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Burman Thyroid Disorders and Diseases PDF
Burman Thyroid Disorders and Diseases PDF
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The faculty and staff of the University of Virginia Office of Continuing Medical Education have no financial affiliations to
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The authors/editors listed below have identified no professional or financial affiliations for themselves
or their spouse/partner:
Jaime P. Almandoz, MD, BCh; Rebecca S. Bahn, MD; Gabriela Brenta, MD; Rosalinda Y. Camargo, MD, PhD; Maria Grazia
Castagna, MD, Sara Danzi, PhD; Leonidas H. Duntas, MD; James A. Garrity, MD; Hossein Gharib, MD, MACP, MACE;
Rachel Glover, (Acquisitions Editor); Megan R. Haymart, MD; Steven P. Hodak, MD; Jacqueline Jonklaas, MD, PhD;
Irwin Klein, MD; Joanna Klubo-Gwiezdzinska, MD, PhD; Priya Kundra, MD; Geraldo Medeiros-Neto, MD, MACP; Furio
Pacini, MD; Maria Papaleontiou, MD; Geanina Popoveniuc, MD; Mary H. Samuels, MD; Stuart C. Siegel, MD; Marius N.
Stan, MD; Nikolaos Stathatos, MD; Shannon D. Sullivan, MD, PhD; Eduardo K. Tomimori, MD, PhD; Andrew Wolf, MD
(Test Author); and Cynthia F. Yazbeck, MD.
The authors/editors listed below identified the following professional or financial affiliations for themselves
or their spouse/partner:
Kenneth D. Burman, MD (Guest Editor) is an industry funded research/investigator for Pfizer and Eisai; is an author
for UpToDate and Medscape; is on the Advisory Board for the FDA, Endocrine Committee; is the Deputy Editor,
Journal of Clinical Endocrinology & Metabolism; is on the Editorial Board, Medullary Thyroid Cancer Committee, for
the American Thyroid Association.
Leonard Wartofsky, MD, MPH, MACP is a consultant for Asurogen.
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RELATED INTEREST
Endocrinology and Metabolism Clinics of North America, June 2008
(Volume 37, Issue 2)
Thyroid Tumors
Shereen Ezzat, MD, and Sylvia L. Asa, MD, PhD, Guest Editors
VISIT US ONLINE!
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Contributors
GUEST EDITOR
KENNETH D. BURMAN, MD
Director, Endocrine Section, Washington Hospital Center, Washington, DC
AUTHORS
JAIME P. ALMANDOZ, MB, BCh
Fellow, Division of Endocrinology, Diabetes, Metabolism and Nutrition; Mayo School
of Graduate Medical Education, College of Medicine, Mayo Clinic, Rochester, Minnesota
REBECCA S. BAHN, MD
Professor of Medicine, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic,
Rochester, Minnesota
GABRIELA BRENTA, MD
Department of Endocrinology, Dr Cesar Milstein Hospital, Buenos Aires, Argentina
KENNETH D. BURMAN, MD
Director, Endocrine Section, Washington Hospital Center, Washington, DC
ROSALINDA Y. CAMARGO, MD, PhD
Assistant Professor of Medicine, Thyroid Unit, Division of Endocrinology, University
of Sao Paulo Medical School, Sao Paulo, Brazil
MARIA GRAZIA CASTAGNA, MD
Section of Endocrinology and Metabolism, University of Siena, Siena, Italy
SARA DANZI, PhD
Assistant Professor, Department of Biological Sciences and Geology, Queensborough
Community College, Bayside, New York
LEONIDAS H. DUNTAS, MD
Professor of Endocrinology, Endocrine Unit, Evgenidion Hospital, University of Athens,
Athens, Greece
JAMES A. GARRITY, MD
Consultant in Ophthalmology, Professor of Ophthalmology, Department of Ophthalmology,
Mayo Clinic School of Medicine, Mayo Clinic, Rochester, Minnesota
HOSSEIN GHARIB, MD, MACP, MACE
Consultant, Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic,
Rochester, Minnesota
vi
Contributors
MEGAN R. HAYMART, MD
Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Diabetes,
and Hematology/Oncology, Department of Medicine, University of Michigan Health
System, Ann Arbor, Michigan
STEVEN P. HODAK, MD
Clinical Associate Professor of Medicine, Medical Director, Centre for Diabetes and
Endocrinology, Division of Endocrinology and Metabolism, Department of Medicine,
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
JACQUELINE JONKLAAS, MD, PhD
Associate Professor, Division of Endocrinology, Georgetown University Medical Center,
Washington, DC
IRWIN KLEIN, MD
Private Practice, Great Neck, New York
JOANNA KLUBO-GWIEZDZINSKA, MD, PhD
Division of Endocrinology, Department of Medicine, Washington Hospital Center,
Washington, DC; Department of Endocrinology and Diabetology, Collegium Medicum
in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland
PRIYA KUNDRA, MD
Endocrine Section, Washington Hospital Center; Assistant Clinical Professor of Medicine,
Georgetown University Hospital, Washington, DC
GERALDO MEDEIROS-NETO, MD, MACP
Senior Professor of Endocrinology, Division of Endocrinology, Department of Medicine,
University of Sao Paulo Medical School, Sao Paulo, Brazil
FURIO PACINI, MD
Section of Endocrinology and Metabolism, Department of Internal Medicine,
Endocrinology and Metabolism and Biochemistry, University of Siena, Siena, Italy
MARIA PAPALEONTIOU, MD
Fellow, Division of Metabolism, Endocrinology and Diabetes, Department of Medicine,
University of Michigan Health System, Ann Arbor, Michigan
GEANINA POPOVENIUC, MD
Endocrine Fellow, Division of Endocrinology, Georgetown University Medical Center;
Section of Endocrinology, Washington Hospital Center, Washington, DC
MARY H. SAMUELS, MD
Professor of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon
Health and Science University, Portland, Oregon
STUART C. SEIGEL, MD
Fellow, Division of Endocrinology and Metabolism, Department of Medicine, University
of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
MARIUS N. STAN, MD
Consultant in Endocrinology, Division of Endocrinology, Metabolism and Nutrition,
Assistant Professor of Medicine, Mayo Clinic School of Medicine, Mayo Clinic,
Rochester, Minnesota
Contributors
NIKOLAOS STATHATOS, MD
Thyroid Unit, Department of Medicine, Massachusetts General Hospital, Harvard
Medical School, Boston, Massachusetts
SHANNON D. SULLIVAN, MD, PhD
Assistant Professor of Medicine, Georgetown University School of Medicine; Staff
Physician, Department of Endocrinology, Washington Hospital Center, Washington, DC
EDUARDO K. TOMIMORI, MD, PhD
Assistant Professor, Section of Ultrasonography at the Hospital das Clnicas, University
of Sao Paulo Medical School, Sao Paulo, Brazil
LEONARD WARTOFSKY, MD, MPH, MACP
Professor of Medicine, Department of Medicine, Washington Hospital Center,
Washington, DC
CYNTHIA F. YAZBECK, MD
Fellow, Division of Endocrinology and Metabolism, University of Pittsburgh Medical
Center, Pittsburgh, Pennsylvania
vii
Contents
Preface: Thyroid Disorders and Diseases
xiii
Kenneth D. Burman
Thyroid Physiology
165
Nikolaos Stathatos
The thyroid gland produces thyroid hormone, which has clinically important actions practically in every system in the human body. Detailed
knowledge of the physiology of the thyroid gland is critical for the proper
management of thyroid disorders. The molecular biology of thyroid function is being studied in great detail. Clinically important molecules, such
as the thyroid-stimulating hormone receptor and the sodium/iodide symporter, have been identified and well characterized. Such discoveries
have significantly improved our understanding of thyroid physiology.
As a result, new diagnostic and therapeutic approaches for the management of thyroid disorders are now available or in development.
Thyrotoxicosis
175
203
223
Inhalt
present with a triphasic course: a brief period of thyrotoxicosis due to release of preformed thyroid hormone that lasts for 1 to 3 months, followed
by a more prolonged hypothyroid phase lasting up to 6 months, and eventual return to a euthyroid state. However, the types and degree of thyroid
dysfunction are variable in these disorders, and individual patients may
present with mild or more severe cases of thyrotoxicosis alone, hypothyroidism alone, or both types of thyroid dysfunction.
235
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269
Inhalt
283
297
311
Thyroid Nodules
Geanina Popoveniuc and Jacqueline Jonklaas
Thyroid nodules are common entities, clinically important primarily
because of their malignant potential. Serum thyrotropin and thyroid ultrasonography are pivotal in evaluating thyroid nodules. Fine-needle aspiration biopsy is the most accurate tool for diagnosing malignancy and
selecting candidates for surgery. An approach to the initial evaluation
and management of single nodules, functioning nodules, multinodular
glands, incidental nodules, and cysts is discussed, as are therapeutic
interventions for benign nodules. Thyroid cancer discovered during pregnancy is also discussed.
329
xi
xii
Inhalt
351
369
385
405
Preface
Thyroid Disorders and Diseases
Kenneth D. Burman, MD
Guest Editor
Thyroid disorders and diseases are common and thyroid cancer is increasing at an
alarming rate. It seems particularly propitious to have an issue of Medical Clinics of
North America devoted to these general topics at the present time. Indeed, we are
extremely fortunate to have contributions from a group of internationally respected
authorities who review recent developments and put them into a practical clinical
perspective. Important, clinically relevant topics such as thyroid hormone pathophysiology, evaluation and treatment of hyperthyroidism and hypothyroidism, and
approach to thyroid emergencies are discussed. There are many newer aspects of
thyroid pathophysiology and thyroid diseases that are being explored. For example,
the normal TSH reference range in elderly patients is now considered different from
younger individuals; thus, decisions with regard to which patients should be treated
for hypothyroidism are now more complex. The application of modern technology,
such as the use of molecular diagnostic techniques, sonographic elastography, and
surgical approaches to patients with thyroid nodules and cancer, has already modified
clinical practice. The variable and important effects of thyroid hormone excess and
deficiency on cardiac function and lipid metabolism are also discussed. The pathophysiology, assessment, and treatment of Graves ophthalmopathy, a particularly difficult disorder to treat, are reviewed. Diagnostic evaluation and management approach
to patients with thyroid nodules, thyroid cancer, goiters, and thyroiditis are also discussed with practical, clinical advance given. Thyroid function in pregnancy is reviewed with clinical discussion regarding the expected changes in thyroid hormone
metabolism during pregnancy. There are new recommendations regarding the
approach to hypothyroid pregnant women who require additional levothyroxine
therapy during gestation. There is an increasing movement toward developing
evidence-based clinical guidelines. Recent guidelines regarding thyroid nodules and
thyroid cancer, as well as thyroid physiology and perturbations in disease during pregnancy, are also highlighted.
xiv
Preface
Chekhov said Knowledge is of no value unless you put it into practice. We hope
this issue will help you understand important and common thyroid disorders and
diseases and that this knowledge will be applied in both clinical and research spheres
to help humankind.
I am indebted to each of the authors, who eagerly discussed their topics in
a detailed and clinically relevant manner. The editor is also indebted to Ms Forcina
and Ms Glover from Elsevier, without whose assistance this edition could not have
been accomplished.
Kenneth D. Burman, MD
Endocrine Section
Washington Hospital Center
110 Irving Street, NW, Room 2A-72
Washington, DC 20010-2975, USA
E-mail address:
[email protected]
T h y ro i d P h y s i o l o g y
Nikolaos Stathatos,
MD
KEYWORDS
Thyroid physiology Thyroxine Triiodothyronine Deiodinase
Nuclear receptors
The thyroid gland is a butterfly-shaped organ located anteriorly to the trachea at the
level of the second and third tracheal rings. It was so named by Thomas Wharton in
1656, not because of its shape (thyreos in Greek means shield), but because of its
similarity in shape to the nearby thyroid cartilage of the larynx.1
Three major components play a role in regulating the production of thyroid
hormones: First is the thyroid gland itself with its functional unit, the thyroid follicle;
this is the location of synthesis and release into the circulation of thyroid hormone.
The other 2 components are the hypothalamus and the pituitary gland.
THYROID EMBRYOLOGY
Embryologically, the thyroid gland is the earliest endocrine structure to appear during
human development.2 It originates from the embryonic endoderm. The earliest
morphologic evidence for the thyroid gland is the thyroid enlage (or thyroid placode),
a thickening of the endodermal layer in an area overarching the aortic arch.3 The
appearance is evident at about embryonic day 22 in humans. With the development
of modern techniques in molecular biology, there is now evidence that the development of the thyroid enlage is not the first step in the development of the primitive thyroid
follicular cells. The expression of transcription factors (such as the NK2 homeobox
[Nkx2]-1 and paired box [Pax]-8) that are critical for the development of the thyroid
gland has been documented 12 to 24 hours before thickening occurs. It is obvious
that a complex, but recently more clearly elucidated sequence of embryonic events
needs to take place for the normal development of the thyroid gland.3 A defect in
any of these events can lead to number of developmental thyroid anomalies that range
from complete or partial agenesis of the thyroid gland4 resulting in congenital hypothyroidism, to syndromes of reduced sensitivity to thyroid hormone.5
The primitive thyroid gland continues to expand ventrally while remaining attached
to the pharyngeal floor by a stalk, called thyroglossal duct. As the gland expands laterally to form the 2 lobes, the lumen of the thyroglossal duct disappears, and in most
cases the duct itself is no longer present at the end of this process. Occasionally,
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however, a significant remnant is not only detectable after birth or during adult life,6 but
significant abnormality can originate there, including thyroid malignancies.7 Remnants
of thyroid tissue or, occasionally, the only thyroid tissue in the body can be detected as
distantly from the normal adult anatomic position of the thyroid gland as the base of
the tongue, the embryonic origin of the gland.8
Thyroid hormone is first detected in the human fetal circulation at about 11 to 13
weeks of gestation. The responsiveness of the different developing tissues to thyroid
hormones seems to be tightly regulated, as evidenced by a sufficient amount of
thyroid hormone being critical for the proper development of specific cellular functions
in embryonic neural cells9 as well as the expression of different deiodinases at
different time points, usually before specific developmental points. There is evidence,
for example, that the development of specific parts of the brain is preceded by the
increased expression of deiodinases in those regions that allows conversion of
thyroxine (T4) to the more active triiodothyronine (T3). This step seems to be a critical
and necessary one for the proper development of these regions of the brain. A large
body of literature is now available, including guidelines from the major medical organizations (eg, the American Thyroid Association and the Endocrine Society), indicating
the importance of proper management of thyroid dysfunction during pregnancy.10
A developmentally separate part of the thyroid gland is a group of cells that are
present in between the thyroid follicles, called parafollicular cells (also called C-cells).
Parafollicular cells are the main source of the hormone calcitonin, but their embryologic origin is different. These cells originate in the embryonic ectoderm and migrate
into the thyroid gland during the development of the gland itself.
HYPOTHALAMIC-PITUITARY-THYROID AXIS
The functional unit of the thyroid gland is the thyroid follicle (Fig. 3). This follicle is
a cystic structure the wall, made up of a single layer of specialized epithelial cells often
referred to as thyrocytes or follicular cells. The content of the follicle is termed colloid.
Thyroid Physiology
It is largely made up of thyroglobulin (Tg), a large glycoprotein (w660 kDa) that serves
as the main storage form of thyroid hormone.
TSH exerts its effects on thyrocytes through its specific receptor known as the TSH
receptor (TSHR),14 located on the basolateral thyrocyte membrane. TSHR is a 7-transmembrane G-coupled receptor protein. Its structure and role in thyroid pathology has
been extensively studied. Antibodies against this receptor are central in the development of Graves disease, the most common form of hyperthyroidism.15 The intracellular
effects of activation of this receptor are mainly mediated by the stimulation of adenylyl
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Fig. 3. Thyroid histology. (1) Thyroid follicle. (2) Follicular cells. (3) Parafollicular (C-) cells.
Thyroid Physiology
including thyroid cancer. Loss of expression in thyroid cancer cells leads to decreased
iodine uptake in malignant thyrocytes, resulting in a reduced efficacy of radioactive
iodine as both a diagnostic and therapeutic tool. Medications that may induce redifferentiation and reexpression of NIS have been investigated (lithium, rosiglitazone18) or
are currently under investigation (eg, BRAF inhibitors).
Once in the thyrocytes, iodine is organified into tyrosine residues present in Tg. This
process takes place at the apical membrane of these cells facing the colloid (see
Fig. 5). The thyroid peroxidase (TPO) enzyme is a key player in this process, together
with hydrogen peroxide.19 TPO is a selenoprotein (a protein with selenium incorporated into its tertiary structure). The regulation of the activity of this enzyme is quite
complex, iodine being a very important factor. Exposure to excess amounts of iodine
is known to block TPO activity, a phenomenon known as the Wolff-Chaikoff effect.20
Clinically this can lead to hypothyroidism. However, over time thyrocytes can eventually overcome this blockade, and this can lead to increased production of thyroid
hormone. This phenomenon is known as the escape from the Wolff-Chaikoff effect.21
These events are characteristically seen in thyrocytes that are replete of iodine. By
contrast, when a thyrocyte deplete in iodine is exposed to iodine, it increases production of thyroid hormone significantly, often leading to biochemical and clinical hyperthyroidism. This process is known as the Jod-Basedaw effect.22 The mechanism for
this phenomenon is unclear, but it is thought to be caused either by rapid iodination
of poorly iodinated Tg or by the fueling of a subclinical autonomous functioning thyroid
tissue, as in a hot nodule or in Graves disease.23
TPO also seems to be a target in the autoimmune processes such as Hashimoto
thyroiditis. Detection of antibodies against TPO is diagnostic of thyroid autoimmunity,
usually Hashimoto thyroiditis,24 although they are detectable in the majority of patients
with Graves disease as well.25
Another protein closely involved in the organification of iodine together with TPO is
pendrin (see Fig. 5).26 A rare genetic disorder called Pendred syndrome includes the
clinical findings of sensorineural deafness and a goiter attributable to partial iodine
organification defect.27
Tg, as already mentioned, is a large glycoprotein that represents the main storage
form of thyroid hormone. When thyrocytes are stimulated by TSH, Tg is endocytosed
and cleaved to release T4 and/or (T3). Tg is critical for the normal function of the thyroid
gland and its measurement is a very important clinical tool, mainly in the management
of thyroid cancer. It is one of the more immunogenic thyroid-related proteins, and
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antibodies against Tg have been reported even in approximately 20% of people with
no apparent thyroid pathology.
PERIPHERAL ACTIONS OF THYROID HORMONES
Thyroid hormones circulate in blood mainly bound to carrier proteins (less than 1% is
circulating in a free unbound form). It is the small free amount of thyroid hormone that
is thought to be metabolically active at the tissue level. More than 95% of the serum
thyroid hormones are bound to 3 carrier proteins: thyroid-binding globulin (TBG),
transthyretin, and albumin.28 Thyroid hormone has also been shown to be bound to
lipoproteins29 and thyroid hormone autoantibodies of the immunoglobulin G class.30
These carrier proteins function on one hand as an extrathyroidal depot of thyroid
hormone, containing hormone that can be immediately available to peripheral tissues
as needed, while on the other hand protecting them from exposure to excess amounts
of thyroid hormone. The role of these carrier proteins is best illustrated in those
unusual situations whereby genetic mutations lead to altered amounts and/or
structures of these proteins and the resulting clinical and biochemical picture of the
patients carrying these mutations. One such example is a condition known as familial
dysalbuminemic hyperthyroxinemia, the result of mutations of the albumin gene,
which leads to a 60-fold increase in the affinity of albumin for thyroxine.31 Biochemically this results in an elevated level of serum thyroxine, a normal TSH, and
a state of clinical euthyroidism.
Passive diffusion had been postulated to be the main mode whereby thyroid
hormone(s) enter target cells. However, transporting proteins that seem to be critical
in this process have now been identified. Members of this group include the monocarboxylate transporter 8 (MCT8), MCT10, and the organic anion transporting polypeptide 1C1 (OATP1C1).32 Differential tissue expression has been documented, with
OATP1C1, for example, being predominantly expressed in brain capillaries. OATP1C1
has a higher affinity for T4 than for other iodinated compounds.33 The clinical relevance
of transporting proteins is again demonstrated in cases of genetic mutations. For
example, mutations of the gene encoding MCT8 result in a clinical phenotype of
severe psychomotor retardation and elevated levels of serum T3.34
T4 is often referred to as the prohormone, indicating that conversion to the active T3
is required for biological activity. This conversion is catalyzed by a group of selenoproteins called diodinases. Three different isoforms have been described: D1, D2, and D3.
Tissue-specific expression and different functions have been described for each of
these.
Type 1 deiodinase (D1) has been shown to catalyze the conversion of T3 to both the
active triiodothyronine and its inactive counterpart, reverse T3 (rT3).35 However, it
seems to have an increased affinity for rT3. As a result, it has been described a scavenger enzyme with a role of deiodinizing inactive iodothyronines, clearing them from
the circulation, and recycling of iodine. A more recently noted function of D1 is in
the biosynthesis of thyronamines, a class of endogenous compounds that appears
to antagonize actions of thyroid hormone.36 Although their exact role in thyroid physiology remains largely unknown, a promising therapeutic potential has already been
described for thyronamines, as they represent the only endogenous compounds
able to induce hypothermia as a prophylactic or for acute treatment of stroke.37
Type 2 deiodinase (D2) is the main thyroid hormone activator, converting the prohormone T4 to the active T3.38 Furthermore, D2 regulates intracellular T3 actions by regulating the availability of its nuclear receptors (thyroid receptors a and b). D2, together
with D3, is the most important regulator of serum T3 levels.
Thyroid Physiology
Type 3 deiodinase (D3) catalyzes the conversion of T4 to the biologically inactive rT3
and T3 to 3,30 -diiodothyronine, which is also inactive. D3 likely represents the physiologic inactivator of thyroid hormones.39 Rare cases of consumptive hypothyroidism
have been described whereby D3 is overexpressed in hemangiomas. The result is
a state of hypothyroidism caused by excessive degradation of T3 and T4.40
Thyroid hormones exert their actions mainly by binding and activating specific
nuclear receptors. These receptors are transcriptionally active proteins that cause
expression of thyroid hormoneresponsive genes. The actions of thyroid hormones
through these receptors are called genomic.
There are 2 major subtypes of thyroid receptors (TR): TRa and TRb. However, there
are several isoforms (TRa1, TRa2, TRb1, TRb2). Each isoform seems to have a tissuespecific function. For example, T3-mediated cardiovascular effects are mediated by
the TRa1 isoform,41,42 whereas those on plasma cholesterol are mediated by
TRb1.43 Recently, not only has manipulation of specific isoforms been shown to be
clinically possible, but pharmacologic agents such as sobetirome or eprotirome,
selective TRb1 agonists, are currently entered in clinical trials for the management
of hypercholesterolemia.44
More recently, nongenomic actions of thyroid hormone have been described that
are mediated through either nonnuclear actions of these receptors4547 or novel
cell-surface receptors.48,49
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40. Jassam N, Visser TJ, Brisco T, et al. Consumptive hypothyroidism: a case report
and review of the literature. Ann Clin Biochem 2011;48(Pt 2):1869.
41. Johansson C, Vennstrom B, Thoren P. Evidence that decreased heart rate in
thyroid hormone receptor-alpha1-deficient mice is an intrinsic defect. Am J Physiol 1998;275(2 Pt 2):R6406.
42. Gloss B, Trost S, Bluhm W, et al. Cardiac ion channel expression and contractile
function in mice with deletion of thyroid hormone receptor alpha or beta. Endocrinology 2001;142(2):54450.
43. Gullberg H, Rudling M, Forrest D, et al. Thyroid hormone receptor beta-deficient
mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A)
response to thyroid hormone but display enhanced resistance to dietary cholesterol. Mol Endocrinol 2000;14(11):173949.
44. Ladenson PW. Thyroid hormone analogues: ready for prime time. Thyroid 2011;
21(2):1012.
45. Hiroi Y, Kim HH, Ying H, et al. Rapid nongenomic actions of thyroid hormone.
Proc Natl Acad Sci U S A 2006;103(38):141049.
46. Lei J, Nowbar S, Mariash CN, et al. Thyroid hormone stimulates Na-K-ATPase
activity and its plasma membrane insertion in rat alveolar epithelial cells. Am J
Physiol Lung Cell Mol Physiol 2003;285(3):L76272.
47. Moeller LC, Cao X, Dumitrescu AM, et al. Thyroid hormone mediated changes in
gene expression can be initiated by cytosolic action of the thyroid hormone
receptor beta through the phosphatidylinositol 3-kinase pathway. Nucl Recept
Signal 2006;4:e020.
48. Bergh JJ, Lin HY, Lansing L, et al. Integrin alphaVbeta3 contains a cell surface
receptor site for thyroid hormone that is linked to activation of mitogenactivated protein kinase and induction of angiogenesis. Endocrinology 2005;
146(7):286471.
49. Davis PJ, Davis FB, Cody V. Membrane receptors mediating thyroid hormone
action. Trends Endocrinol Metab 2005;16(9):42935.
173
T h y ro t o x i c o s i s
Stuart C. Seigel,
MD,
Steven P. Hodak,
MD*
KEYWORDS
Hyperthyroidism Thyroid metabolic function Thyrotoxicosis
EPIDEMIOLOGY
Several large studies conducted in varying populations have contributed to the understanding of the prevalence of thyrotoxicosis (Table 1).
Generally, the prevalence of thyrotoxicosis is more common in women and populations with iodine deficiency.24 Subclinical hyperthyroidism (SH), a condition associated with thyroid autonomy, is more common in areas of iodine deficiency.2,4,5
CLINICAL PRESENTATION
176
Table 1
Epidemiology of thyroid disease
Study
Study Population
Prevalence of Thyrotoxicosis
Iodine-Sufficient Population
Wickham survey2
NHANES III3
US civilian noninstitutionalized
population aged 12 years and
older
Iodine-Deficient Population
Pescopagano survey4
US civilian noninstitutionalized
population
Colorado Thyroid
Disease Prevalence
Study5
Wickham survey2
Pescopagano survey4
There are multiple imaging modalities that can be used to help determine the cause of
a thyrotoxic state. In this section the usefulness of radioiodine, technetium 99m (Tc
99m) pertechnetate, and ultrasonography is discussed. Although they are all helpful
Table 2
Clinical symptoms and signs of thyrotoxicosis
Symptoms of Thyrotoxicosis in Order
of Decreasing Frequency
Weight loss (most common)
Heat intolerance
Tremor
Palpitations
Anxiety
Increased frequency of bowel movement
Neck enlargement
Shortness of breath
Weight gain
a
Thyrotoxicosis
in the diagnosis of thyrotoxicosis, they each have specific benefits and limitations. An
appreciation of these factors can help the clinician choose the most appropriate test in
any given clinical context.
Radionuclide Imaging
177
178
The most sensitive and specific assay for assessment of suspected thyrotoxicosis is
TSH.15 TSH is reported on a log-linear scale such that very small changes in free T4
are expressed as larger changes in TSH. This situation explains why TSH is considerably more sensitive than direct thyroid hormone measurements in detecting thyroid
hormone excess. If hyperthyroidism is strongly suggested, the presence of an
increased serum free T4 in conjunction with a suppressed TSH at the time of initial
evaluation improves diagnostic accuracy because it confirms that the suppression
of TSH is a result of thyrotoxicosis and not another cause.10
Typically, overt thyrotoxicosis presents with suppression of TSH and increases in
either T4 or T3 or both. However, in milder thyrotoxicosis, TSH may be suppressed
because of T3 toxicosis and present with normal levels of T4 and an isolated increase
of T3. Such a pattern can occur during early stages of Graves disease, TMNG, or an
autonomously functioning thyroid nodule.10,16 For that reason, we recommend assessment of T3 in addition to T4 whenever a clinical suspicion of thyrotoxicosis exists.
The ratio of T3 to T4 may help distinguish whether thyrotoxicosis is caused by
increased or decreased thyroid gland metabolism. Patients with hyperthyroidism related
to Graves disease or TMNG have an increased serum ratio of total T3 to total T4. This
finding is secondary to the production of thyroglobulin, with a higher T3 content and
the increased thyroidal deiodination of T4 to T3 because of an accelerated and disordered thyroid metabolism.17 Usually patients with Graves disease or TMNG have
a T3/T4 ratio greater than 20, whereas patients with thyroiditis have a ratio less than 20.18
Thyrotoxicosis
Thyroid receptor antibodies are not routinely required and are rarely needed to
establish the cause of a thyrotoxic state. However, they do have some clinical usefulness. If thyrotoxicosis develops during pregnancy when radionuclide thyroid scanning
is contraindicated, the measurement of thyroid receptor antibodies may prove useful
for distinguishing Graves disease from gestational thyrotoxicosis. Because maternal
TSH receptor antibodies also cross the placenta, they can stimulate the neonatal
thyroid gland, resulting in fetal goiter or hyperthyroidism.19 Therefore, mothers with
a history of Graves disease, even if already adequately treated with radioiodine or
a thyroidectomy, should have thyroid receptor antibody levels measured at 22 to 26
weeks of gestation to determine whether closer neonatal monitoring is needed.10
Thyroid receptor antibodies may be helpful in establishing the diagnosis of Graves
disease in the approximately 10% of patients who present without overt biochemical
thyrotoxicosis but nonetheless have Graves ophthalmopathy.20
Two major types of assays are used to measure thyroid receptor antibodies. Radioreceptor assays measure the inhibition of binding of labeled TSH to TSH receptors in
the presence of the patients serum or serum IgG fraction. Antibodies measured by
this assay are termed TSH receptor binding inhibitory antibodies (TBIIs).20 TBIIs are
found in 95% of untreated patients with Graves thyrotoxicosis, 50% of patients with
Graves thyrotoxicosis who are in remission after cessation of thionamide therapy,
and 15% of patients with chronic autoimmune thyroiditis.21 In vitro bioassays measure
the ability of the patients serum or serum IgG fraction to increase the levels of cyclic
adenosine monophosphate (cAMP) production in cultured cells. Antibodies measured
by this assay are called thyroid receptor-stimulating antibodies or thyroid-stimulating
immunoglobulins (TSIs). These antibodies are both more sensitive and since they are
positive in 94% of patients with untreated Graves disease, 91% of patients who
relapse after a course of antithyroid medications, and only 10% of patients with
chronic autoimmune thyroiditis.22,23
THYROTOXICOSIS CAUSED BY INCREASED THYROID GLAND METABOLISM
Graves Disease
179
180
modifiable risk factor for Graves ophthalmopathy. Almost 50% of patients with Graves
disease report symptoms of Graves ophthalmopathy, which include the sensation of
dry and gritty eyes, photophobia, excessive tearing, double vision, and a sense of
pressure behind the eyes.28 Of patients with Graves ophthalmopathy, 3% to 5%
have severe disease, with intense pain, inflammation, corneal ulceration or infection,
and optic neuropathy secondary to optic nerve compression.28,29 Enzmann and
colleagues30 showed that in patients without clinical ophthalmopathy, an orbital
computed tomography (CT) scan still showed orbital muscle enlargement in up to
40% of patients. Up to 13% of patients with severe ophthalmopathy have pretibial
myxedema, and 25% of patients with pretibial myxedema have thyroid acropachy.
Laboratory evaluation typically shows an undetectable TSH, an increased free T4
with an increased T3/T4 ratio. Evidence of thyroid enlargement and thyroid bruit
with concomitant ophthalmopathy strongly suggests Graves disease and often obviates radionuclide scanning and thyroid antibody testing. However, a radioactive iodine
uptake and scan may be useful when the diagnosis is in question.10 Radionuclide
testing usually shows diffuse increased homogeneous uptake. If a radioactive uptake
and scan are contraindicated, as is the case during pregnancy or lactation, or are not
feasible because of recent iodine exposure, measurement of Graves diseaseassociated antibodies such as TSI or TBII may be useful if Graves disease is suspected. As discussed previously, color Doppler ultrasonography may show increased
thyroidal blood flow, which can be used to make the diagnosis of Graves disease as
well.10,12,13
There are multiple options for the treatment of Graves disease. In patients with
symptomatic thyrotoxicosis, a resting heart rate more than 90 beats per minute, or
coexistent cardiovascular disease, a b-adrenergic antagonist should be started.10
Adrenergic signs and symptoms such as tremor, tachycardia, systolic hypertension,
nervousness, and anxiety also rapidly respond to b-adrenergic blockade.31 For definitive therapy, patients with overt Graves hyperthyroidism should be treated with antithyroid medication (antithyroid drugs [ATDs]), I 131 ablation, or thyroidectomy.10
In contrast to European physicians, who favor ATDs and thyroidectomy as the therapies of choice, US physicians have been shown to prefer radioactive iodine ablation.32,33 Radioactive iodine ablation is generally well tolerated and is associated
with a relapse rate of about 21%.25 About 80% to 90% of patients with Graves disease
who undergo radioiodine ablation develop hypothyroidism.34 Complications may
include short-term worsening of hyperthyroidism and rarely include thyroid storm.
Pretreatment and posttreatment with ATDs may thus be beneficial.10 In addition,
studies have shown an increased risk of worsening Graves ophthalmopathy in patients
treated with radioactive iodine therapy. This situation is believed to be caused by an
increase in thyrotropin receptor antibody (TRAb) levels as a response to greater
antigen exposure as the thyroid gland is destroyed after treatment.3537
In contrast to radioactive iodine therapy, thyroidectomy results in a relapse rate of
only 5%.25 Concern about possible adverse surgical outcomes has contributed to
the decreased preference for thyroidectomy as the definitive treatment of Graves
disease among physicians in the United States. However, high-volume surgeons
have been shown to have very low complication rates of permanent hypocalcemia
and recurrent laryngeal nerve injury. In addition, recent studies have shown a statistically significant association between increasing surgical experience and improved
patient outcomes.33,38,39
The goal of antithyroid medication is to induce a euthyroid state by decreasing the
production of thyroid hormones. Although spontaneous remission after ATDs is possible, Graves disease recurs in approximately 40% of patients.25 ATDs are generally
Thyrotoxicosis
well tolerated; however, mild adverse side effects, including an abnormal sense of
taste, pruritis, arthralgias, and urticaria, may occur in 1% to 5% of cases.40 Agranulocytosis, a rare but dangerous complication, occurs with an incidence of 0.2% to 0.5% in
patients taking methimazole or propylthiouracil (PTU), and often presents with a fever or
sore throat.41 In addition, both methimazole and PTU may cause hepatotoxicity,
a serious side effect, which is reported in 0.1% to 0.2% of treated patients.42 PTUrelated hepatotoxicity usually takes the form of an allergic hepatitis associated with
markedly increased aminotransferase levels and submassive or massive hepatic
necrosis on liver biopsy.42 The hepatic abnormalities associated with methimazole
therapy are typical of a cholestatic process, with biopsy specimens showing preserved
hepatocellular architecture along with intracanalicular cholestasis and mild periportal
inflammation.42 Antineutrophil cytoplasmic antibody-positive vasculitis has also been
reported to be associated with ATD therapy.42
Given that ATDs, radioactive iodine ablation, and thyroidectomy have been shown
to be effective and relatively safe, it is important to consider the logistics, benefits,
expected speed of recovery, drawbacks, potential side effects, and cost before
committing to a specific treatment modality (Table 3).10 The physician can make a recommendation based on clinical judgment, taking into account the patients personal
values and preferences.
Toxic Adenoma
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182
Table 3
Factors that may play a role in determining the treatment of Graves disease
Modality
Favorable Factors
Contraindications
Radioactive iodine
ablation
Pregnancy
Lactation
Coexisting thyroid cancer
Suspicion of thyroid cancer
Women planning a pregnancy
in 46 months
Inability to comply with
radiation safety
ATDs
Thyroidectomy
Substantial comorbidity,
cardiopulmonary disease,
or end-stage cancer
Pregnancy (relative
contraindication)
Thyrotoxicosis
clones are then believed to further proliferate under the influence of growth factors,
forming small clonal populations of autonomously functional tissue. These small
lesions eventually expand to become clinically relevant autonomously functioning
thyroid nodules.
Patients with TMNG may present with signs and symptoms of subclinical or overt
hyperthyroidism. The diagnosis can be made based on a combination of laboratory,
clinical, and imaging data similar to that described for TAs. However, the pattern of
radionuclide scanning shows multiple nodules with increased uptake. Physical examination may reveal a heterogeneously enlarged thyroid. Nodules may also be palpable;
however, even nodules greater than 1.5 cm elude detection by palpation in up to 60%
of cases.50 A radionuclide uptake and scan typically show areas of both increased and
decreased activity scattered throughout the gland, reflecting the presence of hyperfunctioning nodules distributed within suppressed extranodular thyroid tissue.9
As with toxic solitary nodules, multiple toxic nodules also rarely involute and resolve
spontaneously. Up to 95% of affected patients require definitive management with
thyroidectomy or radioactive iodine ablation.51 In patients undergoing I 131 radioiodine ablation, euthyroidism is achieved in 50% to 60% by 3 months and 80% by 6
months. Retreatment is required in approximately 20% of cases.10 Surgical treatment
with near-total or total thyroidectomy results in euthyroidism within days after surgery.
In contrast to radioactive I 131 therapy, which can result in hypothyroidism, requiring
exogenous replacement in 3% of patients at 1 year and 64% at 24 years, total thyroidectomy results in hypothyroidism nearly 100% of the time.10
Iodine-induced Hyperthyroidism
Box 1
Conditions in which iodine supplementation may lead to IIH
Endemic iodide-deficiency goiter
Euthyroid patients with Graves disease especially after ATD therapy
Patients with multinodular goiters who reside in areas of iodine repletion or deficiency
Nontoxic nodular goiter
Nontoxic diffuse goiter
Nodular functional autonomy
Data from Roti E, Vagenakis AG. Effect of excess iodide: clinical aspects. In: Braverman LE,
Utiger RD, editors. Werners and Ingbars the thyroid. 9th edition. Philadelphia: Lippincott
Williams & Wilkins; 2005. p. 290300.
183
184
Box 2
Iodine-rich products
Iodine-containing vitamins
Kelp
Kombu, an edible kelp
Iodinated contrast agents
Amiodarone
Some forms of gestational trophoblastic disease (GTD) may present with significantly
increased levels of circulating b-hCG. However, these patients rarely experience
symptomatic hyperthyroidism. Walkington and colleagues62 showed that among
196 patients with choriocarcinoma treated with chemotherapy in Sheffield, England,
14 (7%) were found to have biochemical hyperthyroidism, but only 4 were symptomatic. Lockwood and colleagues63 found that women with hCG concentrations of
greater than >400,000 IU/L, consistently had TSH suppression; however, few of these
women showed signs and symptoms of hyperthyroidism.
