Practice Prelim 3
Practice Prelim 3
Practice Prelim 3
Fall 2022
As the name implies, this Practice Prelim is an optional exercise for your own preparation. This
Practice Prelim is derived from a Prelim given in a previous semester.
We encourage you to complete this practice prelim as if it was your own exam. Simply looking
at the answer key loses the practice aspect.
b. Which ONE of the following would be most unlikely to be associated with any
phenotypic effect on morphology, physiology, viability, or fertility of a human? Place an
X in the box next to your answer choice.
monosomy for chromosome 9
heterozygosity for a reciprocal translocation between chromosome 11 and 17
heterozygosity for a 54 Mb deletion
homozygosity for a 41 Mb inversion
Trisomy for chromosome 5
1……AGATCTTGC……GTACTGAAT……TACAGTCCT……
2……AGATCTTGC……GTACTGAAT……TACAGTCCT……
3……AGATTTTGC……GTACGGAAT……TACAATCCT……
4……AGATTTTGC……GTACTGAAT……TACAGTCCT……
5……AGATCTTGC……GTACTGAAT……TACAATCCT……
6……AGATTTTGC……GTACGGAAT……TACAATCCT……
7……AGATTTTGC……GTACGGAAT……TACAATCCT……
8……AGATCTTGC……GTACTGAAT……TACAATCCT……
Assuming that the allele configurations in these eight individuals are representative of
the bigger population, identify the haplotypes present in this population. Indicate the
sequence of each haplotype and its frequency in the population in the below
table. You may NOT need to use all rows (leave unused rows blank).
Haplotypes:
For all parts of this question, answer using 3 digits after the decimal point.
d. Due to a sudden mud slide, 600 people who lived in a nearby mountain
population moved to join the valley population. Before moving down the mountain,
the mountain population was in H-W equilibrium. 60 of the total 600 mountain people
have the genotype aa. What are the allele frequencies of p (A) and q (a) in the new
population, immediately after the 600 mountain people moved to join the valley
population?
p = _______ q = _______
e. Assuming random mating, no mutation, and no selection what will the frequency of
each genotype be in the next generation in this new (mountain + valley) population?
f. Following part (e), is this new (mountain + valley) population in H-W equilibrium?
Explain your answer in 1 sentence.
g. Following part (e), now assume a virus enters the new (mountain + valley) population
that reduces fitness of aa homozygotes by 50%. What will the frequency of each
genotype be in the next generation?
h. Following part (g), Is the population now in H-W equilibrium? If not, when will it reach
equilibrium assuming that the virus persists in the population? Explain in 1 sentence.
Facilitates the
eventual development Requires 2nd hit?
Event
of cancer? (Yes or No)
(Yes or No)
Heterozygosity of a deletion
of a tumor suppressor gene.
Heterozygosity for a
translocation that places
a proto-oncogene adjacent to
a strong promoter.
enz3 enz4
b. In the whole genome Manhattan plot (A), what chromosome(s) contain(s) SNPs in
linkage disequilibrium regarding severe COVID-19 symptoms?
c. Which SNP in (B) numbered 1-4 is the least associated with severe COVID-19
symptoms?
d. Which SNP in (B), numbered 1-4, is definitely causal for severe COVID-19
symptoms? If none apply, write “none.”
e. Which of the four genes shown is in a different linkage block from the others?
f. Which of the four genes is the best candidate for further analysis?