MEDLIFELINE

DRUG
OF
CHOICE
QUICK REVIEW BOOK FOR FMGE, USMLE, NEET,
DNB CET, AIPGMEE, AIIMS 

500+ DRUG OF CHOICE

1st Edition
2018
CONTENTS

GASTROINTESTINAL
1-2
SYSTEM

RESPIRATORY SYSTEM 3-4

CARDIOVASCULAR SYSTEM 5-7

CENTRAL NERVOUS SYSTEM 8-11

DRUG OF PREGNANCY 12-13

RENAL SYSTEM 14

ENDOCRINE SYSTEM 15-16

HEMATOLOGY 17-18

OPTHALMOLOGY 19

DERMATOLOGY 20

ANTIMICROBIAL DRUGS 21-26

 DRUG OF CHOICE FOR
27-28
POISONING

ANTICANCER DRUGS 29-30

ANESTHESIA 31-32

GYNECOLOGICAL DRUGS 33

MISCELLANEOUS 34-36
GASTROINTESTIONAL SYSTEM

Drug of choice for GERD -  Proton Pump Inhibitors (Eg:omeprazole)

Drug of choice for duodenal ulcer -  Proton pump inhibitors  

Drug of choice for stress ulcer -  Cimetidine (Histamine H2 receptor Antagonist )

Drug of choice for dyspepsia -  Proton pump inhibitors 

Drug of choice for erosive esophagitis -  Proton pump inhibitors

Drug of choice for duodenal ulcer -  Proton pump inhibitors

Drug of choice for Zollinger -Ellison syndrome -  Proton pump inhibitors

Drug of choice for morning sickness -  Prochlorperazine  (D2 receptor antagonist)

Drug of choice for NSAIDS induced ulcer  -  Proton Pump Inhibitors

Drug of choice Zollinger- Ellison Syndrome  -  Proton Pump Inhibitors 

Drug of choice for post-operative vomiting -  Ondansetron (5HT3 -receptor

antagonist)

Drug of choice for vomiting induced  by cancer chemotherapy -  Ondansetron

Drug of choice for radiation-induced vomiting -  Ondansetron

Drug of choice for NSAID induced gastric ulcer -  Proton pump inhibitors 

Drug of choice for peptic ulcer - Omeprazole

Drug of choice for vomiting in patients of Parkinson disease -  Domperidone

(Selective dopamine D2 receptor antagonist)

Antiemetic drug of choice -  Prochorpromazine or Metoclopramide

Drug of choice for children in constipation -  Castor oil 

Drug of choice for cleaning bowel before delivery -  Sodium phosphate enema

Drug of choice for cleaning bowel for endoscopy -  Polyethylene glycol

Drug of choice for constipation in chronic renal failure -  Aluminium hydroxide

Treatment of choice for functional constipation -  Dietary fibres

Drug of choice for bedridden patient with constipation -  Phenolphthalein (Contact

laxatives)

GASTROINTESTIONAL SYSTEM 1
Drug of choice for stool softening -  Dioctyl sodium sulfosuccinate

Drug of choice for irritable bowel syndrome -  Tegaserod (5-HT4 agonist)

Drug of choice for increasing motility -  Mosapride (Gastroprokinetic)

Drug of choice for diabetic gastroparesis -  Mosapride

Drug of choice for spasmodic abdominal pain -  Drotaverine ( Phospho- diesterase

inhibitor)

Drug of choice for pain relief in ulcer -  Antacids

Drug of choice for diabetic diarrhea -  Clonidine (Alpha - 2 adrenergic agonist)

Drug of choice for non  infectious diarrhea -  Loperamide 

Drug of choice for secretory diarrhea -  Cholestyramine

Drug of choice for carcinoid syndrome -  Cyprohepatadine

Drug of choice for inducing vomiting -  Apomorphine ( via parenteral route)

Drug of choice shortening gastric emptying time before surgery -  Metoclopramide

Drug of choice for Mendelson's syndrome -  Metoclopramide

Drug of choice for vomiting in children -  Metoclopramide

Drug of choice for inducing  vomiting - Ipecacuhana

Drug of choice for laxative effect in patients with hepatic encephalopathy -

Lactulose

GASTROINTESTIONAL SYSTEM 2
RESPIRATORY SYSTEM

Drug of choice for COPD -  Anticholinergics (Eg:Tiotropium)

First line drugs for tuberculosis -  Rifampicin, Isoniazid, Pyrazinamide, Ethambutol,

Streptomycin

Drug of choice for testing bronchial hyperactivity -  Methacholine (Non- selective

muscarinic receptor agonist)

Drug of choice for pulmonary edema with Congestive heart failure (CHF)

-  Furosemide (Diuretic)

Drug of choice for a vasodilatory shock -  Norepinephrine

Drug of choice for persistent hiccups -  Carbon Dioxide

Drug of choice for apnea in premature infants -  Theophylline

Drug of choice for exercise induced asthma -  Mast cell stabilizers (Eg: Sodium

Cromoglycate)

Drug of choice for asprin induced asthma -  Leukotriene antagonist (Eg:

Montelukast)

Drug of choice for starting treatment of asthma -  Inhaled beta 2 agonist (Eg:

salmeterol)

Drug of choice for bronchospasm with COPD -  Ipratropium Bromide

Drug of choice for smoking cessation -  Nicotine

Drug of choice for liquefying plaques of sputum in patients with cystic fibrosis -

Acetylcysteine

Drug of choice for temporal arteritis -  Corticosteroid

Drug of choice for prophylaxis of exercise induced asthma -  Sodium 

chromoglycate 

Drug of choice for pulmonary edema -  Furosemide

Drug of choice for dry itchy cough -  Codeine

Drug of choice for acute asthma attack -  Salbutamol (Short acting selective beta2-

adrenergic receptor agonist)

Drug of choice for persistent asthma -  Inhaled corticosteroid

RESPIRATORY SYSTEM 3
Drug of choice for an asthmatic patient with hypertension - Amlodipine
Drug of choice for Pneumocystis carinii - Cotrimoxazole
Drug of choice for suppression of cough - Dextromethorphan
Drug of choice for ACE inhibitor induced cough - Asprin
Drug of choice for asthma in diabetes - Ipratropium
Drug of choice for beta blocker induced bronchospasm - Ipratropium
bromide
Drug of choice for mild intermittent - Inhaled beta 2 agonist
Drug of choice for mild persistent - Inhaled low dose corticosteroid or Mast
cell stabilizers or leukotrienes antagonist
Drug of choice for moderate persistent asthma - Inhaled corticosteroid with
long acting beta 2 agonist
Drug of choice for severe persistent asthma - High dose Inhaled
corticosteroid with long acting beta 2 agonists and oral corticosteroid
Drug of choice for poorly controlled asthma - Theophylline
Drug of choice for prophylaxis of asthma - Sodium cromoglycate ( Mast cell
stabilizer)

RESPIRATORY SYSTEM 4
 CARDIOVASCULAR SYSTEM

Drug of choice for torsades de pointes -  Magnesium Sulfate

Drug of choice for dyslipidemia -  HMG -COA Reductase inhibitors 

Drug of choice for hypertriglyceridemia -  Fibric acid

Drug of choice for myocardial infarction pain -  Morphine 

Drug of choice for mild hypertension -  Diuretics

Drug of choice for the hypertensive crisis -  Nitroprusside

Drug of choice for hypertension with BPH -  Prazosin

Drug of choice for hypertension with ischemic heart disease -  Beta-blockers

Drug of choice for hypertension with diabetes mellitus -  ACE Inhibitors

Drug of choice for hypertension with diabetic nephropathy -  ACE inhibitors

Drug of choice for hypertension in young patients -  ACE inhibitors (Eg: Captopril)