Treatment of hyperthyroidism in patients with molar pregnancies should be directed
toward the cause of the increased HCG levels. Extirpation of the tumor results in rapid
resolution of the thyrotoxic state.62,64 In symptomatically thyrotoxic patients with GTD,
in addition to treating the primary tumor, treatment with ATDs may also be helpful.10
Thyrotoxicosis
Although exceptionally rare, it has been shown that patients with molar pregnancy can
develop thyroid storm, which requires appropriately intensive management.64
Testicular Germ Cell Tumors
There have been multiple case reports of thyrotoxicosis in patients with testicular
cancer.65,66 Most patients with hyperthyroidism from testicular germ cell tumors
have metastatic choriocarcinoma.67 The positive correlation between HCG and T4
levels suggests that HCG is also the cause of hyperthyroidism in these patients.68
Of patients with metastatic nonseminomatous germ cell tumors, 3.5% have hyperthyroidism and HCG levels greater than 50,000 IU/L. In addition, 50% of patients with
HCG levels greater than 50,000 IU/L have hyperthyroidism.66
Recognition of thyrotoxic symptoms in patients with metastatic testicular germ cell
tumors can be difficult because they may overlap with those of metastatic disease.66
Therefore, screening thyroid function tests should be obtained in patients with HCG
levels more than 50,000.66
Treatment of these patients with chemotherapy results in rapid decline in HCG and
FT4; however, an initial rapid surge in HCG may occur and can rarely result in thyroid
storm.66 Treatment of hyperthyroidism may include a thionamide and a b-adrenergic
antagonist if necessary in addition to treatment of the primary tumor.10,66
TSH-secreting Pituitary Adenoma
TSH-secreting pituitary adenoma (TSHoma) is a rare disease and accounts for less
than 2% of all pituitary tumors, with an incidence of 1 case per million.69 The number
of recorded cases has tripled in the last decade as a result of the improved sensitivity
of the immunometric assays for TSH. Although the tumor can occur at any age, most
patients are diagnosed between the third and sixth decade of life.70 These tumors are
almost always benign; however, transformation into pituitary carcinoma has been
reported.71
TSHoma presents with increased levels of circulating thyroid hormones in the presence of an unsuppressed TSH. When this pattern of thyroid function tests is present,
the differential diagnosis includes TSHoma and pituitary resistance to thyroid hormone
(PRTH), which is discussed later. Because most TSH-secreting tumors are macroadenomas, sellar imaging is important for confirming the diagnosis. The use of a molar
a subunit/TSH ratio is also helpful when TSHoma is suspected. It is calculated by
dividing the a subunit value (expressed as mg/L) by the TSH value (expressed as
mU/L) and multiplying by 10. A normal ratio should be less than 1. This calculation
is most helpful for assessment of TSH macroadenomas because it is increased in
greater than 80% of cases. The calculation is less reliable in the uncommon setting
of TSH macroadenomas, in which it is reported to be normal in 60% of cases. In addition, the ratio may be falsely increased in some normal patients, and may be substantially higher in normal postmenopausal women. This ratio should therefore be
interpreted with appropriate caution.72,73
The diagnosis of TSHoma is often delayed. It is not infrequently confused with
Graves disease because of the presence of a goiter, which often occurs as a result
of chronic stimulation of the thyroid by the autonomous production of TSH. Inappropriate thyroidectomies and radioiodine ablations have been reported in such patients,
who are often incorrectly diagnosed until they present with headaches and visual field
deficits related to the mass effect of the tumor.74 The initial treatment of choice is
surgical revision of the tumor. If surgery fails or is not possible, somatostatin
analogues and stereotactic radiation therapy can be considered. For thyrotoxic symptoms, ATDs and b-adrenergic blockers are helpful.75
185
186
Thyrotoxicosis
Most affected patients present with a hypothyroid phase. However, 32% of women
have an antecedent hyperthyroid phase, with 93% of the hyperthyroid episodes occurring at 6 months post partum.85 Although most thyrotoxic patients develop symptoms,
about one-third of patients are asymptomatic.86 The thyrotoxicosis typically resolves in
2 to 3 months if left untreated. The TSH is usually low, and free T4 levels are increased
or normal. Most often, TPOAbs are positive, whereas TSI and TBII are negative.
The development of postpartum Graves disease is less common than PPT, but it is
necessary to distinguish between the 2 because management differs. Women with
Graves disease typically have a more pronounced goiter and thyroid bruit. Ophthalmopathy when present is strongly suggestive of Graves disease, as is a marked increase
in the T3/T4 ratio. An I 123 or technetium scan may be necessary to make the distinction between Graves disease and PPT. Both of these agents are excreted in breast
milk, which contraindicates active nursing if a scan is performed. However, both
agents have a short half-life, of 15 hours to 3 days and up to 36 hours for Tc 99m
and I 123, respectively. Breast feeding should be discontinued for an appropriate
period after treatment with one of these agents. Nursing can safely resume thereafter.
b-Adrenergic blockers are also excreted in breast milk but may still be used to reduce
the hyperadrenergic symptoms during the thyrotoxic phase of thyroiditis. If bblockade is required for a nursing mother, the lowest dose possible should be used
to minimize exposure to the nursing infant.10 Although all b-blockers are excreted in
breast milk, some have more favorable pharmacokinetics making use during pregnancy when medically necessary. Water-soluble b-adrenergic blockers with low
protein binding such as atenolol, sotalol, and acebutalol are excreted in high levels
in breast milk and should be avoided.87 Because of their more favorable pharmacokinetics, we recommend use of the nonselective b-adrenergic antagonist propranolol or
the b-1selective agent metoprolol when symptomatic treatment is necessary. For
propranolol, the maximum dose ingested by the infant is reported to be 0.1% of the
maternal dose.88 Metoprolol is rapidly cleared by infants with normal liver function.10,88 Cessation of nursing should not be necessary when either of these medications is used at low to moderate doses.
Silent Painless Thyroiditis
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188
Thyrotoxicosis
Radiation thyroiditis, a side effect of radioactive iodine therapy, is a painful inflammation of the thyroid and occurs in 1% of patients undergoing treatment. It can result in
thyrotoxicosis as a result of the destruction-mediated release of thyroid hormone.34
Treatment usually consists of NSAIDs, and b-blockers; however, steroids should be
considered in patients with refractory pain. External beam radiation can also have
effects on the thyroid, as shown by Nishiyama and colleagues,112 who prospectively
assessed acute reactions of the thyroid to external neck irradiation. These investigators followed thyroid function tests among 22 individuals who underwent radiation
therapy with a treatment field that included the thyroid. Patients showed both mild
biochemical thyrotoxic and hypothyroid phases; however, clinical symptoms did not
occur. Increases in total T4, free T4, and total T3 trended upwards during radiotherapy
but did not reach significance. At 6 months, which was the duration of the study, the
TSH level was significantly higher than the initial baseline levels, whereas the free t4
was significantly lower. The investigators believed the small changes in thyroid
189
190
function were a direct effect of radiation exposure, probably caused by mild thyroid
inflammation.
Thyrotoxicosis Factitia
SPECIAL CASES
Struma Ovarii
Struma ovarii is an ovarian tumor, typically associated with a teratoma, that contains
differentiated and potentially functional thyroid epithelium. Thyrotoxicosis is an unusual
manifestation occurring in only 8% of patients with struma ovarii and is most commonly
caused by autonomous function of the thyroid epithelium of the tumor.10 Patients with
Graves disease have rarely been reported to have persistent or recurrent hyperthyroidism caused by the action of the TRAb on the ectopic thyroid tissue.118
Laboratory evaluation reveals a suppressed TSH, an increased thyroglobulin level,
and T3 level may be increased.119 Radioactive iodine uptake is decreased at the
thyroid; however, a whole-body radioactive iodine scan usually shows positive uptake
in the pelvis.120
Surgical resection is the initial treatment of choice because of the risk of developing
carcinoma. In cases of malignant struma ovarii, total thyroidectomy usually follows
resection of the tumor to facilitate the subsequent use of ablative radioactive iodine
therapy. Preoperative treatment with b-adrenergic blocking agents and ATDs may
be necessary to establish euthyroidism before surgery.10
Metastatic Functioning Differentiated Thyroid Cancer
Thyrotoxicosis caused by metastatic thyroid cancer is rare. Most reported cases are
caused by follicular carcinoma with functioning metastases in the lungs and bones at
presentation. Papillary thyroid carcinoma has been reported in only 5 cases.121
Establishing the diagnosis of metastatic thyrotoxicosis requires the exclusion of
a hyperfunctioning thyroid gland, evidence of radioactive iodine uptake in the metastatic lesions, and failure of the thyrotoxicosis to resolve after thyroidectomy.122
In most reported cases, hyperthyroidism was already established at the time the
thyroid cancer was discovered. In the remainder of the cases, hyperthyroidism
occurred after the diagnosis of thyroid carcinoma.122
The symptoms of hyperthyroidism in these patients can range from those of mild
thyroxicosis to overt thyroid storm, which is reported occasionally.113,123
Treatment of these patients includes local debulking with surgery, interventional
vascular procedures to disrupt tumor blood supply, and radioactive iodine with the
addition of ATDs as needed. Thyrotoxicosis has been reported after thyrotropin injections used for imaging and iodine ablation and should therefore be used with appropriate caution in these patients.10
Thyrotoxicosis
Subclinical Hyperthyroidism
SH is defined as a suppressed TSH, generally to less than 0.3 mIU/L, with a normal
level of T4 and T3. In light of recent studies evaluating the long-term consequences
of this disease, establishing the diagnosis and instituting treatment may be beneficial
in certain patients.
Differing TSH cutoff values have contributed to the variably reported prevalence of
SH reported in the literature. The NHANES III (National Health and Nutrition Examination Survey III) study, which represents the US civilian noninstitutionalized population,
defined SH using a TSH cutoff value of 0.1 mU/L, and found the overall prevalence of
SH to be 0.7%.3 The Colorado thyroid disease prevalence study, which involved participants in a statewide health fair aged 18 years and older, used a TSH cutoff value of
0.3 mU/L and found the overall prevalence of SH to be 2.1%.5 Generally, men and
women more than 65 years of age have the highest prevalence of SH.48
To establish the diagnosis of SH, other causes of a low TSH level should be excluded.
They may include pituitary or hypothalamic disease, euthyroid sick syndrome, certain
medications, such as dobutamine, dopamine, or steroids, and excessive thyroid
hormone ingestion. In addition, excess endogenous thyroid hormone production by
Graves disease or a nodular goiter must be ruled out.124
There are multiple potential consequences of prolonged SH, which have led to the
consideration of treatment. It has been shown that SH is an independent risk factor for
atrial fibrillation.125127 The TEARS study (Thyroid Epidemiology, Audit, and Research
Study) showed that patients with endogenous SH have an increased risk of cardiovascular disease and dysrhythmias.128 The cardiovascular health study showed that
patients with SH had no increased risk of developing heart failure. However, a more
recent study showed that exogenous SH was associated with decreased myocardial
strain on an echocardiogram, implying impaired cardiac function.129,130 Some studies
have shown an association between SH and dementia, whereas others have
not.131,132 An increased risk of hip fracture in men with SH has also been reported.133
SH is generally asymptomatic and typically discovered incidentally. Few patients
with SH (about 0.5% to 0.7%) develop overt hyperthyroidism, whereas most continue
to have SH. About one-third of patients with SH become euthyroid.134
Establishing the diagnosis of SH should include a thorough medical history, a repeat
TSH test over a 3-month to 6-month period to establish that the abnormal thyroid
function tests are not transient, and thyroid ultrasonography to evaluate for nodular
thyroid disease. If nodules are noted on ultrasonography, then a radionuclide scan
to evaluate for a TMNG or a TA should be obtained.
Once the diagnosis of SH is established, treatment is based on age, TSH level,
symptoms, and comorbidities. If the TSH level is persistently less than 0.1 mU/L, treatment should be considered in all patients older than 65 years, postmenopausal
women not on estrogens or bisphosphonates, patients with osteoporosis, cardiac
risk factors or heart disease, and individuals with symptoms of thyrotoxicosis. If the
TSH level is persistently less than normal, but greater than 0.1 mU/L, then treatment
should be considered in individuals older than 65 year and in patients with cardiac
disease or symptoms of thyrotoxicosis. The treatment should be based on the cause
of the thyroid dysfunction and follow the same principles, as described throughout this
article, for the various causes of overt hyperthyroidism.10
Amiodarone-induced Thyrotoxicosis
191
192
Thyrotoxicosis
months) are necessary.10 Potassium perchlorate 250 mg to 500 mg twice a day has
also been used to improve the response to thionamides by decreasing thyroid iodine
uptake and increasing thyroidal iodine discharge.141 However, potassium perchlorate
has been rarely associated with potentially fatal blood dyscrasias and is available in
the United States only through compounding pharmacies that prepare the medication
from reagent-grade chemical stock.143 Our experience is that in many cases of type I
AIT, perchlorate is an indispensable treatment adjunct.
Type 2 AIT, an inflammatory thyroiditis, is treated with corticosteroids and typically
resolves in a few weeks. These patients should be treated with 40 mg prednisone once
daily for 2 to 4 weeks followed by a gradual taper over 2 to 3 months.10
Occasionally, patients may not respond to single modality therapy caused by a mix
of type 1 and type 2 AIT. These patients may require combined antithyroid and antiinflammatory medications.10 The decision to stop amiodarone in the setting of thyrotoxicosis is controversial and should be made on an individual basis.
Hashitoxicosis
Hashimoto thyroiditis is the most common cause of hypothyroidism and goiter in the
United States.89 Patients may present with symptoms of hypothyroidism, goiter, or
both.144 Increased TPOAbs and thyroglobulin antibodies are present in 90% and
20% to 50% of patients, respectively.89 Rarely, patients with Hashimoto thyroiditis
may present with hashitoxicosis or the presence of biochemical hyperthyroidism.
One study145 performed in children found that of 69 total patients with autoimmune
thyroiditis, 11.5% developed hashitoxicosis. All of these patients had spontaneous
resolution of the thyrotoxicosis, with subsequent development of euthyroidism or
hypothyroidism confirming the diagnosis. The duration of hyperthyroidism in these
patients ranged from 31 to 168 days.
It is important to differentiate Graves disease from hashitoxicosis. CFDS may be
helpful because it typically shows significantly increased vascularity in Graves disease
and normal to only slightly increased vascularity in hashitoxicosis; however, the
vascularity can be variable.146 In addition, in Hashimoto thyroiditis, ultrasonographic
examination usually shows a heterogeneous thyroid parenchyma with innumerable
scattered small hypoechoic nodules separated by echogenic septa.146 The presence
of increased TPO and thyroglobulin antibodies with a negative TSI is also suggestive
of hashitoxicosis.
Medication-induced Thyrotoxicosis
193
194
unclear.94 One study found that the combination of IL-2 and IFN-a-2a led to thyroid
dysfunction in 4 of 8 patients. These patients developed a self-limited autoimmune
thyroiditis, with a hyperthyroid phase of 2 weeks followed by a hypothyroid phase
lasting up to 24 weeks.93 Recently, epoprostenol, a prostacyclin analogue used in
the treatment of pulmonary arterial hypertension, has been found to be associated
with seronegative hyperthyroidism. Chadha and colleagues149 found that 6.7% of
patients being treated with epoprostenol developed TSI-negative thyrotoxicosis
with large goiters and increased uptake on thyroid scan. The investigators believe
that epoprostenol can stimulate the thyroid tissue, induce growth of the thyroid gland,
and lead to the development of hyperthyroidism.
SUMMARY
Thyrotoxicosis
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201
H y p o t h y ro i d i s m :
E t i o l o g y, D i a g n o s i s ,
a n d Ma n a g e m e n t
Jaime P. Almandoz,
MB, BCh
a,b
, Hossein Gharib,
b,
KEYWORDS
Hypothyroidism Thyroid-stimulating hormone
Subclinical hypothyroidism Thyrotropin-releasing hormone
Hypothyroidism is the result of inadequate production of thyroid hormone or inadequate action of thyroid hormone in target tissues. Hypothyroidism is commonly
seen in outpatient practice, and improvements in assays and increased awareness
of the condition has led to the evaluation of more patients. The wide array of symptoms of hypothyroidism indicates an effect on metabolism and dysfunction in multiple
organ systems. Primary hypothyroidism is the principal manifestation of hypothyroidism, but other causes include central deficiency of thyrotropin-releasing hormone
(TRH) or thyroid-stimulating hormone (TSH), or consumptive hypothyroidism from
excessive inactivation of thyroid hormone. Subclinical hypothyroidism (SCH) is
present when there is laboratory evidence of primary hypothyroidism with an elevated
TSH but a normal free thyroxine (FT4) level. Treatment in most cases involves oral
administration of exogenous synthetic thyroid hormone.
This review presents an update on the etiology and types of hypothyroidism,
including subclinical disease; drugs and thyroid function; and diagnosis and treatment
of hypothyroidism, with a glance at some controversial issues.
EPIDEMIOLOGY
Mayo School of Graduate Medical Education, College of Medicine, Mayo Clinic, 200 First
Street SW, Rochester, MN 55905, USA
b
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First Street
SW, Rochester, MN 55905, USA
* Corresponding author. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo
Clinic, 200 First Street SW, Rochester, MN 55905.
E-mail address: [email protected]
Med Clin N Am 96 (2012) 203221
doi:10.1016/j.mcna.2012.01.005
medical.theclinics.com
0025-7125/12/$ see front matter 2012 Elsevier Inc. All rights reserved.
204
United States, Europe, and Japan have reported the prevalence of hypothyroidism to
be between 0.6 and 12 per 1000 in women and between 1.3 and 4.0 per 1000 in men.1
The National Health and Nutrition Examination Survey III data estimate the prevalence
of overt hypothyroidism (OH) in the American population at 0.3% and prevalence of
SCH at 4.3%.2 The Colorado Thyroid Disease Prevalence Survey revealed a similar
prevalence of hypothyroidism of 0.4% in a self-selected group not taking thyroid
hormone, but a much higher prevalence of SCH at 8.5%.3 The Colorado survey
involved individuals voluntarily seeking screening, so the estimated prevalence might
be expected to be higher. In the Wickham cohort, 20-year survivor follow-up data indicate the mean annual incidence of hypothyroidism to be 3.5 per 1000 in women and
0.6 per 1000 in men.4 The odds ratio of developing hypothyroidism were increased
from 8 in women and 44 in men with an elevated TSH, to 38 in women and 173 in
men for those that had both an elevation in TSH and positive antibodies.4
ETIOLOGY
Hypothyroidism can arise as primary from the thyroid gland, when there is a defect in
thyroid hormone synthesis and release; or centrally from the hypothalamic-pituitarythyroid axis, when there is a defect in either TRH or TSH signaling to the thyroid
(Table 1). The condition may also be transient or permanent.
Primary Hypothyroidism
Chronic autoimmune (Hashimoto) thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas. It is characterized by diffuse lymphocytic infiltration
of the thyroid gland associated primarily with circulating antithyroid peroxidase (TPO)
Table 1
Causes of hypothyroidism
Primary (Thyroid)
Secondary (Pituitary)
Autoimmune
Surgery
Iatrogenic
Lymphocytic hypophysitis
Thyroidectomy/thyroid surgery
Infection
Medications
Antithyroid medications
Miscellaneous
Tertiary (hypothalamus)
Medications
Medications
Radiation exposure
Systemic illness (usually moderate
or severe)
Thyroid agenesis
Defective hormone synthesis
Thyroid hormone resistance
Hypothyroidism
antibodies; antibodies may also be present against other aspects of the thyroid (thyroglobulin [Tg], TSH receptor, TSH-blocking antibodies).57 This process seems to be
due to an inherited defect in immune surveillance that leads to dysregulation and
subsequent destruction of the thyroid gland.8 As such, patients may present with or
without a goiter.
Detecting serum thyroid autoantibodies is a vital component in diagnosing autoimmune thyroid disease. Positive serum autoantibodies in the absence of abnormalities
in the testing of thyroid function should be interpreted with caution, as more than 20%
of women older than 50 years in the general population have positive TPO antibodies,
and thus antibody positivity does not equal clinical disease,2 although these individuals are more likely than antibody-negative individuals to develop thyroid dysfunction.
Iodine deficiency remains the most common cause of hypothyroidism worldwide,
but is uncommon in North America because of the widespread use of iodized table
salt and other fortified foods.9 A study of bread and cows milk in the Boston area
revealed that the average slice of bread contained 10 mg of iodine, whereas some
brands provided more than 300 mg per slice. This study also showed that all cows
milk samples contained at least 88 mg per 250 mL.10 As recently at 1990, 28.9% of
the worlds population was at risk for iodine deficiency. The recommended daily intake
for iodine is 150 mg for the general population and 225 to 350 mg during pregnancy and
lactation.11 Radioactive iodine (131I) therapy is the most common treatment modality
for hyperthyroidism in the United States. It is also used for treatment of thyroid
remnant ablation following thyroidectomy and treatment of iodine-avid thyroid
cancers. The principal side effect of 131I is hypothyroidism, requiring lifelong thyroid
hormone replacement therapy.12
Excess exposure to iodine can lead to transient hypothyroidism, referred to as the
Wolff-Chaikoff effect.13 This effect is sometimes used in preparing patients with
Graves disease for surgery or treating thyroid storm. Patients with underlying organification defects, for example, Hashimoto thyroiditis, or following 131I therapy can
suffer from prolonged hypothyroidism when exposed to excess iodide.14,15 This situation also occurs in patients on amiodarone therapy and is likely caused by a failure to
escape the Wolff-Chaikoff effect.16 Escape or adaptation to the Wolff-Chaikoff effect
occurs approximately 2 days after initial iodine exposure, and in rats has been shown
to be due to a transcriptional decrease in sodium/iodide symporter messenger RNA
and protein expression, which results in decreased iodide transport into the thyroid.17
External radiation exposure from treatment of nonthyroid cancer increases the
chances of hypothyroidism. The prevalence of hypothyroidism following radiation
for head and neck cancer ranges between 10% and 45% in the literature.18 A recent
systematic review looking at risk factors for developing hypothyroidism after radiation
therapy identified female sex, white race, and concomitant thyroid or neck surgery as
notable factors.19 Considerable variation was seen between studies, but there was
a radiationdose response relationship, with a 50% risk of hypothyroidism with
a dose of 45 Gy. Chemotherapy and age were not associated with an increased risk
of hypothyroidism.
Tyrosine kinase inhibitors have been shown to cause hypothyroidism in 36% to 71%
of patients in prospective data.20 This class of medication has also been shown to
increase the requirement of levothyroxine replacement in those already on thyroid
hormone replacement, by an average dose of 50 mg per day in one study looking at vandetanib.21 It has been suggested by several investigators that this increase in thyroid
hormone requirement is attributable to an induction in type 3 deiodinase activity.22,23
The evidence linking low-dose environmental radiation exposure to autoimmune
thyroid disease and hypothyroidism is inconclusive.24 The Japanese Adult Health
205
206
Survey, when examining 50-year survivors of the Hiroshima and Nagasaki atomic
bombs, found an increase in spontaneous OH with a prevalence of 5.6%.25 There
does not appear to be a link between radiation exposure and positive antithyroid antibody status or antibody-positive hypothyroidism in this cohort. The Hanford Thyroid
Disease Study also failed to find an association between hypothyroidism, autoimmune
thyroiditis, and prolonged 131I exposure in infancy and childhood.26
Infiltrative processes can lead to primary hypothyroidism, and causes include
hemochromatosis, lymphoma, sarcoidosis, and Riedel thyroiditis.2730 Infections of
the thyroid with pathogens such as Pneumocystis jiroveci can cause inadequate
production of thyroid hormone if enough of the gland is damaged. However, infections
of the thyroid are rare because of its encapsulation, high iodide content, and lymphatic
drainage.30
Inflammatory destruction of the thyroid as occurs in thyroiditis leads to transient
thyrotoxicosis by release of thyroid hormone from the injured gland. As hormone
stores are depleted, a transient hypothyroid phase follows until the inflammation
has subsided. Postpartum thyroiditis (PPT) is caused by lymphocytic infiltration and
may occur in 5% to 7% of women worldwide. PPT is more common in women with
thyroid autoantibodies, and those with positive TPO antibodies early in pregnancy
have a 30% to 52% chance of developing PPT. Other autoimmune conditions
increase the incidence of PPT, which is at least 15% in women with type 1 diabetes
mellitus.31 It is widely believed that most women with PPT will recover before the
end of the first postpartum year.32 A recent large-scale prospective study of women
in southern Italy challenged this, showing that 1 in 25 developed the condition and
that 54% had persistent hypothyroidism at the end of the first postpartum year.33
Consumptive hypothyroidism results from excessive production of type 3 deiodinase by vascular endothelium, resulting in conversion of thyroxine (T4) to reverse triiodothyronine (T3) and T3 to diiodothyronine. This rare condition is usually associated
with hemangiomas, and surgical resection is curative.34
Medications
SCH is used to describe an asymptomatic patient who has an elevated serum TSH
and a normal serum FT4 level. This description is only accurate if the hypothalamicpituitary-thyroid axis is intact, there is no ongoing or recent severe illness, and the
pattern is reproducible through time. It suggests a compensated early state of primary
thyroid failure whereby an increased level of TSH is required to maintain levels of
thyroid hormone within the normal range. SCH can occur in the setting of Hashimoto
thyroiditis, prior thyroid surgery, radioiodine therapy, or external beam radiation. Transient SCH has also been reported following an episode of thyroiditis.39
Hypothyroidism
DIAGNOSIS
Symptoms and Presentations
The symptoms of hypothyroidism are often very subjective, and vary according to the
degree of biochemical hypothyroidism. Symptoms typically include fatigue, cold intolerance, dry skin, constipation, vocal changes, and muscle aches. These symptoms,
including proposed scoring systems for the diagnosis of hypothyroidism, have poor
sensitivity and specificity for the condition.40 On physical examination prolonged
ankle-jerk reflex time appears to correlate best with the degree of hypothyroidism;
however, much of the clinical evaluation in current clinical practice has been overshadowed by the use of sensitive assays.40,41
The decrease in circulating thyroid hormones has a negative effect on basal metabolic rate, which has a negative effect on multiple organ systems. The accumulation of
glycosaminoglycans from increased synthesis of hyaluronic acid along with the
decreased metabolic rate can explain many of the presenting features of the affected
patient.
Lipid Metabolism
Some investigators recommend that thyroid function be measured in all patients with
lipid abnormalities, as more than 90% of patients with OH will have abnormal serum
lipid values.42 OH is characterized by increased low-density lipoproteins (LDL) and
apolipoprotein B because of reduced hepatic clearance from a decreased number
of hepatic LDL receptors. A decrease in cholesterylester transfer protein can increase
the levels of high-density lipoproteins (HDL) in hypothyroidism.43 Although there is
a tendency toward elevated cholesterol in hypothyroidism, it seems to arise from an
increase in large-LDL and large-HDL subtypes, which are thought to be less
atherogenic.44
Cardiovascular and Other Changes
207
208
Box 1
Medications that contribute to hypothyroidism
Certain agents may have more than 1 mechanism.
Medications decreasing TSH secretion
Glucocorticoids
Opiates
Dopamine
Bromocriptine
Phentolamine
Octreotide
Growth hormone
Drugs affecting thyroid hormone synthesis and secretion
Iodine
Amiodarone
Thionamides
Thiocyanate
Aminogluthemide
Perchlorate
Lithium
Cytokines (IFN-g, IL-2, GM-CSF)
Drugs altering thyroid hormone metabolism
Rifampicin
Phenytoin
Carbamazepine
Barbiturates
Tyrosine kinase inhibitors
Growth hormone
Glucocorticoids
Propylthiouracil
b-Blockers
Iodinated contrast agents
Clomipramine
Drugs that increase thyroxine-binding globulin
Estrogen
SERMs
Opiates
Mitotane
Clofibrate
Perphenazine
5-Fluorouracil
Hypothyroidism
Laboratory testing is required for the diagnosis of hypothyroidism because the symptoms and examination findings lack sensitivity and specificity. Accordingly, clinical
scoring systems correlate poorly with hypothyroidism and should not be used for
diagnosis. Nonthyroid serum testing such as elevated creatine kinase, hyperlipidemia,
and physical findings such as basal metabolic rate should not be used to diagnose
thyroid dysfunction, but should prompt more specific thyroid testing.
Primary hypothyroidism is manifested by an elevated serum TSH with a low serum
FT4. SCH is present when there is an elevation in TSH but the FT4 is within the normal
reference range. In secondary (pituitary) or tertiary (hypothalamic) hypothyroidism, the
FT4 is low and the TSH is not appropriately elevated. Imaging of the hypothalamus and
pituitary gland should be performed on patients in whom central hypothyroidism is
suspected.
TSH is widely measured using a third-generation chemiluminometric assay. There is
controversy regarding the appropriate upper limit of normal for the reference range.
The authors laboratory currently uses a reference range of 0.3 to 5.0 mIU/L. A
209
210
Universal screening of the general population is controversial, and there is disagreement between professional societies about who should be screened for thyroid hypofunction and when. The United States Preventive Services Task Force does not
recommend routine screening for thyroid disease in adults,63 whereas the American
Thyroid Association (ATA) recommends screening for adults beginning at age 35 years
and every 5 years thereafter.64 The American Association of Clinical Endocrinologists
(AACE) recommends screening in older patients of an unspecified age, particularly if
female.65
Because of the lack of data supporting screening on a population-based level,
a consensus group of representatives from the Endocrine Society, ATA, and AACE
Hypothyroidism
recommended aggressive case finding in pregnant women, those older than 60 years,
and people at risk for thyroid dysfunction. Patients thought to be at risk included those
with a family history of thyroid dysfunction or a personal history of autoimmune
disease.66 Other patients who could fall into the at-risk group include those on medications that affect thyroid function, those with presence of a goiter, those who have
had prior neck surgery, or those with a history of radiation exposure.
Treatment
211
212
Hypothyroidism
213
214
Universal screening for congenital hypothyroidism (CH) is performed in most industrialized countries within the first few days of life. The purpose of this population-based
screening is to prevent intellectual disability in those affected, previously estimated at
1 in 4000 live births in iodine-sufficient regions.110 There are several screening strategies including an initial T4 with a reflex TSH for those below a defined T4 threshold,
a TSH-only test, and a combined TSH and T4 test. Congenital central hypothyroidism
can be missed by TSH-only screening methods, and the estimated birth prevalence of
this disorder is approximately 1 in 29,000.111
Thyroid dysgenesis accounts for 85% of the cases of CH, and of those, two-thirds
are caused by an ectopic thyroid gland, followed by agenesis and hypoplasia. Most of
these cases are sporadic and only 2% of cases are found to have known genetic
mutations. Thyroid dyshormonogenesis is responsible for almost 15% of CH cases
and includes defects in functional thyroid peroxidase, the sodium/iodide symporter.
Transient CH is associated with conditions such as maternal iodine insufficiency or
acute ingestion, and maternal TSH-blocking antibodies.112
In 2007, an article by Harris and Pass113 raised concern that the birth prevalence of
CH had doubled over the previous 2 decades. A 20-year retrospective study from
Quebec determined that their stated increase in birth prevalence of CH was attributable to a lowering of the upper limit of normal in the confirmatory test, from 15 mIU/L to
5 mIU/L. The lowering of this diagnostic threshold identified an additional 49 cases
Hypothyroidism
that would not otherwise have been detected, out of a total of 620 cases. Although
these additional cases were considered to be mild, 86% had permanent hypothyroidism.114 There are no randomized controlled studies demonstrating a therapeutic
benefit in these milder cases of CH, which would have been previously missed, but
it would seem prudent to treat them.
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215
216
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41. Lawson JD. The free Achilles reflex in hypothyroidism and hyperthyroidism.
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42. OBrien T, Dinneen SF, OBrien PC, et al. Hyperlipidemia in patients with primary
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43. Duntas LH. Thyroid disease and lipids. Thyroid 2002;12(4):28793.
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49. Scott KR, Simmons Z, Boyer PJ. Hypothyroid myopathy with a strikingly
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54. Baloch Z, Carayon P, Conte-Devolx B, et al. Laboratory medicine practice
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57. Midgley JE. Direct and indirect free thyroxine assay methods: theory and practice. Clin Chem 2001;47(8):135363.
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94. Anckaert E, Poppe K, Van Uytfanghe K, et al. FT4 immunoassays may display
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95. Kahric-Janicic N, Soldin SJ, Soldin OP, et al. Tandem mass spectrometry
improves the accuracy of free thyroxine measurements during pregnancy.
Thyroid 2007;17(4):30311.
96. Soldin OP, Tractenberg RE, Hollowell JG, et al. Trimester-specific changes in
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97. Yassa L, Marqusee E, Fawcett R, et al. Thyroid hormone early adjustment in
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98. Alexander EK, Marqusee E, Lawrence J, et al. Timing and magnitude of
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99. Leung AS, Millar LK, Koonings PP, et al. Perinatal outcome in hypothyroid pregnancies. Obstet Gynecol 1993;81(3):34953.
100. Davis LE, Leveno KJ, Cunningham FG. Hypothyroidism complicating pregnancy. Obstet Gynecol 1988;72(1):10812.
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102. Contempre B, Jauniaux E, Calvo R, et al. Detection of thyroid hormones in
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103. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during
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104. Negro R, Formoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid
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complications. J Clin Endocrinol Metab 2006;91(7):258791.
105. Negro R, Greco G, Mangieri T, et al. The influence of selenium supplementation
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106. Ashoor G, Maiz N, Rotas M, et al. Maternal thyroid function at 11 to 13 weeks of
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107. Pop VJ, Brouwers EP, Vader HL, et al. Maternal hypothyroxinaemia during early
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108. Li Y, Shan Z, Teng W, et al. Abnormalities of maternal thyroid function during
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109. de Escobar GM, Obregon MJ, del Rey FE. Maternal thyroid hormones early in
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111. Hanna CE, Krainz PL, Skeels MR, et al. Detection of congenital hypopituitary
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221
S u b a c u t e , Si l e n t ,
a n d Po s t p a r t u m
T h y ro i d i t i s
Mary H. Samuels,
MD
KEYWORDS
Thyroiditis Subacute thyroiditis Silent thyroiditis
Postpartum thyroiditis
Thyroiditis is a broad term that indicates thyroid gland inflammation. There are many
types of thyroiditis, which can generally be divided into painful or painless categories.1
Painful types include subacute and suppurative thyroiditis, as well as unusual cases
induced by radioactive iodine administration, trauma, or other rare causes. Painless
types include Hashimoto thyroiditis, the most common type of chronic thyroid
disease, as well as silent, postpartum, drug-induced, and Riedel thyroiditis.
Thyroid function in patients with thyroiditis depends on the type of thyroiditis and, in
certain cases, evolves from thyrotoxicosis to hypothyroidism and eventually to restoration of normal thyroid function. This classic triphasic course of thyroid dysfunction is
characteristic of the 3 entities considered in this article: subacute, silent, and postpartum thyroiditis. The other types of thyroiditis are not discussed further, except in
the context of the differential diagnosis. Table 1 provides a comprehensive summary
of the text of this article and can be referenced throughout the discussion that follows.
SUBACUTE THYROIDITIS
Clinical Findings and Course
Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University,
3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
E-mail address: [email protected]
Med Clin N Am 96 (2012) 223233
doi:10.1016/j.mcna.2012.01.003
medical.theclinics.com
0025-7125/12/$ see front matter 2012 Elsevier Inc. All rights reserved.
224
Subacute Thyroiditis
Silent Thyroiditis
Postpartum Thyroiditis
Clinical findings
Clinical course
Demographics
\:_, 4:1
Peak age, 3040 y
More common in areas of iodine
sufficiency
\ only
Occurs within 12 mo of pregnancy
8%11% of pregnancies
Etiology
Probably viral
Probably autoimmune
Autoimmune
Laboratory findings
Imaging
Pathology
Granulomatous infiltrate
Lymphocytic infiltrate
Lymphocytic infiltrate
Differential diagnosis
Treatment
Long-term outcomes
Recurrence rates
Abbreviations: CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; RaI, radioactive iodine; URI, upper respiratory illness; US, ultrasonography; WBC,
white blood cell count.
Samuels
Table 1
An overview of pertinent findings in subacute, silent, and postpartum thyroiditis
follicular cells.2 Therefore, if patients present early in the course of the disease, they
may have clinical findings of thyrotoxicosis, although this is often mild. This phase
usually lasts about 3 to 6 weeks, ending when the thyroid stores of preformed
hormone are depleted. About one-third of patients subsequently enter a hypothyroid
phase that can last up to 6 months. Thyroid pain has usually resolved by this time, and
the predominant clinical features are those of hypothyroidism with a continued small
goiter. Most patients return to euthyroidism within 12 months of onset of disease.
Demographics
The most comprehensive study of subacute thyroiditis analyzed 94 cases seen over
27 years in Olmsted County, Minnesota. The incidence rate was 3 cases per
100,000 per year in the most recent years of the survey.2 Women seem to be more
affected than men, in a 4:1 ratio.25 The peak age of incidence is 40 to 50 years.
Some studies suggest that there is a seasonal peak of cases during spring, summer,
or fall, but this finding has not always been confirmed. There is no geographic or
familial clustering.
Etiology
Subacute thyroiditis is probably caused by a viral infection of the thyroid gland. Implicated conditions include infections caused by Coxsackie virus, Epstein-Barr virus,
adenoviruses, and influenza viruses; mumps; measles; primary human immunodeficiency virus infection; and a recent well-documented case occurring during an
H1N1 influenza infection.6
Laboratory Findings
A hallmark of subacute thyroiditis is low radioactive iodine uptake (RaIU) during the
thyrotoxic phase, because the inflamed thyroid gland does not trap iodine.7 As the thyrotoxic phase ends, the RaIU returns to normal or even becomes elevated during the
hypothyroid phase. It is not necessary to obtain an ultrasonography of the thyroid in
subacute thyroiditis, but, if ultrasonography is performed, it often shows inhomogeneous hypoechogenic texture, sometimes with nodules, because of the inflammatory
process.2,4,5,7,8
Pathology
A biopsy of the thyroid gland is not usually necessary in subacute thyroiditis. However,
if biopsy is performed due to uncertainty of the diagnosis, its result shows granulomatous infiltrate, sometimes with giant cells, consistent with a viral infection.2
225
226
Samuels
Differential Diagnosis
In a patient who presents with a painful tender thyroid gland, by far the most common
cause is subacute thyroiditis. However, there are other unusual causes of thyroid pain
that must be considered if the patient has a consistent history, unusual symptoms, or
a markedly enlarged gland.9,10 These causes include Hashimoto disease, Graves
disease, radioactive iodine administration, amiodarone-induced thyroiditis, contrast
dyeinduced thyroiditis, acute suppurative thyroiditis, or amyloid goiter.
