to make top the list by the end of the year? Leukapheresis guidance and best practices for optimal chimeric antigen receptor T-cell manufacturing (https://lnkd.in/gPSWSnGy) Registered clinical trials investigating treatment with cell-derived extracellular vesicles: a scoping review (https://lnkd.in/gfYw9uHC) The NK-92 cell line-30 years later: its impact on natural killer cell research and treatment of cancer (https://lnkd.in/gxxhr-HY) Patient access to and ethical considerations of the application of the European Union hospital exemption rule for advanced therapy medicinal products #OpenAccess (https://lnkd.in/gKRfvpEH) Engineered exosome-mediated messenger RNA and single-chain variable fragment delivery for human chimeric antigen receptor T-cell engineering (https://lnkd.in/gKxqcThA) Adipose-derived stem cells applied in skin diseases, wound healing and skin defects: a review #OpenAccess (https://lnkd.in/g_mGpsVG) Dental pulp stem cell-derived extracellular matrix: autologous tool boosting bone regeneration (https://lnkd.in/gT6_QCR7) Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow: a pilot randomized controlled open-label clinical study with 8-year follow-up (https://lnkd.in/g2Q6zN3E)

Out now in the September issue of Cytotherapy: Process development for the production of mesenchymal stromal cell-derived extracellular vesicles in conventional 2D systems #OpenAccess #Exosomes (https://lnkd.in/g3dHE_TN) Substrate elasticity does not impact DNA methylation changes during differentiation of pluripotent stem cells #OpenAccess #StemCell (https://lnkd.in/g6UHFVj6) Adipose-derived stromal vascular fraction cells to treat long-term pulmonary sequelae of coronavirus disease 2019: 12-month follow-up #OpenAccess #StromalCell (https://lnkd.in/gfX9kbwa) Development of a robotic cluster for automated and scalable cell therapy manufacturing #OpenAccess #Manufacturing(https://lnkd.in/gaHTMGDG) You can view the full Table of Contents here: https://lnkd.in/gtDfSWUP Cover Image: Confocal image showing 3D printed GelMA laden H9C2 cells stained with phalloidin after 21 days of culture. Dr. KAVITHA GOVARTHANAN To have your image featured on the cover of a future issue of Cytotherapy, enter the #InstaYourCells competition! Submissions are open to ISCT members and non-members alike, and are open until October 31, 2024: https://lnkd.in/gjg94jZD

Did you know that Cytotherapy cover images are sourced from the #ISCTInstaYourCells contest? Tag your colleagues who capture images that you want to see on the front of our Journal, and encourage them to submit to this year's contest! To learn how you can have your image featured on the cover of a future issue, follow the link below.

In press this week, a case study on neurotoxicity associated with CAR T-cell re-expansion from Humanitas Research Hospital. chiara de philippis, A. Giacomel, U. Pensato, C. Pinton, D. Taurino, Daniele Mannina, Jacopo Mariotti, Barbara Sarina, simona marcheselli, Inna Timofeeva, R. Capizzuto, armando santoro, S. Bramanti https://lnkd.in/gM3Yt7wt

New #OpenAccess article in press! Thong Teck Tan, Ruenn Chai Lai, Wei Kian Sim, Bin Zhang, and Sai Kiang Lim described a novel approach to extracellular vesicle modulation. Extracellular Modulation of Cells by EV (EMCEV) harnesses EV attributes to generate molecules that can influence multiple cells, eliciting a response beyond a single cell. Read more: https://lnkd.in/g2PPXEv7

The August edition is here! In this issue: Current guidelines, challenges and future recommendations for regulation of stem cell research and therapy: a commentary (https://lnkd.in/gM3K2EAV) Neutrophil generation from hematopoietic progenitor cells and induced pluripotent stem cells (iPSCs): potential applications (https://lnkd.in/gpJY-auT) Treatment of post-allogeneic hematopoietic stem cell transplant cytopenias with sequential doses of multipotent mesenchymal stromal/stem cells (https://lnkd.in/gv4xhYG3) Synthetic biology approaches for enhancing safety and specificity of CAR-T cell therapies for solid cancers (https://lnkd.in/gw7DJitB) Check out the full Table of Contents here: https://lnkd.in/gwrXigea Cover Image: Whole tumor draining lymph node of a mouse with an established breast cancer tumor. Basic stains for Tertiary Lymphoid Structures (TLS) include B220 (b cells- red) and PNAd (high endothelial vessels- green). Violet Young

In Press this week, Pauline De Berdt, Elodie Deltour, Eric Pauly, Noelia Gordillo, Frederic Lin, Etienne Sokal, MD, PhD, and Mustapha NAJIMI describe a #SerumFree protocol for the expansion of liver-derived progenitor cells. They demonstrate improved stability and reduced doubling time compared to serum-containing cultures. https://lnkd.in/gxZKFsrM

Don’t miss your last chance to apply to the Innovation Zone Presentations at ISCT Europe 2024! This exclusive platform is designed for disruptive cell and gene therapy start-ups to showcase their groundbreaking technologies and elevate their corporate visibility. Selected applicants will receive a 10-minute presentation slot within the ISCT Europe Program, with the unique opportunity to receive direct feedback from a panel of industry experts including investors in the field. Apply now to claim one of our limited spaces! Applications close Friday, July 26, 2024. https://buff.ly/4eDCV0C

Have you read our July issue yet? If you are looking for a place to start, check out this #OpenAccess publication that ISCT, International Society for Cell & Gene Therapy European Committee wrote in collaboration with The EBMT. The current challenges facing the translation of cell and gene therapies in Europe are explored, with recommendations on expanding registries for real-world assessment, the role of accreditation in protecting patients, and the importance of developing the sector's workforce are highlighted, among other key issues by Fermin Sanchez-Guijo, Joaquim Vives, Annalisa Ruggeri, Christian CHABANNON, Selim Corbacioglu, Harry Dolstra, Dominique FARGE, Nico Gagelmann, Claire Horgan, Jurgen Kuball, bénédicte Neven, Tuula Rintala, Vanderson Rocha, Isabel Sanchez-Ortega, Professor JOHN SNOWDEN, Jaap Jan Zwaginga, Massimiliano Gnecchi, Anna Sureda Balari. https://lnkd.in/geRErgZZ

Now In Press, a new paper by Pedro Silva Couto, Dale Stibbs, Braulio Carrillo Sanchez, Rana Khalife, Theano Panagopoulou, PhD, Ben Barnes, Vaques George, PhD, Rouzbeh R. Taghizadeh, Ph.D., and Qasim Rafiq demonstrates a novel human #MSC line suited for suspension culture that provides a scalable platform for #manufacturing #EVs, enabling future studies. https://lnkd.in/gmtPd4vB