Drug of choice for unilateral artery stenosis -  ACE inhibitors

Drug of choice for hypertension with renal disease -  ACE inhibitors

Drug of choice for hypertension in CHF -  ACE inhibitors

Drug of choice for hypertension in non-diabetic protein urea -  ACE inhibitors

Drug of choice for hypertension in asthma -  ACE inhibitors

Drug of choice for hypertension in patients with Ischemic heart disease -  Beta

blockers

Drug of choice for isolated systolic  hypertension -  Calcium channel blockers

Drug of choice for low renin hypertension -  Calcium channel blockers

Drug of choice for hypertension with bronchial asthma -  ACE inhibiors or CCB's

Drug of choice for hypertension with chronic kidney disease (CKD) -  ACE

Inhibitors

Drug of choice for hypertension preferred in older patients -  Thiazides

Drug of choice for digoxin overdose -  Digifab or Digibind

Drug of choice for group B streptococcal infection -  Ampicillin

Drug of choice for endocarditis -  Amoxicillin

CARDIOVASCULAR SYSTEM 5
Drug of choice for digoxin toxicity -  Potassium   4
1st line drug of choice for CHF -  ACE inhibitors (Eg : Captopril ,Enalapril)

Drug of choice for rapid fast diuresis -  Loop diuretics (Eg: Furosemide)

Drug of choice for multi-focal atrial tachycardia -  Verapamil (Calcium channel

blocker)

Drug of choice for paroxysmal supra-ventricular tachycardia (PSVT)

-  Adenosine (Anti-arrhythmic agent )

Drug of choice for supra-ventricular tachycardia (SVT) -  Verapamil

Drug of choice for digitalis-induced ventricular arrhythmia -  Lignocaine ( Anti-

arrhythmic agent)

Drug of choice for ventricular arrhythmias -  Lidocaine

Drug of choice for ventricular tachycardia and fibrillation -  Lidocaine

Drug of choice for ventricular extra-systole -  Beta blocker (Eg: Atenolol)

Drug of choice for atrial fibrillation -  Digitalis 

Drug of choice for maintaining sinus rhythm - Amiodarone (Anti- arrhythmic agent )

Drug of choice for Wolff- Parkinson-white syndrome -  Procainamide or

Amiodarone  

Drug of choice for digitalis-induced arrhythmia -  Lignocaine

Drug of choice for acute left ventricular failure -  I.V Furosemide

Drug of choice for the scleroderma induced hypertensive crisis -  ACE inhibitors 

Drug of choice for acute long QT syndrome -  MgSo4

Drug of choice for congenital long QT syndrome -  Beta blocker

Drug of choice for hypertension with peripheral vascular disease -  Calcium channel

blockers

Drug of choice for the hypertensive emergency -  Sodium nitroprusside (Vasodilator)

Drug of choice for malignant hypertension -  Nitroprusside (Vasodilator)

Drug of choice for producing controlled hypotension -  Sodium nitroprusside

Drug of choice for pulmonary hypertension -  Bosentan

Drug of choice for atrial flutter and fibrillation -  Ibutilide 

Drug of choice for paradoxical tachycardia -  Digoxin (Digitalis glycosides)

Drug of choice for angina -  Nitrates ( Vasodilator)

Drug of choice for prophylaxis of stable angina -  Beta blockers

Drug of choice for variant angina -  Calcium channel blockers (Eg: Verapamil)

Drug of choice for diabetic dyslipedemia -  Statins (Eg: Atorvastatin, Rosuvastatin)

CARDIOVASCULAR SYSTEM 6
Drug of choice for dysbetalipoproteinemia -  Fibrates (Fenofibrates) 4
Drug of choice for severe hypercholesterolemia -  Nicotinic acid 

Drug of choice for severe hypercholesterolemia -  Rosuvastatin (Statin)

Drug of choice for lowering TAG levels -  Fibrates

Drug of choice for lowering LDL cholesterol level -  HMG CoA reductase inhibitors

Drug of choice for the cardiogenic shock with renal failure -  Dopamine

Drug of choice for rheumatic fever -  Benzathine Penicillin

Drug of choice for increasing HDL cholesterol -  Niacin

Drug of choice for pulmonary edema with Congestive heart failure (CHF) -

Furosemide (Loop diuretic)

Drug of choice for rheumatic fever -  Benzathine Penicillin

Drug of choice for TOF -  Morphine

Drug of choice  for reducing mortility in CHF -  Spironolactone 

Drug of choice for inotropic effect -  Dobutamine

Drug of choice for a hypertensive patient with benign prostatic hyperplasia(BPH) - 

Alpha 1 Blocker (Eg: Prazosin, Terazosin, Doxazosin, Alfuzosin)

Drug of choice for perioperative arrhythmias -  Esmolol (Cardio selective beta

blocker)

CARDIOVASCULAR SYSTEM 7
CENTRAL NERVOUS SYSTEM

Drug of choice for  generalized absent seizure -  Ethosuximide and Sodium valproate

Drug of choice for absence (Petit mal) seizures -  Valproate

Drug of choice for absence seizures in children -  Ethosuximide

Drug of choice for myoclonic seizures in men - Sodium Valproate

Drug of choice for myoclonic seizures in women -  Lamotrigine

Drug of choice for focal seizure -  Lamotrigine

Drug of choice for generalized tonic-clonic seizures (GTCS) -  Lamotrigine

Drug of choice for tonic-clonic seizures -  Sodium Valproate

Drug of choice for infantile seizures -  ACTH

Drug of choice for rhinorrohea -  Citrizine 

Drug of choice for phobias -  SSRI's

Drug of choice for reducing preanesthetic anxiety -  Lorazepam

Drug of choice for status epilepticus -  I.V Lorazepam

Drug of choice for febrile seizures -  Diazepam

Drug of choice for partial seizures - Carbamazepine

Drug of choice for attention deficit hyperactivity disorder -  Methylphenidate

Drug of choice for Alzheimer's disease -  Rivastigmine 

Drug of choice for obsessive-compulsive disorder (OCD) -  Fluoxetine

Drug of choice for drug-induced parkinsonism -  Benzhexol

Drug of choice for parkinsonism -  Ropinirole, Pramipexole

Drug of choice for glioma -  Nitrosourea

Drug which has pain relief properties without opioid disadvantages -  Tramadol

Drug of choice for sedation in patients with severe liver failure -  Lorazepam

Drug of choice for maintenance treatment of generalized anxiety disorder -  Buspirone

CENTRAL NERVOUS SYSTEM 8

Drug of choice for cerebral edema -  Mannitol

Drug of choice for increased intracranial pressure -  Mannitol

Drug of choice for psychomotor seizures -  Carbamazepine

Drug of choice for  mania -  Lithium Carbonate 

Drug of choice for Huntington chorea -  Tetrabenazine

Drug of choice for Parkinsonism -  Ropinirole and Pramipexole

Drug of choice for morning sickness -  Hyoscine

Drug of choice for multiple sclerosis -  Amitriptyline 

Drug of choice for acute attack of migraine -  Sumatriptan /Ergotamine  

Drug of choice for night terrors -  Benzodiazepines

Drug of choice for atypical depression -  MAO inhibitors

Drug of choice for hydrocephalus -  Glycerol or Acetazolamide

Drug of choice for cluster headache -  Sumatriptan

Treatment of choice for cluster headache -  High flow O2

Drug of choice for infantile spasm -  ACTH

Drug of choice for Huntington chorea -  Tetra benzene

Drug of choice for multiple sclerosis -  Interferon B

Drug of choice for pulmonary edema -  Morphine

Drug of choice generalized anxiety disorders -  Diazepam (Benzodiazepines)