During the thyrotoxic phase, the main differential diagnosis is between subacute
thyroiditis and Graves disease. A recent history of neck pain indicates subacute
thyroiditis, whereas the presence of ophthalmopathy or a thyroid bruit indicates
Graves disease. Serum triiodothyronine (T3) levels and T3:T4 ratios tend to be lower
in subacute thyroiditis than in Graves disease, but there is significant overlap in thyroid
hormone levels.11 A definitive diagnosis can be made by RaIU measurement, because
uptake is low in subacute thyroiditis and elevated in Graves disease.7 Care must be
taken to perform the RaIU test while the patient is still thyrotoxic, because RaIU
increases as the patient enters the hypothyroid phase.
During the hypothyroid phase, the main differential diagnosis is between subacute
thyroiditis and Hashimoto disease. A history of neck pain can be helpful but is often
forgotten by patients if there was no obvious intervening thyrotoxic phase brought
to medical attention earlier. Measurement of antithyroid antibodies may be helpful,
because they tend to be absent or in low titer in subacute thyroiditis. In the absence
of a definitive diagnosis, the patient may need monitoring or temporary treatment to
see if the thyroid dysfunction resolves over time.
Treatment
Almost all patients with subacute thyroiditis recover full thyroid function, but about 5%
to 15% have persistent hypothyroidism after 12 months.2,4,5 In addition, recurrence
rates of 1% to 4% have been described.2 Recurrences are managed in the same
manner as the initial occurrence, but, rarely, thyroidectomy has been used for repeated
relapses.2
SILENT THYROIDITIS
Clinical Findings and Clinical Course
The incidence of silent thyroiditis is not well delineated, with reports that it accounts for
0% to 23% of thyrotoxicosis cases.1416 Silent thyroiditis seems to be more prevalent
in areas of higher dietary iodine intake, accounting for up to 30% of cases of thyrotoxicosis in Japan.17 Women are affected more commonly than men, in a 4:1 ratio.13 The
peak age of incidence is 30 to 40 years.
Etiology
During the thyrotoxic phase of silent thyroiditis, TSH levels are low and free T4 levels
may be elevated, depending on the degree of thyrotoxicosis. During the hypothyroid
phase, TSH levels are high and free T4 levels may be low. About 50% of patients have
antithyroid peroxidase (anti-TPO) antibodies.1
Imaging Findings
As in subacute thyroiditis, patients with silent thyroiditis have a low RaIU during the
thyrotoxic phase.1 Similarly, because the thyrotoxic phase ends, the RaIU returns to
normal or becomes elevated during the hypothyroid phase. Ultrasonography of the
thyroid often shows inhomogeneous hypoechogenic texture.19
Pathology
A thyroid gland affected by silent thyroiditis has a diffuse lymphocytic infiltrate that
resembles Hashimoto disease but lacks Hurthle cells, lymphoid germinal center
formation, or fibrosis of Hashimoto disease.18,20
Differential Diagnosis
During the thyrotoxic phase, the main differential diagnosis is between silent thyroiditis
and Graves disease. The presence of ophthalmopathy or a thyroid bruit indicates
Graves disease. Serum T3 levels and T3:T4 (or free T3 to free T4) ratios tend to be lower
in silent thyroiditis than in Graves disease, but there is significant overlap in thyroid
hormone levels.11,21,22 Titers of thyroid receptor antibodies (TRAb) or thyroidbinding inhibitory immunoglobulins are usually much higher in Graves disease than
in silent thyroiditis,11,19,23,24 although there is no cutoff with 100% accuracy. Doppler
ultrasonography tends to show higher blood flow in Graves disease.19,24 A definitive
diagnosis can be made by RaIU measurement, because uptake is low in silent thyroiditis and elevated in Graves disease. Care must be taken to perform the RaIU test while
227
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Samuels
the patient is still thyrotoxic, because RaIU increases as the patient enters the hypothyroid phase.
During the hypothyroid phase, the main differential diagnosis is between silent
thyroiditis and Hashimoto disease. Measurement of antithyroid antibodies is often
not helpful, because they may be present in either case. In the absence of a definitive
diagnosis, the patient may need monitoring or temporary treatment to see if the thyroid
dysfunction resolves over time.
Treatment
Most patients with silent thyroiditis recover full thyroid function, but about 10% to 20%
have persistent hypothyroidism after 12 months.1 Recurrence rates are about 5% to
10% but may be much higher in Japan, with one study from Japan reporting
a long-term recurrence rate of 65%.20 Recurrences are managed in the same manner
as in the initial occurrence, but some patients with multiple recurrences have opted for
radioactive iodine ablation of the gland.20
POSTPARTUM THYROIDITIS
Clinical Findings and Clinical Course
Postpartum thyroiditis is defined as the development of thyroid dysfunction in a previously euthyroid woman within 12 months after pregnancy. Almost all cases occur after
a term pregnancy, although there are reports of cases developing after a miscarriage.
Like subacute and silent thyroiditis, the clinical course is classically triphasic, with an
initial thyrotoxic phase followed by a hypothyroid phase and an eventual return to a euthyroid state, all within 12 months.25 However, the pattern of thyroid dysfunction is quite
variable; 25% to 40% of patients exhibit the classic triphasic course, whereas 20% to
30% develop only thyrotoxicosis and 40% develop only hypothyroidism.2527 The thyrotoxic phase occurs at 2 to 6 months post partum (median time of onset, 13 weeks) and is
usually asymptomatic. However, irritability, heat intolerance, fatigue, and palpitations
are more common in thyrotoxic women with postpartum thyroiditis.28 This phase
typically lasts 2 to 3 months. The hypothyroid phase occurs 3 to 12 months post partum
(median time of onset, 19 weeks) and is often symptomatic, with cold intolerance, dry
skin, loss of energy, and problems with concentration.25,28 Most patients have a small
painless goiter. Given the known effects of altered thyroid function on mood, investigators have questioned whether postpartum thyroiditis may play a role in the development
of postpartum depression.28 However, results from these studies have been mixed,
and one randomized controlled trial of L-T4 therapy in anti-TPOpositive postpartum
women did not report a reduction in the incidence of postpartum depression.29
Demographics
There are several well-defined risk factors that greatly increase a womans chance of
developing postpartum thyroiditis. The best predictor is the presence of anti-TPO antibodies at the end of the first trimester of pregnancy, with 30% to 50% of these women
progressing to postpartum thyroiditis.25,28,30,33 Women with a past history of thyroid
disease have a 40% risk of developing postpartum thyroiditis, whereas those with
type 1 diabetes mellitus or a family history of thyroid disease have a 20% risk.30
Etiology
Postpartum thyroiditis is autoimmune in nature, with an HLA linkage, anti-TPO antibodies in most patients, laboratory findings of immune system activation, and dense
lymphocytic infiltrates in affected thyroid glands.28
Laboratory Findings
As in subacute and silent thyroiditis, patients with postpartum thyroiditis have a low
RaIU during the thyrotoxic phase.1 Similarly, because the thyrotoxic phase ends,
the RaIU returns to normal or becomes elevated during the hypothyroid phase. Ultrasonography of the thyroid almost always shows inhomogeneous hypoechogenic
texture.34
Pathology
Pathology test results of the thyroid gland in postpartum thyroiditis show dense
lymphocytic infiltration consistent with the autoimmune nature of the disease but
without germinal centers or extensive Hurthle cell metaplasia that can be seen in
Hashimoto disease.1
Differential Diagnosis
During the thyrotoxic phase, the main differential diagnosis is between postpartum
thyroiditis and Graves disease. There may in fact be some overlap because both
are autoimmune processes, and women with a history of 1 entity can eventually
develop the other. The presence of ophthalmopathy, a thyroid bruit, or TRAb indicates
Graves disease. T3 levels and T3:T4 ratios are higher in Graves disease than in postpartum thyroiditis. A definitive diagnosis can be made by RaIU measurement because
uptake is low in postpartum thyroiditis and elevated in Graves disease. However, it can
be logistically difficult to perform an RaIU test on a postpartum woman because issues
of breastfeeding and neonatal exposure to the radioactive iodine must be taken into
account.
During the hypothyroid phase, the main differential diagnosis is between postpartum thyroiditis and Hashimoto disease. There is likely overlap, because a significant
number of women with postpartum thyroiditis eventually develop permanent autoimmune hypothyroidism. Measurement of antithyroid antibodies is not helpful because
these antibodies are usually present in either case. In the absence of a definitive
229
230
Samuels
diagnosis, the patient may need monitoring or temporary treatment to check if the
thyroid dysfunction resolves over time (see caveats later).
Treatment
231
232
Samuels
22. Yoshimura Noh J, Momotani N, Fukada S, et al. Ratio of serum free triiodothyronine to free thyroxine in Graves hyperthyroidism and thyrotoxicosis caused by
painless thyroiditis. Endocr J 2005;52:53742.
23. Izumi Y, Takeoka K, Amino N. Usefulness of the 2nd generation assay for anti-TSH
receptor antibodies to differentiate relapse of Graves thyrotoxicosis from development of painless thyroiditis after antithyroid drug treatment for Graves disease.
Endocr J 2005;52:4937.
24. Ota H, Amino N, Morita S, et al. Quantitative measurement of thyroid blood flow
for differentiation of painless thyroiditis from Graves disease. Clin Endocrinol
(Oxf) 2007;67:415.
25. Lazarus JH. The continuing saga of postpartum thyroiditis. J Clin Endocrinol
Metab 2011;96:6146.
26. Kita M, Goulis DG, Avramides A. Post-partum thyroiditis in a mediterranean population: a prospective study of a large cohort of thyroid antibody positive women
at the time of delivery. J Endocrinol Invest 2002;25:5139.
27. Lucas A, Pizarro E, Granada ML, et al. Postpartum thyroiditis: epidemiology and
clinical evolution in a nonselected population. Thyroid 2000;10:717.
28. Stagnaro-Green A, Abalovich M, Alexander E, American Thyroid Association
Taskforce on Thyroid Disease During Pregnancy and Postpartum, et al. Guidelines of the American Thyroid Association for the diagnosis and management
of thyroid disease during pregnancy and postpartum. Thyroid 2011;21(10):
1081125.
29. Harris B, Oretti R, Lazarus J, et al. Randomised trial of thyroxine to prevent postnatal depression in thyroid-antibody-positive women. Br J Psychiatry 2002;180:
32730.
30. Nicholson WK, Robinson KA, Smallridge RC, et al. Prevalence of postpartum
thyroid dysfunction: a quantitative review. Thyroid 2006;16:57382.
31. Stuckey BG, Kent GN, Ward LC, et al. Postpartum thyroid dysfunction and the
long-term risk of hypothyroidism: results from a 12-year follow-up study of women
with and without postpartum thyroid dysfunction. Clin Endocrinol (Oxf) 2010;73:
38995.
32. Guan H, Li C, Li Y, et al. High iodine intake is a risk factor of post-partum
thyroiditis: result of a survey from Shenyang, China. J Endocrinol Invest 2005;
28:87681.
33. Stagnaro-Green A, Schwartz A, Gismondi R, et al. High rate of persistent hypothyroidism in a large-scale prospective study of postpartum thyroiditis in southern
Italy. J Clin Endocrinol Metab 2011;96:6527.
34. Shahbazian HB, Sarvghadi F, Azizi F. Ultrasonographic characteristics and
follow-up in post-partum thyroiditis. J Endocrinol Invest 2005;28:4102.
35. Nhr SB, Jrgensen A, Pedersen KM, et al. Postpartum thyroid dysfunction in
pregnant thyroid peroxidase antibody-positive women living in an area with
mild to moderate iodine deficiency: is iodine supplementation safe? J Clin Endocrinol Metab 2000;85:31918.
36. Kampe O, Jansson R, Karlsson FA. Effects of L-thyroxine and iodide on the development of autoimmune postpartum thyroiditis. J Clin Endocrinol Metab 1990;70:
10148.
37. Negro R, Greco G, Mangieri T, et al. The influence of selenium supplementation
on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab 2007;92:12638.
38. Nikolai TF, Turney SL, Roberts RC. Postpartum lymphocytic thyroiditis. Prevalence, clinical course, and long-term follow-up. Arch Intern Med 1987;147:2214.
39. Azizi F. The occurrence of permanent thyroid failure in patients with subclinical
postpartum thyroiditis. Eur J Endocrinol 2005;153:36771.
40. Premawardhana LD, Parkes AB, Ammari F, et al. Postpartum thyroiditis and longterm thyroid status: prognostic influence of thyroid peroxidase antibodies and
ultrasound echogenicity. J Clin Endocrinol Metab 2000;85:715.
41. Lucas A, Pizarro E, Granada ML, et al. Postpartum thyroiditis: long-term followup. Thyroid 2005;15:117781.
42. Tachi J, Amino N, Tamaki H, et al. Long term follow-up and HLA association in
patients with postpartum hypothyroidism. J Clin Endocrinol Metab 1988;66:
4804.
233
T h y ro i d D i s o rd e r s
D u r i n g P re g n a n c y
Cynthia F. Yazbeck,
MD
, Shannon D. Sullivan,
MD, PhD
b,
KEYWORDS
Pregnancy Hypothyroidism Isolated hypothyroxinemia
Hyperthyroidism Gestational transient thyrotoxicosis
Postpartum thyroiditis Thyroid nodules Thyroid cancer
Thyroid disorders are common in pregnancy and in nonpregnant women of childbearing age, but can be missed because of nonspecific symptoms and normal
changes in the physiology of the thyroid gland during pregnancy. The prevalence of
overt hyperthyroidism complicating pregnancy has been reported to range between
0.4% and 1.7%,1 and an estimated 2% to 3% of women are hypothyroid during pregnancy.2,3 Abnormalities in maternal thyroid function are associated with complications
during pregnancy, and can affect maternal and fetal outcomes. Therefore, it is important to identify thyroid disorders before pregnancy or early in pregnancy so that appropriate treatment can be initiated.
Division of Endocrinology, University of Pittsburgh Medical Center, 200 Lothrop Street, E1140
BST, Pittsburgh, PA 15261, USA
b
Department of Endocrinology, Washington Hospital Center, 110 Irving Street, NW, Suite
2A-72, Washington, DC 20010, USA
* Corresponding author.
E-mail address: [email protected]
Med Clin N Am 96 (2012) 235256
doi:10.1016/j.mcna.2012.01.004
medical.theclinics.com
0025-7125/12/$ see front matter 2012 Elsevier Inc. All rights reserved.
236
increase in TT3 concentration is more progressive. Both TT4 and TT3 reach their
plateau by 20 weeks and are maintained until term.4
Second, human chorionic gonadotropin (hCG) is a thyroid regulator in normal pregnancy because the hormone-specific b subunits and the extracellular receptorbinding domains of human chorionic gonadotropin (hCG) and TSH share multiple
similarities.13 Consequently, high concentrations of hCG during pregnancy stimulate
TSH receptors. In pathologic conditions such as molar pregnancy or choriocarcinoma,
this may lead to gestational hyperthyroidism. In normal pregnancy, the placenta
produces hCG in the first week after conception and the levels peak at week 10, before
decreasing and reaching a plateau by week 20.12 Between 8 and 14 weeks gestation,
the changes in hCG and TSH levels are mirror images of each other, with a significant
negative correlation between the two. Conversely, there is a positive linear relationship
between hCG and free T4 concentrations during early gestation.12
Third, the maternal glomerular filtration rate increases in pregnancy, resulting in
increased renal clearance of iodide, an indirect stimulus to the maternal thyroid
machinery.14 Later in gestation, transplacental passage of iodide and placental
metabolism of iodothyronines further contribute to relative maternal iodine deprivation
and stimulation of the maternal thyroid.15
In the nonpregnant condition, an adequate iodine intake is estimated to be 100 to
150 mg per day. Because of the increased iodine demands in pregnancy, all women
who are planning pregnancy, are pregnant, or are lactating should ingest a minimum
of 250 mg of iodine daily. In North America, this could be achieved by adding a daily
multivitamin or prenatal vitamin that contains 150 mg of potassium iodide to an
iodine-sufficient diet.16
Because thyroid hormone economy differs between healthy pregnant women and
healthy nonpregnant women, laboratory-dependent, pregnancy-specific, and ideally
trimester-specific reference intervals for thyroid function tests (TFTs) are required.
Compared with preconception levels, TSH concentrations are lower throughout pregnancy. TSH is lowest in the first trimester, then increases during the second and third
trimesters.12 Among euthyroid pregnant women additional factors, including smoking
status17 and ethnicity,18 also contribute to TSH differences. According to recent American Thyroid Association (ATA) guidelines, if laboratory-dependent, trimester-specific
ranges for TSH are not available, the recommended reference ranges for TSH are 0.1
to 2.5 mIU/L in the first trimester, 0.2 to 3.0 mIU/L in the second trimester, and 0.3 to
3.0 mIU/L in the third trimester.16
The interpretation of levels of free thyroid hormone in pregnancy is more challenging. At
least in part, this is due to the use of different assays and differences in dietary iodine
intake among study participants.19 The optimal method to assess serum free T4 (fT4)
during pregnancy is measurement of T4 in the dialysate or ultrafiltrate of serum samples
by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS).20
Unfortunately, this method is too technically complex and expensive for routine use. If
LC/MS/MS is not available other assays can be used, as long as the limitations are
considered. Method-specific and trimester-specific reference ranges for fT4 are required.
In general, fT4 and free T3 (fT3) levels increase slightly during the first trimester. fT4 levels
subsequently decrease as pregnancy progresses, with a nadir in the third trimester.19
It has been suggested that TT4 measurements are more reliable than fT4 measurements during pregnancy. TT4 levels are higher in pregnancy compared with the
nonpregnant state, thus, in general, normal TT4 reference ranges can be adjusted
by a factor of 1.5 in pregnancy.19 The fT4 index may also be used in pregnancy, as
the fT4 index corrects TT4 for TBG. Changes in the fT4 index correspond to the
changes in fT4 measured by equilibrium dialysis and tandem mass spectrometry.21
Thyroid disorders are much more common in women than in men. In the last decade,
there has been more attention paid to thyroid dysfunction during pregnancy and its
effects on maternal and fetal well-being. As a result, there has been a debate
regarding the use of universal screening versus targeted high-risk case finding for
thyroid dysfunction during pregnancy. Different studies have shown that targeted
high-risk screening failed to detect 28% to 36% of women with hypothyroidism.2224
A recent study at an academic medical center in the Boston area revealed that targeted thyroid testing in high-risk patients would have missed 80% of pregnant women
with either overt or subclinical hypothyroidism. However, the investigators were
unable to advocate for universal screening, in the absence of data demonstrating
that levothyroxine (LT4) treatment improved outcomes in women with subclinical
hypothyroidism.25
Screening for subclinical hypothyroidism in pregnancy has been shown to be a costeffective strategy under a wide range of circumstances,26 and universal screening has
been supported by some investigators.27 However, there are few prospective randomized trials to substantiate the benefits of universal screening. Negro and colleagues24
showed that universal screening in comparison with case finding did not result in
a decrease in adverse outcomes, but treatment of hypothyroidism or hyperthyroidism
identified by screening a low-risk group was associated with a lower rate of adverse
outcomes.
Data from 2 large, randomized controlled trials are currently pending. Preliminary
results from the Controlled Antenatal Thyroid Study (CATS) have not shown a difference in neuropsychological development among the offspring of women screened
and treated for subclinical thyroid disease or isolated hypothyroxinemia before 16
weeks gestation, compared with control women.28 The National Institutes of Health
Maternal Fetal Medicine Thyrotropin Study (TSH Study), to be completed in 2015, is
screening pregnant women for thyroid dysfunction, and is comparing maternal and
fetal outcomes in women with subclinical hypothyroidism or isolated hypothyroxinemia treated with LT4 versus placebo.29 Because of a lack of consistent evidence to
date demonstrating that universal screening improves population outcomes, several
clinical organizations, including the ATA, recommend obtaining serum TSH early in
pregnancy only in women at high risk for overt hypothyroidism (Box 1).
Thyroid hormone deficiency is found in approximately 3% to 7% of women of childbearing age,2 and an estimated 2% to 3% of women are hypothyroid during pregnancy.2,3 In iodine-sufficient areas, the most common cause is Hashimoto thyroiditis.
Other causes include prior radioactive iodine (RAI) and/or surgical ablation of Graves
disease,30 surgical removal of the thyroid because of multinodular goiter or thyroid
cancer, overtreatment of hyperthyroidism with thionamides, medications that alter
the absorption or metabolism of levothyroxine, and central defects that inhibit the
hypothalamic-pituitary-thyroid axis.
The fetal thyroid gland starts producing small amounts of thyroid hormone at
approximately 10 weeks gestation, until production plateaus at approximately 35
weeks.12 Therefore, particularly in the first trimester of pregnancy, the fetus is entirely
dependent on thyroid hormone from the mother. Maternal hypothyroidism can have
devastating consequences if left untreated.
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238
Box 1
Screening for serum TSH in early pregnancy in high-risk patients
Risk Factors for Overt Hypothyroidism
History of thyroid dysfunction or prior thyroid surgery
Age >30 years
Symptoms of thyroid dysfunction or the presence of goiter
Thyroid peroxidase antibody positivity
Type 1 diabetes mellitus or other autoimmune disorders
History of miscarriage or preterm delivery
History of head and neck radiation
Family history of thyroid dysfunction
Morbid obesity (body mass index 40 kg/m2)
Use of amiodarone or lithium, or recent administration of iodinated radiologic contrast
Infertility
Residing in an area of known moderate to severe iodine sufficiency
Adapted from Stagnaro-Green A, Abalovich M, Alexander E, et al. Guidelines of the American
Thyroid Association for the diagnosis and management of thyroid disease during pregnancy
and postpartum. Thyroid 2011;21(10):1081125; with permission.
Diagnosis
Overt hypothyroidism is defined by a serum TSH higher than the upper limit of the
trimester-specific range and serum fT4 below the trimester-specific reference range,
or serum TSH level of 10 mIU/L or more, irrespective of fT4 levels. Subclinical hypothyroidism is diagnosed when serum TSH is elevated but less than 10 mIU/L, and fT4 is in
the normal range. Differentiating between the two conditions is important because
maternal and fetal outcomes are better established for overt maternal hypothyroidism
than for subclinical hypothyroidism. Isolated hypothyroxinemia is defined as a normal
TSH with an fT4 in the lower 5th or 10th percentile of the reference range.16
Pregnancy Complications
Maternal hypothyroidism has been associated with increased risk of low birth weight,
fetal distress, and impaired neuropsychological development.31,36,46 Haddow and
colleagues46 described a 7-point IQ deficit in 7- to 9-year-old children born to
untreated hypothyroid women when compared with age-matched children born to
euthyroid women. Nineteen percent of children of hypothyroid mothers had IQ scores
of less than 85, compared with 5% of controls. Su and colleagues40 showed an
increased risk of fetal loss (OR 13.45, 95% CI 2.5471.20), low birth weight (OR
9.05, 95% CI 1.0180.90), and congenital malformations of the circulation system
(OR 10.44, 95% CI 1.1594.62) in children of women with clinical hypothyroidism.
Subclinical hypothyroidism was associated with increased fetal distress (OR 3.65,
95% CI 1.449.26), poor vision development (OR 5.34, 95% CI 1.0926.16), and neurodevelopmental delay (OR 10.49, 95% CI 1.01119.19). By contrast, a study by Behrooz and colleagues47 showed that IQ levels and cognitive performance of children
born to LT4-treated hypothyroid mothers was similar between those whose mothers
had high TSH levels (mean 11.3 5.3 mIU/L) and those whose mothers achieved
normal TSH concentrations during pregnancy.
Isolated Hypothyroxinemia
All women with (1) overt hypothyroidism and (2) thyroid peroxidase (TPO) antibody
positive subclinical hypothyroidism should be treated with LT4 during pregnancy to
maintain serum TSH in the trimester-specific goal range. At present, there is insufficient evidence to recommend for or against LT4 treatment in thyroid antibodynegative pregnant women with subclinical hypothyroidism.16 Similarly, data demonstrating
a benefit of LT4 therapy in pregnant women with isolated hypothyroxinemia are not
available, so routine LT4 treatment is currently not recommended in these cases.52
Nonetheless, the ongoing National Institutes of Health CATS and TSH studies will
provide important data regarding the effects of LT4 treatment in these special cases,
and thereby help guide future evidence-based recommendations.
For women who require LT4 treatment during pregnancy, it is crucial to adjust LT4
doses appropriately to account for physiologic pregnancy-induced changes in
economy of thyroid hormone. Adequate treatment with LT4 to maintain TSH within
the target ranges for pregnancy significantly decreases pregnancy-related complications that occur in inadequately treated hypothyroid women.33 The etiology of hypothyroidism has a marked effect on the timing and magnitude of LT4 dose adjustments.
Women with primary hypothyroidism caused by Hashimoto thyroiditis require smaller
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240
dose increases, as do women treated for thyroid cancer, compared with women previously treated for Graves disease, who require the largest dose increases, indicating
that a single recommendation might not apply to all patients. On average, among a large
group of pregnant women with hypothyroidism of varying etiology, the required
increase in LT4 dose was 13% in the first trimester and 26% in the second and third
trimesters.53 Another study showed that an increase in LT4 dose was required in
85% of hypothyroid pregnant women, starting as early as the fifth week of gestation
and plateauing by week 16. The mean LT4 requirement increased 47% during the first
half of pregnancy in that study.5
The goal of treatment is to maintain TSH within trimester-specific reference ranges:
0.1 to 2.5 mIU/L in the first trimester, 0.2 to 3.0 mIU/L in the second trimester, and 0.3
to 3.0 mIU/L in the third trimester. At a minimum, serum TSH should be measured
every 4 weeks during the first half of the pregnancy, then at least once between 26
and 32 weeks of gestation, so that appropriate dose adjustments can be made.16
The recommended therapy is with oral LT4, which should be taken on an empty
stomach (45 minutes before consumption of food, beverages, or other medications).
In addition, calcium, iron, and prenatal vitamin supplements should be avoided within
4 hours of ingestion of LT4, as these can decrease absorption and lead to inadequate
circulating thyroxine levels.
A high proportion of pregnant women with hypothyroidism who are taking LT4 have
suboptimal TSH levels at 11 to 13 weeks of gestation.37 Because most women do not
have their first prenatal obstetric visit until the 8th to 12th week of pregnancy, one
strategy is to empirically increase the levothyroxine dose as soon as pregnancy is
confirmed. In the Thyroid Hormone Early Adjustment in Pregnancy (THERAPY) trial,
an empiric increase by 2 additional LT4 tablets per week (29% increase), when instituted immediately on confirmation of pregnancy, significantly reduced the risk of
maternal hypothyroidism throughout pregnancy, with a safety profile superior to that
of an increase of 3 additional tablets per week (43% increase).54 Recent ATA guidelines endorse this recommendation, or the alternative option of empirically increasing
LT4 dose by approximately 25% to 30% on confirmation of pregnancy.16 After
delivery, the patient should be instructed to return to her prepregnancy dose of LT4,
and serum TSH should be checked again 6 weeks after delivery.
Iodine sufficiency is crucial in pregnancy. Indeed, maintaining the increased iodine
requirements in pregnancy has been shown to prevent cretinism and improve motor
skills in offspring. The recommended daily iodine dose in pregnancy and lactation is
250 mg of iodine daily. This dosage may be achieved by supplementing an iodinesufficient diet with a daily oral prenatal multivitamin containing 150 mg of potassium
iodide. Caution should be advised because supplemental iodine is not found in all
prenatal multivitamins, so women should be advised to take a prenatal vitamin that
provides iodine, in addition to ensuring adequate dietary iodine intake.
EUTHYROIDISM WITH AUTOIMMUNE THYROID DISEASE
a minimum, serum TSH should be monitored throughout pregnancy in thyroid antibodypositive euthyroid women, and LT4 therapy should be initiated if serum TSH is
greater than 2.5 mIU/L.
HYPERTHYROIDISM DURING PREGNANCY
Clinical features of hyperthyroidism may be mistaken for normal symptoms of pregnancy, such as palpitations, heat intolerance, dyspnea, and nervousness. Graves
disease may present as a new diagnosis during pregnancy in a woman with no history
of hyperthyroidism, as a recurrence from previous Graves disease that was in remission, or as an exacerbation of stable disease treated with antithyroidal drugs (ATD).
Exacerbations of Graves disease being treated with ATDs typically occur early in pregnancy or soon after delivery.64
On physical examination, women with Graves disease usually have a palpable
goiter, with or without a bruit. In some instances, Graves ophthalmopathy is present.
Graves dermopathy may rarely be seen. On laboratory evaluation, TSH is usually suppressed or lower than the trimester-specific reference range and fT4 is high. Women
with Graves disease usually have positive TSH receptor antibodies (TRAb), which
helps differentiate Graves disease from other causes of hyperthyroidism. Ultrasonography of the thyroid may also be helpful in certain circumstances, for example, to
differentiate between toxic multinodular goiter, a single toxic nodule, or the heterogeneous thyroid echotexture that is consistent with Graves disease. Use of radiolabeled
iodine for diagnosis is contraindicated in pregnancy and lactation.
Outcomes
Lack of control of hyperthyroidism significantly increases the risk of pregnancy complications and poor fetal outcomes. Millar and colleagues65 showed that, compared with
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242
the risk in nonhyperthyroid women, the risk of low birth weight infants was 9.24 (95% CI
5.515.6) among women with uncontrolled hyperthyroidism during pregnancy, 2.36
(95% CI 1.44.1) in women whose hyperthyroidism was controlled at some point
during pregnancy, and 0.74 (95% CI 0.23.1) in women whose hyperthyroidism was
controlled at presentation so that euthyroidism was maintained throughout pregnancy.
The risk of severe preeclampsia was also significantly higher among women with
uncontrolled hyperthyroidism compared with hyperthyroid women with controlled
thyroid levels during pregnancy (OR 4.7, 95% CI 1.119.7).65 In addition, in a cohort
of 60 women with overt hyperthyroidism in pregnancy, stillbirth was more common
in untreated women (50%) than in partially treated (16%) and adequately treated
hyperthyroid women (0%).66 Overt untreated maternal hyperthyroidism is also associated with an increased risk of miscarriage,67 maternal heart failure during pregnancy,68
maternal gestational hypertension, and fetal growth restriction.69 Uncontrolled
maternal hyperthyroidism may cause central congenital hypothyroidism, due to
impaired maturation of the fetal hypothalamic-pituitary thyroid system in a hyperthyroid
fetal environment.70
TRAbs cross the placental barrier, and in high titers can stimulate the fetal thyroid
gland, which may result in fetal hyperthyroidism.71 Fetal thyrotoxicosis causes fetal
tachycardia, goiter, oligohydramnios, intrauterine growth retardation, and accelerated
bone maturation.72 Neonatal hyperthyroidism may occur within 24 to 72 hours after
delivery in cases of high maternal TRAb titers. Before delivery, the fetus is protected
by ATDs that cross the placenta. Neonatal hyperthyroidism is usually a transient
condition, lasting between 2 and 3 months. Treatment of the neonate with ATDs is
indicated until resolution of the hyperthyroidism.73
Treatment
Preconception counseling As already described, uncontrolled hyperthyroidism affects
maternal and fetal outcomes poorly. It is imperative to provide preconception counseling to women with hyperthyroidism so that the best therapeutic option to control
the disease before pregnancy can be implemented. In the preconception period, treatment options for Graves disease include RAI ablation, total thyroidectomy, or ATDs.
Surgery is a reasonable option in cases of high TRAb titers or in women planning to
conceive in the subsequent 2 years, because TRAb titers tend to increase following
RAI therapy and take longer to trend downwards.74 RAI is absolutely contraindicated
during pregnancy and lactation because of the high risk of transferring RAI to the fetus
with resultant fetal thyroid ablation and congenital hypothyroidism. If RAI ablation is
desired near pregnancy or lactation, special considerations should be kept in mind,
and these are listed in Box 2.
Antithyroid drugs Two ATDs, methimazole (MMI) and propylthiouracil (PTU), are used
to treat hyperthyroidism. Both drugs cross the placenta. The goal of ATD therapy in
pregnant women with hyperthyroidism is to maintain maternal serum fT4 at or just
above the upper limit of normal for pregnancy using the smallest ATD dose possible.
This treatment strategy minimizes the potential for overtreatment, which may result in
fetal hypothyroidism75 and goiter.76 In this regard, Momotani and colleagues77
showed a strong relationship between maternal and fetal thyroid function: the rates
of transient neonatal hypothyroxinemia were 10% when maternal fT4 was maintained
in the upper one-third of the normal range, 36% when maternal fT4 was maintained in
the lower two-thirds of the normal range, and 100% when maternal fT4 was maintained below the normal range. There was no relationship between the dose or the
type of ATD used and neonatal thyroid function.
Box 2
Considerations for RAI therapy in women of child-bearing age
1. RAI is absolutely contraindicated during pregnancy and lactation
2. A pregnancy test should be performed on all women of child-bearing age before RAI
3. Conception should be delayed by a minimum of 6 months after RAI to allow adequate time
for diagnosis and treatment of consequent hypothyroidism
4. Lactation should be delayed for at least 6 months following RAI therapy
5. RAI might increase TRAb titers and it may take up to 1 year for the titers to decline after RAI.
Therefore, if TRAb titers are high before treatment, surgery might be a better option
6. Prepregnancy counseling regarding the need to adjust LT4 dose at diagnosis of pregnancy is
important
Adapted from Patil-Sisodia K, Mestman JH. Graves hyperthyroidism and pregnancy: a clinical
update. Endocr Pract 2010;16(1):11829; with permission.
In rare cases, use of MMI in the first trimester has been associated with congenital
abnormalities, including fetal aplasia cutis,78 choanal atresia, omphalocele, total situs
invertus,79 esophageal atresia,80 tracheo-esophageal fistula, hypoplastic nipples, and
psychomotor delay.81 PTU, on the other hand, has not been associated with these
fetal abnormalities. A major risk associated with PTU is acute liver failure, resulting
in a need for liver transplant in approximately 1 in 10,000 treated adults.82,83 To
decrease the risk of congenital abnormalities associated with first-trimester MMI
use, women taking MMI before pregnancy should be switched to PTU once pregnancy is confirmed, or alternatively, before conception. After the first trimester,
consideration should be given to switching from PTU to an equivalent dose of MMI
to avoid maternal liver injury.16 Clinical experience has demonstrated an approximate
conversion ratio from PTU to MMI of 10:1 to 15:1 (eg, 100 mg PTU 5 7.510 mg
MMI84).
After delivery, Graves disease may worsen or relapse, necessitating that ATDs are
restarted or the dose increased. In the past, women taking ATDs were advised against
breastfeeding because little was known about their effects on the newborn when
delivered via breast milk. More recent studies, however, have demonstrated that
ATDs are safe in lactating women. The use of PTU (as high as 750 mg daily) or methimazole (2030 mg daily) have not been associated with an increased risk of infant
hypothyroidism, and no adverse effects on physical or cognitive childhood development have been observed.85,86
Surgery Thyroidectomy during pregnancy is rarely indicated, but should be consid-
ergic symptoms or in preparation for surgery. Long-term use should be avoided and
has been associated with intrauterine growth retardation, fetal bradycardia, neonatal
hypoglycemia, and spontaneous abortion.88,89 Labetolol, a pregnancy category C
medication, is the preferred b-blocker for use during pregnancy and lactation.
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244
Cold iodine The use of cold (ie, nonradioactive) iodine during pregnancy should be
Box 3
Indications for TRAb measurement during pregnancy
1. Mothers with active hyperthyroidism
2. Previous history of treatment with RAI
3. Previous history of delivering an infant with hyperthyroidism
4. Thyroidectomy for treatment of hyperthyroidism in pregnancy
Adapted from Laurberg P, Nygaard B, Glinoer D, et al. Guidelines for TSH-receptor antibody
measurements in pregnancy: results of an evidence-based symposium organized by the European Thyroid Association. Eur J Endocrinol 1998;139(6):584; with permission.
The reported prevalence of PPT varies widely across studies, from 1.1% to 16.7%
(mean 7.5%) among parous women.98 Women with a previous history of PPT have
a 70% risk of developing recurrent PPT in future pregnancies.99 PPT incidence is
higher in women with autoimmune disease: 10% to 25% in women with type 1 diabetes mellitus,98,100 14% in women with systemic lupus erythamatosus,101 and
25% in women with autoimmune hepatitis.102 An estimated 30% to 50% of women
with positive thyroid autoantibodies in the first trimester will develop PPT.95,103,104
Diagnosis
Screening for PPT is recommended in women with a history of thyroid disease, PPT,
postpartum depression, or autoimmune disease, and in women with signs and/or
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246
Most women with PPT do not require treatment in the hyperthyroid state, which is
generally mild and transient. Propranolol, 10 to 20 mg daily, can be used as needed
for adrenergic symptoms. ATDs are ineffective in the treatment of PPT because it is
a destructive process and does not involve overproduction of thyroid hormone. In
the hypothyroid phase, TSH should be tested every 4 to 8 weeks, even if the patient
is asymptomatic. Levothyroxine treatment is indicated when TSH elevation persists
longer than 6 months postpartum, or if symptoms of hypothyroidism are severe, the
patient is breastfeeding, or another pregnancy is desired. Therapy should be
continued for 6 to 12 months after initiation, followed by an attempt to wean the LT4
by halving the dose every 6 to 8 weeks. If the patient is pregnant, breastfeeding, or
trying to conceive, weaning LT4 therapy is not indicated and therapy should be
continued.16
Various attempts have been made to prevent PPT in women at risk. A single,
randomized controlled trial by Negro and colleagues107 showed that compared with
placebo, selenium administration during pregnancy significantly decreased the prevalence of PPT in women with positive thyroid antibodies (28.6% vs 48.6%). In another
study, the postpartum use of LT4 in women with thyroid autoimmunity (defined as
positive TPO antibody titers) did not prevent PPT but, as expected, reduced symptoms of hypothyroidism associated with PPT when it did occur.108
EVALUATION OF THYROID NODULES AND THYROID CANCER IN PREGNANCY
Not uncommonly, thyroid nodules and thyroid cancer are diagnosed in women during
or around the time of pregnancy, posing important diagnostic and therapeutic
dilemmas when considering the best interests of both the mother and her developing
child. Differentiated thyroid cancer (DTC) occurs approximately 3-fold more frequently
in women than in men, with peak onset in the female reproductive years.109,110 Many
women come under closer medical evaluation around pregnancies than at any other
time in their lives, contributing to increased detection and diagnosis of thyroid nodules
and DTC. In addition, normal physiologic changes in pregnancy include an increase in
maternal thyroid volume, including increased size of thyroid nodules, which further
increases detection rates.111 Management of thyroid nodules and thyroid cancer diagnosed during pregnancy concerns both the affected mother and her fetus, therefore
these cases require special consideration to ensure the best overall outcomes.
