Kiho Lee
North Kingstown, Rhode Island, United States
350 followers
351 connections
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Experienced Scientist with 10+ years of work experience developing anti-infective and…
Activity
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It's our favorite time of year again! We're thrilled to announce this year's finalists for the LabCentral Ignite Golden Ticket! 🏆 Our Golden Ticket…
It's our favorite time of year again! We're thrilled to announce this year's finalists for the LabCentral Ignite Golden Ticket! 🏆 Our Golden Ticket…
Liked by Kiho Lee
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We are thrilled to announce that PhagePro, led by 2020 Termeer Fellow, Minmin Yen, Ph.D., MPH (she/her), has been awarded a significant START grant…
We are thrilled to announce that PhagePro, led by 2020 Termeer Fellow, Minmin Yen, Ph.D., MPH (she/her), has been awarded a significant START grant…
Liked by Kiho Lee
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I am thrilled to announce that my latest research paper has been published! 🎉📚 You can read it here "https://rdcu.be/dQlI7". A big thank you to my…
I am thrilled to announce that my latest research paper has been published! 🎉📚 You can read it here "https://rdcu.be/dQlI7". A big thank you to my…
Liked by Kiho Lee
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Bildung
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서울대학교 (Seoul National University)
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- Stress response to ROS and osmotic stress in C. elegans
- Signaling pathway and target gene identification of transcription factor -
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Publications
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An Intestine-Derived Neuropeptide Controls Avoidance Behavior in Caenorhabditis elegans
Cell Reports
See publicationAdjusting to a continuously changing environment is a key feature of life. For metazoans, environmental changes include alterations in the gut microbiota, which can affect both memory and behavior. The bacteriovorous nematode Caenorhabditis elegans discriminates between pathogenic and non-patho- genic food sources, avoiding the consumption of pathogens. Here, we demonstrate the role of the in- testine in regulating C. elegans avoidance to Pseudo- monas aeruginosa by an insulin-like neuropeptide…
Adjusting to a continuously changing environment is a key feature of life. For metazoans, environmental changes include alterations in the gut microbiota, which can affect both memory and behavior. The bacteriovorous nematode Caenorhabditis elegans discriminates between pathogenic and non-patho- genic food sources, avoiding the consumption of pathogens. Here, we demonstrate the role of the in- testine in regulating C. elegans avoidance to Pseudo- monas aeruginosa by an insulin-like neuropeptide encoded by ins-11. The transcriptional expression of ins-11 is controlled through transcription factor hlh-30 and the p38 mitogen-activated protein kinase (MAPK) pathway. ins-11 negatively controls signal pathways in neurons that regulate aversive learning behavior. Attenuation of ins-11 increased avoidance behavior and survival on pathogenic bacteria but decreased opportunities to find a food source as well as lowered energy storage and the number of viable progeny. Our findings support a role for the intestine in avoidance and identify an advanta- geous role for negative feedback that allows C. elegans to actively balance noxious and favorable environments.
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Apoptosis in C. elegans: lessons for cancer and immunity.
Frontiers in Cellular and Infection Microbiology
doi:10.3389/fcimb.2013.00067/full
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Identification of genes interacting with rnt-1 through large-scale RNAi screening in Caenorhabditis elegans.
G3 (Bethesda)
G3 (Bethesda) 3, 1779–1784 (2013).
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Stabilization of RNT-1 Protein, Runt-related Transcription Factor (RUNX) Protein Homolog of Caenorhabditis elegans, by Oxidative Stress through Mitogen-activated Protein Kinase Pathway.
Journal of Biological Chemistry
Journal of Biological Chemistry 287, 10444–10452 (2012).
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An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs
Expert Opinion on Drug Discovery
More activity by Kiho
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Thank you WIT WebInTravel for the feature! We are delighted to announce that TOURVIS (part of the TIDESQUARE Group) has become the first OTA in…
Thank you WIT WebInTravel for the feature! We are delighted to announce that TOURVIS (part of the TIDESQUARE Group) has become the first OTA in…
Liked by Kiho Lee
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We are so grateful to announce that PhagePro is one of the recipients of the MassVentures START Phase I grants! Huge thank you to MassVentures, the…
We are so grateful to announce that PhagePro is one of the recipients of the MassVentures START Phase I grants! Huge thank you to MassVentures, the…
Liked by Kiho Lee
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K바이오 영감발전소가 된 '오름테라퓨틱 5년과 두 차례 빅딜' 느긋한 몸짓, 느릿한 말투, 두상이 다 드러나도록 짧게 친 머리. 대중 앞에 나서는 일도 드물고, 나선다 해도 할 일만 마치고 조용히 사라진다. 그렇게 수면 아래서 무언가 열심히 하고는, 짠 하고 나타나…
K바이오 영감발전소가 된 '오름테라퓨틱 5년과 두 차례 빅딜' 느긋한 몸짓, 느릿한 말투, 두상이 다 드러나도록 짧게 친 머리. 대중 앞에 나서는 일도 드물고, 나선다 해도 할 일만 마치고 조용히 사라진다. 그렇게 수면 아래서 무언가 열심히 하고는, 짠 하고 나타나…
Liked by Kiho Lee
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Thank you Nature Portfolio for supporting phage therapy. We were able to get a big paper published on these 100 phage therapy cases. This issue…
Thank you Nature Portfolio for supporting phage therapy. We were able to get a big paper published on these 100 phage therapy cases. This issue…
Liked by Kiho Lee
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We are pleased to invite you to a guest lecture by Professor Myunghoon Roh from Salve Regina University, USA, at the University of Sarajevo - Faculty…
We are pleased to invite you to a guest lecture by Professor Myunghoon Roh from Salve Regina University, USA, at the University of Sarajevo - Faculty…
Liked by Kiho Lee
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Very proud of this work but disappointed with the findings on how diverse representation in COVID-19 trials evolved over the pandemic. Among 157…
Very proud of this work but disappointed with the findings on how diverse representation in COVID-19 trials evolved over the pandemic. Among 157…
Liked by Kiho Lee
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A few weeks ago, our CEO Minmin Yen, Ph.D., MPH (she/her) had the amazing opportunity to travel to the Netherlands with The Termeer Foundation. Many…
A few weeks ago, our CEO Minmin Yen, Ph.D., MPH (she/her) had the amazing opportunity to travel to the Netherlands with The Termeer Foundation. Many…
Liked by Kiho Lee
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Yesterday during Innovation for Health the finals of the Annual Global Investor Forum Start-up Pitch contest - Powered by Axon lawyers took place at…
Yesterday during Innovation for Health the finals of the Annual Global Investor Forum Start-up Pitch contest - Powered by Axon lawyers took place at…
Liked by Kiho Lee
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