Drug of choice for pain in terminal illness -  Morphine

Drug of choice for pain of acute myocardial infarction -  Morphine

Drug of choice for chronic cancer pain -  Morphine

Drug of choice for borderline personality disorder -  Buspirone (5 HT partial agonist) 

Drug of choice for neonate with respiratory depression due to use of morphine to

control severe labour pain -  Naloxone

Drug of choice for sedation in liver failure patients -  Lorazepam

Drug of choice for decreasing anxiety in children preoperatively - Antihistaminics

Drug of choice for sedation in patients with porphyrias -  Benzodiazepines

Drug of choice for trigeminal neuralgia -  Carbamazepine

Drug of choice for status absence -  Benzodiazepines

Drug of choice for convulsion in lidocaine treated patients - Diazepam

Drug of choice for tardive dyskinesia -  Diazepam

Drug of choice for convulsion in tetanus patients -  Diazepam

Drug of choice for delirium caused by ketamine -  Diazepam

CENTRAL NERVOUS SYSTEM 9

Drug of choice for febrile seizures -  Diazepam

Drug of choice for endoscopic and colonscopy -  Midazolam

Drug of choice for hypnosis in elderly -  Zolpidem

Drug of choice for diabetic neuropathy -  Topiramate

Drug of choice for neuropathic pain -  Lamotrigine or Topiramate or Gabapentin 

Drug of choice for reducing alcohol craving -  Naltrexone

Drug for decreasing relapse of alcoholism -  Acamprosate (NMDA receptor

antagonist) or Naltrexone

Drug of choice for alcohol detoxification -  Disulfiram

Drug of choice for smoking cessation -  Bupropion

Drug of choice for depression in parkinson disease -  SSRI's 

Drug of choice for parkinson disease -  Levodopa

Drug of choice for psycosis in parkinson disease -  Clozapine

Drug of choice for depression -  SSRI's

Drug of choice for restless leg syndrome -  Ropinirole

Drug of choice for violent behaviour -  Haloperidol

Drug of choice for psychotic depression -  Loxapine

Drug of choice for neutropenia in felty's syndrome -  Lithium

Drug of choice for patients with extra pyramidal symptoms (EPS) -  Clozapine

Drug of choice for negative symptoms -  Clozapine

Drug of choice for treatment resistant schizophrenia -  Clozapine

Drug of choice for elderly with schizophrenia -  Clozapine

Drug of choice for peripheral neuropathy -  Lamotrigine

Drug of choice for bulimia -  SSRI's (Eg: Fluoxetine)

Drug of choice for acute mania -  Lithium 

Drug of choice for serotonin syndrome -  Cyproheptadine

Drug of choice for nocturnal enuresis -  Desmopressin 

Drug of choice for major depression -  SSRI's

Drug of choice for heat stroke -  Chlorpromazine

Drug of choice for OCD  -  SSRI's or Clomipramine

Drug of choice for sleep walking -  Carbamazepine

Drug of choice for cluster headache -  Lithium

Drug of choice for cyclical vomiting -  Lithium

Drug of choice for bipolar mood disorder -  Lithium

CENTRAL NERVOUS SYSTEM 10

Drug of choice for reducing hyper excitement in acute mania -  Haloperidol 

Drug of choice for reducing excitement in chorea -  Haloperidol

Drug of choice for reducing hyper excitement in acute schizophrenia -  Haloperidol 

Drug of choice for reducing excitment in delerium -  Haloperidol

Drug of choice for post traumatic stress disorder -  SSRI's 

Drug of choice for somatic pain -  NSAID's

Drug of choice for bipolar depression -  Lithium

Drug of choice for depression with hypotension -  SSRI's

Drug of choice for depression with heart disease -  SSRI's

Drug of choice for depression with insomnia -  Amytriptyline

Drug of choice for pain in asprin allergic patients -  Paracetamol

CENTRAL NERVOUS SYSTEM 11

DRUG OF CHOICE IN PREGNANCY

Drug of choice for ectopic pregnancy -  Methotrexate

Drug of choice for induction of labor -  Oxytocin

Drug of choice for postpartum hemorrhage -  Oxytocin

Drug of choice for hypertension in pregnancy -  Alpha-Methyldopa

Drug of choice for endometriosis -  Danazol

Drug of choice for asthma -  Beta 2 agonists

Drug of choice for postpartum breast engorgement -  Oxytocin

Drug of choice for seizures in eclampsia -  Magnesium sulphate 

Drug of choice in seizures during pregnancy -  Phenobarbitone

Drug of choice for the hypertensive emergency in pregnancy -  Labetalol

Drug of choice for postpartum hemorrhage -  Oxytocin

Drug of choice for falciparum malaria in pregnancy -  Quinine

Drug of choice for cerebral malaria -  Quinine

Drug of choice for gonorrhea -  Penicillin or Ceftriaxone

Drug of choice for toxoplasmosis in pregnancy -  Spiramycin

Drug of choice for malaria in pregnancy -  Chloroquine

Drug of choice for acne -  Erythromycin (oral ) / Benzylbenzoate (Topical)

Drug of choice for  epilepsy in pregnancy -  Phenobarbitone

Drug of choice for mania in pregnancy -  Olanzapine

Drug of choice for hyperthyroidism -  Propylthiouracil

Drug of choice for hypothyroidism -  Levothyroxine

Drug of choice for bacterial vaginosis in 1st trimester -  Clindamycin

Drug of choice cholera in pregnancy -  Furazolidone

Drug of choice for typhoid fever in pregnancy -  Ceftrixone or Ampicillin

Drug of choice for amoebiasis -  Metronidazole ( Contraindicated in 1st trimester )

Drug of choice for amoebiasis in 1st trimester -  Furazolidone

Drug of choice  deep  vein thrombosis -  Heparin

DRUG OF CHOICE IN PREGNANCY 12

Drug of choice  for preventing neural tube defect - Folic acid 

Drug of choice for anticoagulation in pregnancy - Heparin

Drug of choice for mania - Lithium

Drug of choice for mysthenia gravis - Neostigmine

Drug of choice for thromboflebitis - Aspirin

Drug of choice for urinary tract infection during pregnancy - Ampicillin

Drug of choice for HIV in pregnancy - Zidovudine and Nevirapine

Drug of choice for resistant typhoid - Ceftriaxone

Drug of choice for tuberculosis - INH with rifampicin

Drug of choice for vitamin B12 deficiency - Cynacobalamin

Drug of choice for iron deficiency - Ferrous sulphate

Drug of choice for antiplatelet action - Aspirin

Drug of choice for anxiety -  Benzodiazepines

Drug of choice for pain -  Aspirin / Paracetamol

Drug of choice for depression in pregnancy - Tricyclic antidepressant

Drug of choice for superficial thrombophlebitis -   Asprin

Drug choice for bacterial vaginosis in 1st trimester in pregnancy -  Clindamycin

Drug choice for rosacea -  NSAIDS

Drug choice for seizures -  Benzodiazepines 

Drug choice for seizure maintenance - Phenobarbitone

Drug choice for rheumatoid arthritis -  Aspirin

Drug choice for schizophrenia -  Phenothiazines (Eg: Haloperidol)

