Search Results (1,337)

Urban parks enhance residents’ quality of life and health by fostering a harmonious relationship between people and nature, so effective park design needs to prioritize ecological protection, sustainable landscapes, and practical spatial structures to achieve these benefits. This study takes the typical case of urban park renovation and reconstruction—Kowloon Walled City Park—as an example to conduct research and divides the interior of the park into four types of areas: contemporary built-up area; historical relic area; natural–folk custom area; and ecological conservation area. Based on 405 valid questionnaire data for respondents, this study conducts empirical research using a combination of the Semantic Differential (SD) method, Importance Performance Analysis (IPA) model, and unordered multivariate logit choice model, comprehensively describes and analyzes individual spatial perception and preferences, and further discusses the potential factors affecting individual perception preferences. The results show that there are differences in many characteristics between different areas in Kowloon Walled City Park. At the same time, people generally prefer park areas that integrate modern and traditional elements, natural and cultural environments, and pay attention to the balance between naturalness and sociality in park design. These results provide useful information for planners, developers, and others, as well as data for designing urban park construction with higher practical value and natural benefits. Full article

Architecture is the stone book of history, and the evolution of architectural styles showcases a non-verbal history constructed through images. As an important part of China’s historical and cultural heritage, the architectural forms and styles of Tibetan Buddhist temples were initially modeled on Tang dynasty temple architecture and gradually evolved into the most significant architectural types in regions such as Tibet and Qinghai in China. Religious architecture has also played a significant role in shaping regional cultural landscapes. Existing research on Tibetan Buddhist temples is primarily focused on qualitative studies of individual temple buildings. This research takes the spatiotemporal evolution of architectural styles of Tibetan Buddhist temples as an entry point and, for the first time, employs ArcGIS technology to visualize the spatial and geographical distribution of Tibetan Buddhist temples from the 7th to the 18th century, establishing a comprehensive academic vision that encompasses both historical stratification and cross-regional spatial correlations. By analyzing the cultural symbolic features embodied in the construction styles of Tibetan Buddhist temples and the visual characteristics reflected in their decorative arts, we propose two spatiotemporal dimensions for the formation and transmission of Tibetan Buddhist temple architectural styles: “Westward Transmission” and “Eastward Diffusion”. Firstly, from the 7th to the 9th centuries, the architectural style and construction techniques of Tang dynasty Buddhist temples were transmitted westward along the Tang–Tibet ancient road, integrating with local Tibetan elements to form the Tubo architectural style, which was further refined into the “Sino–Tibetan Combined Style” with strong visual characteristics around the 13th century. Subsequently, along with the spread of Tibetan Buddhism, this temple architectural style underwent an eastward diffusion from the 13th to the 18th century, reaching regions, such as Sichuan, Qinghai, Gansu, Inner Mongolia, Hebei, and Beijing, presenting a spatial gradient from west to east in the geographical dimension. On this basis, in this research, we construct a historical evolution mapping of Tibetan Buddhist temple architectural styles based on bidirectional transmission, attempting to elucidate that the intrinsic driving forces are religious and the cultural identity that guided the bidirectional transmission mechanism of these architectural styles under the historical context of the formation and dissemination of Tibetan Buddhism from the 7th to the 18th century. Full article

The historic city of Macau is China’s 31st world heritage site, and its residents have actively contributed to preserving its heritage and will continue to reside there for the foreseeable future. Residents’ satisfaction with the current urban environment is closely related to the landscape characteristics of the towns surrounding the historic center of Macau. This study aims to analyze the relationship between landscape characteristics and residents’ satisfaction, determine the key factors affecting their satisfaction and how they are combined, and provide a scientific basis for urban planning. This study used a decision tree machine learning model to analyze 524 questionnaire survey responses that addressed five aspects of the historic town’s landscape: the architectural, Largo Square, street, mountain and sea, and commercial landscapes. The data-driven approach helped find the best decision path. The results indicate that (1) the layout of Largo Square, the commercial colors and materials, the location of the former humanities and religion center, and the commercial signage system are the primary factors influencing residents’ satisfaction. (2) Incorporating decision tree parameters with information entropy as the splitting criterion and a minimum sample split number of two (with no maximum depth) led to the best performance when investigating residents’ satisfaction with Macau’s historic town landscape characteristics. (3) A reasonable layout for Largo Square (satisfaction > 3.50), prominent and harmonious commercial colors and materials (satisfaction > 3.50), rich cultural and religious elements (satisfaction > 4.50), and an excellent commercial signage system (satisfaction > 4.00) can significantly improve residents’ satisfaction. This provides important empirical support and a reference for urban planning and landscape design in Macau and other historical and cultural cities. Full article