Because thyroid cancer is most commonly detected within thyroid nodules, thyroid
nodules should be evaluated with neck ultrasonography and fine-needle aspiration
(FNA), when indicated, to rule out malignancy. During pregnancy, both thyroid ultrasonography and FNA can be performed safely at any time, without risk of harm to the
pregnancy. For this reason, thyroid nodules detected in pregnancy may be evaluated
in the same way as in nonpregnant individuals. That being said, if a suspicious nodule
is detected late in pregnancy and intervention will undoubtedly be delayed until after
delivery, it is reasonable to postpone FNA until after delivery. Detection of a thyroid
nodule in a pregnant woman should prompt measurement of levels of serum thyroid
hormone (TSH, fT4) so that maternal hypothyroidism or hyperthyroidism can be
treated promptly and associated complications prevented.108
If thyroid malignancy is diagnosed in a pregnant woman, the recommended course of
treatment differs from that in a nonpregnant individual. Despite these differences in
management, however, most evidence suggests that DTC diagnosed during or around
the time of pregnancy does not affect maternal or fetal morbidity or mortality. In the same
regard, pregnancy does not increase a womans risk for developing thyroid cancer.
When thyroid cancer is diagnosed during pregnancy, a decision must be made
regarding performing total thyroidectomy during the pregnancy or postponing surgical
resection until the postpartum period. In low-risk cases of DTC, postponing thyroidectomy until after delivery does not affect the course of disease and eliminates the risks
associated with surgery during pregnancy.108 Risks specific to thyroidectomy that
may adversely affect a pregnancy include (1) difficulty resecting the thyroid because
of increased gland volume in pregnancy, (2) uncontrolled maternal hypothyroidism
postoperatively, and (3) transient or permanent maternal hypocalcemia caused by
damage to the parathyroid glands. Anesthesia at any time during pregnancy is complicated by multiple factors, including increased maternal blood volume and cardiac
output, and can result in maternal hypotension and fetal hypoperfusion.112,113 In the
majority of cases, for which thyroidectomy is not performed during pregnancy, monitoring should consist of a repeat neck ultrasonogram each trimester to rule out rapid
growth of malignant tissue, with consideration of immediate surgical intervention if this
should occur, and close monitoring of maternal TFTs (see later discussion).108
In cases of advanced DTC or in undifferentiated forms of thyroid cancer (eg, medullary, anaplastic, or insular variants), which are more aggressive and more likely to
progress if intervention is delayed, thyroidectomy may be performed in the second
247
248
The physiology of the thyroid gland changes during pregnancy as a result of the
effects of increased TBG and hCG levels and enhanced iodine metabolism. It is
249
250
with transient hyperthyroidism in the first 6 months postpartum, followed by transient hypothyroidism, then a return to the euthyroid state by 1 year postpartum.
PPT has been associated with an increased risk of permanent hypothyroidism
and a possible link to PPD. Most women with PPT do not require treatment in
the hyperthyroid state, which is generally mild and transient. Levothyroxine is
indicated in certain cases in the hypothyroid phase.
Thyroid nodules detected in pregnancy may be evaluated with thyroid ultrasonography and FNA when necessary, which are both safe to perform at any
time during pregnancy. When thyroid cancer is diagnosed during pregnancy,
a decision regarding definitive treatment must be made. In most cases, delaying
thyroidectomy and RAI ablation (if indicated) until postpartum does not alter
maternal morbidity or mortality. In high-risk cases, thyroidectomy can be performed in the second trimester. RAI ablation is absolutely contraindicated during
pregnancy and lactation. Similarly to nonpregnant individuals with thyroid
cancer, TSH suppression with levothyroxine is indicated during pregnancy in
women with thyroid cancer.
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55. Negro R, Formoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid
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T h y ro i d H o r m o n e a n d
t h e C a rd i o v a s c u l a r
System
Sara Danzi,
a
PhD ,
Irwin Klein,
MD
b,
KEYWORDS
Thyroid hormone Cardiovascular system Heart
Hemodynamics
258
Fig. 1. Sites of action of thyroid hormone on the heart and cardiovascular system. CETP, cholesteryl ester transport protein; CYP7A, cholesterol 7a-hydroxylase; HCN2, hyperpolarization
activated cyclic nucleotide-gated potassium channel 2; MHC, myosin heavy chains; SERCA2,
sarcoplasmic reticulum (SR) Ca21 ATPase; SREBP-2, sterol regulatory element binding protein
2; VO2, maximal oxygen uptake.
Several families of thyroid hormone transporters have been identified, including the
Na1-taurocholate cotransporting polypeptide (NTCP), the Na1-independent organic
anion transporting polypeptides (OATPs), the heterodimeric L-type amino acid transporters (LAT), and the monocarboxylate transporters (MCTs).6,9 These proteins transport a variety of ligands but only MCT8 and MCT10 are highly specific for
iodothyronines and are expressed in heart (Danzi and Klein, unpublished data,
2011). Conversely, the cardiac plasma membrane transporters that are responsible
for thyroid hormone uptake have not been well characterized. Both MCT8 and
MCT10 were identified as monocarboxylate transporters and only recently found to
be thyroid hormone transporters in an experimental cell system.6 In humans, MCT8
gene mutations are the cause of Allan-Herndon-Dudley syndrome (AHDS), an X-linked
syndrome with specific thyroid and neurologic abnormalities.10
Although both MCT8 and MCT10 facilitate uptake and efflux of both T4 and T3 in
experimental cell systems, our recent data suggest that T4 is not transported into
the heart (Danzi and Klein, unpublished data, 2011). MCT10 has greater affinity for
T3 than T4 and has a greater capacity to transport T3 than MCT8.11 As 1 of 2 thyroid
hormone transporters shown to be expressed in rat or human heart, the MCT8
knockout mouse heart has not been characterized phenotypically.12 The mechanism
of transport for thyroid hormone via MCT8 and MCT10 in a variety of tissues seems to
be via facilitative diffusion. Radiolabeled T3 transport in rat neonatal ventricular myocytes is adenosine triphosphate (ATP) dependent, inhibited by excess unlabeled T3,
and Na1-dependent. In that system, the magnitude of transport of T3 is greater than
2.5-fold higher than T4 (Fig. 2).7
Nuclear Receptors
Fig. 2. Effects of T3 on the cardiac myocyte. T3 has both genomic and nongenomic effects on
the cardiac myocyte. Genomic mechanisms involve T3 binding to thyroid hormone receptor
(TRs), which regulate transcription of specific cardiac genes. Nongenomic mechanisms
include direct modulation of membrane ion channels as indicated by the dashed arrows.
AC, adenylyl cyclase; b-AR, b-adrenergic receptor; Gs, guanine nucleotide binding protein;
Kv, voltage-gated potassium channels; NCX, sodium calcium exchanger; PLB, phospholamban, TRE, thyroid hormone response element.
variant of the TRb gene, TRb1, are expressed. These receptor proteins are bound to
thyroid hormone response elements (TREs) in the promoter region of certain T3responsive genes.13,14 TRs activate transcription of positively regulated genes in the
presence of T3 by recruiting coactivator complexes, and repress transcription in the
absence of ligand by recruiting corepressor complexes.15
It seems that the nuclear content of TRs are in turn regulated by T3 such that, in the
myocardium of hypothyroid animals, TRa-1 and a-2 mRNA levels are increased. After
72 hours of treatment with thyroid hormone, TRa-1 and TRa-2 mRNA levels
decrease.16 In a study of human hearts, comparison of TR mRNA in left ventricular
tissue of patients with dilated cardiomyopathy showed decreased levels of TRa-1
and decreased TRa-1/TRa-2 ratios compared with normal donor hearts.17 After
heterotopic cardiac transplantation, the expression of TRa-1 and TRa-2 is altered in
the rat heart.18
Transcriptional Regulation of Cardiac Myocyte Genes
259
260
Table 1
T3-regulated cardiac genes
Positively Regulated
Negatively Regulated
a-MHC
b-MHC
SERCA2
Phospholamban
Na1/K1 ATPase
b1-Adrenergic receptor
determined by SR Ca21 release via the ryanodine receptors,20 and reuptake into the
SR by the Ca21 ATPase. PLB, an integral SR protein that regulates SERCA2 activity,
is the mechanism by which b-adrenergic agonists exert positive inotropic action on the
heart.21 Varying degrees of impaired SR calcium uptake have been associated with
human and experimental models of heart failure.22 PLB-deficient transgenic mice
showed increased contractility and knockout of PLB in the hypothyroid animal in
the study by Kranias and colleagues,23 which resulted in measures of contractility
similar to that in wild-type animals treated with thyroid hormone, thus confirming
the importance of the family of thyroid hormoneresponsive genes in determining
cardiac contractility.13 Similarly, in a series of studies using transgenic overexpression of SERCA2 in hypothyroid mice, myocyte contractile function was restored to
levels seen in euthyroid animals, confirming the role of SERCA2 in mediating the
effects of thyroid disease on the heart.24
The cardiac phenotype is extremely sensitive to changes in serum T3. In a rat model
of thyroid hormone deficiency, administration of 5 mg/kg of T3 induced transcription of
the positively regulated, cardiac-specific, a-MHC within 30 minutes.25 Maximal transcription, at more than euthyroid levels, occurred 6 hours after hormone administration, showing that the receptor saturating dose of T3 is lower than previously
suggested and the half-life of T3 in vivo was 7 hours.25 In experimental animal models
of the low T3 syndrome, when T4 levels remain normal, the genotype, phenotype, and
contractile function are those seen with more classic hypothyroidism.26
CARDIOVASCULAR HEMODYNAMICS
Hyperthyroidism
Cardiac contractility is enhanced including both systolic and diastolic function, and
cardiac output and resting heart rate are increased in hyperthyroidism.27 A decrease
in systemic vascular resistance decreases afterload and improves myocardial efficiency.28 An increase in blood volume and an increase in venous return cause the preload of the heart to increase, further augmenting cardiac output.29 The increase in
cardiovascular hemodynamics allows for increased blood flow leading to enhanced
perfusion to provide for the substrate and oxygen demands of peripheral tissues
(Fig. 3, Table 2).1
An increase in cardiac mass occurs in hyperthyroidism, both in animals and
humans. Hypertrophy, usually increased left ventricular mass, results from sustained
volume overload and the resulting increase in cardiac work and is a compensatory
adaptation that, in turn, increases protein synthesis in the terminally differentiated
cardiac myocyte.30 Recent studies have shown that, in contrast with mean systemic
pressures, pulmonary artery pressure is increased in hyperthyroidism, which in turn
Fig. 3. Effects of thyroid hormone on cardiovascular hemodynamics. T3 affects tissue thermogenesis, systemic vascular resistance, blood volume, cardiac contractility, heart rate,
and cardiac output, as indicated by the arrows.
imparts an increase in right ventricular strain, increasing chamber size, mass, and
filling pressure. The consequences of this may include the appearance of right heart
or backward failure with neck vein distension and peripheral edema.31,32
Heterotopic cardiac transplantation into the abdominal cavity of a host animal
provides a vascularly perfused, spontaneously beating, nonworking heart exposed
to the same plasma thyroid hormone levels as the in situ working heart.30 When these
animals are exposed to excess amounts of thyroid hormone, only the in situ working
heart became hypertrophic. This finding confirms the hypothesis that it is the excess
workload resulting from the cardiovascular hemodynamics of hyperthyroidism that is
responsible for the increase in cardiac mass.
The clinical manifestations of hyperthyroidism include characteristic cardiac-related
signs and symptoms that are independent of the cause of the increased levels of
Table 2
Changes in cardiovascular hemodynamics accompanying thyroid dysfunction
Parameter
Normal
Hyperthyroid
Hypothyroid
15001700
7001200
21002700
7284
88130
6080
25
3540
Unknown
% Ejection fraction
60
>60
<60
6080
2540
>80
5.8
>7.0
<4.5
100
105.5
84.5
261
262
Sinus tachycardia is the most common rhythm disturbance in patients with hyperthyroidism.45 However, atrial fibrillation caused by hyperthyroidism (especially subclinical
There are reports of pulmonary artery hypertension in patients with thyrotoxicosis.31,32,34 An apparent failure of pulmonary arterial resistance to decline, similar
to that seen in the systemic circulation, results in significant increases of both mean
and peak pulmonary artery pressures. These pressures usually normalized with
a return to a chemically euthyroid state.32 Although primary pulmonary hypertension
is a rare, often fatal, disease of unknown cause that primarily affects young women,
the frequency of both Graves disease (and chronic autoimmune thyroiditis, Hashimoto
disease) is increased in this patient population as well, suggesting the value of routine
thyroid function tests in all patients with pulmonary hypertension.4,34
Cholesterol Metabolism
Increased low-density lipoprotein (LDL) cholesterol occurs in the setting of hypothyroidism and in proportion to the increase in serum TSH levels.42,50 Thyroid hormone
alters cholesterol metabolism through a variety of mechanisms, including a decrease
in LDL receptor expression but, perhaps more importantly, a decrease in biliary excretion. Further support for the role of thyroid hormone in the regulation of cholesterol
metabolism comes from a recent study that describes a liver-selective thyroid
hormone agonist, eprotirome, that can synergistically lower cholesterol levels in
statin-treated patients.50 Not only was high-density lipoprotein significantly decreased
but a unique ability to lower Lp(a), an especially atherogenic lipid particle, was seen.
Amiodarone-Induced Thyroid Disease
263
264
benzofuran antiarrhythmic, does not alter thyroid function and confirms this
concept.52,53 Amiodarone inhibits the 50 -monodeiodination of T4 in the liver and pituitary, thereby decreasing serum T3 and increasing serum T4 levels. Serum TSH levels
initially remain normal. In patients with underlying goiter, autoimmune thyroid disease,
defects in thyroid hormone biosynthesis, and in some patients without any risk factors,
there may be a progression to overt chemical and clinical hypothyroidism with
a marked increase in serum TSH levels.51,54
Thyroid function should be measured every 3 months in all patients receiving amiodarone and for at least 6 months after stopping treatment because the effect on
thyroid function can occur at any time after initiating treatment (and, because of the
long half-life of the drug, alterations in thyroid function may still occur up to 1 year after
discontinuing therapy).52
Less common than amiodarone-induced hypothyroidism, but perhaps more challenging, is the development of amiodarone-induced thyrotoxicosis. The development
of this condition may be signaled by the new onset or recurrence of ventricular irritability, decreased warfarin sodium dose requirements, or the return or worsening of
heart failure symptoms.52 Early studies distinguished 2 forms of amiodaroneinduced thyrotoxicosis. Type I occurs primarily in patients with preexisting thyroid
disease and most commonly in iodine-deficient areas. These patients frequently
have some measures of thyroid autoimmunity, including antithyroid antibodies.51 In
contrast, type II disease was identified as a form of thyroiditis, presumably mediated
by a variety of proinflammatory cytokines. This process is destructive, causing release
of preformed thyroid hormone, which may continue for weeks or months and most
often is associated with low to absent radioiodine uptake.54 Clinically important is
the report that amiodarone-induced thyrotoxicosis is associated with a 3-fold
increased risk for major adverse cardiovascular events.55
Therapy for these patients is especially challenging because the use of iodine 131 is
almost always ineffective and treatment with antithyroid drugs has marginal effectiveness.40,51,52,54 Treatment with corticosteroids may provide benefit and, in most cases,
lowers serum levels of both T4 and T3 within 2 to 3 weeks.54 In patients unresponsive
to glucocorticoids with evidence of hyperthyroidism, including weight loss, tachycardia, palpitations, worsening angina, ventricular tachycardia, or other untoward
cardiac effects, treatment with antithyroid therapy such as methimazole is variably
effective.54 Total thyroidectomy with preoperative treatment with b-blockers can be
performed safely and is an effective means of reversing the hyperthyroidism rapidly.55
Discontinuation of amiodarone is a cardiology decision.
ALTERATIONS IN THYROID HORMONE METABOLISM THAT ACCOMPANY
HEART DISEASE
are almost identical to the changes in gene expression in heart failure and include the
genes that encode the contractile proteins, a-MHC and b-MHC, the sodium calcium
exchanger (NCX1), SERCA2, PLB, and the b-adrenergic receptor (b-AR).3 The net
effect of these alterations in gene expression is to alter cardiac contractility, calcium
cycling, and diastolic relaxation of the myocardium.22,44
Interleukin 6 (IL-6) and tumor necrosis factor-a (TNF-a) levels are increased in the
low T3 syndrome and can impair the expression and the activity of hepatic monodeiodinase, leading to decreased metabolism of T4. The cardiac myocyte seems to transport T3 in marked preference to T4 and is exquisitely sensitive to changes in serum
T3.60 Evidence is accumulating that suggests that low T3 levels contribute to the heart
failure phenotype and that normalization of T3 might improve cardiac function in this
setting. A recent study of T3 treatment of humans with NYHA Class III or IV heart failure
has shown beneficial effects.8 Further studies are required to determine whether
thyroid hormonebased treatments may be useful in selected patients with heart
failure.3,8
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266
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37. Olsen B, Klein I, Benner R, et al. Hyperthyroid myopathy and the response to
treatment. Thyroid 1991;1:13741.
38. Kahaly G, Kampmann C, Mohr-Kahaly S. Cardiovascular hemodynamics and
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46. Sawin CT, Geller A, Wolf PA, et al. Low serum thyrotropin levels as a risk factor for
atrial fibrillation in older persons. N Engl J Med 1994;33:1249.
47. Nakazawa H, Lythall DA, Noh J, et al. Is there a place for the late cardioversion of
atrial fibrillation? A long-term follow-up study of patients with post-thyrotoxic atrial
fibrillation. Eur Heart J 2000;21:327.
48. Ventrella S, Klein I. Beta-adrenergic receptor blocking drugs in the management
of hyperthyroidism. Endocrinologist 1994;4:3919.
49. Petersen P, Hansen JM. Stroke in thyrotoxicosis with atrial fibrillation. Stroke 1988;
19:15.
50. Ladenson PW, Kristensen JD, Ridgway EC, et al. Use of the thyroid hormone
analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 2010;362:90616.
51. Martino E, Bartalena L, Bogassi F, et al. The effects of amiodarone on the thyroid.
Endocr Rev 2001;22:240.
52. Cohen-Lehman J, Dahl P, Danzi S, et al. Effects of amiodarone on thyroid function. Nat Rev Endocrinol 2010;6:3441.
53. Kathofer S, Thomas D, Karle CA. The novel antiarrhythmic drug dronedarone:
comparison with amiodarone. Cardiovasc Drug Rev 2005;23:217.
54. Bogazzi F, Bartalena L, Cosci C, et al. Treatment of type II amiodarone-induced
thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study. J Clin Endocrinol Metab 2003;88:1999.
55. Williams M, Lo Gerfo P. Thyroidectomy using local anesthesia in critically ill
patients with amiodarone-induced thyrotoxicosis: a review and description of
the technique. Thyroid 2002;12:523.
56. DeGroot LJ. Dangerous dogmas in medicine: the nonthyroidal illness syndrome.
J Clin Endocrinol Metab 1999;84:15164.
267
268
T h e Eff e c t o f Th y ro i d
D i s o rde r s on Li p i d
Levels and Metabolism
Leonidas H. Duntas,
MD
a,
*, Gabriela Brenta,
MD
KEYWORDS
Thyroid Cholesterol Hypothyroidism TSH
Hyperthyroidism Lipids
270
article published by Mason and colleagues4 in the New England Journal of Medicine
revealed the significance of cholesterol values in hyperthyroidism and hypothyroidism.
Shortly thereafter, mainstream studies were published concerning the induction of
hypothyroidism through cholesterol feeding to rabbits and the discovery that thyroid
hormone supplementation inhibited the development of this lesion.5 Subsequently,
thyroid functioning has been firmly associated with cholesterol levels, whereas the
incidence of hypothyroidism has consistently been reported to be significantly higher
in patients with hypercholesterolemia.6 The rise of cholesterol together with arterial
hypertension, which is usually from the increased peripheral resistance, constitutes
a major risk factor for atherosclerotic cardiovascular disease in hypothyroidism.7
In a multicenter study evaluating the prevalence of hypothyroidism in 752 hypercholesterolemic patients, primary hypothyroidism amounted to 3.7%, SCH to 2.4% and
overt hypothyroidism to 1.4%.8 The overall prevalence of hypothyroidism was calculated at 4.3% in patients with hypercholesterolemia. In contrast, in thyrotoxicosis
cholesterol synthesis is increased, but this is simultaneously counterbalanced by an
enhanced rate of degradation and excretion.9 In addition, free fatty acid release and
fatty acid oxidation have been described as being higher in hyperthyroidism, and
this impairment may promote insulin resistance.10
The biochemical and molecular alterations induced by thyroid hormones in lipids
during thyroid dysfunctions are variable, therefore constituting a complex field of
study. This article updates the current knowledge concerning the impact of thyroid
disease on lipid metabolism and pathophysiology and reviews the effect of thyromimetics on lipids and the controversy surrounding thyroxine treatment of SCH.
Cholesterol is generated within the body through hydrolysis of the molecules acetyl
coenzyme A (CoA) and acetoacetyl-CoA, which form 3-hydroxy-3-methylglutarylCoA (HMG-CoA) that is then reduced to mevalonate by the rate-limiting enzyme
HMG-CoA reductase. Cholesterol is transported within the blood by lipoproteins
called, based on increasing density, chylomicrons, very low-density lipoprotein
(VLDL), intermediate-density lipoprotein (IDL), LDL, and high-density lipoprotein
(HDL). As shown by centrifugational analysis, cardioprotective HDL may be subdivided into HDL2 (lipid content, 59%67%) and HDL3 (4%44%).11 Cholesterol
synthesis is mediated by the sensing of intracellular cholesterol in the endoplasmic
reticulum via SREBP 1 and 2, the transcription factor that positively regulates the
expression of LDL receptor and cholesterol synthesis, and which is bound to two other
proteins, SCAP (SREBP-cleavage-activating protein) and INSIG1 (insulin-induced
gene 1).12 The SREBP-2 gene is regulated by thyroid hormone. After cleavage by
specific proteases, namely S1P (sphingosine-1-phosphate) and S2P, SREBP migrates
to the nucleus and acts as a transcription factor to bind to the sterol regulatory
element, which stimulates the transcription of the low-density lipoprotein LDL receptor
and HMG-CoA reductase genes. Increased serum triglycerides have been associated
with proatherogenic changes in lipoproteins, for instance reduction of cardioprotective HDL and generation of small dense LDL.13,14
Reverse Cholesterol Transport
Cholesterol is removed from the extrahepatic tissues by HDL and is transferred back
to the liver by a pathway named reverse cholesterol transport, the most important and
effective antiatherogenic process of the human body.
Thyroid hormones have variable effects on lipid metabolism, because thyroid function
regulates cholesterol synthesis and degradation and mediates the activity of key
enzymes.15 The cholesterol-lowering effect of thyroid hormones mainly occurs
through an increased expression of LDL receptors at the hepatic and peripheral levels.
The fact that T3 regulates LDL receptors was discovered more than 40 years ago after
the observation that in conditions of hypothyroidism, LDL cholesterol elimination was
reduced (Fig. 2).9,16 It was subsequently shown that the number of LDL receptors in
human murine fibroblasts and hepatocytes was regulated by T3,17 and that in hypothyroid rats, the hepatic levels of LDL receptor mRNA were decreased (see
Fig. 2).18,19 The causative mechanisms consist of an indirect effect through the
Fig. 1. The cholesterol transport from the peripheral tissues to the liver is mediated by HDL.
LPL delipidates chylomicrons and VLDL, leading to production of IDL and transport of phospholipids into HDL, which carry cholesterol from extrahepatic tissues to the liver. Free
cholesterol is esterified by LCAT to cholesteryl ester, which is transported by CETP from
HDL2 to VLDL and IDL. CETP, cholesteryl-esters transfer protein; FC, free cholesterol; HDL,
high density lipoproteins; HL, hepatic lipase; IDL, intermediate density lipoproteins; LCAT,
lecithin-cholesterol acyltransferase; LPL, lipoprotein lipase; Tg, triglyceride; TH, thyroid
hormones; VLDL, very low-density lipoproteins.
271
272
Fig. 2. Pathogenetic mechanism of increased low-density lipoprotein (LDL) in hypothyroidism. Hypothyroidism reduces the expression of LDL mRNA and the number of LDL receptors and the binding of LDL to LDL receptor, leading to increased half-life of LDL levels,
reduced degradation of LDL in the fibroblasts, enhanced residence time in serum, and
susceptibility to oxidation.
The lipid profile in hypothyroidism is characterized by increased total and LDL cholesterol levels with increased or normal HDL levels. Usually the HDL2 subfraction, and not
the HDL3, is elevated.38 Triglyceride levels are not markedly affected or are at most
slightly elevated. However, it has been recorded that the levels of lipoprotein (a)
may be increased.39 All of these abnormalities are reversed by treatment with L-T4.
The most frequent form of dyslipidemia, as shown in a study of 295 overt hypothyroid
patients, is type IIA or pure hypercholesterolemia (56%), followed by type IIb (hypercholesterolemia and hypertriglyceridemia; 34%) and type IV (hypertriglyceridemia;
1.5%), whereas only 8.5% had no lipid abnormalities.39
The pathophysiologic mechanism behind these lipid abnormalities has been determined to be a decreased biosynthesis and degradation of lipoproteins, with a predominance in the reduction of catabolic pathways.18 The reduction in the number of LDL
receptors results in an excess of LDL particles, which circulate in plasma and are
prone to oxidation (see Fig. 2). A lower activity of the enzymes lipoprotein lipase25,26
and hepatic lipase24 has been extensively described in overt hypothyroidism, together
with a decrease in the activity of CETP.27 These changes in enzymatic activity could
account for the increased levels of lipoproteins possessing high atherogenic potential,
such as VLDL and VLDL remnants/IDL, in plasma of hypothyroid patients. Similar to
what occurs with LDL particles in excess, aberrant receptors of macrophages can
also dispose of these remnants and initiate the transformation into foam cells and
oxidation of LDL.40,41 Paraoxonase 1 (PON1) activity, which is an HDL-associated lactonase that protects against macrophage-mediated LDL oxidation, is reportedly
decreased in thyroid disorders,42 and therefore researchers have postulated that
the increased LDL oxidation in hypothyroidism is caused to some extent by the
reduced PON1 activity.43
Regarding LDL size, except for one study,44 most agree that there is an absence of
small LDL in hypothyroidism.4547
Although HDL particles may attain increased levels in hypothyroidism, the net effect
of the impaired activity of the lipoprotein remodeling enzymes on HDL functional
capacity remains to be determined.
Serum concentrations of nonHDL cholesterol (nonHDL-C) have also been reportedly increased in hypothyroidism, presumably caused by the disturbed metabolism of
273
274
LDL and remnants.48,49 Replacement therapy with LT4 reduces nonHDL-C levels,
thus potentially contributing to cardioprotection, taking into consideration that assessment of nonHDL-C, which constitutes a secondary target of therapy, was proposed
in patients at increased risk for cardiovascular disease.48,50
IMPACT OF SUBCLINICAL HYPOTHYROIDISM ON THE LIPID PROFILE
Concerning SCH, several older studies, in the 1970s and 1980s, showed a lipoprotein
derangement and hypothesized that this could be associated with increased cardiovascular risk.5153 Although 1% to 11% of all patients with dyslipidemia have SCH, the
results of epidemiologic studies analyzing lipid levels according to thyroid status are
highly controversial.54 The U.S. Colorado study, with a population sample of 25,862
subjects,55 showed that patients with SCH had higher levels of total cholesterol
compared with the remaining euthyroid population. However, in an Austrian population
study of 6014 subjects,56 SCH was found to yield similar cholesterol levels to those of
euthyroids, whereas cholesterol values were higher only in the group with overt hypothyroidism. Likewise, a cross-sectional analysis of a population sample57 of the third U.S.
National Health and Nutrition Examination Survey (NHANES III) showed that, although
cholesterol and triglyceride levels were higher in patients with SCH than in euthyroid
subjects, after adjusting for variables such as sex, race, age, and whether the patient
was under lipid lowering drugs, SCH was not related to an abnormal lipid profile. In
contrast, another study that distributed patients into groups according to severity of dyslipidemia58 showed a larger incidence of SCH was found in the group with the highest
levels of serum cholesterol. These findings are consistent with the results of a recent
study showing a high prevalence of SCH in a population of 1610 women older than
50 years with dyslipidemia.59
A plausible explanation for the discrepancy between these study results may reside
in the great heterogeneity of the populations studied. Among factors involved are
differences in TSH levels used to define SCH and in selection criteria according to
age, sex, race, degree of smoking,60 or insulin resistance.61 In fact, good evidence
has been provided that the association of TSH with LDL cholesterol is modified by
insulin sensitivity. Insulin-resistant patients with high normal TSH are more susceptible
to higher cholesterol serum levels. These results have been replicated in the Fermantle
study, a community-based observational study, including 117 women with type 2 diabetes mellitus.62 Therefore, although hyperinsulinemia may determine an increased
hepatic output of VLDL particles, hypothyroidism might meanwhile suppress their
removal, resulting in the net effect of accumulation of modified lipoproteins. Moreover,
researchers have reported that in SCH, LDL particles have an impaired composition
and become triglyceride-rich lipoproteins.62 VLDL remnants and IDL tend to accumulate in circulation.49,63 Furthermore, both atherogenic alterations have been associated with a reduction of hepatic lipase activity.63,64 However, fractional clearance
rates of triglycerides and cholesteryl esters have been reportedly equal in patients
with SCH and controls, indicating that lipolysis and remnant removal of triglyceriderich lipoproteins were normal.65 Nevertheless, transfer of triglycerides to HDL was
reduced when compared with controls.
All of these findings have resulted in the hypothesis that TSH has no cutoff threshold
for its association with lipids.
EFFECT OF L-T4 THERAPY ON LIPID PROFILE IN SUBCLINICAL HYPOTHYROIDISM
Treatment of severe hypothyroidism with L-T4 reverses lipid abnormalities. In subclinical forms of the disease, however, the results are less conclusive. Numerous
intervention studies are being conducted to evaluate lipid changes in SCH. A frequently
quoted meta-analysis66 involving a selection of 13 intervention studies registered a reduction in lipids, especially in patients in whom the baseline total cholesterol level was
greater than 240 mg/dL. After the publication of this meta-analysis, other placebocontrolled studies were performed. In 66 women with TSH greater than 5 mU/L treated
over 50 weeks with L-T4, a significant reduction of 3.2% and 8% in total cholesterol
and LDL, respectively, was seen at the end of the treatment period.67 In another trial,
subclinical hypothyroid patients were randomized to placebo or L-T4 for a 6 months.68
A reduction of 9% and 13% in total cholesterol and LDL, respectively, was shown,
although the results were criticized because no significant difference was seen between
the levels of cholesterol in the placebo and treated groups by the end of the study. Nevertheless, in a subsequent study by this research group, carotid intima-media thickness
values were found to be higher in the subclinical hypothyroid group, and cholesterol
levels after treatment were clearly lower than those in the placebo group.69
L-thyroxine administration has exhibited a significant cholesterol-lowering effect in
hypercholesterolemic patients with antibody-positive, high-normal (2.04.0 mIU/L)
TSH levels compared with those with low-normal (0.401.99 mU/mL) TSH levels.70
Thus, it has been suggested that the known associations of overt and SCH with hyperlipidemia may be extended into the normal range of thyroid function.70
This assumption was further confirmed in the large, population-based, fifth Troms
study71 recruiting 5143 Norwegian subjects in whom a slight but significant association between TSH levels and total cholesterol and LDL was reported. Further analysis
of a subgroup of 84 patients with TSH levels between 3.5 and 10 mU/L also showed
significantly higher levels of total cholesterol and LDL compared with the control
group. The Nord-Trndelag Health (HUNT) study,72 another epidemiologic study,
also conducted in Norway, enrolling 30,565 participants, similarly showed that a linear
increase of total cholesterol, LDL-C, nonHDL-C, and triglycerides, and a decrease in
HDL cholesterol is seen within the normal range of TSH.
A double-blind crossover study involving 100 subjects with TSH greater than 6.1
mU/L showed a significant decrease in total cholesterol and LDL after 12 weeks of
treatment with 100 mg L-T4.73 Similarly, in a trial using individually adjusted doses of
L-T4, the authors noted a reduction of cholesterol levels, especially in patients with
TSH greater than 8 mU/L.74
According to the results of most of the intervention studies, L-T4 has a hypolipemic
effect in SCH, whereas the therapeutic benefit is greater with a higher initial value of
cholesterol and TSH.
Cardiovascular Risk
275
276
are reduced in hyperthyroid patients.86,87 Although this finding can be partly attributed
to malnutrition and weight loss, the high uptake of cholesterol into cells and its larger
excretion in bile salts through the gut can all contribute to the hypolipemic effect
observed in these patients.16,17,39 Nevertheless, although LDL serum levels are low in
hyperthyroidism, which may account for an antiatherogenic benefit, LDL particles are
more prone to oxidation.88,89 Furthermore, HDL, and more specifically subfraction
HDL2, has been found reduced in hyperthyroidism (43 to 27).
In adipose tissue, lipolysis is also augmented, with elevation of nonesterified fatty
acids (NEFA) in plasma, with their consequent oxidization and enhanced ketogenesis
in the liver.90,91 However, mild hypertriglyceridemia has been paradoxically observed
in hyperthyroidism. A plausible explanation for this phenomenon would be that hepatic
lipogenesis is augmented, accompanied by an increased fatty acyl-CoA availability for
hepatic reesterification, although evidence shows a direct stimulation of hepatic lipogenesis by thyroid hormones.92
Normalization of lipid changes on reversal of the thyrotoxic state has been noted by
several authors, although the magnitude of the response depends on factors such as
the duration and modality of treatment of the thyroid dysfunction and the characteristics of each individual.93,94
THYROMIMETICS: MODES OF ACTION AND PERSPECTIVES
The notion that the T3 effect on plasma cholesterol levels is mediated through TRb1
has ignited research into the development of thyroid hormone receptor isoform bselective analogs, the thyromimetics that specifically target TRb1, either through
selective hepatic uptake and/or through higher binding affinity to TRb1, to treat hypercholesterolemia, while avoiding adverse effects in the heart or skeleton.95 They may
protect from atherosclerosis by promoting reverse cholesterol transport and activating
hepatic lipase. They reduced serum cholesterol levels by 25% and serum triglycerides
by 75% in chow-fed mice and also attenuated diet-induced hypercholesterolemia.
Sobetirome reduced plasma HDL cholesterol levels, increased expression of the
hepatic HDL receptor SR-BI, stimulated activity of cholesterol 7alpha-hydroxylase,
and increased fecal excretion of bile acids.96,97
Eprotirome (KB2115), another TRb1-selective agent, has been shown to be capable
of lowering cholesterol, triglycerides, and lipoprotein(a) in hypercholesterolemic
patients receiving statins.98 Thus, a randomized, placebo-controlled, double-blind,
multicenter trial showed that the addition of placebo or eprotirome at a dose of 25,
50, or 100 mg daily for 12 weeks to ongoing statin treatment significantly decreased
the mean level of serum LDL cholesterol, apolipoprotein B, triglycerides, lipoprotein(a)
up to a mean reduction from baseline of 7%, 22%, 28%, and 32%, respectively.97
Eprotirome therapy was shown to be safe, TSH and T3 levels were not influenced,
and it was not associated with adverse effects. New phase III studies with thyromimetics in dyslipidemic patients, combined or not with statins, are currently ongoing. It is
reasonably expected that they will improve the lipid profile, potentially accelerate
energy expenditure and, consequently, vitally lessen the risk of cardiovascular disease.
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22. Ness G, Lopez D, Chambers C, et al. Effects of L-triiodothyronine and the thyromimetic L-94091 on serum lipoprotein levels and hepatic low density lipoprotein
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24. Valdemarsson S, Nilsson-Ehle P. Hepatic lipase and the clearing reaction: studies
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281
T h e Eff e c t o f
Medications on
T h y ro i d F u n c t i o n
Te st s
Priya Kundra,
MD
a,b,
*, Kenneth D. Burman,
MD
a,b
KEYWORDS
Thyroid function Medication Hormone Euthyroid state
Abnormal results of thyroid function tests are possible effects of drugs and medications. The pathways of thyroid hormone synthesis, secretion, transport, metabolism,
and absorption offer numerous targets for medication interactions (Fig. 1A, B). Normal
thyroid secretion depends on thyroid-stimulating hormone (TSH), which is inhibited by
thyroid hormones and stimulated by endogenous thyrotropin-releasing hormone
(TRH). Circulating iodide is trapped by a specific iodide symporter protein in thyroid
cells, after which it is oxidized and incorporated into tyrosine residues of thyroglobulin,
which then couple to form thyroxine (T4) and triiodothyronine (T3). T4 and T3 are
released from thyroglobulin and then secreted into the circulation. In the periphery,
T4 is converted to T3 in the liver and other tissues by the action of 50 -T4 monodeiodinases. Type 1 50 -deiodinase predominates in the liver, kidneys, and thyroid; type 2
50 -deiodinase predominates in the brain, pituitary and skin. About 80% of T4 and T3
are metabolized by deiodination and 20% by other pathways that include conjugation
with glucuronide and sulfate. T4 and T3 may be conjugated with glucuronide and
sulfate in the liver, excreted in the bile, and partially hydrolyzed in the intestine; the
T4 and T3 formed there may be reabsorbed in the gastrointestinal (GI) tract. In tissues,
T3 and T4 are bound to nuclear receptor proteins that interact with regulatory regions
of the genes, influencing their expression. In serum, most circulating T4 and T3 bind to
proteins including thyroxine-binding globulin (TBG), transthyretin, and albumin. A
small percentage (approximately 0.3% of T3 and 0.03% of T4) are unbound and available for binding to tissue T3 receptors. This article focuses on the groups of medications affecting production, regulation, secretion, transport, binding, metabolism, and
absorption of T4 and T3. It also focuses on the medications that can clinically influence
a
Endocrine Section, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010,
USA
b
Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20007, USA
* Corresponding author. Endocrine Section, Washington Hospital Center, 110 Irving Street NW,
Washington, DC 20010.