Drug choice for seborrhic dermatitis -  Salicylic acid 

Drug choice for psoriasis -  Topical corticosteroids / salicyclic acid

Drug choice for  shigella dysentry -  Ampicillin

DRUG OF CHOICE IN PREGNANCY 13

11
 RENAL SYSTEM

Drug of choice for RPGN – Cyclophosphamide

Drug of choice for lupus nephritis – Cyclophosphamide 

Drug of choice for nephrotic syndrome – Steroids 

Drug of choice for steroid-resistant nephrotic syndrome – Cyclosporine

Drug of choice for steroid-dependent nephrotic syndrome – Cyclophosphamide

Drug of choice for urinary retention - Bethanechol 

Drug of choice for enuresis – Imipramine

Drug of choice for hemorrhagic cystitis – Mesna 

Drug of choice for patient allergic to thiazides and loop diuretics -  Ethacrynic acid

Drug of choice for forced alkaline diuresis -  Furosemide

Drug of choice for cerebral edema -  Mannitol (Osmotic diuretic )

Drug of choice for malignant hypertension -  Furosemide

Drug of choice for edema in liver cirrhosis -  Furosemide

Drug of choice for hypercalcemia -  Furosemide (Loop diuretic )

Drug of choice for edema in congestive heart failure -  Furosemide 

Drug of choice for edema in renal failure -  Furosemide 

Drug of choice for idiopathic hypercalciuria - Thiazide (Eg: hydrochlorothiazide)

Drug of choice for calciuria due to hyperparathyroidism -  Thiazides

Drug of choice for nephrogenic diabetes insipidus -  Thiazides

Drug of choice for lithium induced nephropathy - Thiazides

Drug of choice for hyperuricemia in renal failure -  Allopurinol

Drug of choice for gout in renal failure -  Allopurinol

Drug of choice for lesh nyhan syndrome -  Allopurinol 

Drug of choice for urate nephropathy -  Allopurinol (Xanthine oxidase inhibitor )

Drug of choice for alkalization of urine -  Acetazolamide 

Drug of choice for conn syndrome(primary hyperaldosteronism -  Spironolactone

Drug of choice for secondary hyperaldosteronism -  Spironolactone

Drug of choice for thiazide induced hypoklemia -  Spironlactone

RENAL SYSTEM 14
 ENDOCRINE SYSTEM

Drug of choice for acute & chronic adrenal insufficiency -  Hydrocortisone (Shortest

acting glucocorticoid)

Drug of choice for congenital adrenal hyperplasia -  Hydrocortisone 

Drug of choice for tumor induced brain edema -  Dexamethasone ( Long acting

glucocorticoid )

Drug used for mineralocorticoid replacement -  Fludrocortisone

Drug of choice for Premenstrual syndrome -  SSRI's (Eg: Fluxetine)

Drug of choice for dysfunctional uterine bleeding -  NSAIDS

Drug of choice for androgenic alopecia -  Finasteride (5 Alpha reductase inhibitor)

Drug of choice for hypothyroidism -  Levothyroxine

Drug of choice for hypothyroidism in children ( cretinism) -  Thyroxine

Drug of choice for myxedema coma -  Levothyroxine

Drug of choice for reducing thyroid gland vascularity -  Potassium iodide

Drug of choice for hyperprolactinemia -  Bromocriptine

Drug of choice for acute gout -  NSAID (Indomethacin)

Drug of choice for chronic gout -  Allopurinol (Xanthine oxidase inhibitor )

Drug of choice for thyroid storm -  Propylthiouracil

Drug of choice for making patient euthyroid before surgery -  Potassium iodide 

Drug of choice for thyroid cancer -  Levothyroxine

Drug of choice for  grave's disease -  Methimazole (Antithyroid drug)

Drug of choice for thyroid ablation -  I 131

Drug of choice for thyroid storm in India -  Potassium iodide

Drug of choice for reducing somatic manifestations of hyperthyroidism -  Propranolol

Drug of choice for diabetic ketoacidosis (DKA) -  Regular Insulin

Drug of choice for pheochromocytoma -  Phenoxybenzamine (Alpha blocker)

Drug of choice for acute hypercalcemia -  Furosemide (Loop diuretic)

Drug of choice for hypercalcemia due to malignancy -  Bisphosphonate

Drug of choice for vaginal atrophy -  Topical estrogen or HRT

ENDOCRINE SYSTEM 15
Drug of choice lithium-induced diabetes mellitus -  Amiloride

Drug of choice for steroid-induced osteoporosis -  Zolindrate (Bisphosphonates )

Drug of choice for osteoporosis -  Reloxifen (SERM- selective estrogen recptor

modulator) 

Drug of choice for prostate cancer -  GnRH Analogues (Eg: buserelin )

Drug of choice for neurogenic diabetes insipidus -  Desmopressin

Drug of choice for nephrogenic diabetes insipidus -  Thiazides 

Drug of choice for acute adrenal insufficiency -  Hydrocortisone (I.V)

Drug of choice for postprandial hyperglycemia -  Nateglinide (Maglitinide derivative)

Drug of choice for type 2 diabetes mellitus (DM) -  Metformin  (Bigunides )

Drug of choice for type 1 diabetes mellitus (DM)  -  Regular Insulin

Drug of choice for diabetes mellitus in pregnancy -  Regular Insulin

Drug of choice for uncontrolled diabetes mellitus -  Regular  Insulin 

Drug of choice for diabetic ketoacidosis -  Regular Insulin

Drug of choice for diabetes in renal and hepatic failure -  Regular Insulin 

Drug of choice for controlling glucose level during infections in diabetes -  Regular

Insulin

Drug of choice for diabetes in renal failure -  Repaglinide ( Maglitinide derivative)

Drug of choice for prevention of breast cancer -  Tamoxifen

Drug of choice for prevention of diabetes -  Metformin 

Drug of choice for severe hypoglycemia in case of insulinoma -  Diazoxide

(Potassium channel opener) 

Drug of choice for emergency contraception -  Mifepristone 

Drug of choice for polycystic ovarian disease -  Clomiphene citrate 

Drug of choice for oligospermia -  Clomiphene citrate  

Drug of choice for corpus luteum insufficiency -  Clomiphene citrate  

Drug of choice for anovulatory infertility -  Clomiphene citrate 

Drug of choice for post coital contraception -  Mifepristone

Drug of choice for hirsutism -  Cyproterone acetate (Androgen receptor antagonist )

Drug of choice for large prostate -  Finasteride ( 5 alpha reductase inhibitor )

Drug of choice for inducing labour -  Oxytocin

Drug of choice for BPH -  Tamsulosin

Drug of choice for postmenopausal osteoporosis -  Raloxifene or Bisphosphonates

Drug of choice for prevention of postmenopausal osteoporosis -  Vitamin D &

Calcium 

ENDOCRINE SYSTEM 16
 HEMATOLOGY

Drug of choice for microcytic anemia -  Ferrous Sulfate

Drug of choice for iron deficiency anemia in pregnancy -  Ferrous sulphate

Drug of choice for warfarin overdose -  Vitamin K 

Drug of choice for heparin overdose -  Protamine sulphate

Drug of choice for hairy cell leukemia -  Cladribine

Drug of choice for chronic lymphocytic leukemia -  Fludarabine

Drug of choice for chronic myeloid leukemia (CML) -  Imatinib 

Drug of choice for chemotherapy-induced anemia -  Erythropoietin

Drug of choice for anemia due to chronic kidney disease (CKD) -  Erythropoietin 

drug of choive for autoimmune hemolytic anemia -  Prednisolone

drug of choice for transient ischemic attack (TIA) -  Aspirin

Drug of choice for multiple myeloma -  Melphalan

Drug of choice for heparin-induced thrombocytopenia -  Argatroban

Drug of choice for chemotherapy-induced leukopenia -  Sargramostim

Drug of choice for chemotherapy-induced thrombocytopenia -  Oprelvekin

1ST line drugs for multiple myeloma -  Prednisolone, Prednisolone,

Cyclophosphamide

Drug of choice for heparin-induced thrombocytopenia -  Argatroban

Drug of choice for  bleeding due to heparin -  Hirudin

Drug of choice for warfarin overdose -  Vitamin K

Drug of choice for heparin overdose -  Protamine

Thrombolytic agent of choice in acute myocardial infarction -  Streptokinase 

drug of choice for arterial fibrillation induced clotting -  Warfarin 

drug of choice for prevention of stroke -  Aspirin 

drug of choice for prevention of deep vein thrombosis -  Low molecular weight 

heparin

HEMATOLOLGY 17
Drug  of choice for preventing bleeding due to thrombolytic therapy -  Epsilion amino