We assess the ecosystem services across the entire Baltic Sea using ecosystem model simulations and historical socio-economic data. Our approach covers 150 years, aggregated for the years around 1880, 1960, and 2010. The ecosystem services assessed include commercially usable wild fish biomass and wild plant biomass, water quality regulation (nitrogen and phosphorus retention), carbon storage, biodiversity and habitats, as well as active recreation and landscape aesthetics. In 2010, the commercially usable fish biomass in the entire Baltic Sea was 9.24 million tons. The total retention of nitrogen in the Baltic Sea was 884,135 t/a, phosphorus retention was 32,058 t/a, and carbon storage was 3,668,100 t/a. Between 1880 and 2010, the Baltic Sea-wide average biodiversity index decreased from 73 to 60, the active recreational quality index decreased from 76 to 69, and the observational recreation index declined from 91 to 78. In 2010, the most monetarily significant single ecosystem service in the Baltic Sea was nitrogen retention with EUR 26,822 million/a, followed by cultural ecosystem services. Other relevant services were fish catches (EUR 277 million/a), phosphorus retention (EUR 3854 million/a), and carbon storage (202 million/a). The latter recently showed a steep increase due to rising prices for CO₂ certificates. Full article

Despite the advances in modern cancer therapy, malignant diseases are still a leading cause of morbidity and mortality worldwide. Conventional treatment methods frequently lead to side effects and drug resistance in patients, highlighting the need for novel therapeutic approaches. Recent findings have identified the existence of non-canonical micropeptides, an additional layer of the proteome complexity, also called the microproteome. These small peptides are a promising class of therapeutic agents with the potential to address the limitations of current cancer treatments. The microproteome is encoded by regions of the genome historically annotated as non-coding, and its existence has been revealed thanks to recent advances in proteomic and bioinformatic technology, which dramatically improved the understanding of proteome complexity. Micropeptides have been shown to be biologically active in several cancer types, indicating their therapeutic role. Furthermore, they are characterized by low toxicity and high target specificity, demonstrating their potential for the development of better tolerated drugs. In this review, we survey the current landscape of known micropeptides with a role in cancer progression or treatment, discuss their potential as anticancer agents, and describe the methodological challenges facing the proteome field of research. Full article

This study focuses on the environmental colors of the Historic Center of Macau, seeking pathways to develop an urban color system to construct a high-quality urban aesthetic environment and enhance the overall visual image of the city. Based on Lenclos’s color geography and Shingo Yoshida’s environmental color planning method, this study conducted on-site color measurement, extraction, photographic documentation, numerical analysis, and color cataloging of the architecture, plazas, landscapes, and primary public facilities in Macau’s historical district. Through comprehensive environmental color investigation and analyses, the study aimed to construct a color system for Macau’s historical district, finally identifying 60 characteristic colors emblematic of the area. This study also uncovered issues, such as the lack of a unified management mechanism for environmental colors, insufficient coherence and correlation among regional colors, or the scarcity of striking colors. Ultimately, the proposed systematic approach to urban color can offer effective concepts for planning, design, and management, facilitating the creation of color expressions that align with Macau’s unique characteristics and thereby elevating the city’s overall visual image. Full article

Garlic constitutes a significant small-scale agricultural commodity in China. A key factor influencing garlic prices is the planted area, which can be accurately and efficiently determined using remote sensing technology. However, the spectral characteristics of garlic and winter wheat are easily confused, and the widespread intercropping of these crops in the study area exacerbates this issue, leading to significant challenges in remote sensing image analysis. Additionally, remote sensing data are often affected by weather conditions, spatial resolution, and revisit frequency, which can result in delayed and inaccurate area extraction. In this study, historical data were utilized to restore Sentinel-2 remote sensing images, aimed at mitigating cloud and rain interference. Feature combinations were devised, incorporating two vegetation indices into a comprehensive time series, along with Sentinel-1 synthetic aperture radar (SAR) time series and other temporal datasets. Multiple classification combinations were employed to extract garlic within the study area, and the accuracy of the classification results was systematically analyzed. First, we used passive satellite imagery to extract winter crops (garlic, winter wheat, and others) with high accuracy. Second, we identified garlic by applying various combinations of time series features derived from both active and passive remote sensing data. Third, we evaluated the classification outcomes of various feature combinations to generate an optimal garlic cultivation distribution map for each region. Fourth, we developed a garlic fragmentation index to assess the impact of landscape fragmentation on garlic extraction accuracy. The findings reveal that: (1) Better results in garlic extraction can be achieved using active–passive time series remote sensing. The performance of the classification model can be further enhanced by incorporating short-wave infrared bands or spliced time series data into the classification features. (2) Examination of garlic cultivation fragmentation using the garlic fragmentation index aids in elucidating variations in accuracy across the study area’s six counties. (3) Comparative analysis with validation samples demonstrated superior garlic extraction outcomes from the six primary garlic-producing counties of the North China Plain in 2021, achieving an overall precision exceeding 90%. This study offers a practical exploration of target crop identification using multi-source remote sensing data in mixed cropping areas. The methodology presented here demonstrates the potential for efficient, cost-effective, and accurate garlic classification, which is crucial for improving garlic production management and optimizing agricultural practices. Moreover, this approach holds promise for broader applications, such as nationwide garlic mapping. Full article