E-mail address: [email protected]
284
thyroid hormone homeostasis and on medications that we think are potentially significant or relevant. It does not include all possible medications that may influence
thyroid function tests. Box 1 provides a summary of the drugs involved with altered
thyroid function tests discussed in this article.
TSH SUPPRESSION
Many agents can acutely suppress serum thyrotropin levels to subnormal levels,
including dopamine, glucocorticoids, octreotide, and bexarotene. Dopamine infusions
at greater than 1 mg/kg/min are known to block TSH release.1,2 Glucocorticoids,
particularly dexamethasone, at as low a dose as 0.5 mg/d and hydrocortisone at
100 mg/d, inhibit TSH secretion. However, clinically higher doses of dexamethasone
(ie, >4 mg per day) inhibit extrathyroidal T3 production, leading to lower TSH values.
Brabant and colleagues3 showed that 4 mg of intravenous dexamethasone led to
a rapid decrease in TSH concentrations and a decrease in TT3. Also, short-acting
octreotide at 100 mg/d inhibits TSH release.4 However, dopamine, glucocorticoids,
and octreotide generally do not lower TSH concentrations to undetectable values
(eg, less than 0.01 mU/mL). Bexarotene, a retinoid X receptor ligand, is known to
suppress the pituitary TSH-b promoter, leading to central hypothyroidism. Sherman5
showed that, in patients with T cell lymphoma receiving bexarotene, serum TSH levels
decreased in proportion to the dose of bexarotene, with the greatest decrease for
doses of more than 300 mg/m2 with a mean TSH of 0.05 mU/L. Patients developed
symptoms of hypothyroidism and thyroid hormone levels returned to normal following
Box 1
Drugs causing thyroid dysfunction
Decrease TSH secretion:
Glucocorticoids: inhibit TSH release
Dopamine: blocks TSH release
Octreotide: inhibits TSH release
Bexarotene: suppresses pituitary TSH-b promoter
Alter thyroid hormone secretion:
Decrease thyroid hormone secretion: iodide, amiodarone, lithium
Increase thyroid hormone secretion: iodide, amiodarone
Decrease T4 absorption:
Cholesystramine, colestipol, sucralfate, ferrous sulfate, aluminum hydroxide, omeprazole
Alter T4 and T3 transport in serum:
Increase serum TBG: estrogens, heroin, methadone, mitotane, fluorouracil
Decrease serum TBG: androgens, anabolic steroids
Displacement from protein-binding sites: furosemide, salicylates, meclofenamate, heparin
Alter T4 and T3 metabolism:
Increase hepatic metabolism: phenobarbital and rifampin
Increase hepatic metabolism and displace from binding proteins: phenytoin and
carbamazepine
Cytokine mediated:
Interferon (IFN) a
Immune reconstitution:
Alemtuzumab
Hypothyroidism (tyrosine kinase inhibitors):
Sunitinib: ? destructive thyroiditis,? blockade of iodine uptake,? inhibition of peroxidase
activity
Imatinib: ? induction of uridine diphosphate-glucuronosylotransferases (UGTs)
discontinuation of bexarotene. Smit and colleagues6 also discovered that, in athyreotic subjects, bexarotene given for 6 weeks decreased free thyroxine (FT4) levels
but the ratio of T4 sulfate/FT4 increased by 48%, possibly secondary to induction
of T4 sulfation. There seemed to be a greater induction of the enzyme responsible
for T4 conjugation with sulfate leading to an increased ratio of sulfated T4/FT4 (T4
sulfate/FT4) because more T4 was present in the sulfated form and less in the free
form.
EFFECTS OF IODINE
Iodine has varied effects on the thyroid gland depending on the dose and duration of
iodine exposure and on the underlying thyroid condition. Short-term iodine exposure
(usually up to 710 days) can inhibit thyroid hormone secretion. This is called the
Wolff-Chaikoff effect. However, with continued iodine exposure, there is an escape
285
286
from this inhibition and hyperthyroidism can result (termed escape from the WolffChaikoff effect or the Jod-Basedow phenomenon). Several agents can cause
iodide-induced hyperthyroidism and many of these can also cause hypothyroidism.
Iodide-induced hyperthyroidism generally develops in individuals with multinodular
goiter (MNG) or hyperfunctioning thyroid adenoma secondary to the Jod-Basedow
phenomenon, in which iodine serves as a substrate for thyroid hormone synthesis.
Iodide-induced hypothyroidism generally develops secondary to a failure to escape
from the Wolff-Chaikoff effect in chronic autoimmune thyroid disease, or Graves
hyperthyroidism. Iodide inhibits thyroidal organification (Wolff-Chaikoff) but usually
in up to 48 hours there is a decrease in sodium iodide symporter activity to allow restoration of organification (hence escape from Wolff-Chaikoff).
HYPOTHYROIDISM
The use of radiocontrast dyes and amiodarone are the most common medicationinduced causes of hypothyroidism. Pharmacologic doses of iodine (up to 180 mg/d)
can induce hypothyroidism in euthyroid patients with chronic thyroiditis.7 In a large
male cohort of more than 600 individuals, overt hypothyroidism (TSH >10 mU/L) developed in 5% of patients receiving amiodarone, but subclinical hypothyroidism (TSH
4.510 mU/L) developed in an additional 25%.8 Hashimoto thyroiditis is the most
common risk factor for the development of amiodarone-induced hypothyroidism (AIT).
AIT typically occurs between 6 and 12 months of treatment with amiodarone. If amiodarone cannot be discontinued, levothyroxine (L-T4) therapy can be initiated. Amiodarone administration to euthyroid subjects results in a decrease in serum T3 levels and an
increase in serum T4, free T4, reverse T4, and TSH levels. These results are related to
a decrease in intracellular T4 transport, inhibition of type 1 50 -deiodinase and pituitary
type 2 50 -deiodinase, as well as antagonizing T3 binding to its nuclear receptor in the
pituitary.9 The dose of L-T4 needed to normalize TSH may be higher in patients treated
with amiodarone as a result of the decreased intrapituitary T3 production caused by
inhibition of pituitary type 2 50 -deiodinase. Basaria and Cooper10 outlined surveillance
and management of AIT (Fig. 2).
HYPERTHYROIDISM
Radiocontrast agents, which contain as much as 140 to 180 mg/mL of iodine, may
cause hyperthyroidism within several weeks after exposure. Generally, pharmacologic
doses of iodine (180 mg/d) can cause hyperthyroidism in patients with nontoxic
nodular goiter, solitary autonomous goiter, or underlying Graves disease.7 The
frequency, timing, and duration of hyperthyroidism caused by various radiocontrast
dyes may vary, in part depending on the underlying condition, but these issues
have not been well studied. Amiodarone can cause hyperthyroidism by 2 mechanisms: iodine-induced hyperthyroidism or induction of thyroiditis. In the United States,
3% to 5% of patients treated with amiodarone become hyperthyroid, usually between
4 months and 3 years after the initiation of the drug.8 There are 2 types of amiodaroneinduced hyperthyroidism. Type 1 typically occurs in individuals with nontoxic MNG or
Graves disease and type 2 is a drug-induced destructive thyroiditis. Many patients
have an overlap syndrome between type 1 and type 2 disease. Basaria and Cooper10
compared AIT type 1 and 2 (Table 1).
Traditionally, large doses of antithyroid drugs have been used to treat type 1 AIT,
including methimazole 40 to 80 mg per day or propylthiouracil (PTU) 400 to 800 mg
per day. For patients with type 2, prednisone is considered to be the treatment of
choice. With daily prednisone at doses of 40 to 60 mg, there is rapid improvement
If symptomatic or
pregnant: LT4
treatment
If asymptomatic, repeat
TSH in 3 months
LT4 therapy
in thyroid function in most patients. Basaria and Cooper10 also comment on surveillance and management of amiodarone-induced hyperthyroidism (Fig. 3).
Our experience is that many patients may have an overlap between these 2 types of
hyperthyroidism. Treatment approaches should be individualized and the patients
monitored closely.
Table 1
AIT type 1 and 2
Factor
AIT Type 1
AIT Type 2
No
Physical examination
Goiter, nodule(s)
Duration of amiodarone
12 y
>2 y
Thyroid autoantibodies
Absent
Radioiodine uptake
Niedrig
Very low
Thyroid ultrasound
Heterogeneous
Increased flow
Therapy
Prednisone
Subsequent hypothyroidism
No
Often
Reprinted from Basaria S, Cooper DS. Amiodarone and the thyroid. Am J Med 2005;118:711, published by Elsevier; with permission.
287
288
LITHIUM
There are 3 different types of thyroid dysfunction associated with IFN a treatment: (1)
autoimmune (often subclinical) hypothyroidism, (2) destructive thyroiditis, and (3)
Graves-like hyperthyroidism. Hypothyroidism is more common than hyperthyroidism.
Immune modulation may be a cause because IFN a is associated with development of
antithyroid peroxidase antibodies in approximately 20% of patients. These abnormalities can occur as early as 4 weeks and as late as 23 months after initiation. In patients
treated with IFN a, hypothyroidism occurs in 2.4% to 19%, with most patients having
thyroid peroxidase (TPO) antibodies (87%).14 Hypothyroidism can be transient,
subsiding after discontinuation of IFN a. Koh and colleagues15 showed that as
many as 56% of patients had permanent hypothyroidism. In hypothyroidism, levothyroxine therapy is indicated without the need to withdraw IFN therapy. Destructive
thyroiditis usually occurs in the first few weeks of IFN treatment in close temporal relationship with the appearance of thyroid autoantibodies, especially thyroglobulin antibodies. In addition, ribavarin along with IFN for the treatment of hepatitis C does not
modify the thyroid autoantibody pattern, but is associated with a higher risk of hypothyroidism.16 Thyrotoxicosis is frequently mild and transient without overt clinical
manifestations and may be diagnosed only by obtaining frequent thyroid function
tests. The duration of destructive thyroiditis is variable, ranging from a few weeks to
a few months. IFN treatment may also cause hyperthyroidism, which may occur after
a transient phase of destructive thyroiditis or following a period of hypothyroidism.
Hyperthyroidism related to IFN is associated with thyroid-stimulating immunoglobulin
(TSI) antibodies and increased uptake on technetium scintigraphy, but not with
features of ophthalmopathy. TSH measurements should be performed every 8 to 12
weeks during IFN a treatment. When destructive thyroiditis is present, treatment
with b-blockade is often useful to control the signs and symptoms of thyrotoxicosis.
When IFN causes hyperthyroidism, antithyroid agents such as methimazole or propylthiouracil may be administered if clinically indicated in the setting of thyrotoxicosis.
ALEMTUZUMAB
289
290
T4 and T3 are metabolized enzymatically mainly by deiodination but also by glucuronidation and sulfation. Phenobarbital and rifampin increase T4 and T3 metabolism by
stimulating hepatic microsomal drug-metabolizing enzyme activity.29,30 Patients with
hypothyroidism who are treated with phenobarbital cannot augment thyroid hormone
production and secretion, thereby exacerbating their hypothyroidism. Phenytoin and
carbamazepine augment the rate of thyroid hormone metabolism and displace thyroid
hormone from the serum binding proteins, principally TBG.31 In 9 euthyroid patients
treated with phenytoin at therapeutic levels, mean serum T4 decreased to 60% of
that of the control group and mean T3 decreased to 78% of that of the control
group.31In 10 euthyroid patients treated with carbamazepine at therapeutic levels,
mean serum T4 decreased to 74% of that of the control group and mean T3 decreased
to 83% of that of the control group. Serum FT4 concentrations remained unchanged
by ultrafiltration and TSH levels remained within normal range in patients treated with
phenytoin and carbamazepine. Hypothyroid patients treated with T4 may need
a higher LT4 dose when treated with any of these agents.
MEDICATIONS THAT INTERFERE WITH GI ABSORPTION OF EXOGENOUS
LEVOTHYROXINE
levothyroxine (eg, 50150 mg per day) is absorbed, mostly in the jejunum and the upper
part of the ileum.32 The bile acidbinding resins, cholestyramine and colestipol, bind
thyroid hormones and decrease their absorption. A decrease in serum T4 concentrations and an increase in serum TSH concentrations occurred when cholestyramine
was administered to patients with hypothyroidism treated with T4.33 Calcium
carbonate reduces the absorption of exogenous T4. In a prospective cohort of 20
hypothyroid patients taking 1200 mg of elemental calcium (as calcium carbonate)
for 3 months, the mean serum-free and total T4 concentrations decreased significantly
during coadministration of calcium carbonate, by 8% and 7% respectively.34 The
mean serum TSH concentration increased by 69%, with 20% of patients having serum
TSH concentrations greater than the normal range. These changes resolved after
calcium carbonate was discontinued. Sucralfate, ferrous sulfate, and aluminum
hydroxide also bind T4 in the gut, but their effect is smaller and also less consistent
than those described earlier.3537 Normal gastric acid secretion seems to be necessary for normal thyroid hormone absorption. Centanni and colleagues38 showed
that, in 10 patients treated with omeprazole for multinodular goiter, a 37% increase
in the dose of levothyroxine was required after 6 months to obtain similar TSH levels
to those of patients treated without omeprazole. Italian coffee (espresso) has also
been shown to interfere with T4 intestinal absorption. Benvenga and colleagues39 reported 8 patients in whom coffee given with L-T4 compared with water lowered the
average and peak incremental increases in serum T4. These changes are unrelated
to change in intragastric pH and result from an interaction that makes L-T4 less available for absorption. It is unknown whether these effects are applicable more widely
with varying types of coffee, and to what extent these findings apply clinically.
SUNITINIB
291
292
Imatinib belongs to the 2-phenylaminopyridine class and targets BCR-ABL, plateletderived growth factor receptor, and c-kit receptor tyrosine kinases. De Groot and
colleagues49 treated 11 patients (10 with medullary thyroid cancer and 1 with GIST)
on levothyroxine and imatinib (400800 mg) for an average of 6 months. TSH levels
increased to 384% (228%) of upper limits, whereas FT4 and FT3 decreased respectively to 59% (17%) and 63% (4%). De Groot and colleagues49 suggested induction of UGTs involved in conjugation and T4/T3 clearance as a cause of
hypothyroidism. In athyreotic patients, thyroidal compensation does not occur and
the dose of levothyroxine sodium should be increased in a timely manner.
SUMMARY
293
294
26. Samuels MH, Pillote K, Asher D, et al. Variable effects of nonsteroidal antiinflammatory agents on thyroid test results. J Clin Endocrinol Metab 2003;
88(12):5710.
27. Jain R, Uy HL. Increase in serum free thyrosine levels related to intravenous
heparin treatment. Ann Intern Med 1996;124(1 Pt 1):745.
28. Jaume JC, Mendel CM, Frost PH, et al. Extremely low doses of heparin release
lipase activity into the plasma and can thereby cause artifactual elevations in
the serum-free thyroxine concentration as measured by equilibrium dialysis.
Thyroid 1996;6:79.
29. Oppenheimer JH, Bernstein G, Surks MI. Increased thyroxine turnover and
thyroidal function after stimulation of hepatocellular binding of thyroxine by
phenobarbital. J Clin Invest 1968;47:1399.
30. Isley WL. Effect of rifampin therapy on thyroid function tests in a hypothyroid
patient on replacement L-thyroxine. Ann Intern Med 1987;107:517.
31. Surks MI, DeFesi CR. Normal serum free thyroid hormone concentrations in
patients treated with phenytoin or carbamezipine. JAMA 1996;275:14958.
32. Hays MT. Thyroid hormone and the gut. Endocr Res 1988;14(2-3):20324.
33. Harmon SM, Siefert CF. Levothyroxine-cholestyramine interaction reemphasized.
Ann Intern Med 1991;115:658.
34. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption
of levothyroxine. JAMA 2000;283:2822.
35. Sherman SI, Tielens ET, Ladenson PW. Sucralfate causes malabsorption of
L-thyroxine. Am J Med 1994;96(6):5315.
36. Campbell NR, Hasinoff BB, Stalts H, et al. Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism. Ann Intern Med 1992;117(12):10103.
37. Sperber AD, Liel Y. Evidence for interference with the intestinal absorption of
levothyroxine sodium by aluminum hydroxide. Arch Intern Med 1992;152(1):
1834.
38. Centanni M, Gargano L, Canettieri G, et al. Thyroxine in goiter, Helicobacter pylori
infection, and chronic gastritis. N Engl J Med 2006;354:1787.
39. Benvenga S, Bartolone L, Pappalardo MA, et al. Altered intestinal absorption of
L-thyroxine caused by coffee. Thyroid 2008;18(3):293301.
40. Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J Clin
Oncol 2007;25(7):88496.
41. Desai J, Yassa L, Marqusee E, et al. Hypothyroidism after sunitinib treatment for
patients with gastrointestinal tumors. Ann Intern Med 2006;145:6604.
42. Rini BI, Tamaskar I, Shaheen P, et al. Hypothyroidism in patients with metastatic
renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2007;99:813.
43. Grossmann M, Premaratne E, Desai J, et al. Thyrotoxicosis during sunitinib treatment for renal cell carcinoma. Clin Endocrinol 2008;69(4):66972.
44. Mannavola D, Coco P, Vannachi G, et al. A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake. J Clin
Endocrinol Metab 2007;92(9):35314.
45. Salem AK, Fenton MS, Marion KM, et al. Effect of sunitinib on growth and function
of FRTL-5 thyroid cells. Thyroid 2008;18(6):6315.
46. Wong E, Rosen LS, Mulay M, et al. Sunitinib induces hypothyroidism in advanced
cancer patients and may inhibit thyroid peroxidase activity. Thyroid 2007;17(4):
3515.
47. Alexandrescu DT, Popoveniuc G, Farzanmehr H, et al. Sunitinib-associated
lymphocytic thyroiditis without circulating antithyroid antibodies. Thyroid 2008;
18(7):80912.
295
A p p ro a c h t o a n d
Tre a t m e n t o f T h y ro i d
D i s o rd e r s i n t h e E l d e r l y
Maria Papaleontiou,
MD
, Megan R. Haymart,
MD
b,
KEYWORDS
Older adults Thyroid cancer Longevity
Thyroid function Hyperthyroidism Hypothyroidism
Thyroid nodule Age
Interpretation of thyroid function tests in older adults is difficult because of the agedependent physiologic changes in thyroid function, coexistent chronic illness, and
polypharmacy.14 However, thyroid dysfunction is common in older adults and may
be associated with significant morbidity if not treated. The classic symptoms of thyroid
dysfunction are usually absent or may be overlooked in older patients, making the
diagnosis and subsequent management challenging.
The management of thyroid disorders in older adults remains controversial. There
has been conflicting literature regarding the approach. Despite the ongoing debate,
current guidelines suggest considering treatment on an individual basis according
to symptoms and possible treatment benefit.5 However, in older patients the risk of
harm from treatment complicates the decision-making process.
The objective of this article is to review the epidemiology, clinical presentation, risks
and complications, and management of thyroid disorders in older adults, including
hyperthyroidism, hypothyroidism, thyroid nodules and thyroid cancer.
THYROID FUNCTION IN OLDER ADULTS
Several studies have investigated the role of thyroid function in the aging process.
Recent reports have shown increased levels of serum thyrotropin (TSH) with
increasing age, independent of antithyroid antibody presence1; by contrast, others
have demonstrated decreased serum TSH in older adults.2,3 Populations in which
298
It has been clearly demonstrated that age is independently associated with an increased
risk of developing atrial fibrillation. Atrial fibrillation is estimated to be present in up to
20% to 35% of older patients suffering from hyperthyroidism,19,26,27 and is especially
common in those with hyperthyroidism secondary to toxic nodule(s).19 Long-standing
low serum TSH concentration in older patients is associated with a 3-fold increased
risk of developing atrial fibrillation.28 Because of the greater incidence of underlying
cardiac disease, the risk of developing atrial fibrillation is increased in patients older
than 60 years. Atrial fibrillation in older adults may sometimes be the only clinical sign
of hyperthyroidism. However, the degeneration of the sinus node and fibrotic changes
in the cardiac conduction system make the presence of palpitations less likely. In addition, frequent use of b-blockers or amiodarone in these patients can mask the arrhythmia.
By contrast, younger hyperthyroid patients often present with sinus tachycardia.20
Cardiovascular mortality
Overt hyperthyroidism, and less often subclinical hyperthyroidism, can be accompanied by several cardiovascular changes including widened pulse pressure, exercise
intolerance, increased risk for atrial fibrillation, and increased cardiac mass.29 Several
cross-sectional and case-control studies have found that decreased levels of serum
TSH are associated with increased cardiovascular mortality in older adults.30 In addition, subclinical hyperthyroidism has been shown to be associated with left ventricular
hypertrophy, which is a predictor of cardiovascular mortality.29
Osteoporosis
Contradicting studies exist regarding the association of symptoms and signs of ophthalmopathy in Graves disease with increasing age. Most studies published on this
subject have demonstrated a positive correlation between prevalence and severity
of ophthalmopathy with increasing age.19,35 However, one prospective cohort study
found ophthalmopathy to be more frequent in younger patients than in older adults
with Graves disease (46% vs 6%; P<.001).20
Management
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300
Estimates of the prevalence and incidence of hypothyroidism among older adults are
variable, depending on populations studied and criteria used to define the condition.40
A large screening study (N 5 25,000) revealed that 10% of men and 16% of women
aged 65 to 74 years had TSH levels above the upper limit of the reference range.41
The most recent National Health and Nutrition Examination Survey (NHANES) reported
that compared with men in the same age range, a significantly greater number of
women aged 50 to 69 met criteria for subclinical and clinical hypothyroidism.6 Moreover, a study evaluating geriatric patients under medical care demonstrated that 15%
of the women and 17% of the men had previously undiagnosed hypothyroidism.42
The incidence of hypothyroidism steadily increases with advancing age, predominantly because of a rising incidence of autoimmune thyroiditis (Hashimoto).4345 In
a survey by Reinhardt and Mann,46 the reported incidence of Hashimoto thyroiditis
was 67% in a patient population with a mean age of 73 years (N 5 24). A survey of
patients in the endocrinology clinic revealed that 47% of patients aged 55 years
and older presenting with primary hypothyroidism carried a diagnosis of autoimmune
thyroiditis, whereas 27% had postsurgical hypothyroidism and 10% had post-RAI
hypothyroidism.47
A high index of suspicion is required for a diagnosis of hypothyroidism in older
adults because symptoms and signs such as fatigue, weakness, constipation, dry
skin, and cold intolerance may be attributed to other diseases common in older
patients, medication side effects, or aging itself.3,48 Psychiatric symptoms, such as
depression, are also common in older adults with hypothyroidism. A prospective study
by Doucet and colleagues49 compared 24 clinical symptoms and signs of hypothyroidism between older (n 5 67; mean age 79.3 years) and younger (n 5 54; mean
age 40.8 years) patients. It was concluded that the mean number of clinical signs in
older adults was 6.6, compared with 9.3 in the younger population. Fatigue and weakness were the most common symptoms in older adults, with cold intolerance, paresthesia, weight gain, and abdominal cramps being less common.
Risks, Complications, and Sequelae
Cognitive impairment
Hypothyroidism in older adults has been associated with impairment of several cognitive domains including memory, attention and concentration, language, executive
function, and perceptual and visuospatial function.50,51 Severe hypothyroidism may
mimic depression and dementia. Neuropsychiatric symptoms usually improve with
treatment and restoration of a euthyroid state.52
The relationship between subclinical hypothyroidism and cognition is less clear. It is
postulated that older adults may be more vulnerable to the effects of subclinical hypothyroidism, given age-related changes to the hypothalamic-pituitary-thyroid axis.
However, several studies in older adults did not show a significant association
between mildly elevated TSH and reduced cognitive performance.53,54
Cardiovascular effects
Myxedema coma occurs almost exclusively in older adults with long-standing primary
hypothyroidism, and is usually precipitated by a concomitant medical illness. Patients
may present with a rapid development of stupor, seizures, or coma along with respiratory depression. Hallmark signs of myxedema coma include localized neurologic
signs, hypothermia, bradycardia, hyponatremia, and hypoglycemia.55 Myxedema
coma is a severe and life-threatening clinical state in older adults, with a mortality
rate as high as 40%.5759
Management
Despite the high prevalence of thyroid hormone use in this population, there are no
concrete data on when and at what dose to initiate thyroid hormone replacement in
older adults. Somwaru and colleagues60 collected data on thyroid hormone medication
from community-dwelling individuals aged 65 years and older (mean age 72.8 years)
enrolled in the Cardiovascular Health Study (N 5 5888) over a span of 16 years. It
was concluded that thyroid hormone use is common in patients older than 65, with
up to 20% being treated with levothyroxine. The incidence of thyroid hormone replacement in adults aged 85 years and older was more than twice as frequent as that in
adults aged 65 to 89 years (hazard ratio 2.34; 95% confidence interval 1.433.85).60
Older patients often have lower dose requirements for levothyroxine, which may be
related to several factors including declining metabolic clearance, slow progression of
underlying thyroid failure, declining body mass, and interactions with other medications.61 On average, older adults with primary hypothyroidism receive initial daily
doses that are 20 mg lower and maintenance daily doses that are 40 mg lower than
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302
It is known that the prevalence of thyroid nodules increases with age.74 By the age of 65
years, nearly 50% of individuals in iodine-sufficient areas have thyroid nodules when
evaluated with ultrasonography.75 A survey by Cavaliere and colleagues76 showed
that the prevalence of multinodular goiter in older adults in an iodine-deficient area
was 74% in patients aged 55 to 75 years and 54% in patients aged 76 to 84 years.
Thyroid nodules may be benign adenomas, cysts, cancers, or inflammation.
Management
The approach to the management of a solitary thyroid nodule in an older adult is the
same as that in a younger patient. With the discovery of a new thyroid nodule,
a complete history and physical examination should be performed. Pertinent questions should include history of head and neck or whole-body irradiation, exposure
to ionizing radiation, and family history of thyroid cancer or syndromes such as
multiple endocrine neoplasia. Physical findings such as palpable cervical lymphadenopathy, hoarseness, or fixation of the nodule to surrounding tissue raise suspicion
for malignancy.
As per recent ATA guidelines,77 initial evaluation constitutes measurement of serum
TSH. If the TSH is subnormal, the next step consists of a radionuclide thyroid scan
using either technetium pertechnetate or RAI. A diagnostic thyroid ultrasonogram
should be performed in all patients with known or suspected thyroid nodules when
TSH is found to be normal or high. Ultrasonographic features associated with a higher
likelihood of malignancy include hypoechogenicity, increased intranodular vascularity,
Thyroid cancer is the only cancer for which age is included in the American Joint
Committee on Cancer TNM staging system.8587 The mortality rates of patients with
thyroid cancer increase starting at age 45 years.88 A steady decline in survival rates
has been reported with increasing age, regardless of the degree of differentiation of
the thyroid cancer.89,90 A large retrospective study (N 5 53,856) demonstrated lower
10-year survival rates in patients older than 45 years with papillary (47%85% vs
97%), follicular (57%66% vs 98%), medullary (63%80% vs 88%), and anaplastic
(5-year survival rate: 13% vs 55%) thyroid cancer.78 Extension of thyroid cancer
outside the gland significantly worsened the prognosis in older patients, whereas it
did not alter the favorable prognosis in younger patients.9194 In a study of the
SEER database, the presence of lymph node metastases had no effect on survival
in patients younger than 45 years. However, in patients 45 years or older, there was
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304
an associated 46% increased risk of death with lymph node positivity (P<.001).95
Distant metastases are also a serious prognostic sign in older patients with thyroid
cancer91; this may be related to thyroid cancer being less RAI-avid in older patients
than in younger patients.85,96
Recurrence rates of thyroid cancer have also been shown to be influenced by age.86
Cady and colleagues91 demonstrated that women older than 50 years had a 32% risk
of thyroid cancer recurrence compared with 10% in those younger than 50.
Management
The modalities used for the management of thyroid cancer in older adults are essentially the same as those used in younger patients. Frequently the surgical approach
for a thyroid cancer larger than 1 cm is near-total or total thyroidectomy. Thyroid
lobectomy alone may be sufficient for tumors smaller than 1 cm. Central neck
dissection should accompany total thyroidectomy in patients with clinically involved
central or lateral neck lymph nodes.77 Even though older patients may exhibit
a higher surgical risk because of comorbidities, age by itself is not a contraindication
to thyroidectomy.
Postoperative RAI ablation of thyroid remnants is indicated for all patients with
known iodine-avid distant metastases, gross extrathyroidal extension of the tumor
regardless of tumor size, or primary tumor size greater than 4 cm, even in the absence
of other risk factors.77 Dosimetry-guided RAI ablation therapy may be preferable to
fixed-dose RAI ablation treatment strategies in older patients with advanced thyroid
cancer, as evidenced by a study showing that administered activities above 7.4
GBq (200 mCi) will exceed the maximal safe level in a substantial number of patients
older than 70 years.97 Older age, renal failure, and liver failure are associated with
lower clearance of radioiodine.97
Unstimulated thyroglobulin should be periodically assessed. One year after RAI
ablation, measurement of thyroglobulin under TSH stimulation is useful because
it is more sensitive. If the stimulated level is greater than 2 ng/mL, diagnostic
imaging studies should be performed for localization of persistent versus recurrent
disease.
Thyroxine-suppression therapy is used for the treatment of differentiated thyroid
cancers. Jonklaas and colleagues98 showed that aggressive thyroid hormone
suppression therapy was independently associated with longer overall survival in
high-risk patients, and that moderate thyroid hormone suppression led to improved
overall survival in stage II patients. Because outcome is good regardless of intervention, survival was not altered in stage I patients. The TSH-suppressive doses of 2 to 2.2
mg/kg often required in younger patients with thyroid cancer may be excessive in older
adults, as thyroxine degradation is reduced with age.99 In the Framingham Heart
Study, individuals older than 60 years with TSH values of 0.1 mIU/L or less had an
adjusted relative risk of 3.8 for developing atrial fibrillation during a 10-year followup, and those with TSH values between 0.1 and 0.4 mIU/L had an adjusted relative
risk of 1.6.28 The beneficial effect of TSH suppression is a considerable reduction in
recurrence rates of differentiated thyroid cancer, but this should be weighed against
potential complications.
Indications for external beam radiation include the presence of aggressive and
unresectable cancer, painful bone metastases, or risk of spinal cord compression.77 Current clinical trials for novel therapies in thyroid cancer treatment, for
example, tyrosine kinase inhibitors, are promising, and older age may not preclude
participation.
Table 1
Unique features of the approach and management of thyroid disorders in older adults
Thyroid Disorder
Hyperthyroidism
Overt
Subclinical
Hypothyroidism
Overt
Subclinical
Thyroid nodules
Thyroid cancer
SUMMARY
Thyroid gland dysfunction is prevalent in older adults and may be associated with
significant morbidity if misdiagnosed and untreated. Factors contributing to misinterpretation of thyroid function tests in older adults include age-dependent physiologic
changes, comorbidities, and polypharmacy. Moreover, clinical signs and symptoms
of thyroid dysfunction may be subtle or absent, making diagnosis more difficult. As
thyroid disorders are often amenable to effective treatments that can improve the
quality of life of patients, a high index of clinical suspicion is warranted.
Treatment of hyperthyroidism in older adults is usually similar to that for younger
adults, with antithyroid medications, RAI ablation, or surgery. Side effects of antithyroid medication occur more commonly in older adults, and surgery is less favorable
because of the increased risk of morbidity and mortality.
There are no concrete guidelines as to when and at what dose to initiate levothyroxine replacement therapy in older adults with hypothyroidism. However, after
assessing the cardiovascular tolerance of a starting dose, the dose should be gradually increased by 12.5 to 25 mg every 4 to 6 weeks until adequate replacement is
confirmed by serum TSH measurement.
Thyroid nodules are more common in older adults and are managed with an initial
measurement of TSH, followed by an ultrasonogram if TSH is normal or high. Depending on nodule size and ultrasonographic features, ultrasound-guided FNA may be
performed.
With increasing age, the incidence of thyroid cancer shifts from well-differentiated to
poorly differentiated types. Thyroid cancer is unique because age is included in the
staging system. The modalities used for the management of thyroid cancer in older
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306
adults are in essence the same as those used in younger patients. These methods
include surgery, and when appropriate, postoperative RAI ablation, serial thyroglobulin measurements, and thyroxine-suppression therapy (Table 1).
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2. Mariotti S, Franceschi C, Cossarizza A, et al. The aging thyroid. Endocr Rev 1995;
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T h e E v a l u a t i o n an d
Tre a t m e n t o f G r a v e s
Ophthalmopathy
Marius N. Stan, MDa, James A. Garrity,
Rebecca S. Bahn, MDa,*
MD
KEYWORDS
Graves ophthalmopathy Graves disease
Thyrotropin receptor autoantibodies Radioactive iodine
Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic School of Medicine, Mayo
Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
b
Department of Ophthalmology, Mayo Clinic School of Medicine, Mayo Clinic, 200 First Street
Southwest, Rochester, MN 55905, USA
* Corresponding author.
E-mail address: [email protected]
Med Clin N Am 96 (2012) 311328
doi:10.1016/j.mcna.2012.01.014
medical.theclinics.com
0025-7125/12/$ see front matter 2012 Elsevier Inc. All rights reserved.
312
Stan et al
The annual adjusted incidence rate of Graves hyperthyroidism is 0.50 per 1000 population,12 with some 25% to 50% of these patients having clinical eye involvement.
Fig. 1. Immunopathogenesis of Graves ophthalmopathy. Circulating autoantibodies directed against the thyrotropin receptor activate this receptor on orbital fibroblasts; this
results in their increased secretion of hyaluronic acid, and the differentiation of a subset
into mature adipocytes. In addition, activated T cells infiltrate the orbit, interact with autoreactive B cells, and secrete proinflammatory cytokines. These cellular changes lead to the
extraocular muscle enlargement, orbital adipose tissue expansion, and orbital inflammation
characteristic of the disease. XRT, radiotherapy.
Most patients with GO show mild signs and symptoms including corneal irritation,
periocular swelling, eyelid retraction, conjunctival erythema/chemosis, and mild extraocular muscle dysfunction. A much smaller proportion of patients (approximately 5%)
experience severe disease including significant inflammation/congestion, excessive
proptosis, and sight-threatening corneal ulceration or optic neuropathy. Although
GO is overall more frequent in women than in men, men are overly represented in
severe forms of the disease, with a female-to-male ratio of 1:4.13 Subclinical eye
involvement is common, with approximately 70% of hyperthyroid patients showing
evidence of GO on magnetic resonance imaging (MRI) or orbital computed tomography (CT) scanning.14 The overall incidence of GO varies depending on the diagnostic
criteria; the annual adjusted incidence rate of clinically significant GO in Olmsted
County, Minnesota is 16 women and 3 men per 100,000 population.15 A bimodal
age distribution is followed, with peak incidence of GO in women occurring between
age 40 to 44 years and 60 to 64 years, and in men between 45 to 49 years and 65 to 69
years. The other peripheral manifestations of GD, dermopathy and acropachy, occur
with lower frequency and almost always develop in patients with more severe GO.16
DIAGNOSIS
There is no single clinical finding or laboratory test that is diagnostic of GO. A careful
history and physical examination often allows for a firm diagnosis of GO to be made.
Although the diagnosis is generally straightforward without the need for additional
laboratory or imaging data in a thyrotoxic patient with bilateral proptosis, it can be
more difficult in a euthyroid patient with unilateral proptosis. In this instance, CT scanning or MRI with special attention paid to the orbits is indicated, and may identify an
orbital mass lesion, an infiltrative process, idiopathic orbital inflammation (pseudotumor), or other orbital abnormality. If the imaging is compatible with GO, the finding
of elevated TRAb is helpful in making the diagnosis in a euthyroid patient.2 Although
the absence of elevated TRAb in this setting does not rule out the diagnosis of GO,
it makes the diagnosis less likely and necessitates further evaluation and/or observation over time. The differential diagnosis of GO regarding particular findings on physical examination is outlined in Table 1.
CLINICAL EVALUATION
The clinical evaluation and management of GO, as well as any accompanying hyperthyroidism, is optimally performed in a multidisciplinary clinic having both endocrine
and ophthalmologic expertise in the condition as well as access to ancillary specialties.17 All patients with GO, except for the mildest cases, should be examined by
both an ophthalmologist and an endocrinologist. Proper management of GO is based
on accurate determination of both the severity of the disease, or extent of ocular
dysfunction or involvement, and its clinical activity, or degree of active inflammation
present. Although severity and activity may peak simultaneously, often the two are
not congruent, with peak activity preceding the most significant clinical expressions
of the disease.18
The degree of severity can be classified as mild, moderate to severe, or sightthreatening, following quantitative assessment of lid aperture width, proptosis
measurement, diplopia score (1 5 intermittent [ie, when tired or on awakening]; 2 5
inconstant [ie, only at extremes of gaze]; 3 5 constant), degrees of abduction in eye
muscle movement, examination of the cornea for evidence of exposure keratitis or
ulceration, and assessment of optic nerve function (Table 2).17
313
314
Stan et al
Table 1
Differential diagnosis
Differential Diagnosis
Symmetry
Prevalencea
Proptosis
Primary cancer
Metastatic cancer
Orbital meningioma
Orbital myositis
IgG4 disease
Sarcoidosis
Wegener granulomatosis
Carotid cavernous fistula
Paranasal sinus mucocele
Unilateral
Unilateral
Unilateral
Uni-/bilateral
Uni-/bilateral
Uni-/bilateral
Uni-/bilateral
Unilateral
Unilateral
Uncommon
Uncommon
Common
Common
Uncommon
Rare
Rare
Uncommon
Uncommon
Periocular inflammation/
congestion/edema
Allergy
Nephrotic syndrome
Facial cellulitis
Bilateral
Bilateral
Unilateral
Common
Uncommon
Uncommon
Diplopia
Orbital myositis
Myasthenia gravis
Contralateral blowout fracture
Uni-/bilateral
Uni-/bilateral
Unilateral
Common
Common
Uncommon
Lid retraction
Midbrain disease
Contralateral ptosis
Sympathomimetic drugs
Thyrotoxicosis
Unilateral
Unilateral
Bilateral
Bilateral
Uncommon
Uncommon
Common
Common
The activity of GO can be graded using a clinical activity score (CAS) that
ranges from 0 to 10 and predicts response to anti-inflammatory therapies.18 The
CAS is generated by the addition of 1 point for the presence of each the following
features: chemosis, eyelid swelling, eyelid erythema, conjunctival erythema, caruncular swelling, pain in primary gaze, and pain with ocular movement. In addition, if the
patient has been examined within the 3 months prior, additional points may be given
for decreased visual acuity, worsened diplopia, and increased proptosis compared
with that visit. GO is considered active in patients with a CAS of 3 or more out of 7
(if no previous assessment is available), or 4 out of 10 on the complete scale.