capronic acid

Drug of choice for treatment of deep vein thrombosis -  Low molecular weight

heparin

Drug of choice for pulmonary embolism -  Low molecular weight heparin 

Drug of choice for anemia in chronic renal failure -  Erythropoietin

HEMATOLOLGY 18
 OPTHALMOLOGY

Drug of choice for open-angle glaucoma -  Prostaglandins analogs

Drug of choice for closed-angle glaucoma -  Acetazolamide

Drug of choice for secondary glaucoma -  Beta blocker

Drug of choice for inclusion conjunctivitis -  Ceftriaxone

Drug of choice for trachoma -  Azithromycin

Drug of choice for primary open angle glaucoma (POAG) -  Timolol

Drug of choice for Xerostomia -  Cevimeline

Drug of choice for corneal ulcer -  Cyclopentolate

Drug of choice for hypertension with glaucoma -  Timolol

Drug of choice for iridocyclitis -  Atropine

Which beta blocker is the drug of choice in open-angle glaucoma -  Timolol

Drug of choice for hepatic keratitis -  Idoxuridine

Drug of choice for fungal corneal ulcer -  Natamycin

Drug of choice for uveal herpetic keratitis - Acyclovir

Drug of choice for preventing meiosis during cataract surgery - Flurbiprofrn

Drug of choice for mild allergic conjunctivitis -  Topical antihistaminics

Drug of choice for decreasing intra ocular pressure before surgery -  Osmotic

diuretics ( Eg: Manitol)

Drug of choice for decreasing high intra ocular pressure -  Osmotic diuretics 

Drug of choice for recurrent anterior uveitis -  NSAID's

Drug of choice for reducing intra ocular pressure in diabetes -  Osmotic diuretics

OPTHALMOLOGY 19
 DERMATOLOGY

Drug of choice for taenia -  Topical azoles (Eg: clotriamazole ) 

Drug of choice for erythrodermic psoriasis -  Methotrexate

Drug of choice for psoriatic arthropathy -  Methotrexate

Drug of choice for severe psoriasis -  Methotrexate 

Drug of choice for severe erythrodermic  psoriasis -  Cyclosporine

Drug of choice for pustular psoriasis -  Retinoid

Drug of choice for impetigo herpetiformis -  Systemic Steroids

Drug of choice for dermatitis herpetiformis -  Dapsone 

Treatment of choice for acute eczema  -  Moist compresses

Treatment of choice for subacute eczema -  Creams & Moisturizers

Treatment of choice for chronic eczema  -  Ointment

Drug of choice for impetigo -  Mupirocin

Drug of choice for solar lentigenes -  Tretinoin

Drug of choice for chancroid -  Ceftriaxone 

Drug of choice for pemphigus vulgaris -  Prednisolone

Drug of choice for vitiligo -  Corticosteroids

Drug of choice for atopic dermatitis -  Topical corticosteroids

Drug of choice for severe excerebation of atopic dermatitis -  Systemic corticosteroids

Drug of choice for reducing recurrence of melanoma -  Alpha interferon with vaccine

Drug of choice for lichen simplex chronicus -  Corticosteroids

Drug of choice for seborrhic dermatitis in scalp -  Selenium shampoo

Drug of choice for acne rosacea -  Oral tetracycline

Drug of choice for tinea capitis -  Griseofulvin

Drug of choice for the scleroderma induced hypertensive crisis  -  Ace inhibitors

(Eg:Captopril, Enapril etc)

Treatment of choice for lichen planus -  Topical glucocorticoids

Drug of choice for systemic dermatophytosis -  Griseofulvin

Drug of choice for steven johnson syndrome -  IV Immunoglobulins

DERMATOLOGY 20
ANTIMICROBIAL DRUGS

Drug of choice  for cholera -  Doxycycline

Drug of choice  for chlamydiae -  Tetracycline ( Eg:Doxycycline)

Drug of choice  for tropical sprue -  Tetracycline 

Drug of choice  for relapsing fever -  Tetracycline

Drug of choice  for rocky spotted mountain fever -  Tetracycline

Drug of choice  for tick typhus -  Tetracycline 

Drug of choice  for scrubs typhus -  Tetracycline  

Drug of choice for syphilis -  Penicillin G

Drug of choice for toxoplasmosis -  Cotrimoxazole

Drug of choice for legionella -  Azithromycin or Levofloxacin

Drug of choice for lymphogranuloma venereum (LGV) -  Azithromycin

Drug of choice for kala-azar -  Sodium Stibogluconate

Oral drug of choice for kala-azar -  Miltefosine

Drug of choice for plague -  Streptomycin

Drug of choice  for brucella -  Streptomycin

Drug of choice  for tularemia -  Streptomycin

Drug of choice  for rhinoscleroma -  Streptomycin

Drug of choice for actinomycosis -  Penicillin-G

Drug of choice for leprosy -  Dapsone

The most effective drug against Mycobacterium leprae -  Rifampicin

Drug of choice for herpes zoster -  Valaciclovir

Drug of choice for herpes simplex -  Acyclovir

Drug of choice for influenza -  Oseltamivir

Drug of choice for blood fluke -  Praziquantel 

Drug of choice for lung fluke -  Praziquantel

Drug of choice for typhoid (Enteric fever) -  I.V Ceftriaxone

Drug of choice for leptospirosis -  Penicillins

ANTIMICROBIAL DRUGS 21
Drug of choice for scabies -  Permethrin

Oral drug of choice for scabies -  Ivermectin

Drug of choice for filariasis -  Diethyl Carbamazine (DEC)

Drug of choice for listeria monocytogenes -  Ampicillin

Drug of choice for enterococcus fecalis -  Ampicillin

Drug of choice for toxoplasmosis -  Cotrimoxazole

Drug of choice for toxoplasmosis in pregnancy -  Spiramycin

Drug of choice for schistosomiasis -  Praziquantel

Drug of choice for  leishmaniasis -  Amphotericin B

Drug of choice for Aspergillosis -  Amphotericin B

Drug of choice for roundworm (Ascaris) -  Albendazole (Anti helminthic agent ) 

Drug of choice for pinworm (Enterobius vermicularis) -   Albendazole (Anti

helminthic agent )

Drug of choice for hookworm -  Albendazole (Anti helminthic agent )

Drug of choice for whip worm -  Albendazole (Anti helminthic agent )

Drug of choice for trichinae worm ( Trichinella spiralis) -  Albendazole (Anti

helminthic agent )

Drug of choice for guinea worm (Dracunculus medinensis) -  Albendazole  (Anti

helminthic agent)

Drug of choice for hydatid disease -  Albendazole

Drug of choice for filarial worm -  Ivermectin (Anti helminthic agent )

Drug of choice for threadworm (Strongyloides stercoralis) -  Ivermectin (Anti

helminthic agent )