This study aims to investigate the cognitive mechanisms of rural residents amidst the renewal of suburban historical and cultural villages by examining the interplay between nostalgia, collective memory, subjective well-being, and place identity in rural tourism destinations. Using Naobao Village as a case study—a suburban historical and cultural village in Hohhot, Inner Mongolia—this research employs a comprehensive approach integrating experimental methods and questionnaire surveys. The findings demonstrate that analyzing the interaction among the four emotions can elucidate the cognitive mechanism of residents. Moreover, it uncovers that positive tourism effects significantly influence residents’ perception of their living environment with positive effects on collective memory, subjective well-being, and place identity. In the theoretical model for generating cognition among residents in suburban historical and cultural villages, subjective well-being and collective memory play crucial mediating roles. This study offers a novel perspective for spatial reconstruction and cultural evolution of tourist landscapes in suburban rural tourist destinations. Full article

Wild populations of New England cottontails (NECs, Sylvilagus transitionalis) are declining and occupy a small proportion of their historic range. To conserve this species, wild-caught cottontails participate in a reintroduction breeding program. To increase the program’s productivity, this study described breeding behavior in pairings with (n = 3 pairings) and without (n = 9 pairings) reproductive success. Females were paired with two males consecutively and behaviors were recorded using 24 h continuous video footage. Activity peaked between 19:00 and 06:00. Copulation was only observed in successful pairings, and the gestation period was 31 days. Successful pairings had a significantly higher rate of follows (p < 0.001) and a lower rate of dashes (p < 0.0001) compared to unsuccessful pairings. Females had significantly higher rates of charge (p < 0.0005), chase (p < 0.0003), and dash (p < 0.0016) than males. Males had higher rates of follow (p < 0.005) than females. Males and females altered their behavior in the presence of different potential mates, suggesting that mate compatibility may influence breeding program productivity. This study significantly expands the understanding of NEC breeding behavior and is applicable to the management of this imperiled species living at low densities in fragmented landscapes. Full article

The standard of care for advanced or metastatic urothelial carcinoma (mUC) was historically identified with platinum-based chemotherapy. Thanks to the advances in biological and genetic knowledge and technologies, new therapeutic agents have emerged in this setting recently: the immune checkpoint inhibitors and the fibroblast growth factor receptor inhibitors as the target therapy for patients harboring alterations in the fibroblast growth factor receptor (FGFR) pathway. However, chasing a tumor’s tendency to recur and progress, a new class of agents has more recently entered the scene, with promising results. Antibody–drug conjugates (ADCs) are in fact the latest addition, with enfortumab vedotin being the first to receive accelerated approval by the U.S. Food and Drug Administration in December 2019, followed by sacituzumab govitecan. Many other ADCs are still under investigation. ADCs undoubtedly represent the new frontier, with the potential of transforming the management of mUC treatment in the future. Therefore, we reviewed the landscape of mUC treatment options, giving an insight into the molecular basis and mechanisms, and evaluating new therapeutic strategies in the perspective of more and more personalized treatments. Full article

Climate change intensifies the frequency and severity of extreme weather events, profoundly altering demographic landscapes globally and within the United States. This study investigates their impact on migration patterns, using propensity score matching and LASSO techniques within a larger regression modeling framework. Here, we analyze historical population trends in relation to climate risk and exposure metrics for various hazards. Our findings reveal nuanced patterns of climate-induced population change, including “risky growth” areas where economic opportunities mitigate climate risks, sustaining growth in the face of observed exposure; “tipping point” areas where the amenities are slowly giving way to the disamenity of escalating hazards; and “Climate abandonment” areas experiencing exacerbated out-migration from climate risks, compounded by other out-migration market factors. Even within a single county, these patterns vary significantly, underscoring the importance of localized analyses. Projecting population impacts due to climate risk to 2055, flood risks are projected to impact the largest percentage of areas (82.6%), followed by heatwaves (47.4%), drought (46.6%), wildfires (32.7%), wildfire smoke (21.7%), and tropical cyclone winds (11.1%). The results underscore the importance of understanding hyperlocal patterns of risk and change in order to better forecast future patterns. Full article