Dysthyroid optic neuropathy (DON) is a severe complication of GO that affects
approximately 5% of GO patients, and may lead to loss of vision. The condition may
present as unexplained deterioration in vision or change in intensity or quality of color
vision.19 Corneal breakdown with subsequent ulceration is another sight-threatening
complication, and may be found in patients who experience corneal exposure in the
setting of poor blinks, excessive upper lid retraction, and/or lagophthalmos (inability
to fully close the eye), which can be exacerbated with greater amounts of proptosis.
Globe subluxation is a form of partial displacement of the globe from the orbit whereby
the eyelids are repositioned behind the protruding globe. It is typically seen with greater
amounts of proptosis and lid retraction, and is associated with pain and risk of loss of
vision caused by optic nerve compromise with repeated episodes As immediate treatment is essential for each of these conditions, patients in whom they occur or are suspected should be referred urgently to an ophthalmologist.
Clinical assessment of GO also includes evaluation of the impact of the disease on
the patients quality of life (QOL). The QOL has been shown to be impaired in GO, with
both physical and mental health being adversely affected. Patients have poorer selfimage, more sleep disturbance, and more impaired social and work functioning
than controls.20 Several QOL questionnaires have been developed and validated for
a
b
Degree of Severity
Lid Retraction
Proptosisa
Diplopia
Corneal Exposure
<2 mm
Mild
<3 mm
Transientb or absent
Absent
Normal
2 mm
Moderate or severe
3 mm
Inconstantb or constant
Mild
Normal
Sight threatening (1 of
last 2 categories)
Not contributory
Not contributory
Not contributory
Not contributory
Ulceration
Compromised
Proptosis refers to the variation compared with the norm for each race or to the patients baseline if available.
Intermittent diplopia: present when the patient is fatigued; inconstant diplopia: present at extremes of gaze; constant diplopia: present in primary gaze.
Table 2
GO severity assessment
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Stan et al
use in patients with GO.2022 While being essential for treatment evaluation in clinical
studies, such instruments may also be useful in clinical practice to aid in decisions
regarding disease intervention.
RISK FACTORS FOR GO DEVELOPMENT OR PROGRESSION
Several risk factors have been identified that predispose to the development or
progression of GO (Table 3). Among the most carefully studied factors in randomized
trials have been the various treatment options for Graves hyperthyroidism. Risks in
these studies ranged from 33% for radioactive iodine (RAI) compared with 10% for
antithyroid drugs and 16% for surgery,31 to 39% for RAI compared with 21% for antithyroid drugs.32 In one large randomized study, patients were treated with RAI with or
without concurrent corticosteroid (to determine whether this might be preventive), or
methimazole.37 Within 6 months of treatment, progression was seen in 15% of
patients treated with RAI alone, in approximately 3% of patients treated with methimazole, and in no patients treated with RAI plus corticosteroid. By 1 year most patients
with progression had improved, with only 5% of the RAI group experiencing persistent
worsening that required additional treatment. Overall, studies suggest that antithyroid
drug therapy or thyroidectomy do not affect the course of GO, whereas there is a small
but significant increased risk of worsening following RAI therapy in patients with active
disease. By contrast, it appears that patients with inactive GO may be treated with RAI
without increased risk.17,38
Smoking is the risk factor most strongly and consistently linked with the development or progression of GO and with poorer response to therapy.32,39,40 Several
studies suggest that smokers develop more severe GO, that the risk is proportional
to the number of cigarettes smoked per day, and that former smokers have significantly lower risk than current smokers.33,41 In a recent randomized trial of patients
with newly diagnosed GD treated with either RAI or antithyroid drugs, smoking was
found to be a more important risk factor for GO than was RAI.32 Regardless of which
Table 3
Risk factors for GO development or deterioration
Risk Factor
Relative
Risk
Details
References
Genetics
23
Ancestry
11
24
Gender
11
25,26
Thyroid dysfunction
111
2729
Mechanical factors
30
Thyroid hormone
levels
29,31,32
Smoking
1111
33,34
TSH receptor
antibody
11
35,36
Radioactive iodine
11
31,32,37
therapy they received, more than 40% of smokers either developed GO or experienced deterioration of their eye involvement. This rate was almost double that of
nonsmokers. In another study wherein hyperthyroid patients with established GO
were treated with RAI, smoking was found to add additional risk for GO over that
conferred by RAI alone, and GO progression was prevented when RAI was combined
with steroids in only 14.9% of smokers compared with 63.8% of nonsmokers.42
Second-hand smoking has also been linked, albeit indirectly, with GO development.34
Although no intervention trial of smoking cessation has been successfully undertaken,
there is retrospective evidence that quitting is associated with a better outcome.33
Counseling and aiding GO patients to stop smoking is the standard of care.17,43
The relationship between TRAb level and disease activity or progression has been
studied by several groups. TRAb level was found in one study to be strongly correlated with the CAS or degree of proptosis in euthyroid patients with untreated GO
of moderate severity.36 In another study, 159 GO patients were followed for 1 to
2 years, with TRAb levels recorded every 3 months.35 Using specific levels of TRAb
as threshold points at various times following the diagnosis of GO, the prognosis of
GO was predictable as being either mild or severe in 50% of patients. Both hyperthyroidism and hypothyroidism have also been shown in multiple reports to be associated with increased risk for development or deterioration of GO. When GO patients
in a referral population were stratified into groups using a severity index, approximately twice as many patients with current thyroid dysfunction were identified in
the groups having more severe GO than in the more mildly affected groups.27 The
impact on GO of early supplementation with levothyroxine (to avoid hypothyroidism
following RAI therapy) was studied in a group of patients receiving levothyroxine
beginning 2 weeks following RAI.28 The investigators compared GO progression in
these patients with a historical cohort of patients who did not receive levothyroxine
until they were documented to be hypothyroid following RAI therapy (permissive
hypothyroidism). The investigators found the relative risk of GO development or
worsening in the permissive hypothyroidism group compared with the early treatment
group to be 1.64 (95% confidence interval: 1.12.6), and additionally documented
more severe GO in the former. The association between hypothyroidism following
RAI therapy and progression of GO was later confirmed in a prospective cohort of
114 patients followed for 2 years.29 Based on these studies, it has become widely
accepted that hypothyroidism following treatment of Graves hyperthyroidism is
a risk factor for GO, warranting active prevention.43 The complication of DON
has its own risk factors that include smoking, advanced age, and the presence of
diabetes.44
INITIAL MANAGEMENT
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In both active and inactive GO, the use of local measures can afford good symptomatic relief.17 Ocular lubrication with artificial tears (administered 46 times per day) or
gels (applied at nighttime) benefits the corneal symptoms of dryness, photophobia,
and grittiness. The application of viscous gels or ointment at bedtime lengthens the
duration of action and is useful for patients with nocturnal lagophthalmos, who typically have prominent symptoms on awakening. Cool compresses and sunglasses
are also helpful with ocular irritation. Temporary relief from diplopia may be obtained
from botulinum toxin A injected in the extraocular muscles, and symptomatic lid
retraction may improve with injection into the levator palpebralis.47 This effect is
temporary, however, and in the authors experience botulinum injections have not
been as helpful as initially hoped.
Approximately two-thirds of patients with mild disease experience spontaneous
improvement within about 6 months, and thus need no treatment beyond local
measures.5 In these patients, observation every few months is appropriate until the
inactive stage is reached, and rehabilitative surgery can be performed if needed.
However, in some patients with mild disease the QOL is significantly diminished
and additional intervention may be warranted.17
ANTIOXIDANT THERAPY
Antioxidant therapy generally carries with it few side effects and may have a beneficial
effect on GO outcome. An early intervention study consecutively assigned patients to
allopurinol (300 mg daily) plus nicotinamide (300 mg daily) or placebo.48 A promising
result was noted in this nonrandomized study, with a total eye score index showing
improvement in 82% of treated patients compared with 27% of those receiving
placebo. Selenium was recently reported to improve mild GO in a trial conducted
by the European Group on Graves Orbitopathy (EUGOGO) consortium.49 Patients
were randomized to receive selenium (100 mg twice daily), pentoxifylline, or placebo.
Evaluation at 6 months, with confirmation at 12 months, documented an improvement
not only in several ocular parameters but also in QOL, compared with placebo or pentoxifylline. The selenium-treated group did not experience any significant side effects,
and in particular there was no increase in blood glucose levels, as has been noted in
studies of selenium treatment in other diseases. An important caveat is that these
subjects were from a population with marginally decreased selenium levels, leaving
unanswered the question of selenium-related benefit in patients living in seleniumsufficient regions.
IMMUNOMODULATORY THERAPY
Oral glucocorticoids (GC) have long been used as treatment for GO (often in starting
doses of between 40 and 100 mg/d with tapering over 1024 weeks for a cumulative
dose of 26 g), but more recent evidence suggests that the intravenous (IV) route is
more effective. The two modes of GC administration have been assessed separately
in several clinical trials and directly compared in 4.50 In the largest trial, 70 patients with
severe and active GO were randomized to receive either prednisolone (starting at 100
mg/d and tapered by 10 mg daily at weekly intervals for a total dose of 4.0 g) or IV
methylprednisolone (500 mg weekly 6 weeks then 250 mg weekly 6 weeks for
a total dose of 4.5 g).51 After 3 months, the composite outcome (improvement in 3
or more of the following: proptosis, intraocular pressure, diplopia, muscle size, lid
fissure width, visual acuity) was met in 77% of patients treated with IVGC and in
51% of those treated with oral GC. More importantly, the use of IVGC was associated
with improved QOL and less need for subsequent surgery. Mild side effects were
observed in 17% in the IVGC group and included palpitations (the most common),
weight gain, gastrointestinal distress, and sleeplessness. By contrast, more significant
side effects were reported with the use of oral GC and included cushingoid features,
secondary adrenal insufficiency, weight gain, hypertension, myalgias, hirsutism,
depression, hyperglycemia, and osteoporosis. Although similar efficacy and an
equally favorable side-effect profile for IVGC were found in a comparable trial,52 of
concern is that fatal acute hepatotoxicity has been reported in 4 GO patients treated
with IVGC.53 Severe hepatotoxicity appears to be dose dependent, as it occurs only in
patients receiving a cumulative dose of greater than 8 g of methylprednisolone.54
Other severe complications of IVGC reported in a recent survey of members of the
European Thyroid Association include cardiovascular or cerebrovascular events,
autoimmune encephalitis, and liver test abnormalities (>4-fold upper limit of normal).55
In light of these reports, it has been suggested that patients being considered for IVGC
therapy be screened for chronic viral infections, underlying autoimmunity, and preexistent hepatic abnormalities, and that liver function be followed during therapy.17,56
Retrobulbar injection of GCs was evaluated in a study of triamcinolone compared
with placebo, with 25 patients in each arm.57 The outcome was improved field of vision
without diplopia and decreased muscle size on orbital CT in the triamcinolone group.
However, because the effect was small and was associated with a risk of injury to the
globe, retrobulbar GC injection is not a recommended therapy for GO.
Nonsteroidal immunomodulators have been studied in an attempt to identify agents
that can supplant the need for high doses of GC or prevent GO remission after GC
therapy is discontinued. Cyclosporine, the first of these agents to be investigated,
showed an additive effect to oral steroids and extended the benefits of discontinued
GC.58 However, in a direct comparison with GC therapy, cyclosporine was less effective in reducing the total eye score (combination of extraocular muscle thickness,
proptosis, and visual acuity), and the side-effect profile was significant (eg, pneumonia, renal failure, hepatitis, hypertension).59 As the combination of cyclosporine
with oral GC therapy was more effective than either agent alone, cyclosporine is
sometimes used with benefit in oral GCresistant patients or as a steroid-sparing
agent. Azathioprine was compared with placebo in one study in which no benefit
was identified.60 By contrast, IV immunoglobulins (IVIg) have been found to be as
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effective as oral GC in patients with active GO. Studies have found the response rate
to be between 62% (defined by an index of extraocular muscle area, proptosis,
diplopia, and intraocular pressure) and 76% (assessed by a composite severity
score).61,62 The individual features that improved included soft tissue changes,
diplopia, visual acuity, and proptosis. A low rate of side effects was seen, none of
them serious. In these studies, IVIg were administered on 2 consecutive days every
3 weeks for 6 cycles in the former study, and daily for 5 days, repeated every 3 weeks
for 3 cycles and then 1 dose every 3 weeks for an 9 additional cycles in the latter.
Somatostatin analogues have been studied in 4 placebo-controlled trials which, in
aggregate, demonstrated no clinically significant benefit and significant gastrointestinal side effects.6366
Rituximab is an anti-CD20 chimeric monoclonal antibody that induces transient Bcell depletion, blocks early B-cell activation and differentiation, and inhibits cytokine
secretion, antigen presentation, and T-cell activation.67 This agent has been identified
in case series to have a potentially beneficial effect on GD and GO.6871 In these case
series with a total of 17 patients, rituximab treatment was associated with a decrease
in the CAS of 3 to 4 points on average. However, as no randomized control trial of rituximab treatment in GO has yet been completed, its true efficacy is unknown. Given
its side-effect profile (potential for infections, worsening hypertension, serum sickness, and so forth) and high cost, use of this agent in GO is currently best limited to
centers performing randomized controlled trials.
Most randomized trials of orbital radiotherapy (OR) in GO have studied patients with
moderate to severe disease and have shown a positive impact on ocular dysmotility,
without improvement in disease progression.7276 The exception is a single trial using
a somewhat different patient population, which failed to identify any clinically meaningful difference between OR and sham OR on the contralateral orbit.77 Several
studies addressed radiation dose and treatment duration to minimize exposure and
side effects. One trial randomized patients to either 1 Gy/wk, 1 Gy/d, or 2 Gy/d, for
a total dose of 20 Gy, and found 1 Gy/wk to be best tolerated and most effective in
terms of regression in subjective signs and improvement in eye motility.75 Another
study found the lower total dose of 2.4 Gy to be as effective as higher doses.78 A study
of OR in patients with mild GO concluded that in these patients motility was improved,
but that the treatment did not affect soft tissue swelling, proptosis, or QOL.74 At
present, several centers are using low cumulative-dose OR (<10 Gy) in selected active
mild and moderate to severe GO, especially when significant diplopia or restricted
motility is present. Several studies of OR used in conjunction with oral GC therapy
have demonstrated the combination to be superior to oral GC used alone in expediting
resolution of the active inflammatory phase of the disease.76,79 A study of OR in which
the therapy was used in conjunction with either oral GC or IVGC found IVGC to be
better tolerated and somewhat more effective than oral GC in this regimen.80 Whether
IVGC therapy benefits from the addition of OR was examined in a nonrandomized
study that suggested lack of additional benefit.81 However, this finding has to be
considered provisional until randomized clinical trials of IVGC with or without OR
have been completed. The side-effect profile of OR includes retinopathy in 1% to
2% overall, with higher risk in patients with diabetes mellitus in whom the therapy is
contraindicated owing to the lower threshold for radiation retinopathy in such
patients.82,83
A caveat to the therapeutic trials discussed here is that although investigators
studied various parameters or indices (proptosis, diplopia score, soft tissue features,
QOL, CAS, and in many cases a composite score) to ascertain benefit, none is
uniformly agreed to consistently represent improvement in GO. However, in
summary it may be said that approximately 40% to 80% of GO patients treated with
immunomodulatory therapy experience benefit, that patients with inactive disease are
not likely to respond, and that IVGC therapy appears to be the most effective of the
treatment options that have been well studied to date. Risks and benefits of these
treatments should be carefully discussed with the patient who is best fully involved
in the therapeutic decision-making process.
THYROIDECTOMY AND THYROID ABLATION
Corneal ulceration, globe subluxation, and DON are sight-threatening disorders that
require emergent therapy. DON is multifactorial in etiology, and generally occurs
when the optic nerve is compressed by enlarged extraocular muscles at the orbital
apex.86 Response to therapy is not well studied because of the rarity of this condition
(3%5% of GO patients) and the lack of a uniformly accepted definition.87 Therapy for
DON consists of IVGC, orbital decompression surgery, or both modalities.88 A direct
comparison between the 2 modalities showed that 83% of patients needed additional
therapy with IVGC following decompressive surgery, whereas only 56% of patients
needed further therapy for DON (decompression surgery or OR) following IVGC
therapy.89 Although both approaches suffered from a significant failure rate, DON ultimately resolved in all cases as patients failing one approach responded to the other.
Mainly based on these data showing overall excellent results, the EUGOGO
consensus statement advises starting with IVGC therapy and observing the response
over a 2- to 3-week period.17 A commonly followed regimen is the administration of 1.0
g methylprednisolone for 3 consecutive days, repeated 1 week later.90 If no improvement is seen or deterioration is noted, patients should be referred promptly for orbital
decompression surgery. Surgery may be indicated as first-line therapy if the corneal
exposure from proptosis is significant, if congestive features are prominent, or if
side effects of steroids are to be avoided. Sight-threatening corneal breakdown or
ulceration typically results from one or a combination of the following: excessive proptosis, excessive eyelid retraction, incomplete blinks, or incomplete eyelid closure.
321
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Stan et al
Initial treatment includes the frequent use of topical lubricants, intensive topical antibiotics where appropriate, moisture chambers, and surgical procedures to temporarily
cover the globe until healing has taken place. Occasionally orbital decompression,
eyelid surgery or even corneal grafting is required.17
REHABILITATIVE TREATMENT
After the eye disease has been inactive for 3 to 6 months, a patient may be evaluated
for rehabilitative surgery, which can have a positive impact on both ocular function and
QOL. Intervening earlier before a stable baseline is reached may increase the likelihood that additional surgery will be needed in future. The surgical sequence is generally orbital decompression (if needed), followed by extraocular muscle surgery (if
needed), with eyelid procedures (if needed) performed last. Thus, changes induced
by one intervention can be addressed in a subsequent step. Indications for orbital
decompression include excessive proptosis, orbital congestion, corneal exposure,
side effects of steroids, deep orbital pain, and enhanced cosmesis. Patients with
DON, or those who have shown intolerance or insufficient response to immunosuppressive therapy or who have debilitating retrobulbar or periorbital pain, may also
benefit from this surgery. Decompressive surgery involves removal of one or more
orbital walls, retrobulbar fat, or both, to expand the retrobulbar space, decrease orbital
pressure, and allow the globe to recede. The extent of the surgery generally depends
on the degree and distribution of extraocular muscle involvement; the improvement in
proptosis is directly related to the number of orbital walls removed.91,92 Following
decompression surgery, preexisting diplopia may worsen or new diplopia develop
in 10% to 50% of patients.93,94 If diplopia is mild, the use of prisms inserted in the
eyeglass lens may suffice. The goal of extraocular muscle surgery (strabismus
surgery) is single vision in primary gaze and the reading position; diplopia with deviant
gaze may persist after surgery. Multiple surgeries over an extended period are
Asses activity
Asses severity
Evaluate for sightthreatening complications
GO confirmed
Sight-threatening
complications present
Sight-threatening
complications absent
Active disease
Inactive disease
Mild severity
Mild severity
- Local measures
Moderate-to-severe
Moderate-to-severe
- Rehabilitative surgery
after 3 months
observation
Optimum care of the patient with GO is achieved through teamwork between the
endocrinologist and ophthalmologist, with input from ancillary specialists as needed.
If no sight-threatening complications of the disease are initially identified, an accurate
determination of disease activity and severity narrows the available treatment options
to those most likely to benefit the patient (Fig. 2). Smoking and possible dysthyroidism
constitute important modifiable risk factors for disease progression that should be
addressed on diagnosis. Of importance is early assessment of the impact of disease
on patients QOL, and their priorities and expectations regarding management. Once
this information has been gathered, careful discussion between patients and physicians can define the initial management plan, which includes the timing of the next visit
and general parameters for a future change in course.
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T h y ro i d N o d u l e s
Geanina Popoveniuc,
MD
a,b
, Jacqueline Jonklaas,
a,
MD, PhD *
KEYWORDS
Thyroid nodule TSH Ultrasonography FNA biopsy
Elastography Molecular markers Indeterminate cytology
Malignancy
INTRODUCTION
Thyroid nodules are common entities, frequently discovered in clinical practice, either
during physical examination, but also incidentally, during various imaging procedures.
They are clinically important primarily due to their malignant potential. For this reason
the initial evaluation should always include a history and physical examination
focusing on features suggestive of malignancy. Serum thyrotropin (TSH) and thyroid
ultrasonography (US) are pivotal in the evaluation of thyroid nodules, as they provide
important information regarding thyroid nodule functionality and the presence of
features suspicious for malignancy, respectively. Fine needle aspiration (FNA) biopsy
is the most accurate and reliable tool for diagnosing thyroid malignancy and selecting
candidates for surgery, particularly if performed under ultrasound guidance. The
cytology findings from FNA biopsies will fall into an indeterminate category in approximately 25% of the cases, in which case malignancy cannot be safely excluded. The
recent use of panels of gene mutations and molecular markers, when combined with
the cytologic diagnosis, show promising results in improving the preoperative diagnosis of indeterminate thyroid nodules, thus reducing the number of unnecessary
surgeries. Other tools for predicting the malignant potential of thyroid nodules still
under investigation include elastography and 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) scanning. An approach to the initial evaluation and
management of single nodules, functioning nodules, multinodular glands, incidental
nodules, and cysts are discussed. Therapeutic interventions for benign nodules,
when needed, may include surgery, radioiodine (131-I) therapy, or percutaneous
J.J. is supported by grant 1UL1RR031975 from the National Center for Research Resources,
National Institutes of Health. Funding for publication of the figures in this article was provided
by the Graduate Medical Education office at Washington Hospital Center.
Disclosure Summary: The authors have nothing to disclose.
a
Division of Endocrinology, Georgetown University Medical Center, 4000 Reservoir Road, NW,
Washington, DC 20007, USA
b
Section of Endocrinology, Washington Hospital Center, 110 Irving Street, NW, Washington,
DC 20010, USA
* Corresponding author. Division of Endocrinology, Georgetown University Medical Center,
Suite 230, Building D, 4000 Reservoir Road, NW, Washington, DC 20007.
E-mail address: [email protected]
Med Clin N Am 96 (2012) 329349
doi:10.1016/j.mcna.2012.02.002
medical.theclinics.com
0025-7125/12/$ see front matter 2012 Elsevier Inc. All rights reserved.
330
Thyroid Nodules
Box 1
Etiology of thyroid nodules
Benign etiology
Follicular adenoma
Hurthle cell adenoma
Colloid cyst
Simple or hemorrhagic cyst
Lymphocytic thyroiditis
Granulomatous thyroiditis
Infectious processes
Malignant etiology
Malignancy of follicular or C-cell origin
Papillary carcinoma
Follicular carcinoma
Hurthle cell carcinoma
Medullary thyroid carcinoma
Anaplastic carcinoma
Malignancy of other origin
Thyroid lymphoma
Malignancy metastatic to the thyroid
331
332
Table 1
Features suggestive of increased potential for thyroid carcinoma in a patient with thyroid
nodule
Patient History or
Characteristics
Findings on Physical
Examination
Firm nodule
Lymphadenopathy
Age <20
Abnormal cervical
lymphadenopathy
Age >70
Male sex
Symptoms of compression:
hoarseness, dysphagia,
dysphonia, dyspnea, cough
Abbreviations: MEN, multiple endocrine neoplasia; MTC, medullary thyroid cancer; PTC, papillary
thyroid cancer; TSH, serum thyrotropin.
Thyroid Nodules
Fig. 1. Diagnostic studies available for evaluating thyroid nodules. (Modified from figure
provided by Dr BR Haugen, University of Colorado at Denver and Health Sciences Center,
Aurora, CO; with permission.)
be a valuable addition. Other imaging studies, including MRI, CT, and 18FDG-PET
scans may be helpful in certain circumstances.
Serum Markers
The risk of malignancy in thyroid nodules increases as the serum TSH increases
TSH measurement should be part of the initial workup in every patient with a thyroid
nodule and be used as a guide for further management (Fig. 2).1,24,25 A normal or
high TSH level should raise concerns for possible malignant potential of a nodule,
whereas a low TSH is an indicator of benignity in most cases. Therefore, the next
step in the evaluation of a patient with a low TSH would be an iodine-123 (123-I) or
pertechnetate scintigraphy scan, to explore the possibility of an autonomously functioning nodule. Hyperfunctioning thyroid nodules are almost always benign and generally do not require further cytologic investigation,26,27 but a nonfunctioning or cold
nodule in a patient with low TSH may indicate malignant potential. Recent studies
have investigated the relationship between serum TSH concentration and thyroid
cancer. TSH was found to be an independent predictor of malignancy in thyroid
nodules.28 The risk of malignancy rises in parallel with serum TSH, even within the
normal range, and higher TSH levels were found to be associated with advancedstage thyroid cancer.26,2931
Calcitonin is a sensitive marker for detection of C-cell hyperplasia and MTC, as well
as for surveillance and prognosis of MTC.32 Calcitonin levels of more than 10 pg/mL
were found to have high sensitivity for the detection of MTC,33 with the specificity being
enhanced by pentagastrin stimulation, when calcitonin levels exceed 100 pg/mL.
Even though calcitonin screening was proved to be cost-effective and a useful tool
in the evaluation algorithm for thyroid nodules,34 it is not widely recognized in US,1
partly because of the low prevalence of medullary thyroid cancer and lack of
pentagastrin availability.
Serum thyroglobulin measurement is neither sensitive nor specific for the diagnosis
of thyroid cancer in nodular thyroid disease, being more influenced by iodine intake
and thyroid gland size.35 Therefore, it is not recommended to be routinely measured
in the initial evaluation of a thyroid nodule.1
333
334
Fig. 2. Algorithm for initial evaluation of a patient with thyroid nodule. (Modified from Cooper
DS. Revised American Thyroid Association management guidelines for patients with thyroid
nodules and differentiated thyroid cancer. Thyroid 2009;19(11):1167214; with permission.)
Thyroid Ultrasonography
Thyroid Nodules
Fig. 3. US image of a thyroid nodule (arrowheads) containing multiple fine punctuate echogenicities (arrow) with no comet-tail artifact, indicating high suspicion for malignancy. FNA
and surgery confirmed PTC. (Reproduced from Frates MC. Management of thyroid nodules
detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology 2005;237:794800; with permission.)
Fig. 4. Color Doppler US of a thyroid nodule showing marked internal vascularity, indicating
increased likelihood of malignancy. Histology demonstrated PTC. (Reproduced from Frates
MC. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound
consensus conference statement. Radiology 2005;237:794800; with permission.)
335
336
Table 2
Ultrasound characteristics of thyroid nodules predictive of malignancy
Ultrasound Feature
Microcalcifications
26.159.1
85.895.0
24.370.7
41.894.2
Hypoechogenicity
26.587.1
43.494.3
11.468.4
73.593.8
Irregular margins
or no halo
17.477.5
38.985.0
9.360.0
38.997.8
Solid
69.075.0
52.555.9
15.627.0
88.092.1
Intranodule
vascularity
54.374.2
78.680.8
24.041.9
85.797.4
92.5
66.7
74.8
Reproduced from Frates MC. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology 2005;237(3):794800; with
permission.
lesion (Fig. 5) with no microcalcifications lowers the probability for being cancer to
1.0%.44 US findings such as isoechogenicity and spongiform appearance (defined
as aggregations of multiple microcysts in more than 50% of the nodule) are features
highly suggestive of benignity.41
The number of nodules and their size are not predictive of malignancy, as a nodule
smaller than 1 cm is as likely as a larger nodule to harbor neoplastic cells in the presence of suspicious US features.44,45 Choosing an arbitrary size as cutoff for the likelihood of cancer or stratifying the risk in a multinodular goiter based on the dominant
nodule has fallen into disfavor.38
US identification of cervical lymph nodes demonstrating microcalcifications,
increased vascularity, cystic changes, and rounded shape, along with coexisting ipsilateral thyroid nodules, are also very important clues for malignant etiology.42
Evidence of extracapsular growth, which may range from invasion of the thyroid
capsule to perithyroidal muscle infiltration and recurrent laryngeal nerve extension,
is another strong indicator of malignancy.42,43
Fig. 5. US image of a cystic thyroid nodule (arrowheads). (Reproduced from Frates MC.
Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound
consensus conference statement. Radiology 2005;237:794800; with permission.)
Thyroid Nodules
Screening for thyroid nodules by US, or by any other types of imaging studies, is not
recommended in the general population because of the minimal aggressiveness and
indolent course of most of the thyroid cancers. Current ATA guidelines1 recommend
diagnostic thyroid sonography to be performed only in patients with known or suspected thyroid nodules, or in the presence of risk factors.24,46
Other diagnostic imaging techniques, such as MRI and CT scans, are not indicated
for routine thyroid nodule evaluation, but they may be helpful for the assessment of
nodule size, substernal extension of a nodular goiter, and airway compression.25
Elastography
FNA, in conjunction with US, forms the cornerstone of thyroid nodule evaluation
Thyroid FNA biopsy is the most reliable, safe, and cost-effective diagnostic tool used
in the evaluation of thyroid nodules.52,53 FNA under US guidance is preferred over the
palpation-guided approach because of lower rates of false-negative and nondiagnostic cytology.54 This is particularly true for nodules that are nonpalpable, located deeply
in the thyroid bed, or have a predominantly cystic component.1
The decision to pursue FNA sampling should be based on a risk-stratifying
approach that includes history, US characteristics, and nodule size (Table 3). Subcentimeter nodules should be biopsied only if there is more than 1 suspicious US characteristic, extracapsular growth, abnormal cervical lymph nodes, or high-risk history
(see Table 1). Otherwise, a cutoff size of 1 cm can be used for solid nodules that
have only 1 suspicious sonographic feature, such as microcalcifications or hypoechoic appearance. Mixed cystic-solid nodules should undergo biopsy if they are
more than 1.5 cm in size and the solid component should be targeted for biopsy.
Purely cystic and spongiform lesions are considered to have low risk for malignancy;
therefore, they could be either monitored or biopsied if larger than 2 cm (see Table 3).
Cytologic diagnosis
FNA based on an adequate sample is 95% accurate for diagnosing thyroid cancer
Almost 20% of FNA results are nondiagnostic, because of sampling error or poor
preparation technique.55 In such cases, it is recommended that a repeat FNA be
337
338
Table 3
Sonographic and clinical features of thyroid nodules and recommendations for FNA
Nodule Sonographic or Clinical Features
High-risk history
Nodule with suspicious sonographic features
>5 mm
Recommendation A
Recommendation I
Alle
Recommendation A
1 cm
Recommendation B
And hypoechoic
>1 cm
Recommendation B
11.5 cm
Recommendation C
1.52.0 cm
Recommendation B
2.0 cm
Recommendation C
Spongiform nodule
2.0 cmb
Recommendation C
Solid nodule
Thyroid Nodules
Indeterminate cytology
The cytology findings from some FNA biopsies fall into an indeterminate category
in which malignancy cannot reliably be excluded
Panels of gene mutations may serve as markers of which patients with cytologically indeterminate nodules may safely avoid surgery
Current management for most patients with indeterminate cytology at FNA biopsy
consists of diagnostic surgery to establish a histopathological diagnosis. However,
only 1040% of these cases will turn out to be malignant,59,62 leading to more than
60% of surgeries being unnecessary, with their associated risks and costs. The evaluation of genetic markers associated with thyroid carcinoma (PTC: BRAF, RAS, RET/
PTC; FTC: PAX8/PPARg1) in the cytology specimen has been shown to improve
preoperative diagnosis of thyroid nodules in large prospective studies, particularly
when used in combination with cytologic features.63,64 For example, in a Korean population, the combination of both cytology and BRAF mutation status increased the
specificity of testing from 36% to 95% compared with FNA cytology alone.65 The
use of molecular markers, in the form of a panel of gene mutations, in patients with
indeterminate cytology on FNA samples has been shown to increase the probability
of cancer from 24% to 89% if any mutation is identified, whereas the lack of any mutation decreases the risk to 11%.66 Cost-effectiveness analysis using a molecular panel
of gene markers, coupled with classical cytologic findings, to increase the predictive
power of diagnostic interpretations shows promising results when compared with the
surgical approach, and is likely to be used in the future in clinical practice.67
Currently, there are 2 commercially available assays that provide molecular testing of
the thyroid cytologic specimens from FNA biopsy. Veracyte Afirma Gene Expression
Classifier, promoted by Genzyme (Cambridge, MA, USA), evaluates messenger RNA
(mRNA) expression levels for 142 genes. It has a negative predictive value of 96%
when evaluated in samples with indeterminate cytology, thus helping patients with
benign lesions to avoid unnecessary surgeries.68 The recent cost-effectiveness analysis by Li and colleagues67 predicts that routine application of the gene expression classifier lowers the rate of surgeries for benign nodules from 57% (with current practice) to
14%. miRInform Thyroid is another commercially available assay provided by Asuragen
(Austin, TX, USA), which analyzes a panel of 7 molecular markers most commonly
encountered in thyroid cancers (BRAF, KRAS, HRAS, NRAS, RET/PTC1, RET/PTC3,
PAX8/PPARg). In contrast to the Veracyte product, it is thus designed to improve the
preoperative cytologic diagnosis of indeterminate thyroid nodules by predicting which
nodules are most likely to be malignant. Its clinical validation still needs to be determined, but the analytical specificity was found to be 99%, and the sensitivity 95%.
In addition to genetic markers, immunohistochemical staining of cytology specimens and other novel serum markers may be of use. With respect to immunohistochemical markers, galectin-3 is a protein marker that was also shown to improve
preoperative diagnosis in indeterminate follicular lesions when used in combination
with conventional cytomorphological diagnostic procedures.69,70 However, recent
data have shown that galectin-3 is more useful for diagnosing PTC than FTC.71
Measurement of serum TSH receptor mRNA, which serves as an indicator of circulating thyroid cancer cells, may be useful for helping determine which nodules with
indeterminate cytology are malignant. TSH receptor mRNA concentrations greater
than 1 ng/mg had a positive predictive value of greater than 90% for carcinoma.72
The use of 18FDG-PET scan in the preoperative diagnosis of thyroid nodules with
indeterminate cytology has high sensitivity, but histologic diagnosis is still required
to distinguish benign from malignant etiology in 18FDG-PETpositive nodules.7376
339
340
However, the use of 18FDG-PET could potentially reduce the number of unnecessary
thyroidectomies by 39% to 46%.73,74 It has limited value in selecting candidates for
surgery among patients with the cytologic diagnosis of follicular neoplasm, as the
glucose metabolic activity is similar in benign and malignant nodules with follicular
pattern cytology.45
INITIAL EVALUATION OF SINGLE NODULES, FUNCTIONING NODULES, MULTINODULAR
GLANDS, INCIDENTAL NODULES, AND CYSTS
A patient with a multinodular thyroid has the same risk of having a malignancy as
a patient with a single thyroid nodule
An algorithm for the initial evaluation of a thyroid nodule is shown in Fig. 2. Tests that
direct the evaluation along different pathways depending on their results include TSH
values, US findings, FNA results, scintigraphy findings, and results of molecular
testing. Most nodules will be found to be benign based on cytology. Such nodules
do not require immediate further diagnostic evaluation or treatment,1 but can simply
be monitored.
With respect to TSH values, a scintigraphy scan (123-I or technetium 99mTc pertechnetate) should be performed in patients with thyroid nodules and serologic
evidence of low or low-normal TSH concentration for further evaluation of nodule functionality. Nodules that are interpreted as hot on scintigraphy represent hyperfunctioning nodules and should not be considered for FNA biopsy because they are
very rarely malignant.25 The isofunctioning or nonfunctioning nodules, also named
cold nodules, have a risk for cancer between 5% and 15%, and therefore should
be aspirated for further evaluation. The ability to assess nodular functioning with radioisotope scanning is generally limited in lesions smaller than 1 cm.35
US examination, in addition to providing information about the appearance and size
of nodules, will also document the number of nodules. Of note, the prevalence of
thyroid cancer in patients with a multinodular goiter is the same as in patients with
a solitary nodule and is independent of the number of nodules. However, the likelihood
of malignancy per nodule decreases as the number of nodules increases.77 If 2 or
more nodules larger than 1 cm are present, the selection of nodules for FNA biopsy
should be made on the basis of the previously described suspicious US characteristics. Otherwise, the largest nodule should be targeted for biopsy.1
Thyroid incidentalomas discovered by CT or MRI should initially undergo US evaluation, with further management being guided based on the sonographic characteristics, as mentioned previously. In contradistinction, incidentalomas detected by
18FDG-PET examination have a high risk of malignancy, and US evaluation, along
with FNA biopsy, should be performed.25
Totally cystic lesions are generally considered benign and, unless a solid component is present, further diagnostic investigation is not required (see Table 3).
TREATMENT FOR BENIGN NODULES
Thyroid Nodules
A 50% increase in the volume of a previously biopsied thyroid nodule is a reasonable trigger for repeating an FNA
Benign thyroid nodules require further long-term follow-up because of the risk of falsenegative results after initial FNA, which is about 5%.93 Serial US at 6 to 18 months from
the initial FNA is the recommended investigation for the follow-up examination of
341
342
Thyroid Nodules
In the case of aggressive or rapidly growing thyroid cancer, surgery during the
second trimester is safest
The etiology and behavior of thyroid nodules discovered during pregnancy as
compared with the general population is unknown.98 As a consequence, the evaluation should be similar to that for nonpregnant patients, except for the contraindication
to radionuclide scanning. If a patient is found to have persistently suppressed serum
TSH levels after the first trimester, the radionuclide scan and possible subsequent
FNA can be safely postponed until after delivery and cessation of lactation.1 In euthyroid or hypothyroid pregnant women with thyroid nodules, consensus guidelines
recommend that an FNA biopsy should be performed.1 An argument can be made,
however, for deferring the FNA until after delivery unless there are worrisome clinical
features that would perhaps lead to a recommendation for a thyroidectomy during
pregnancy. If a diagnosis of malignancy results from the FNA, but postponement of
thyroidectomy until the patient is post partum is the intended plan before the FNA,
this simply exposes the patient to anxiety regarding a diagnosis about which she
can take no action.