Drug of choice for pork tapeworm (Taenia solium ) -  Praziquantel 

Drug of choice for beef tapeworm (Taenia saginata) -  Praziquantel 

Drug of choice for fish tapeworm (Diphyllobothrium latum ) -  Praziquantel 

Drug of choice for dog tapeworm (Echinococcus granulosus) -  Praziquantel 

Drug of choice for dwarf tapeworm (Hymenolepis nana) -  Praziquantel 

Drug of choice for liver fluke (Fasciola hepatica) - Triclabendazole

Drug of choice for blood fluke  -  Praziquantel

Drug of choice for lung fluke -  Praziquantel 

Drug of choice for community acquired pneumonia -  Clarithromycin 

Drug of choice for surgical prophylaxis -  Cefazolin 

Drug of choice for pneumocystis carnii -  Cotrimoxazole

Drug of choice for cholera in children -  Cotrimoxazole 

ANTIMICROBIAL DRUGS 22
Second line drug of choice for filariasis -  Ivermectin

Drug of choice for tapeworm infestation -  Praziquantel

Drug of choice for strongyloidiasis (Threadworm) -  Ivermectin

Drug of choice for onchocerciasis (River Blindness) -  Ivermectin

Drug of choice for tetanus -  Metronidazole

Drug of choice for listeria  -  Ampicillin

Second line drug of choice for listeria -  SMZ -TMP (Sulphamethoxazole

,Trimethoprim)

Drug of choice for MRSA -  Vancomycin

Drug of choice for vancomycin-resistant  staph aureus (VRSA) -  Linezolid 

Drug of choice for neonatal meningitis -  Ampicillin + 3rd generation Cephalosporin

Drug of choice for bacteriosides fragialis -  Clindamycin

Drug of choice for pseudomembranous colitis -  Metronidazole

Drug of choice for amebiasis -  Metronidazole

Drug of choice for trench mouth -  Metronidazole

Drug of choice for bacterial vaginosis -  Metronidazole

Drug of choice for amoebic liver disease -  Metronidazole

Drug of choice for trichomoniasis -  Metronidazole

Drug of choice for giardiasis -  Metronidazole

Drug of choice for extraluminal amebiasis -  Metronidazole

Drug of choice for antibiotic-induced colitis -  Metronidazole

Drug of choice for anaerobic infections -  Metronidazole

Drug of choice for gonorrhea -  Ceftriaxone

Drug of choice for H.pylori eadication -  Metronidazole

Drug of choice for whooping cough -  Erythromycin

Drug of choice for cat scratch disease -  Erythromycin

Drug of choice for campylobacter infections -  Erythromycin

Drug of choice for gonococcal urethritis -  Azithromycin

Drug of choice for chancroid  -  Azithromycin

Drug of choice for legionellosis -  Azithromycin

Drug of choice for trachoma -  Azithromycin

Drug of choice for inflammed acne -  Minocycline

Drug of choice for cystic acne -  Isotretinoin

Drug of choice for urinary tract infection -  Norfloxacin

ANTIMICROBIAL DRUGS 23
Drug of choice for Plasmodium vivax -  Chloroquine

Drug of choice for Plasmodium falciparum - Artemisinin combination therapy (

Artesunate + Pyrimethamine + Sulfadoxine )

Drug of choice for cerebral malaria  -  Artesunate

Drug of choice for malaria -  Chloroquine

Drug of choice for chloroquine-resistant malaria -  Artemisinin combination therapy

( Artesunate + Pyrimethamine + Sulfadoxine )

Drug of choice for brucella -  Streptomycin with doxycycline 

Drug of choice for candida -  Fluconazole

Drug of choice for aspergillosis -  Voriconazole

Drug of choice for dermatophytosis  -  Topically (Azole), Systemic (Griseofulvin)

Drug of choice for Chagas disease -  Nifurtimox, Benznidazole 

Drug of choice for dysuria -  Phenazopyridine

Drug of choice for gonorrhea  -  Procaine Penicillin

Drug of choice for syphilis  -  Procaine penicillin 

Drug of choice for rickettsial infection -  Tetracycline

Drug of choice for plague -  Tetracycline

Drug of choice for anthrax -  Doxycycline

Drug of choice for toxoplasmosis -  Trimethoprim Sulphamethoxazole

Drug of choice for Haemophilus influenza type B -  Rifampicin 

Drug of choice for prophylaxis of tuberculosis -  Isoniazid

Drug of choice for diarrhea in HIV patient -  Octreotide

Drug of choice for acyclovir-resistant herpes -  Foscarnet

Drug of choice for hepatitis B -  Limuvidine

Drug of choice for hepatitis C -  Ribavarine & Interferon 2 alpha

Drug of choice for lava migrans -  Albendazole

Drug of choice for inflammatory -  Sulphasalazine

Drug of choice for  prophylaxis of newborn to TB mother -  INH

Drug of choice for accidental exposure of HIV to  health care workers -  Zidovudine

with Lamivudine

Drug of choice for salmonella -  Ceftriaxone

Drug of choice for meningitis -  Ceftriaxone

Drug of choice for gonorrhea -  Ceftriaxone

Drug of choice for resistant pneumococcal  infections -  Ceftriaxone

ANTIMICROBIAL DRUGS 24
Drug of choice for filarial worm -  Di Ethyl Carbamazepine

Drug of choice for Platyhelminthes -  Praziquantel 

Drug of choice for trichomoniasis -  Metronidazole

Drug of choice for extended spectrum bacterial lactamase -  Carbapenem 

Drug of choice for otitis media -  Amoxicillin

Drug of choice for Nocardia -  Sulfonamides

Drug of choice for neurosyphilis - Aqueous penicillin

Drug of choice for donovanosis  - Azithromycin or Doxycycline

Drug of choice for Neisseria -  Ceftriaxone

Drug of choice for Cryptococcus -  For induction( Amphotericin) , for maintenance

 (Fluconazole)

Drug of choice for Neurocysticercosis -  Albendazole

Drug of choice for typhoid (Enteric fever) -  I.V Ceftriaxone

First line drugs for tuberculosis -  Rifampicin, Isoniazid, Pyrazinamide, Ethambutol,

Streptomycin

Drug of choice for tuberculosis in renal failure -  Rifampicin

Drug of choice for prevention of tuberculosis in susceptible individuals -  INH

Drug of choice for treatment of tuberculosis in HIV positive  patients taking protease

inhibitor -  Rifabutin

Drug of choice for MDR strains of tuberculosis -  Amikacin 

Drug of choice for latent tuberculosis -  INH

Drug of choice for INH resistant  patients of latent tuberculosis -  Rifampin

Drug of choice for leprosy -  Rifampin

Drug of choice for lepra 1 reaction -  Glucocorticoids 

Drug of choice for lepra 2 reaction -  Glucocorticoids 

Treatment of choice for multibacillary leprosy -  Rifampin with Dapsone &

Clofazamine

Drug of choice for hot water born tuberculosis in hospital (M.xenopi) - 

Clarithromycin

Drug of choice for cutaneous TB caused by atypical mycobacteria -  Clarithromycin

Drug of choice for meningococcal prophylaxis -  Ciprofloxacin

Drug of choice for meningococcemia -  Ceftriaxone

Drug of choice for post spleenectomy sepsis -  Ceftriaxone

ANTIMICROBIAL DRUGS 25
Drug of choice for gram negative sepsis -  Piperacillin with Toberamycin