The Maasai Mara and the wider Mau River Basin in East Africa provide fundamental ecosystem services that support people, wildlife, livestock and agriculture. The historical indigenous land use of the Mara and wider Mau basin was wildlife conservation and pastoralism with highland agriculture. However, land policy changes, the rise of community conservancies and the increase in human populations have mediated unprecedented land use shifts over time. We analyze land use and land cover change (LULCC) trends from 1990 to 2040 in the Mara and the wider Mau River Basin landscape. The study examines land use and land cover change trends, establishes factors driving the trends, and assesses the implications of these trends on biodiversity. Multi-temporal satellite images, together with physical and social economic data, were collated to generate future scenarios for transitions for forest, shrubland, grassland, cropland, wetlands and built-up areas between 1990 and 2040. Agricultural expansion is the chief driver of LULCC in the Mara and the wider Mau River Basin, particularly since 2015. There was insignificant change to the forest cover after 2015, which was in part due to government intervention on forest encroachment and boundaries. The anthropogenic choice of tilling the land in the basin caused a decline in grasslands, forests and expanded shrublands, particularly where there was clear tree cutting in the Mau forest. Land use and land cover trends have generated undesirable impacts on ecosystem services that support wildlife conservation. Full article

Just over thirty years is the span of a generation. It is also the time that has passed since the discovery of the gene responsible for cystic fibrosis. Today, it is safe to say that this discovery has revolutionized our understanding, research perspectives, and management of this disease, which was, thirty years ago, a pediatric condition with a grim prognosis. The aim of this review is to present the advances that science and medicine have brought to our understanding of the pathophysiology of the disease and its management, which in many ways, epitomizes modern molecular genetic research. Since the discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in 1989, modeling the CFTR protein, deciphering its function as an ion channel, and identifying its molecular partners have led to numerous therapeutic advances. The most significant advancement in this field has been the discovery of protein modulators that can target its membrane localization and chloride channel activity. However, further progress is needed to ensure that all patients can benefit from a therapy tailored to their mutations, with the primary challenge being the development of treatments for mutations leading to a complete absence of the protein. The present review delves into the history of the multifaceted world of CF, covering main historical facts, current landscape, clinical management, emerging therapies, patient perspectives, and the importance of ongoing research, bridging science and medicine in the fight against the disease. Full article

We used cluster analysis on 200-year-old tree-ring chronologies to examine the patterns that emerge from self-organization, driven by environmental heterogeneity, that might drive diversification in ponderosa pine (Pinus ponderosa). We determined the natural patterns on the landscape and then tested these groups against historically separated varieties within this species that could be evidence of diversification. We used 178 previously collected tree-ring chronologies from the western United States that were archived in the International Tree-Ring Databank. We explored a variety of clustering techniques, settling on Ward’s clustering with Euclidian distance measures as the most reasonable clustering process. These techniques identified two (p = 0.005) to ten (p = 0.01) potential natural clusters in the ponderosa pine chronologies. No matter the number of clusters, we found that the ponderosa pine varieties ponderosa and benthamiana always cluster together. The variety scopulorum differentiates clearly on its own, but brachyptera is a mix of diverse groups, based on the environmental driving factors that control tree-ring chronology variability. Cluster analysis is a useful tool to examine natural grouping on the landscape using long-term tree-ring chronologies, enabling the researcher to examine the patterns of environmental heterogeneity that should lead to speciation. From this analysis, we suggest that the brachyptera variety should be more varied genetically. Full article

Building on the observation of gaps in current research, this study provides a comprehensive analysis of the spatial patterns of heritage sites along the Silk Road, focusing on how historical trade routes shaped what are now recognized as heritage sites. Using data from the United Nations Educational, Scientific and Cultural Organization (UNESCO) World Heritage List, the research examines heritage sites across Eurasia and North Africa, with a specific emphasis on the Silk Road corridors. This study employs a spatiotemporal approach, categorizing sites into northern overland routes and southern maritime routes to highlight regional variations in network development. The key findings of this study reveal the significant influence of historical trade routes on the development of settlements, cities, and cultural landmarks along the Silk Road. These findings identify clear trends in the Silk Road network’s evolution over time, illustrating a shift in its spatial focus across different historical periods. Initially, the network was centered in the eastern Mediterranean during the Classical Period. In the medieval period, this focus expanded to include a dual core area in both the eastern Mediterranean and Central Asia. By the late Medieval period, the network had shifted again, with a new core emerging in Europe. This chronological and spatial analysis allows for a detailed examination of the Silk Road network’s heritage landscape evolution. The study underscores the interconnectedness of heritage sites across these regions, contributing to a deeper understanding of how landscape connectivity and trade network dynamics evolved over time. Furthermore, by identifying patterns of network development and shifts in centrality and density, this research offers valuable insights for the conservation and management of heritage landscapes. These findings are particularly crucial for preserving the historical and cultural integrity of Silk Road heritage sites. Full article