Previous studies have demonstrated similar cancer behavior in pregnant patients
diagnosed with PTC when compared with the general population,99,100 with no differences in survival rates or recurrences in pregnant women operated for PTC during or
after delivery.100 Rates of complications after thyroid surgery are higher in pregnant
women than their nonpregnant counterparts, however.101 Because additional retrospective data suggest that delaying surgery for less than 1 year from the time of the
differentiated thyroid cancer diagnosis has no impact on patient outcome,102 postponing the surgery until after delivery seems a reasonable approach. If more advanced
or aggressive disease is present at the time of diagnosis, or a decision is made to
pursue thyroidectomy for thyroid cancer discovered early in pregnancy, surgery
should be ideally performed in the second trimester of pregnancy,103 as this may
decrease the risk of early miscarriage and premature delivery.
T4 suppressive therapy to maintain a serum TSH level between 0.1 and 1.0 mU/L is
a reasonable approach in pregnant patients diagnosed with thyroid cancer on the
basis of an FNA and who are awaiting thyroidectomy.104
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76. Kresnik E, Gallowitsch HJ, Mikosch P, et al. Fluorine-18-fluorodeoxyglucose
positron emission tomography in the preoperative assessment of thyroid
nodules in an endemic goiter area. Surgery 2003;133(3):2949.
77. Frates MC, Benson CB, Doubilet PM, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin
Endocrinol Metab 2006;91(9):34117.
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78. Lazarus JH. Guidelines for the use of radioiodine in the management of hyperthyroidism: a summary. Prepared by the Radioiodine Audit Subcommittee of the
Royal College of Physicians Committee on Diabetes and Endocrinology, and the
Research Unit of the Royal College of Physicians. J R Coll Physicians Lond
1995;29(6):4649.
79. Bennedbaek FN, Hegedus L. Treatment of recurrent thyroid cysts with ethanol:
a randomized double-blind controlled trial. J Clin Endocrinol Metab 2003;
88(12):57737.
80. Valcavi R, Frasoldati A. Ultrasound-guided percutaneous ethanol injection
therapy in thyroid cystic nodules. Endocr Pract 2004;10(3):26975.
81. Tarantino L, Francica G, Sordelli I, et al. Percutaneous ethanol injection of hyperfunctioning thyroid nodules: long-term follow-up in 125 patients. AJR Am J Roentgenol
2008;190(3):8008.
82. Papini E, Panunzi C, Pacella CM, et al. Percutaneous ultrasound-guided ethanol
injection: a new treatment of toxic autonomously functioning thyroid nodules?
J Clin Endocrinol Metab 1993;76(2):4116.
83. Lippi F, Manetti L, Rago T. Percutaneous ultrasound-guided ethanol injection for
treatment of autonomous thyroid nodules: results of a multicentric study
[abstract]. J Endocrinol Invest 1994;17(Suppl 2):71.
84. Verde G, Papini E, Pacella CM, et al. Ultrasound guided percutaneous ethanol
injection in the treatment of cystic thyroid nodules. Clin Endocrinol (Oxf) 1994;
41(6):71924.
85. Castro MR, Caraballo PJ, Morris JC. Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J Clin Endocrinol Metab 2002;87(9):41549.
86. Papini E, Bacci V, Panunzi C, et al. A prospective randomized trial of levothyroxine suppressive therapy for solitary thyroid nodules. Clin Endocrinol (Oxf) 1993;
38(5):50713.
87. Papini E, Petrucci L, Guglielmi R, et al. Long-term changes in nodular goiter:
a 5-year prospective randomized trial of levothyroxine suppressive therapy for
benign cold thyroid nodules. J Clin Endocrinol Metab 1998;83(3):7803.
88. Wemeau JL, Caron P, Schvartz C, et al. Effects of thyroid-stimulating hormone
suppression with levothyroxine in reducing the volume of solitary thyroid
nodules and improving extranodular nonpalpable changes: a randomized,
double-blind, placebo-controlled trial by the French Thyroid Research Group.
J Clin Endocrinol Metab 2002;87(11):492834.
89. Zelmanovitz F, Genro S, Gross JL. Suppressive therapy with levothyroxine for
solitary thyroid nodules: a double-blind controlled clinical study and cumulative
meta-analyses. J Clin Endocrinol Metab 1998;83(11):38815.
90. La Rosa GL, Ippolito AM, Lupo L, et al. Cold thyroid nodule reduction with Lthyroxine can be predicted by initial nodule volume and cytological characteristics. J Clin Endocrinol Metab 1996;81(12):43857.
91. Parle JV, Maisonneuve P, Sheppard MC, et al. Prediction of all-cause and
cardiovascular mortality in elderly people from one low serum thyrotropin result:
a 10-year cohort study. Lancet 2001;358(9285):8615.
92. Fiore E, Rago T, Provenzale MA, et al. L-thyroxine-treated patients with nodular
goiter have lower serum TSH and lower frequency of papillary thyroid cancer:
results of a cross-sectional study on 27 914 patients. Endocr Relat Cancer
2010;17(1):2319.
93. Carmeci C, Jeffrey RB, McDougall IR, et al. Ultrasound-guided fine-needle aspiration biopsy of thyroid masses. Thyroid 1998;8(4):2839.
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94. Tan GH, Gharib H, Reading CC. Solitary thyroid nodule. Comparison between
palpation and ultrasonography. Arch Intern Med 1995;155(22):241823.
95. Brauer VF, Eder P, Miehle K, et al. Interobserver variation for ultrasound determination of thyroid nodule volumes. Thyroid 2005;15(10):116975.
96. Asanuma K, Kobayashi S, Shingu K, et al. The rate of tumour growth does not
distinguish between malignant and benign thyroid nodules. Eur J Surg 2001;
167(2):1025.
97. Oertel YC, Miyahara-Felipe L, Mendoza MG, et al. Value of repeated fine needle
aspirations of the thyroid: an analysis of over ten thousand FNAs. Thyroid 2007;
17(11):10616.
98. Tan GH, Gharib H, Goellner JR, et al. Management of thyroid nodules in pregnancy. Arch Intern Med 1996;156(20):231720.
99. Morris DM, Herzon FS, Segal MN, et al. Coexistent thyroid cancer and pregnancy. Arch Otolaryngol Head Neck Surg 1994;120(11):11913.
100. Moosa M, Mazzaferri EL. Outcome of differentiated thyroid cancer diagnosed in
pregnant women. J Clin Endocrinol Metab 1997;82(9):28626.
101. Kuy S, Roman SA, Desai R, et al. Outcomes following thyroid and parathyroid
surgery in pregnant women. Arch Surg 2009;144(5):399406 [discussion: 406].
102. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical
therapy on papillary and follicular thyroid cancer. Am J Med 1994;97(5):41828.
103. Mestman JH, Goodwin TM, Montoro MM. Thyroid disorders of pregnancy. Endocrinol Metab Clin North Am 1995;24(1):4171.
104. Rosen IB, Korman M, Walfish PG. Thyroid nodular disease in pregnancy: current
diagnosis and management. Clin Obstet Gynecol 1997;40(1):819.
349
A p p ro a c h t o a n d
Tre a t m e n t o f G o i t e r s
Geraldo Medeiros-Neto, MD, MACPa,*,
Rosalinda Y. Camargo, MD, PhDb, Eduardo K. Tomimori,
MD, PhD
KEYWORDS
Simple goiter Multinodular goiter Sonography Surgery
L-thyroxine therapy Radioiodine ablation
Simple and nodular goiters are common and geographically widespread conditions.
Since remote times, goiter has been described as an enlargement of the neck, and
a pictorial description of this anomaly has been present in several cultures and civilizations.1 The Chinese identified goiter in people living in the countryside and empirically treated them successfully with extracts of dry sea sponges. The traditional
Chinese medical doctors were not aware of the iodine-rich content of dry sea sponges
and they must have discovered the efficacy of this treatment by trial and error. When
Roman armies were crossing the Alps to conquer the Celtic tribes, it was noted that
most of the villagers had goiters (Quis tumidum guttur miratur in Alpibus?: Do not
be surprised to observe goitrous [people] in the Alps). The Latin guttur may be the
obvious root for the French, English, and Italian words for the enlargement of the
neck (goiter, goiter, and gozzo). During medieval and Renaissance periods, many
sculptures, paintings, and works of folk art depicted goitrous people; most of them
were villagers from the Alps and other mountainous regions of Europe. Goiter was
common in Switzerland, as indicated by medical reports.1 In South America, goiter
was observed after the Spanish and Portuguese conquerors started the process of
colonization. It is debatable if the indigenous civilizations in the Andes mountains
had a goiter or not, but after the miscegenation of the local population, goiter became
common in the Andes. In the Alps, the Andes, and the Himalayas as well as in China,
Brazil, Indonesia, Thailand, Vietnam, and other countries, goiter was the visible
This article was partially supported by a grant from Instituto da Tiroide-Sao Paulo, Brazil- www.
indatir.org.br.
The authors declare that they have nothing to disclosure.
a
Division of Endocrinology, Department of Medicine, University of Sao Paulo Medical School,
Rua Artur Ramos, 96 5A, 01454-903 Sao Paulo, Brazil
b
Thyroid Unit, Division of Endocrinology, University of Sao Paulo Medical School, Rua
Mirassol, 216 apartment 82, 04044-010 Sao Paulo, Brazil
c
Section of Ultrasonography at the Hospital das Clnicas, University of Sao Paulo Medical
School, Rua Artur Ramos, 241 - Room 63, 01454-011 Sao Paulo, Brazil
* Corresponding author.
E-mail address: [email protected]
Med Clin N Am 96 (2012) 351368
doi:10.1016/j.mcna.2012.01.010
medical.theclinics.com
0025-7125/12/$ see front matter 2012 Elsevier Inc. All rights reserved.
352
Medeiros-Neto et al
consequence of chronic iodine deficiency, but this was clearly shown only at the
beginning of the nineteenth century, when iodine was discovered. Later, iodine drops
were used to cure goiters in Geneva, Switzerland, but a few cases of excessive thyroid
function and dramatic cardiac arrhythmias were detected with deaths from the excessive iodine administered to goitrous elderly people.2 Iodine started to be widely distributed to afflicted populations in the mountainous regions of Europe late in the
nineteenth century. The first attempt at an epidemiologic approach to prevent
endemic goiter was made in France and Switzerland in the early twentieth century.
In the United States, Marine and Taylor1 reported on clinical and pathologic aspects
of multinodular goiters, and general prophylaxis with iodine administration was suggested. Later, several countries started their own programs to distribute iodine to their
populations. Most of the studies of the prevalence of goiters were based on physical
examination of schoolchildren. If more than 5% of all schoolchildren had thyroid
enlargement, supplementation of iodine through salt was recommended. In 1986,
the International Council for Control of Iodine Deficiency Disorders started a new
period of globalization in the permanent fight against iodine-deficiency disorders,
including goiter. Almost 2 billion people are still at risk of iodine deficiency and its
consequences, mostly pregnant women and their babies, as well as children of school
age.3
Iodine deficiency was and still is a major cause for goiter in schoolchildren, young
adults, and elderly people. As discussed in the following sections, goiter may have
a familial incidence and a strong genetic predisposition. Other causes of goiter may
relate to smoking, natural goitrogens, autoimmune disorders, dyshormonogenesis,
certain iodine-rich drugs, and environmental agents. The approach to a patient with
a goiter should consider and evaluate many and multiple factors that induce an
abnormal growth of the thyroid gland.
WHAT IS A GOITER?
Fig. 1. Relationship between the median urinary iodine concentration and the prevalence
of goiter (measuring volume by echography) at 57 locations in 12 European countries.
(From Delange F, Benker G, Caron P, et al. Thyroid volume and urinary iodine in European
schoolchildren; standardization values for assessment of iodine deficiency. Eur J Endocrinol
1997;136:182; with permission.)
EPIDEMIOLOGY
Studies on the epidemiology of SDG and MNG in a given population have been
hampered by selection criteria, influence of environmental factors, methodology
for measuring size, and morphology, as well as methods for evaluating thyroid
function.5,6
Survey of a representative sample of the adult population from a geographic area of the
United Kingdom7 indicated that 15.5% of the individuals had a palpable goiter, with
a female/male ratio of 4.5:1. No relation to iodine excretion was found. In the Framingham,
United States, study8 the iodine intake was high (urinary iodine 246 mg iodine/L), and MNG
was found by palpation in only 1% of individuals between 30 and 50 years of age. MNG is
a frequent clinical entity in countries with a history of chronic iodine deficiency. After
correction of the iodine deficiency most schoolchildren, young adults, and middle-aged
individuals do not present with an SDG. However, older individuals who have suffered
from lack of proper iodine nutrition since childhood may have a clinically visible and
palpable MNG. It is estimated that about 6% of elderly individuals in a given population,
previously suspected to have iodine deficiency, may have visible MNG.9
EVOLUTION OF SDG AND MNG
The evolution of SDG (either endemic or sporadic) is limited to primary and secondary
factors.6 Primary factors are functional heterogeneity of normal follicular cells, caused
by genetics, and acquisition of new inheritable qualities by replicating epithelial cells.
An important primary factor is gender (females are affected more than males). Later,
with the evolution of SDG and MNG, several functional and structural anomalies in
growing goiters emerge (Fig. 2).
353
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Medeiros-Neto et al
Fig. 2. Mild iodine deficiency associated or not with smoking, presence of natural goitrogenic drugs, familial goiter, genetic markers, and gender (female) decreases the inhibition
of serum T4 on the pituitary thyrotrophs. Increased TSH production causes diffuse goiter followed by nodule formation. After decades of life, a large MNG is present with cystic areas,
hemorrhage, fibrosis, and calcium deposits. (From Medeiros-Neto G, Henneman G. Multinodular goiter. 2010. Available at: http://www.thyroidmanager.org. Accessed November 7,
2011; with permission.)
Secondary factors are mostly linked to persistent increased levels of serum thyroidstimulating hormone (TSH) (induced by iodine deficiency), presence of natural goitrogens, dyshormonogenesis, nutritional deficiencies, oxidative stress, smoking, and
environmental and endocrine disruptors.
The secondary factors discussed later stimulate thyroid cell growth or function, and,
because of presumed differences in cellular responsiveness, aggravate the expression
of heterogeneity, which leads to further growth and focal autonomic function of the thyroid
gland. Local necrosis and cyst formation (sometimes with bleeding and fibrosis) may be
the anatomic end stage of such processes (see Fig. 2).
Iodine Deficiency
an inverse relation is found between urinary iodine excretion and thyroid volume (see
Fig. 1). Physiologic stresses, such as pregnancy, may increase the need for iodine and
require thyroid hypertrophy to increase iodine uptake. Moreover, increased renal
clearance of iodine occurs during normal pregnancy.10 Increased need for thyroxine
(T4) during pregnancy may also lead to significant transfer of thyroid hormone from
the mother to the fetus. Mutations in the thyroglobulin gene may impair the efficiency
of thyroid hormone synthesis and release, leading to a decrease inhibition of TSH at
the pituitary level. The high TSH released from the thyrotrophs continuously stimulates
growth of the thyroid gland.6
Natural Goitrogens
Natural goitrogens (Table 1) may be considered significant determinants of the prevalence of goiter, either in iodine-deficient areas or in localities where iodine intake is
abundant, as in the coal-rich Appalachian area of eastern Kentucky.15 Goitrogenic
effects may be related to the consumption of certain foodstuffs (cassava, millet,
babassu coconut, pinon, vegetables from the genus Brassica, and soybean).1627
The goitrogenic factor in cassava is related to the hydrocyanic acid liberated from
the cyanogenetic glucoside (linamarin) and converted endogenously to thiocyanate.
These compounds, competitively, inhibit trapping and promote the efflux of intrathyroidal iodine.16 Pearl millet is one of the most important food crops in the semiarid
tropics (large portions of Africa and Asia). Millet porridge is rich in C-glucosylflavones
and also contains thiocyanate. Both are additive in their antithyroid effects. Babassu
coconut is largely consumed in northern Brazil, and studies have shown the presence
of flavonoids in the edible part of the nut.17 Studies of soy isoflavones in experimental
animals suggest possible adverse effects like enhancement of reproductive organs,
modulation of endocrine function, and antithyroid effects. Antithyroid effects may
also be extended by increasing the loss of T4 from the blood via bile into the gut,
and may cause goiter when iodine intake is limited.18,19
Table 1
Natural goitrogens associated with goiter prevalence
Goitrogens
Agent
Millet, soy
Flavonoids
Action
Impairs thyroperoxidase activity
Cyanogenic glucosides
metabolized to
thiocyanates
Flavonoids
Inhibits thyroperoxidase
Cruciferous vegetables:
cabbage, cauliflower,
broccoli, turnips
Glucosinolates
Seaweed (kelp)
Iodine excess
Malnutrition
Vitamin A deficiency
Iron deficiency
Selenium
Selenium deficiency
Adapted and modified from Medeiros-Neto G, Knobel M. Iodine deficiency disorders. In: Jameson
JL, De Groot LJ, editors. Endocrinology. 6th edition. Philadelphia: WB Saunders Co; 2010; with
permission.
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Medeiros-Neto et al
Excess consumption of iodine-rich kelp (dry seaweed, 80200 mg iodine per day) has
caused sporadic and even endemic goiter in humans. In these cases, goiter is
common in some families and more frequent in girls at puberty, which suggests the
influence of additional genetic and hormonal factors. The organification of iodine
and, consequently, the synthesis of T4 and triiodothyronine (T3) were lower than
normal, and iodine-rich colloid goiter was observed in patients from the goiterendemic coast of Hokkaido, Japan.20
Generalized malnutrition (protein-caloric deprivation) has been recognized as an
additive factor in the prevalence of goiter in populations with mild iodine deficiency.2127
Epidemiologic data recorded in 5-year-old to 14-year-old South African children
showed that vitamin A supplements are effective in treating goiter in areas of mild iodine
deficiency. It has also an additional benefit: through suppression of the pituitary TSHb
gene, vitamin A supplements can decrease TSH secretion and the subsequent overstimulation of the thyroid. These events reduce the risk of goiter.21,22 Iron, selenium,
and zinc are essential for normal thyroid hormone metabolism. Iron deficiency impairs
thyroid hormone synthesis by reducing activity of heme-dependent thyroid peroxidase.
Iron-deficiency anemia blunts and iron supplementation improves the efficacy of iodine
supplementation.23
Natural goitrogenesis, protein-caloric malnutrition, iron, selenium, and zinc as well
as environmental disruptors have a limited if any effect in a normal iodine environment.
In clinical practice, these factors are of minor pathologic action in patients with SDG or
MNG.
Oxidative stress has been previously evaluated10 and considered an important
factor in goitrogenesis. Certain drugs may induce damage to the follicular cells, with
a possible induction of goiter.
Heterogeneity of Thyroid Cells
Cells of the thyroid gland are often polyclonal rather than monoclonal in origin.14 From
a functional aspect, it seems that through developmental processes the thyroid
epithelial cells forming a follicle are functionally polyclonal and possess widely
different qualities regarding biochemical steps leading to growth and to thyroid
hormone synthesis.6 As a consequence, there is marked heterogeneity of growth
and function within the thyroid and even within a single follicle.14
An example of genetic qualities acquisition is the identification in the last few years
of constitutively activating somatic mutations not only in solitary toxic adenoma but
also in hyperfunctioning nodules of MNGs.13
Environmental Disruptors Affecting Thyroid Function
Tobacco smoking is a major source of thiocyanate in humans, which inhibits the function of the iodide transporter in the lactating mammary gland. Smoking during the
period of breastfeeding dose-dependently reduces breast-milk iodine content to about
half and, consequently, exposes the infant to increased risk of iodine deficiency.31
To identify further candidate regions, the first extended genome-wide linkage analysis
was performed to detect susceptibility loci in 18 Danish, German, and Slovakian families.38 Assuming genetic heterogeneity and a dominant pattern of inheritance, 4 novel
candidate loci on chromosomes 3p, 2q, 7q, and 8p were identified. An individual
contribution was attributable to 4 families for the 3p locus and to 1 family for each
of the other loci, respectively. From the candidate regions identified earlier and the
established environmental factors, nontoxic goiter can consequently be defined as
a complex disease. However, a more prevalent putative locus, present in 20% of
the investigated families, has been identified.38
Moreover, the sum of several weak genetic variations in different genomic regions
could lead to goiter predisposition. Therefore, the widely accepted risk factors such
as iodine deficiency, smoking, old age, and female gender are likely to interact with
or trigger the genetic susceptibility.36
Thyroglobulin gene mutations have been implicated in the genesis of nontoxic
goiter.4144 Two studies from Spain have indicated monoallelic mutations in the TG
gene causing euthyroid diffuse goiter.41,42 In 1 patient a homozygous mutation in exon
43 induced the synthesis of an abnormal TG protein that was mostly retained in the endoplasmic reticulum.44 Thus, the defective TG protein that reached the colloidal space was
rapidly hydrolyzed and thyroid hormone released into the circulation. However, serum
TSH level was mildly increased and a large diffuse goiter was present (Fig. 3). The high
iodine intake had a positive role for generation of barely normal serum T3 and T4 levels.
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Medeiros-Neto et al
Fig. 3. A large diffuse goiter in a 39-year-old woman with serum TSH 4.19 mIU/mL, free T4 5
0.63 ng/dL, low serum Tg (4.2 ng/mL) not responsive to stimulation by rhTSH. Iodine nutrition was normal, as confirmed by a urinary iodine of 239 mg/L. A thyroglobulin gene mutation in exon 43 (Ala 2215 Asp) led to an expressive retention of TG-mutated protein in the
endoplasmic reticulum. Hormone synthesis and release were only mildly affected, possibly
by the high iodine ingestion. Goiter was probably caused by excessive and persistent TSH
stimulation. (Data from Pardo V, Vono-Toniolo J, Rubio IG, et al. The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and
congenital hypothyroidism with wide phenotype variation. J Clin Endocrinol Metab 2009;94:
293844.)
CLINICAL EVALUATION
Most patients with SDG and MNG have few or no symptoms except for those with large
MNG. Many patients are referred to hospital for cosmetic reasons or, more frequently, for
compression of cervical structures causing tracheal deviation. Rarely dyspnea, cough,
and dysphasia are present. Often patients have a family history of goiter and nodules
removed by surgery in their relatives. SDG commonly develops slowly in school-age children during adolescence. Goiter asymmetry is common. In older people, MNG is the most
frequently diagnosed entity. Aside from cosmetic complaints, a sudden transient pain
with enlargement of a side of the MNG secondary to hemorrhage is the major complaint
by patients. Compression symptoms are more often seen when there is an intrathoraxic
extension of the MNG (Fig. 4). Such goiters develop insidiously in elderly individuals when
there is a substantial growth into the thorax (anterior mediastinum); they may lead to
compression of the subclavia arterial/venous flow with the surge of collateral circulation
in the upper thoracic region. Intrathoraxic localization may cause respiratory distress in
30% to 85% of patients referred for surgery.5,6 Tracheal compression results in dyspnea,
stridor, cough, and a sensation of shock. Intrathoraxic MNG symptoms of respiratory
distress are amplified in a recumbent position (Fig. 5). Several patients with MNG may
present signs and symptoms related to subclinical hyperthyroidism/clinical hyperthyroidism. These symptoms are probably caused by autonomous nodules inside the
MNG13 or, more frequently, by an excess of nutritional iodine or iodinated drugs, or radiological contrasts containing iodine.6
LABORATORY INVESTIGATION AND IMAGING PROCEDURES
TSH assays are sensitive in detecting thyroid dysfunction and are therefore preferred as a first approach by more than half of clinicians.45,46 Depending on the geographic localization of the attending physician (North and South America, Europe,
Fig. 4. An elderly woman with a large and long-standing MNG that migrated to the upper
mediastinal region with subsequent compression of the subclavian system. Note the subcutaneous enlarged venous circulation (A). Scintillographic studies after a tracer dose of 131I
(B) before and (C) after simulation by 0.45 mg of rhTSH. (From Silva MN, Rubio IG, Romao R,
et al. Administration of a single dose of recombinant human thyrotrophin enhances the efficacy of radioiodine treatment of large compressive multinodular goitres. Clin Endocrinol
(Oxf) 2004;60:302; with permission.)
and Asia/Oceania), thyroidologists frequently also ask for thyroid hormone determination (free T4, free T3, total T4, total T3) in the initial evaluation of the patient. Antithyroid peroxidase (anti-TPO) antibodies are measured by half of clinicians. The
information provided by a positive anti-TPO test is relevant for future treatment
with radioiodine (as a risk factor for thyroiditis and hypothyroidism). Serum thyroglobulin (Tg) is an important marker for the rare condition of a mutation in the TG
gene leading to a paradoxic low Tg serum level in a large MNG (see Fig. 3).
Imaging Procedures
Sonography of the thyroid
It is widely accepted that neck palpation is imprecise both for assessment of thyroid
morphology and size (weight) determination. Therefore, sonography has been
Fig. 5. Familial diffuse goiter. Cervical CT of a large SDG. A large goiter (230 mL) in a 42-yearold woman from an iodine-sufficient area. The thyroid volume apparently started to grow
after her third pregnancy. Her mother and 2 sisters also have goiters. The patient complained of dyspnea, compression symptoms, and stridor. Serum TSH level was 6.0 mIU/mL,
free T4 1.1 ng/dL, and anti-TPO was negative. Serum TG level was increased (186 ng/mL).
Note the tracheal compression with a reduced area (8 18 mm).
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Medeiros-Neto et al
Scintillography of thyroid isotope imaging has little place in the evaluation of SDG or
MNG. However, isotope uptake by the MNG may be measured before and after stimulation by recombinant human TSH (rhTSH) (see Fig. 4). It has been clearly shown that
after rhTSH stimulation, the uptake of the nodules (within the MNG) increases dramatically. This finding indicates a therapeutic choice for a dose of radioiodine preceded by
rhTSH.
CT and MRI
There is no ideal therapeutic option for SDG.47 As discussed earlier, SDG results from
a combination of genetic factors and environmental conditions. Frequently a mild
iodine deficiency is present.4 Therefore, iodine supplementation seems to be an
adequate approach (400 mg iodine for 812 months). A significant reduction was
observed in SDG. However, in patients with MNG, iodine therapy may induce autoimmune thyroiditis and also the risk of iodine-induced hyperthyroidism (Jod-Basedow
In the United States (and possibly in most other countries), surgery is the preferred
treatment for patients with euthyroid, large obstructive, and substernal MNG.45,46
This preference was clearly shown in questionnaires sent to members of the American
Thyroid Association and the European Thyroid Association. Small MNGs were preferentially treated with suppressive L-T4 therapy by more than half of the responders to
the questionnaire. By contrast, European thyroidologists tended to treat MNG with
radioiodine (131I) alone or preceded by rhTSH as an alternative to surgery. In countries
Table 2
Treatment of nontoxic MNGs
Therapeutic Options
Data Favoring
Data Against
Kommentare
Surgery
Rapid goiter
reduction
and cervical
decompression
obtained
Pathologic
examination
Standard therapy
when highvolume thyroid
surgeons are
available
Not all patients may
be eligible
Elderly patients may
be high risk
L-T4
Outpatient
treatment
Low cost
Prevent new nodule
formation
Association with
iodine
may be more
effective
Goiter reduction in
only 30%
Treatment is for life
TSH suppressed
Possible subclinical
hyperthyroidism
Effects in bone
and heart
Compliance may
be low
Currently indicated
in small MNG
Association with
iodine
may result in
higher
efficacy
May be
recommended as
first option
Goiter volume
reduced
(50%) after 1 y
Few side effects
Low cost for the
public
health system,
specially in
emergent
countries
Reduction of goiter
sizes gradual
Larger goiters may
have a lower
reduction
Transient thyroiditis
Increased levels of T4
and T3
hypothyroidism
(30%)
and
L-T4 plus iodine
Radioiodine
(preceded by
rhTSH)
Adapted and modified from Hegedus, L, Paschke R, Krohn K, et al. Multinodular goiter. In: Jameson
LJ, De Groot LJ, editors. Endocrinology. 6th edition. Philadelphia: Saunders-Elsevier; 2010. p. 163649;
with permission.
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Medeiros-Neto et al
with a past history of chronic iodine deficiency, MNG is common in elderly patients,
many of whom are considered to have a higher risk for surgery because of the presence of other chronic disorders, hence the need for an alternative therapeutic procedure to replace the obvious surgical intervention. In most patients with large MNG,
near total or total thyroidectomy is the procedure of choice.4859 Complications of
surgery such as injury to the recurrent laryngeal nerve tracheal lesions, nonintentional
removal of the parathyroid glands resulting in permanent hypoparathyroidism with lifelong need for continuous treatment are, apparently, more common in large and substernal goiters rather than those undergoing surgery for cervical goiters.5557 To
minimize the risks of complications, those patients with substernal goiters should
be referred to an experienced thyroid surgeon.11 However, in many settings, thyroid
surgeons may not be easily available and general surgeons are indicated for MNG
surgery. Frequently a subtotal thyroidectomy is performed, and the recurrence risk
of MNG may reach 60% of patients within many years of the surgical procedure.51,58
Another point of controversy is the use of L-T4 after a subtotal thyroidectomy. Total
removal of the thyroid (MNG) leads to hypothyroidism and treatment with L-T4 is
mandatory. Patients who are left with a substantial residual thyroid tissue may be
treated with L-T4.51 The use of routine L-T4 therapy is questioned by others.52 Because
of the high long-term recurrence rate after subtotal thyroidectomy for MNG, most clinicians treat these patients with L-T4.45,46
A reoperation for the recurrent MNG accounts for approximately 10% to 15% of
thyroidectomies (mostly subtotal surgery), resulting in a 3-fold to 10-fold increase in
risk of surgical complications, as indicated earlier.5 An alternative is the use of radioiodine preceded by rhTSH stimulation, as discussed in the last section of the therapeutic approaches to MNG.
L-T4suppressive
L-T4suppressive therapy is used extensively in Europe, the United States, and Latin
America, according to their respective surveys.45,46 A beneficial effect of L-T4 has
been shown in diffuse goiters in many controlled trials.6066 A goiter reduction of
20% to 40% can be expected in 6 to 12 months of therapy, the goiter returning to
the pretreatment size after L-T4 withdrawal. The efficacy of L-T4 depends on the degree
of TSH suppression. For nontoxic MNG, there are controlled studies in which sonography was used for objective size monitoring. A randomized, double-blind trial showed
that the goiter volume was reduced by 15% (9 months of L-T4 therapy). In the placebo
group, the goiter continued to increase in size by more than 20% in the 9-month
period.60 The goiter volume returned to baseline values after discontinuation of the
therapy. Others61 studied 62 patients with nodular goiter. Thirty per cent of patients
were regarded as responders (reduction >50% of the initial volume). In the control
group, 87% showed no change or an increase in goiter size. Another randomized
trial62 compared L-T4 with 131I therapy. The median reduction of goiter volume in the
radioiodine-treated group was 38% to 44%, whereas only 7% of the L-T4treated
patients had a significant goiter reduction.
An Italian group63 treated 83 goitrous patients (nodular goiter) with suppressive
doses of L-T4, comparing the results with a control group. The L-T4 therapy was
extended for 5 years. There was a decrease in nodular size in the L-T4treated group
and a mean volume increase in the control group. After 5 years, sonograms detected
28.5% new nodules in the control group but only 7.5% in the L-T4treated group.
Long-term TSH suppression by L-T4 induced volume reduction in a subgroup of
thyroid nodules but effectively prevented the appearance of new nodules. Another
recently controlled study from Italy67 studied patients with MNG treated with L-T4
compared with a control group for 1 year. These investigators concluded that L-T4
reduced significantly the goiter volume, compared with the control group. Thyroid
volume was evaluated by sonography.
A study conducted in Brazil65 evaluated 42 women with a nodular goiter. Twenty-one
patients were treated with 2.7 mg/kg of L-T4 for 1 year. Six of the 21 treated patients had
a greater than 50% reduction of the goiter. Nodule volume has been evaluated by
sonography. Nodule volume reduction has been observed in only 2 (of 24 patients)
who received a placebo. These investigators concluded that L-T4 therapy is associated
with 17% of reduction of a single colloid nodule and may inhibit growth in other patients.
They also conducted a meta-analysis of 6 prospective controlled trials and concluded
that 4 of 7 studies favor treatment with L-T4. More recently, a study conducted in Germany66 in a large cohort (1024 patients), in a multicenter setting evaluated L-T4 alone,
L-T4 plus iodine, iodine alone, and placebo in thyroid nodules. Nodular volume was
reduced by 17.3% in the group receiving L-T4 and iodine compared with 7.3% in the
group treated with L-T4 alone. Both treatments were more effective in goiter (nodule)
reduction compared with placebo. These investigators concluded that in a region
with sufficient iodine the combination of L-T4 plus iodine is more effective than another
component alone or placebo. The treatment of single nodules or MNG with L-T4 is an
open issue, because the reduction of the nodule/MNG is obtained in only about onethird of patients. The possible unwanted effects of L-T4 therapy have also to be
considered.5,6
Radioiodine in the Treatment of MNG
Acute adverse effects are caused by the surge of thyroid hormone in blood and the
goiter increase in volume (in the first 48 hours of radioiodine therapy), which may cause
local tenderness, tracheal compression, and, frequently, cardiac symptoms. These
conditions may be minimized by the use of corticoids and b-blockers.74
Several recent articles7783 have indicated that these adverse effects are probably
dose dependent and are negligible with lower rhTSH doses.
In the case of patients with MNG with subclinical/clinical hyperthyroidism, it is recommended to precede the ablation with 60 days of a high dose of methimazole and
363
364
Medeiros-Neto et al
a low-iodine diet. Both precautions reduce the amount of thyroid hormone within the
MNG and prevent the possible complications of a surge of thyroid hormone after
ablation.75
Long-term adverse effects of combined rhTSH plus
131
SDG and MNG affect millions of people worldwide. The main causes are mild iodine
deficiency, natural goitrogens, smoking, and other environmental agents. Clinical
evaluation is based on TSH, free T4, and anti-TPO determinations followed by ultrasonographic imaging. Large goiters with substernal invasion may require CT or MRI.
More recently, it has been accepted that there is a strong genetic influence in some
familial goiters, and it is suggested that goiters are derived from a combination of
genetic and environmental factors. Goiters are frequently treated by L-T4suppressive
therapy (small goiters), subtotal thyroidectomy, followed by L-T4 therapy. Radioiodine
alone or preceded by rhTSH is widely used in Europe and other countries. Each of
these therapeutic options has advantages and disadvantages, with acute and longterm side effects.
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and cooked leaves. Food Chem Toxicol 2003;41:11937.
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babassu and mandioca: a staple food in goiter areas of Brazil. Eur J Endocrinol
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18. Schroder-van der Elst JP, Smit JW, Romijn HA, et al. Dietary flavonoids and iodine
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19. Doerge DR, Chang HC. Inactivation of thyroid peroxidase by soy isoflavones,
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20. Suzuki H, Higuchi T, Sawa K, et al. Endemic coast goitre in Hokkaido, Japan. Acta
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21. Zimmermann MB, Jooste PL, Mabapa NS, et al. Vitamin A supplementation in
iodine-deficient African children decreases thyrotropin stimulation of the thyroid
and reduces the goiter rate. Am J Clin Nutr 2007;86:10404.
22. Ingenbleek Y. Vitamin A deficiency impairs the normal mannosylation, conformation and iodination of the thyroglobulin: a new etiological approach to endemic
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23. Zimmermann MB. The influence of iron status on iodine utilization and thyroid
function. Annu Rev Nutr 2006;26:36789.
24. Brauer VF, Schweizer U, Kohrle J, et al. Selenium and goiter prevalence in borderline iodine sufficiency. Eur J Endocrinol 2006;155:80712.
25. Kralik A, Eder K, Kirchgessner M. Influence of zinc and selenium deficiency on parameters relating to thyroid hormone metabolism. Horm Metab Res 1996;28:2236.
26. Ruz M, Codoceo J, Galgani J, et al. Single and multiple selenium-zinc-iodine deficiencies affect rat thyroid metabolism and ultrastructure. J Nutr 1999;129:17480.
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28. Brucker-Davis F. Environmental disrupters of thyroid hormone action. In:
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44. Pardo V, Vono-Toniolo J, Rubio IG, et al. The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation. J Clin Endocrinol Metab 2009;
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45. Bonnema SJ, Bennedbaek FN, Ladenson PW, et al. Management of the nontoxic
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46. Bonnema SJ, Bennedbaek FN, Wiersinga WM, et al. Management of the nontoxic
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53(1):512.
47. Samuels MH. Evaluation and treatment of sporadic nontoxic goitersome
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367
368
Medeiros-Neto et al
A p p ro a c h t o a n d
Tre a t m e n t o f
D i ffe re n t i a t e d
T h y ro i d C a rc i n o m a
Furio Pacini,
MD*,
MD
KEYWORDS
Thyroglobulin rhTSH
Radioiodine therapy
131
I whole-body scan
370
affects women more often than men, and in 2006 it was predicted to be one of the top
7 leading causes of new cases of cancer in women, representing 3% of all cancers in
women, about 1% in men, and about 1.4% of all cancers in children.4 The onset of
PTC occurs between the ages of 30 and 50 years. The incidence of PTC in the United
States is 5.7 per 100,000 person-years, with a rate of 8.8 per 100,000 woman-years
and 2.7 per 100,000 man-years.5 Among women, PTC was higher among whites
(10.39 per 100,000 woman-years) and lower among blacks (4.9 per 100,000
woman-years). Among men, PTC was higher among whites (3.58 per 100,000
woman-years) and lower among blacks (1.56 per 100,000 woman-years).5 Follicular
thyroid cancer (FTC) tends to occur in patients who are older (>40 years of age)
than patients who have papillary cancer. The incidence of FTC in the United States
is 0.82 per 100,000 person-years, with a rate of 1.06 per 100,000 woman-years and
0.59 per 100,000 man-years. The incidence of follicular cancer did not vary substantially by race/ethnicity,5 although it is well known that its frequency is affected
by iodine intake.6 The incidence of anaplastic thyroid cancer in the United States
is 0.21 per 100,000 person-years, without substantial difference by race/ethnicity
and sex.