Drug of choice for gram positive sepsis -  Vancomycin with Gentamicin 

Drug of choice for toxic shock syndrome (Group A strep.) -  Penicillin with

Clindamycin

Drug of choice for  necrotizing fasciitis (Group A streptococcus) -  Penicillin

Drug of choice for prophylaxis of cardiac lesions in infective endocarditis - 

Amoxicillin

Drug of choice for impetigo -  Penicillin G

Drug of choice for meningococcal meningitis - Penicillin G 

Drug of choice for severe falciparum and chlorquinine resistant malaria -  Quinine 

Drug of choice for enterococcus faecium -  Linezolid

Drug of choice for animal bite -  Amoxicillin

Drug of choice for otitis media -  Amoxicillin

Drug of choice  for dirty wound prophylaxis -  Cefazolin 

Drug of choice for pneumococcal pneumonia in adults - Amoxicillin

Drug of choice for typhus fever -  Chloramphenicol

Drug of choice for lice infection -  1% permethrin

Drug of choice for dental prophylaxis in infective endocarditis -  Clarithromycin

Drug of choice for cellulitis -  Oxacillin 

Drug of choice for  severe infection  in penicillin allergic patient -  Vancomycin

Drug of choice for microspora -  Albendazole 

Drug of choice for serious upper urinary tract infections -  Aminoglycosides

Drug of choice for serious upper respiratory infections by atypical pathogens - 

Doxycycline

Drug of choice for endocardial prophylaxis in patients allergic to penicillin - 

Vancomycin

Drug of choice for histoplasmosis -  Amphotericin B

Drug of choice for invasive streptococcal infection - Clindamycin

Drug of choice for dermatitis herpetiformis -  Aspirin 

Drug of choice for cryptoccocus  -  Fluconazole

Drug of choice for vulvovaginal candidiasis -  Fluconazole

Drug of choice for pyrazinamide induced hyperuricemia -  Aspirin

Drug of choice for systemic fungal infection -  Amphotericin B

Drug of choice for CMV  retinitis -  Gancyclovir

Drug of choice for condyloma accuminata -  Podophyline

ANTIMICROBIAL DRUGS 26
DRUG OF CHOICE FOR POISONING

Drug of choice for paracetamol poisoning -  N-Acetyl cysteine

Drug of choice for organophosphate poisoning -  Atropine 

Drug of choice for methotrexate toxicity -  Folinic Acid

Drug of choice for ethylene glycol poisoning -  Fomepizole

Drug of choice for warfarin poisoning -  Vitamin k 

Drug of choice for heparin poisoning -  Potassium  sulphate

Drug of choice for acute mercury -  Dimercaprol

Drug of choice for theophylline poisoning -  Beta blockers

Drug of choice for iron poisoning -  Deferoxamine

Drug of choice for copper poisoning -  D- Penicillamine or Zinc acetate 

Drug of choice for acute arsenic poisoning -  Dimercaprol

Drug of choice for carbamate poisoning -  Atropine 

Drug of choice for calcium channel blocker poisoning -  Calcium with Glucagon

Drug of choice for lead poisoning -  DMSA

Drug of choice for anticholinergic  drug poisoning -  Physostigmine

Drug of choice for methylxanthines poisoning -  Beta blocker

Drug of choice for ergot alkaloid poisoning -  Sodium nitroprusside 

Drug of choice for alpha 1 agonist poisoning -  Phentolamine

Drug of choice for beta 2 agonist poisoning -  Propranolol 

Drug of choice for carbon dioxide poisoning -  Hyperbaric oxygen

Drug of choice for chronic mercury poisoning -  N-acetyl- penicillamine

Drug of choice for beta blocker poisoning -  Glucagon

Drug of choice for antipsychotic poisoning -  Sodium bicarbonate with lidocaine

Drug of choice for INH poisoning -  Vitamine B6

Drug of choice for cyanide poisoning -  Amyl Nitrate

Drug of choice for opiod overdose -  Naloxone

DRUG OF CHOICE FOR POISONING 27

Drug of choice for aspirin poisoning -  Vitamin k fresh frozen plasma 

Drug of choice for benzodiazepines  poisoning -  Flumazenil

Drug of choice for iodine poisoning -  Starch

DRUG OF CHOICE FOR POISONING 28

ANTICANCER DRUGS

Drug of choice for breast cancer -  Tamoxifen

Drug of choice for glioma -  Nitrosourea

Drug of choice for colorectal cancer -  5 Fluorouracil

Drug of choice for choriocarcinoma -  Methotrexate

Drug of choice for pancreatic carcinoma -  Gemcitabine

First line chemotherapy for cervix carcinoma -  Cisplatin

Drug of choice for the brain tumor -  Lomustine

Drug of choice for prostate carcinoma -  Flutamide

Drug of choice for insulinoma -  Streptozotocin

Drug of choice for polycythemia vera -  Busulphan or Chlorambucil

Drug of choice for carcinoma of endometrium -  Progestins 

Drug of choice for kaposi sarcome -  IF2 alpha

Drug of choice for CLL -  Chlorambucil or Fludarabine

Drug of choice for  acute myelocytic leukemia -  Cytarabine with Mitoxantrone

Drug of choice for wilm's tumor -  Vincristine with Danctinomycin

Drug of choice for acute promyeloblastic leukemia -  Retinoic acid

Drug of choice for hairy cell leukemia -  Cladarabine

Drug of choice for thyroid carcinoma -  I 131 with Doxarubicin and cisplatin

Drug of choice for stomach cancer -  Fluorouracil with Cisplatin

Drug of choice for CML -  Imatinib or Busulfan

Drug of choice for acute lymphocytic leukemia(ALL) -  Vincristine + Prednisolone +

Mercaptopurine + Cyclophosphamide +Methotrexate

Drug of choice for  ovarian cancer -  Cisplatin with Paclitaxel

Drug of choice for lung cancer -  Cisplatin  with Taxane

Drug of choice for malignant melanoma -  Dacarbazine

Drug of choice for testicular cancer -  Bleomycin+ Etoposide + Cisplatin 

ANTICANCER DRUGS 29
Drug of choice for  advanced ovarian and breast cancer -  Pacitaxel + Docetaxel+

Cisplatin

Drug of choice for head and neck cancer -  Cisplatin + 5 -Fluorouracil

Drug of choice for small cell lung cancer -  Cisplatin with Etoposide

Drug of choice for glioblastoma multiforme -  Temozolomide

Drug of choice for severe pancytopenia caused by anticancer drugs -  Erythropoietin

Drug of choice for reducing anticancer drug induced toxicity -  Amifostine

Drug of choice for brain cancer -  Nitosoureas

Drug of choice for hemorrhagic cystitis caused by cyclophosphamide -  MESNA

Drug of choice for  increasing neutrophils in immuno suppressed patients -  Lithium

Drug of choice for multiple myeloma -  Vancristine + Adriamycin + Dexamethosone

(VAD)

Drug of choice for malignant meningitis -  Methotrexate

Drug of choice for prophylaxis of CNS in case of leukemias -  Methotrexate

ANTICANCER DRUGS 30
28
 ANESTHESIA

Drug of choice for anesthesia of pediatric patients -  Sevoflurane

The anesthetic agent of choice for daycare surgery -  Propofol

Drug of choice for spinal anesthesia -  Tetracaine

Drug of choice for surgical procedure in children -  Ketamine 

Drug of choice for inducing a child with  congenital heart disease -  Midazolam

Gas used for laproscopic surgery -  Carbon dioxide 

Drug of choice for general anesthesia  in patients with porphyrias -  Ketamine

Drug of choice for local anesthesia in malignant hyperthermia -  Procaine

Drug of choice for fast induction -  Sevoflurane

Drug of choice for thiopentone induced shivering -  Pethidine

Drug of choice for induction and facilitating communication in psychiatric patients -  

