Carole Ho

Carole Ho

South San Francisco, California, United States
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  • Denali Therapeutics Graphic

    Denali Therapeutics

    South San Francisco, CA

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    South San Francisco, California, United States

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    Cambridge, MA

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    South San Francisco

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    Mountain View, CA

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    Stanford

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  • Stanford University Graphic

    Stanford University

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    Chief Resident, Neurology 2002

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Publications

  • TEDMED: What if we could identify who would respond to a medicine before starting treatment

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  • Parallel discovery of Alzheimer's therapeutics.

    Science translational medicine

    As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid deposition. This effort has resulted in slow progress and disappointing outcomes. Here, we describe a "portfolio approach" in which multiple distinct drug development projects are undertaken simultaneously. Although a greater upfront investment is…

    As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid deposition. This effort has resulted in slow progress and disappointing outcomes. Here, we describe a "portfolio approach" in which multiple distinct drug development projects are undertaken simultaneously. Although a greater upfront investment is required, the probability of at least one success should be higher with "multiple shots on goal," increasing the efficiency of this undertaking. However, our portfolio simulations show that the risk-adjusted return on investment of parallel discovery is insufficient to attract private-sector funding. Nevertheless, the future cost savings of an effective AD therapy to Medicare and Medicaid far exceed this investment, suggesting that government funding is both essential and financially beneficial.

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