Despite the increasing incidence, the mortality from thyroid cancer has declined
over the last 3 decades. In the European Union from 1992 to 2002, the mortality for
thyroid cancer declined in both men and women ( 23% and 28%, respectively).7
It is unclear how much of the decline in mortality is due to early diagnosis rather
than improved treatment of the disease. The age-adjusted death rate was 0.5 per
100,000 men and women per year, increasing from 0.1% in those younger than 20
years to 30% in their seventh and eighth decades.8
PATHOGENESIS OF DTC
Management of DTC
371
372
cancers), and has higher sensitivity compared with FNAC. Hence measurement of
calcitonin should be an integral part of the diagnostic evaluation of thyroid nodules.41
In the case of undifferentiated thyroid carcinoma, the diagnosis is usually based on
typical clinical aspects: large, hard mass invading the neck and causing compressive
symptoms (dyspnea, cough, vocal cord paralysis, dysphagia, and hoarseness).
Cervical metastases are palpable on examination in 40% of patients.
TREATMENT OF DTC
Surgery
The initial treatment of DTC is total or near-total thyroidectomy whenever the diagnosis is made before surgery. Less extensive surgical procedures may be accepted
in the case of unifocal DTC diagnosed at final histology after surgery performed for
benign thyroid disorders, provided that the tumor is small, intrathyroidal, and of favorable histologic type (classic papillary or follicular variant of papillary or minimally invasive follicular). The initial treatment of DTC should always be preceded by careful
exploration of the neck by US to assess the status of lymph node chains. Clinically
evident lymph node metastases are present in approximately one-third of patients
with PTC at presentation. Microscopic metastases are present in one-half. The
most common site of lymph node involvement is the central compartment (level 6).
The lateral lymph node chains (levels 24) are the next most common sites of cervical
node involvement. Lymph nodes in the posterior triangle of the neck (level 5) may also
develop metastases. Unlike papillary carcinoma, cervical metastases from follicular
carcinomas are uncommon. The benefit of prophylactic central node dissection in
the absence of evidence of nodal disease is controversial. There is no evidence that
in PTC prophylactic central node dissection may improve the recurrence or mortality
rate, but it does allow accurate staging of the disease that may guide subsequent
treatment and follow-up.37,38 Compartment-oriented dissection of lymph nodes
should be performed in cases of preoperatively suspected and/or intraoperatively
proven lymph node metastases. Prophylactic lymph node dissection is not indicated
in FTC. In expert hands, surgical complications such as laryngeal nerve palsy and
hypoparathyroidism are extremely rare (<1%2%).37,38
Staging and Risk Assessment
Both papillary- and follicular-differentiated thyroid cancer have usually a good prognosis, with an overall mortality of less than 10%.42 This favorable prognosis results
from the combination of the biological properties of most thyroid carcinomas and
effective primary therapy. In the last several years, an increased emphasis has been
placed on using individual estimates of risk to guide postablative remnant ablation
and follow-up in patients with DTC. Several different risk stratification systems have
been published, the most popular being the American Joint Committee on Cancer/
Union Internationale Contre le Cancer system.43 All of the systems have been developed to predict the risk of death but not of recurrence and, being based on clinical
pathologic factors available soon after diagnosis and initial surgical therapy, do not
change over time. To overcome this limitation, both the American Thyroid Association
(ATA) and the European Thyroid Association (ETA) have recently published practical
guidelines37,38 in which they grade the risk of recurrence in 3 categories of increasing
risk based on tumor-related parameters (pTNM and histologic variant) integrated with
other clinical features, including the result of the postablative whole-body scan (WBS)
and serum Tg measurement (Table 1).
Management of DTC
Table 1
Risk stratification according to the ATA and ETA guidelines
ATA Risk Stratification
Low Risk
Intermediate Risk
High Risk
Microscopic invasion of
tumor into the
perithyroidal soft tissues at
initial surgery
Cervical lymph node
metastases or
131
I uptake outside the
thyroid bed on the
posttherapeutic WBS
Tumor with aggressive
histology or vascular
invasion
Low Risk
High Risk
Complete surgery
Patients with unifocal
microcarcinoma (<1 cm)
with no extension beyond
the thyroid capsule and
without lymph node
metastases
Data from Pacini F, Schlumberger M, Dralle H, et al. European Thyroid Cancer Taskforce. European
consensus for the management of patients with differentiated thyroid carcinoma of the follicular
epithelium. Eur J Endocrinol 2006;154:787803; and Cooper DS, Doherty GM, Haugen BR, et al.
Revised American Thyroid Association management guidelines for patients with thyroid nodules
and differentiated thyroid cancer. Thyroid 2009;19:1167214.
Recent reports have developed the new concept of Ongoing Risk Stratification or
Delayed Risk Stratification (DRS), which better defines the patient risk based on the
results of the initial treatment.44,45 This concept is based on the continuous integration of the initial risk stratification (at the time of diagnosis) with the clinical, radiologic, and laboratory data becoming available during follow-up. Although the risk
stratification guidelines proposed by ATA38 and ETA37 are a good starting point for
initial decision-making, they are less accurate in predicting the long-term outcome
in patients with DTC. Indeed, both systems have a very low positive predictive value
(PPV), due to a large number of patients (about 60%) who are classified at intermediate/high risk being in complete remission at the end of follow-up.45 This drawback
is probably due to the lack of consideration of the effects of the initial therapy. When
patients are restratified according to the results of the 8- to 12-month control after
initial treatment, a significant number of patients who were initially considered
(misleadingly) as high risk were reclassified as low risk and, most interestingly,
almost all of these patients continued to be in apparent remission up to the end of
follow-up.45 This DRS allows improved modulation of the subsequent follow-up
373
374
Table 2
Indications for remnant ablative therapy
RAI is Recommended
Management of DTC
Levothyroxine Therapy
FOLLOW-UP
Short-Term Follow-Up
The aim of follow-up is the early discovery and treatment of persistent or recurrent
locoregional or distant disease. Most recurrences develop and are detected in the first
5 years after diagnosis, whereas local or distant recurrence may develop in late followup, even 20 years after the initial treatment in a few cases.
After 2 to 3 months of initial treatment thyroid function tests (FT3, FT4, TSH) should
be obtained to check the adequacy of LT4 suppressive therapy. At 6 to 12 months, the
follow-up is aimed to ascertain whether the patient is free of disease and is based on
physical examination, neck US, and basal and rhTSH-stimulated serum Tg measurement, with or without diagnostic WBS.37,38 At this time most (nearly 80%) of the
patients will belong to the low-risk category, and will disclose normal results in neck
US and undetectable (<1.0 ng/mL) basal and stimulated serum Tg values in the
absence of serum Tg antibodies. Diagnostic WBS does not add any clinical information in this setting, and may be omitted.55,56
Recently, new methods for serum Tg measurement with functional sensitivity less
than 0.1 ng/mL became available. Using these assays some investigators reported
that an undetectable basal serum Tg value (<0.1 ng/mL) may give the same information
as a stimulated serum Tg value, thus avoiding the need for Tg stimulation.5764
However, the higher negative predictive value (NPV) of these tests is at the expense
of a very low specificity and PPV (Table 3), and there is a risk of exposing large numbers
of patients, probably free of disease, to extensive testing and/or unnecessary
treatment. In clinical practice, when the basal serum Tg level is up to 0.1 ng/mL and
the neck US result is unremarkable, patients may be considered free of disease
(NPV 5 100%) and can avoid an rhTSH stimulation. On the contrary, when basal serum
Tg is greater than 0.1 ng/mL but less than 1.0 ng/mL, it is not possible to distinguish
between absence or presence of disease. In these cases, an rhTSH stimulation test
may still be informative because it may detect those patients in whom serum Tg level
increases to more than 1 ng/mL. In these patients a more intensive follow-up may be
useful.63
375
376
Table 3
Diagnostic accuracy of basal serum thyroglobulin using sensitive assays
References
Criterion
Tg FS
Sens
(%)
Spec
(%)
PPV
(%)
NPV
(%)
FP
(%)
FN
(%)
Schlumberger
et al,59 2007
Clinical status
944
0.11
78
63
NA
NA
37
22
Smallridge
et al,57 2007
rhTSH-Tg
(>2.0 ng/mL)
194
0.11
91.6
73.5
44
97.5
26.4
8.4
Iervasi et al,58
2007
rhTSH-Tg
(>2.0 ng/mL)
160
0.11
100
90.1
34.7
100
10
Rosario and
Purisch,60
2008
THW-Tg
(<1.0 ng/mL)
178
0.11
80
81.6
41.6
96.1
18.4
20
Spencer et al,62
2010
rhTSH-Tg
(>2.0 ng/mL)
1029
0.05
99.3
66.5
53.8
99.5
33.4
1.1
Castagna
et al,45,63 2011
Clinical status
215
0.11
83.3
85.5
58.3
95.4
14.4
16.6
Malandrino
et al,64 2011
rhTSH-Tg
(>2.0 ng/mL)
425
0.11
91.6
84.3
35.1
99.0
15.7
8.4
Abbreviations: FN, false negative; FP, false positive; FS, functional sensitivity; NPV, negative predictive value; PPV, positive predictive value; Sens, sensitivity; Spec, specificity.
Long-Term Follow-Up
The subsequent follow-up of patients considered free of disease at the time of their
first follow-up will consist of physical examination, basal serum Tg measurement on
LT4 therapy, and neck US once a year. No other biochemical or morphologic tests
are indicated unless some new suspicion arises during evaluation. The question of
whether a second rhTSH-stimulated Tg test should be performed in patients free of
disease is a matter of debate. Recent studies reported that this procedure has little
clinical utility in patients who had no biochemical (undetectable serum Tg) or clinical
(imaging) evidence of disease at the time of their first control after initial therapy. In
this group, the second test confirmed complete remission in almost all patients
(Table 4).55,56,6568
At the time of the first control after initial therapy, about 20% of patients may have
detectable basal or stimulated serum Tg levels. If serum Tg level is detectable in the
basal condition, the chance of a visible disease in the patient is very high, hence
Table 4
Prevalence of recurrences in patients free of disease at the first control after initial therapy,
based on stimulated serum Tg measurement, neck ultrasonography, and diagnostic WBS
References
Stimulus
Follow-up (y)
Recurrence (%)
315
Hypothyroidism
12
0.6
256
Hypothyroidism
5.0
0.9
68
rhTSH
3.3
1.4
68
rhTSH
3.0
1.5
89
rhTSH
3.0
1.1
715
Hypothyroidism/rhTSH
7.0
1.1
Management of DTC
imaging techniques must be applied. If serum Tg level is detectable in the low range
after rhTSH stimulation, the chance of serum Tg to convert from detectable to undetectable level during follow-up is about 50%,69 therefore observation is all that is
required. On the contrary, the trend of serum Tg level to increase over time is a hallmark of possible disease to be localized by imaging techniques including therapeutic
doses of 131I.37,38 During the evaluation of metastatic patients, positron emission
tomography with fludeoxyglucose F 18 (18F FDG-PET) scanning is gaining more attention as a diagnostic and prognostic tool.70 The sensitivity of 18F FDG-PET is not superior to that of traditional techniques, such as computed tomography and magnetic
resonance imaging, therefore the main indication for 18F FDG-PET is in patients with
metastasis who have lost 131I uptake. Patients who have negative results on 131I
WBS and positive results on 18F FDG-PET show a group of tumors with more aggressive and less differentiated phenotype carrying a worse prognosis compared with
patients who have positive results on 131I WBS and negative results on 18F FDGPET.70
TREATMENT OF METASTATIC DISEASE
Table 5
Results of clinical trials with tyrosine kinase inhibitors in DTC
Stable
Disease >6
Months (%)
Median
PFS (mo)
References
Phase
Drug
Partial
Response (%)
Gupta-Abramson
et al,75 2008
II
Sorafenib
30
23
53
20
Kloos et al,74
2009
II
Sorafenib
41
15
56
15
Hoftijzer et al,80
2009
II
Sorafenib
32
25
34
13.5
Ahmed et al,76
2011
II
Sorafenib
19
18
82
<24
Sherman et al,81
2008
II
Motesanib
93
14
35
Cohen et al,73
2008
II
Axitinib
45
31
46
18.1
II
Sunitinib
28
29
50
12.8
Bible et al,78
2010
II
Pazopanib
39
49
NR
11.7
Sherman et al,79
2011
II
Lenvatinib
58
45
46
13.3
377
378
macronodules may benefit from 131I therapy, but the definitive cure rate is very low.71
Bone metastases have the worst prognosis even when aggressively treated by
a combination of 131I therapy and external beam radiotherapy.37,38 Brain metastases
are rare and usually carry a poor prognosis. Surgical resection and external beam
radiotherapy represent the only therapeutic options.
Treatment of distant metastases with 131I therapy provides complete remission in only
one-third of patients with distant metastases. The other patients have 131I refractory
disease defined as no 131I-avid lesions or 131I-avid lesions that do not benefit from
repeated treatment courses of 131I. These patients are candidates for systemic therapies. The selection is based on clinical prognostic indicators, including age, performance status, histology, extent and location of disease, and progression rate.
Usually patients who are treated are those with significant progressive disease and
with low life expectancy. In these patients, chemotherapy has limited effectiveness,
with a response rate typically less than 20% and short lasting.72
Recently, molecules that block kinase activity at distal steps in the mitogenactivated protein kinase pathway have been identified as logical candidate drugs for
refractory thyroid cancer. Tyrosine kinase inhibitors being tested against DTC in phase
I and II trials include axitinib, lenvatinib, motesanib, pazopanib, sorafenib, sunitinib,
and vandetanib. None of these are specific for 1 oncogene protein, but they target
several tyrosine kinase receptors and proangiogenic growth factors. The results of
phase I and II clinical trials have clearly confirmed the clinical benefits of these
compounds. No compound has yet achieved the regulatory approval of Food and
Drug Administration and European Medicines Agency for the therapy of advanced
and progressive DTC, but some treatment guidelines recommend the use of available
agents for selected patients with progressive metastatic disease based on the phase II
results.38 The results of phase I and II clinical trials conducted so far are promising,
with a partial response ranging from 14% to 49% and stable disease ranging from
34% to 82% (Table 5).7381
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to those of traditional thyroid hormone withdrawal. J Nucl Med 2008;49:76470.
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58. Iervasi A, Iervasi G, Ferdeghini M, et al. Clinical relevance of highly sensitive Tg
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80. Hoftijzer H, Heemstra KA, Morreau H, et al. Beneficial effects of sorafenib on
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2008;3(359):3142.
383
T h y ro i d E m e r g e n c i e s
Joanna Klubo-Gwiezdzinska, MD, PhDa,b,
Leonard Wartofsky, MD, MPH, MACPc,*
KEYWORDS
Myxedema coma Thyrotoxic storm Diagnosis
Management
Thyroid emergencies are rare, life-threatening conditions resulting from either severe
deficiency of thyroid hormones (myxedema coma) or, by contrast, decompensated
thyrotoxicosis with the increased action of thyroxine (T4) and triiodothyronine (T3)
exceeding metabolic demands of the organism (thyrotoxic storm). The understanding
of the pathogenesis of these conditions, appropriate recognition of the clinical signs
and symptoms, and their prompt and accurate diagnosis and treatment are crucial
in optimizing survival.
MYXEDEMA COMA
Epidemiology and Precipitating Events
386
Table 1
Factors precipitating thyroid emergencies: myxedema coma and thyrotoxic storm
Precipitating Factors
Myxedema Coma
Thyrotoxic Storm
Drugs
Withdrawal of L-thyroxine
Anesthetics
Sedatives
Tranquilizers
Narcotics
Amiodarone
Lithium carbonate
Drugs
Withdrawal of antithyroid drug treatment
Radioactive iodine treatment
Thyroxine/triiodothyronine overdosage
Cytotoxic chemotherapy
Aspirin overdosage
Iodinated contrast dyes
Organophosphates
Infections, sepsis
Sepsis, infection
Cerebrovascular accidents
Seizure disorder
Pulmonary thromboembolism
Low temperatures
Burn injury
Trauma
Metabolic disturbances
Acidosis
Hypoglycemia
Hyponatremia
Hypercapnia
Metabolic disturbances
Diabetic ketoacidosis
Hypoglycemia
Other
Gastrointestinal bleeding
Ingestion of raw bok choy
Other
Parturition
Emotional stress
Patients with myxedema coma generally present in the winter months, suggesting
that external cold may be an aggravating factor.5 Some abnormalities such as hypoglycemia, hypercalcemia, hyponatremia, hypercapnia, and hypoxemia, may be either
precipitating factors or secondary consequences of myxedema coma. Moreover, the
comatose state is associated with the risk of aspiration pneumonia and sepsis. In
hospitalized patients, drugs such as anesthetics, narcotics, sedatives, antidepressants, and tranquilizers may depress respiratory drive and thereby either cause or
compound the deterioration of the hypothyroid patient into coma.6,7 The effect of
these drugs should be taken into consideration as a potential causative mechanism.
In fact, Church and Callen8 described a 41-year-old male patient without any history
of thyroid disease who developed myxedema coma after being administered combined therapy with aripiprazole and sertraline.
There is also a report of myxedema coma induced by chronic ingestion of large
amounts of raw bok choy. This Chinese white cabbage contains glucosinolates, which
break down products such as thiocyanates, nitriles, and oxazolidines, and inhibit
iodine uptake and production of thyroid hormones by the thyroid gland. When eaten
raw, digestion of the vegetable releases the enzyme myrosinase, which accelerates
production of the aforementioned thyroid disruptors.9
Clinical Signs and Symptoms
Thyroid Emergencies
might lead inexorably to vascular collapse and death, some authorities have advocated the routine use of antibiotics in patients with myxedema coma. Underlying
hypoglycemia may further compound the decrement in body temperature.
Although coma is the predominant clinical presentation, a history of disorientation,
depression, paranoia, or hallucinations (myxedema madness) may often be elicited.
The neurologic findings may also include cerebellar signs (poorly coordinated
purposeful movements of the hands and feet, ataxia, adiadochokinesia), poor memory
and recall, or even frank amnesia, and abnormal findings on electroencephalography
(low amplitude and a decreased rate of a-wave activity). Status epilepticus has been
also described11 and up to 25% of patients may experience seizures possibly related
to hyponatremia, hypoglycemia, or hypoxemia.
Respiratory System
Patients diagnosed with myxedema coma are at increased risk for shock and potentially fatal arrhythmias. Typical electrocardiographic (ECG) findings include
bradycardia, varying degrees of block, low voltage, flattened or inverted T waves,
and prolonged Q-T interval, which can result in torsades de pointes ventricular tachycardia.15 Myocardial infarction should also be ruled out by the usual diagnostic procedures, because aggressive or injudicious T4 replacement may increase the risk of
myocardial infarction. Moreover, cardiac contractility is impaired, leading to reduced
stroke volume and cardiac output. Reduced stroke volume in severe cases may also
be due to the cardiac tamponade caused by the accumulation of fluid rich in mucopolysaccharides within the pericardial sac.
Electrolyte Disturbances and Renal Manifestations
The gastrointestinal tract in myxedema may be marked by mucopolysaccharide infiltration and edema of the muscularis, as well as neuropathic changes leading to gastric
atony, impaired peristalsis, and even paralytic ileus. Ascites may occur, and has been
documented in one report of 51 cases.22 Another potential complication is
387
388
In contrast to the tendency to thrombosis seen in mild hypothyroidism, severe hypothyroidism is associated with a higher risk of bleeding caused by coagulopathy related
to an acquired von Willebrand syndrome (type 1) and decreases in factors V, VII, VIII,
IX, and X.25 The von Willebrand syndrome is reversible with T4 therapy.26 Another
cause of bleeding may be disseminated intravascular coagulation associated with
sepsis. Patients with myxedema coma have increased preponderance to severe infections, including sepsis, because of granulocytopenia and a decreased cell-mediated
immunologic response. Such patients may also present with a microcytic anemia
secondary to hemorrhage, or a macrocytic anemia caused by vitamin B12 deficiency,
which may also worsen the neurologic state.
Diagnosis
To summarize the aforementioned clinical manifestations, the typical patient presenting with myxedema coma is a woman in the later decades of life who may have
a history of thyroid disease and who is admitted to hospital, typically in winter, with
pneumonia. Physical findings could include bradycardia, macroglossia, hoarseness,
delayed reflexes, dry skin, general cachexia, hypoventilation, and hypothermia,
commonly without shivering. Laboratory evaluation may indicate hypoxemia, hypercapnia, anemia, hyponatremia, hypercholesterolemia, and increased serum lactate
dehydrogenase and creatine kinase. On lumbar puncture there is increased pressure
and the cerebrospinal fluid has high protein content.
Although an elevated serum thyrotropin (TSH) concentration is the most important
laboratory evidence for the diagnosis, the presence of severe complicating systemic
illness or treatment with drugs such as dopamine, dobutamine, or corticosteroids may
serve to reduce the elevation in TSH levels.27,28 There may also be a pituitary cause for
the hypothyroidism, in which case an increased TSH would not be found.
Treatment
One of the most controversial aspects of the management of myxedema coma is which
thyroid hormone preparation to give and how to give it (dose, frequency, and route of
administration). The optimum treatment remains uncertain, because of the scarcity of
clinical studies and obvious difficulties with performing controlled trials. There is
Thyroid Emergencies
a necessity to balance the need for quickly attaining physiologically effective thyroid
hormone levels against the risk of precipitating a fatal tachyarrhythmia or myocardial
infarction. All patients should have continuous ECG monitoring, with reduction in
thyroid hormone dosage should arrhythmias or ischemic changes be detected.
Parenteral preparations of either T4 or T3 are available for intravenous administration. Although oral forms of either T3 or T4 can be given by nasogastric tube in the
comatose patient, this route is fraught with risks of aspiration and uncertain absorption, particularly in the presence of gastric atony or ileus. The single intravenous bolus
of T4 was popularized by reports30 suggesting that replacement of the entire estimated pool of extrathyroidal T4 (usually 300600 mg) was desirable to restore nearnormal hormonal status. This initial loading dose is followed by the maintenance
dose of 50 to 100 mg given daily (either intravenously or by mouth if the patient is
adequately alert). Larger doses of T4 probably have no advantage and may, in fact,
be more dangerous.31 There is also evidence showing improved outcomes with lower
doses of thyroid hormone.32 Rodriguez and colleagues1 performed a prospective trial
in which patients were randomized to receive either a 500-mg loading dose of T4 followed by a 100-mg daily maintenance dose, or only the maintenance dose. The overall
mortality rate was 36.4%, with a lower mortality rate in the high-dose group (17%) than
in the low-dose group (60%). Although suggestive, the difference was not statistically
significant.
The rate of conversion of T4 to T3 is reduced in many systemic illnesses (the euthyroid sick or low T3 syndrome),28 hence T3 generation may be reduced in myxedema
coma as a consequence of any associated illness (hypothyroid sick syndrome). As
a consequence, some clinicians suggest that small supplements of T3 should be given
along with T4 during the initial few days of treatment, especially if obvious associated
illness is present. When therapy is approached with T3 alone, it may be given as a 10to 20-mg bolus followed by 10 mg every 4 hours for the first 24 hours, dropping to 10 mg
every 6 hours for days 2 to 3, by which time oral administration should be feasible.6 T3
has a much quicker onset of action than T4, and increases in body temperature and
oxygen consumption may occur 2 to 3 hours after intravenous T3, compared with 8
to 14 hours after intravenous T4. The other advantage of T3 is that it crosses the
blood-brain barrier more rapidly than T4, which may be particularly important in
patients with profound neuropsychological symptoms.33 One clinical example of the
possible benefit of T3 is a case report of a patient with myxedema coma and cardiogenic shock who responded to T3 therapy but not to T4 therapy.34 On the other hand,
treatment with T3 alone is associated with large and unpredictable fluctuations in
serum T3 levels, and high serum T3 levels during treatment have been associated
with fatal outcomes.35 A more conservative but seemingly rational approach is to
provide combined therapy with both T4 and T3.36 Rather than administer 300 to
500 mg T4 intravenously initially, a dose of 4 mg/kg lean body weight (or about 200
300 mg) is given, and an additional 100 mg is given 24 hours later. By the third day,
the dose is reduced to a daily maintenance dose of 50 mg, which can be given by
mouth as soon as the patient is conscious.36 Simultaneously with the initial dose of
T4, a bolus of 10 mg T3 is given and intravenous T3 is continued at a dosage of 10
mg every 8 to 12 hours until the patient is conscious and taking maintenance T4. Clinical improvement has been seen with even a single dose of only 2.5 mg of T3.37
Hypothermia
389
390
achieved. Too aggressive warming may cause peripheral vasodilatation, which may
then lead to hypotension or shock.
Hypotension
Low serum sodium may cause a semicomatose state or seizures even in euthyroid
patients, and the severe hyponatremia (105120 mmol/L) in profound myxedema is
likely to contribute substantially to the coma in these patients. Mortality rates in critically ill patients with symptomatic hyponatremia have been reported to be 60-fold
higher than in patients without hyponatremia.38 The appropriate management of
severe hyponatremia often requires administration of a small amount of hypertonic
saline (50100 mL 3% sodium chloride), enough to increase sodium concentration
by about 2 mmol/L early in the course of treatment, followed by an intravenous bolus
dose of 40 to 120 mg furosemide to promote a water diuresis.39 A small, quick
increase in the serum sodium concentration (24 mmol/L) is effective in acute hyponatremia because even a slight reduction in brain swelling results in a substantial
decrease in intracerebral pressure.40 On the other hand, too rapid correction of hyponatremia can cause a dangerous complication, the osmotic demyelinization
syndrome. In patients with chronic hyponatremia, this complication is avoided by
limiting the sodium correction to less than 10 to 12 mmol/L in 24 hours and less
than 18 mmol/L in 48 h. After achieving a sodium level of more than 120 mmol/L,
restriction of fluids may be all that is necessary to correct hyponatremia. It must be
emphasized that fluid or saline therapy requires careful monitoring of volume status
based on clinical parameters and measurements of central venous pressure, especially in patients with significant cardiovascular decompensation.
The other therapeutic option is treatment with an intravenous vasopressin antagonist, conivaptan. Conivaptan has been approved by the US Food and Drug
Administration for the treatment of hospitalized patients with euvolemic and hypervolemic hyponatremia in a setting of the syndrome of inappropriate secretion of
antidiuretic hormone, hypothyroidism, adrenal insufficiency, or pulmonary disorders.41 The rationale for application of conivaptan in this clinical setting is based
on the high vasopressin levels observed in myxedema coma. Current dosing
Thyroid Emergencies
recommendations are for a 20-mg loading dose to be infused over 30 minutes followed by 20 mg/d continuous infusion for up to 4 days. Unfortunately, no data are
available on the use of conivaptan in severe hyponatremia (<115 mEq/L) in hypothyroid patients.42,43
General supportive measures
Even with this vigorous therapy, the prognosis for myxedema coma remains grim, and
patients with severe hypothermia and hypotension seem to do the worst. In the
past the mortality rate was as high as 60% to 70%, but this has now been reduced
to 20%25% with the advances in intensive care management.44 Several prognostic
factors may be associated with a fatal outcome,1,5,32,35,45 and include older age,
persistent hypothermia or bradycardia, lower degree of consciousness by Glasgow
Coma Scale, multiorgan impairment indicated by an APACHE II score (Acute Physiology and Chronic Health Evaluation) of more than 20, or SOFA score (Sequential
Organ Failure Assessment) of more than 6. The most common causes of death are
respiratory failure, sepsis, and gastrointestinal bleeding. Early diagnosis and prompt
treatment, with meticulous attention to the details of management during the first 48
hours, remain critical for effective therapy.
THYROTOXIC STORM
Thyroid crisis or thyrotoxic storm is characterized by severely exaggerated manifestations of thyrotoxicosis. The underlying cause of thyrotoxicosis is commonly Graves
disease or toxic multinodular goiter. Rarely, thyrotoxic storm may occur with subacute
thyroiditis or factitious thyrotoxicosis caused by intentional thyroxine overdose.46,47
Epidemiology and Precipitating Events
391
392
The clinical diagnosis is based on the identification of signs and symptoms that
suggest decompensation of several organ systems. Some of these cardinal manifestations include fever out of proportion to an apparent infection and dramatic diaphoresis. Hyperthermia in thyroid crisis can represent defective thermoregulation by the
hypothalamus and/or increased basal metabolic rate, increased oxidation of lipids
being responsible for more than 60% of the resting energy expenditure.58 The other
key components of thyrotoxic storm include tachycardia out of proportion to the fever,
and gastrointestinal dysfunction, which can include nausea, vomiting, diarrhea and, in
severe cases, jaundice. As the storm progresses, symptoms of central nervous
system dysfunction simulating an encephalopathic picture will appear, which may
include increasing agitation and emotional lability, confusion, paranoia, psychosis,
and coma.59 Patients have been reported who presented with thyroid storm associated with status epilepticus and stroke and with bilateral basal ganglia infarction.60
In patients with neurologic symptoms, a high index of suspicion for cerebral sinus
thrombosis should be considered, because of the higher prevalence of this condition
in severe hyperthyroidism.61 Paralysis observed in thyroid crisis might be due to not
only the cerebrovascular accident but also thyrotoxic periodic paralysis with hypokalemia, as frequently may present in Asian men.62 In older patients, the thyrotoxic storm
may present as so-called masked or apathetic thyrotoxicosis.63
Cardiovascular Manifestations
Thyroid Emergencies
The most common symptoms are diarrhea and vomiting, which can aggravate volume
depletion, postural hypotension, and shock with vascular collapse. The diffuse
abdominal pain, possibly caused by impaired neurohormonal regulation of gastric
myoelectrical activity with delayed gastric emptying,71 may even lead to a presentation
such as acute abdomen72 or intestinal obstruction.73 The liver function abnormalities
and presence of jaundice warrant immediate and vigorous therapy. Although most
presentations of an acute abdomen in thyrotoxicosis are medical in nature, surgical
conditions may also occur.74
Electrolyte Disturbances and Renal Manifestations
A moderate leukocytosis with a mild shift to the left is a common finding, even in the
absence of infection. Hyperthyroidism may be associated with hypercoagulability
caused by increased concentrations of fibrinogen, factors VIII and IX, tissue plasminogen activator inhibitor 1, von Willebrand factor, increase in red blood cell mass
secondary to erythropoietin upregulation, and a tendency to augmented platelet
plug formation.78 Major thromboembolic complications are responsible for 18% of
deaths caused by thyrotoxicosis.7983
Diagnosis
393
394
Table 2
Semiquantitative scale assessing the presence and severity of the most common signs and
symptoms
Criteria
Score
Thermoregulatory Dysfunction
Temperature
Temperature
Temperature
Temperature
Temperature
Temperature
5
10
15
20
25
30
0
10
20
30
Gastrointestinal Dysfunction
Absent
Diarrhea, nausea, vomiting, abdominal pain
Unexplained jaundice
0
10
20
5
10
15
20
25
0
5
10
15
Atrial Fibrillation
Absent
Present
0
10
0
10
Based on the total score, the likelihood of the diagnosis of thyrotoxic storm is: unlikely, <25;
impending, 2544; highly likely, >45.
Data from Burch HB, Wartofsky L. Life-threatening thyrotoxicosis. Thyroid storm. Endocrinol
Metab Clin North Am 1993;22:26377.
Thyroid Emergencies
To avoid a disastrous outcome, a complex approach to management is recommended.87 First, specific antithyroid drugs must be used to reduce the increased thyroid
production and release of T4 and T3. The second approach comprises treatment
intended to block the effects of the remaining but excessive circulating concentrations
of free T4 and T3 in blood. The third arm involves treatment of any systemic decompensation, for example, congestive heart failure, and shock. The final component
addresses any underlying precipitating illness such as infection or ketoacidosis.
Therapy directed to the thyroid gland
395
396
Given the presence and likelihood of high levels of circulating T4 and T3 in a large
vascular pool and tissue distribution space, in severe cases treatment with antithyroid
drugs alone is not sufficient. Plasmapheresis and therapeutic plasma exchange are
effective alternative therapies, which can reduce T4 and T3 levels within 36 hours.
Plasma or albumin solution given during therapeutic plasma exchange provides
new binding sites to reduce circulating levels of free thyroid hormones.98100 However,
this effect is transient and lasts only about 24 to 48 hours, and thus should be followed
by a more definitive therapy. Early thyroidectomy has been reported to reduce the
mortality rate from 20% to 40% under standard treatment to less than 10%.101
Peritoneal dialysis or experimental hemoperfusion through a resin bed102 or charcoal columns103 has also been used. Another therapeutic adjunct is the oral administration of cholestyramine resin, resulting in removal of T4 and T3 by binding thyroid
hormone entering the gut via enterohepatic recirculation, with the subsequent excretion of the resin-hormone complex.104
Hughes105 was the first to treat a patient with thyrotoxic storm with a b-adrenergic
blocker to ameliorate the manifestations of thyroid hormone excess. Propranolol is the
most commonly used agent in the United States. The oral dosage of 60 to 80 mg every
4 hours or intravenous doses of 0.5 to 1 mg followed by subsequent doses of 2 to 3 mg
given intravenously over 10 to 15 min every several hours are recommended, alongside constant cardiac rhythm monitoring.87,106,107 There may be a theoretical benefit
derived from the inhibitory effect of propranolol on the conversion of T4 to T3,108 but
a significant effect is seen only with oral doses higher than 160 mg/d. Usage of bblockers not only corrects the heart rate and diminishes the oxygen demand of the
cardiac muscle, but also improves agitation, convulsions, psychotic behavior, tremor,
diarrhea, fever, and diaphoresis. In some patients, there may be a relative risks or
contraindications to the use of these agents. In patients with a history of bronchospasm or asthma and treatment with either selective b1-blockers or reserpine,
guanethidine should be considered instead. A short-acting b-adrenergic blocker,
esmolol, has also been used successfully in the management of thyroid storm. An
initial loading dose of 0.25 to 0.5 mg/kg is followed by continuous infusion of 0.05
to 0.1 mg/kg per minute.109,110
The other important medications characterized by a high therapeutic potency and
modest ability to inhibit peripheral conversion of T4 to T3 are steroids. An initial
dose of 300 mg hydrocortisone followed by 100 mg every 8 hours during the first 24
to 36 hours should be adequate. Thyroid storm has been reported to recur when
steroids had been discontinued after initial clinical improvement.111 The additional
rationale behind the routine use of steroids is perhaps theoretical and unproven, but
relates to possible relative adrenal insufficiency secondary to increased metabolic
demands and more rapid turnover of cortisol.
Some authorities have suggested that the supplemental administration of 1a(OH)
vitamin D3 might accelerate the reduction of serum T4 and T3.112 In a recent study,
the administration of 2 g/d L-carnitine in thyrotoxic storm facilitated a dose reduction
of methimazole. The mechanism appears to be related to an inhibition by L-carnitine of
T3 and T4 entry into cell nuclei.113,114 Although these preliminary findings are of
interest, the utility of this adjunct to therapy requires confirmation.
Therapy directed at systemic decompensation
Thyroid Emergencies
is necessary in elderly patients with congestive heart failure or other cardiac compromise. Intravenous fluids containing 10% dextrose in addition to electrolytes will better
restore depleted hepatic glycogen. Vitamin supplements may be added to the intravenous fluids to replace probable coexistent deficiency. Hypotension not readily
reversed by adequate hydration may temporarily require pressor and/or glucocorticoid therapy.
For fever, acetaminophen rather than salicylates is the preferred antipyretic,
because salicylates inhibit thyroid hormone binding and could increase free T4 and
T3, thereby transiently worsening the thyrotoxic crisis. Hyperthermia also responds
well to external cooling with alcohol sponging, cooling blankets, and ice packs.
Some investigators advocate the use of the skeletal muscle relaxant dantrolene,115
but significant risk associated with its use precludes routine recommendation.
When present, congestive heart failure should be treated routinely. Although less
commonly used today, when digoxin is used, larger than usual doses may be required
because of its increased turnover in the thyrotoxic state.
Therapy directed at the precipitating illness
The therapy is not complete unless a diagnosis of the possible precipitating event is
made and early treatment as indicated for that underlying illness is implemented.
This is not a problem in obvious cases, when trauma, surgery, labor, or premature
withdrawal of antithyroid drugs are known to have been the precipitants of thyrotoxic
crisis, and which may require no additional management. However, when none of the
latter precipitating factors is apparent, a diligent search for some focus of infection
must be performed. Routine cultures of urine, blood, and sputum should be obtained
in the febrile thyrotoxic patient, and cultures of other sites may be warranted on clinical
grounds. Broad-spectrum antibiotic coverage on an empiric basis may be required
initially while awaiting results of cultures.
Conditions such as ketoacidosis, pulmonary thromboembolism, or stroke may
underlie thyrotoxic crisis, particularly in the obtunded or psychotic patient, and require
the same vigorous management as routinely indicated.
Prognosis
Even with early diagnosis, death can occur, and reported mortality rates have
ranged from 10% to 75% in hospitalized patients.85,116,117 In most patients who
survive thyrotoxic crisis, clinical improvement is dramatic and demonstrable within
the first 24 hours. During the recovery period of the next few days, supportive
therapy such as corticosteroids, antipyretics, and intravenous fluids may be tapered
and gradually withdrawn, based on patient status, oral intake of calories and fluids,
vasomotor stability, and continuing improvement. After the crisis has been resolved,
attention may be turned to consideration of the definitive treatment of thyrotoxicosis. Should thyroidectomy be considered, thyrotoxicosis will need to have been
adequately treated preoperatively, to obviate any likelihood of another episode of
crisis during the surgery. Total thyroidectomy is the procedure of choice, in view
of reports of recurrent severe thyrotoxicosis and thyroid crisis after less than total
thyroidectomy.118
Radioactive iodine as definitive treatment is often precluded by the recent use of
inorganic iodine in virtually all cases of storm, but it could be considered at a later
date, in which case antithyroid thionamide therapy is continued to restore and maintain euthyroidism until such a time as ablative therapy can be administered.
Continuing treatment with antithyroid drugs alone, in the hope of the patients
sustaining a spontaneous remission, is also possible.
397
398
SUMMARY
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400
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