Thiopentone

Drug of choice for lie detecting in criminals -  Thiopentone

Drug of choice for surgery in patient with shock , sepsis and hypotensive patients -

Ketamine

Drug of choice for dental procedures -  Nitrous oxide

Drug of choice for ENT surgeries -  Nitrous oxide

Drug of choice for head and neck operations -  Nitrous oxide

Drug of choice for obstetrical surgeries -  Nitrous oxide 

Drug of choice for maxillofacial surgeries -  Nitrous oxide

Drug of choice for neurosurgical procedures -  Isoflurane 

Drug of choice for surgery in renal failure -  Isoflurane

Drug of choice for cardiothoracic  procedures -  Isoflurane 

Drug of choice for hypotensive anesthesia -  Isoflurane 

Drug of choice for  epidural block -  Bupivacaine

Drug of choice for  spinal anesthesia -  Lidocaine

Drug of choice for local anesthesia -  Lidocaine

ANESTHESIA 31
Drug of choice for  patient allergic to lidocaine -  Prilocaine

Drug of choice for  prilocaine induced methaemoglobinaemia -  Methylene blue

Drug of choice for regional block -  Lidocaine

Drug of choice for local anesthesia in cardiac patients -  Mepivacaine

Drug of choice for  local anesthesia in epileptic patient -  Mepivacaine

Drug of choice for  local anesthesia in hypotensive patient -  Mepivacaine

Drug of choice for  local anesthetic induced cardiac arrhythmia -  Bretylium 

Drug of choice for  reducing spasticity in multiple sclerosis -  Baclofen

Drug of choice for  spinal spasticity -  Baclofen

Drug of choice for  muscle relaxation in patients with renal failure -  Atracurium

Drug of choice for  muscle relaxation in patients with hepato bilary atresia - 

Atracurium

Drug of choice for  muscle relaxation in patient with hepatic and renal failure -

Atracurium

Drug of choice for  muscle relaxation for short procedures -  Succinylcholine

ANESTHESIA 32
 GYNECOLOGICAL
DRUGS

Drug of choice for hypotonic uterus -  Oxytocin

Drug of choice for atrophic vaginitis -  Topical estrogens 

Drug of choice for cervical cencer -  Cisplatin

Drug of choice for endometrial cancer -  Medroxyprogesterone acetate

Drug of choice for ovarian cancer -  Cisplatin

Drug of choice for mood change in premenstrual tension - SSRI's

Drug of choice for reducing vascularity in fibroid uterus before surgery -  GnRH

analogues

Drug of choice for dysfunctional uterine bleeding (DUB)-  Medroxyprogesterone 

Drug of choice for long term contraception -  Levonorgestrel 

Drug of choice for vulvovaginal candidiasis  in pregnancy - 1 % Clotriamazole

GYNECOLOGICAL DRUGS 33
 MISCELLANEOUS

Drug of choice for delayed hypersensitivity -  Promethazine

Drug of choice for reversal of neuromuscular  blockade -  Neostigmine

Drug of choice for edema by liver cirrhosis -  Spironolactone

Drug of choice for resistant edema  -  Spironolactone

Drug of choice for septic shock -  Norepinephrine

Drug of choice for anaphylactic shock -  Adrenaline

Drug of choice  for steroid-induced osteoporosis -  Alendronate

Drug of choice for erectile dysfunction -  Sildenafil

Drug of choice for clonidine-induced rebound hypertension -  Phentolamine,

Tolazoline

Drug of choice for congenital megacolon -  Bethanecol

Drug of choice for postoperative urinary retention -  Bethanecol

Drug of choice for paralytic ileus -  Bethanecol 

Drug of choice for dystonia -  Benzhexol

Drug of choice for akathisia -  Propranolol

Drug of choice for the malignant neuroleptic syndrome(MNS) -  Dantrolene

Drug of choice for Wegener’s granulomatosis -  Cyclophosphamide

Drug of choice for hepatic encephalopathy -  Lactulose

Drug of choice for cisplatin-induced vomiting -  Ondansetron

Drug of choice for cardiac arrest -  Adrenaline

Drug of choice for sjogren syndrome -  Cevemeline

Drug of choice for postural hypotension -  Midodrine

Drug of choice for levodopa-induced vomiting -  Domperidone 

Drug of choice for methotrexate toxicity -  Folinic Acid

Drug of choice for temporal arteritis -  Steroids

Drug of choice for hepatic encephalopathy -  Lectulose

MISCELLANEOUS 34
Drug of choice for CSOM  -  Ciprofloxacin

Drug of choice for otosclerosis -  Sodium fluoride

Drug of choice for tonsillitis -  Penicillin  

Drug of choice for pheochromocytoma -  Phenoxybenzamine

Drug of choice for erectile dysfunction -  Sildenafil Citrate

Drug of choice for priapism -  Adrenaline

Drug of choice for aortic dissection -  Esmolol

Drug of choice for perioperative cardiac arrhythmias -  Esmolol

Treatment of choice for dengue hemorrhagic fever -  Platelets 

Treatment  of choice for dengue shock syndrome -  Colloids 

Drug of choice for Wilson disease  -  Zinc Acetate

Drug of choice for neonatal meningitis -  Cefotaxime

Drug of choice for Lambert Eaton syndrome -  3,4-aminopyridine + pyridostigmine

Drug of choice for arthritis mutilans -  Etanercept

Drug of choice for guillian barre syndrome -   I.V immunoglobulin’s

Drug of choice for transverse myelitis -  I.V methylprednisolone

Drug of choice for chronic inflammatory demyelinating polyneuropathy -  I.V

methylprednisolone

Drug of choice for Paget’s disease of bone -  Bisphosphonate

Drug of choice  for post-menopausal osteoporosis -  Alendronate

Drug of choice for edema by liver cirrhosis -  Spironolactone

Drug of choice for a vasodilatory shock -  Norepinephrine

Drug of choice for otitis media -  Amoxicillin

Drug of choice for endometriosis -  Danazol

Drug of choice for reducing vertical transmission from HIV mother to fetus -

Nevirapine 

Drug of choice for diarrhea in carcinoid tumor -  Octreotide

Drug of choice for diarrhea in HIV patient -  Octreotide

Drug of choice for hepatitis B -  Entecavir

Drug of choice for  supression of premature labour -   Isoxsuprine

Drug of choice for short term increase in blood pressure -  Mephenteramine

Drug of choice for mountain sickness -  Acetazolamide

Drug of choice for narcolepsy -  Modafinil

Drug of choice for hypotension during spinal anesthesia -  Ephedrine

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Drug of choice for myasthenia gravis -  Neostigmine

Drug of choice for low tension glaucoma -  Latanoprost

Drug of choice for bruxism -  Botulinum toxin A

Drug of choice for blepharospasm -  Botulinum toxin A

Drug of choice for priapism -  Adrenaline

Drug of choice for pupillary dilation without cycloplegia -  Phenylephrine

Drug of choice for motion sickness -  Scopolamine

Drug of choice for morning sickness -  Prochlorperazine

Drug of choice for vertigo -  Cinnarizine

Drug of choice for ureteric colic -  Diclofenac

Drug of choice for spasmodic pain -  Drotavarine

Drug of choice for cholinergic crisis -  Atropine 

Drug of choice for hyperhydrosis -  Atropine

Drug of choice for iridocyclitis -  Atropine

Drug of choice for corneal ulcer -  Atropine

Drug of choice for vagal mediated bradycardia -  Atropine

Drug of choice for sick sinus syndrome -  Atropine

Drug of choice for preventing reflux laryngospasm -  Atropine

Drug of choice for CHF -  Dobutamine

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