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Connective Tissue Disorders: DR Josephine Ojoo MBCHB FRCP CCST (Resp) Dip Hiv Med Senior Lecturer Maseno University
Connective Tissue Disorders: DR Josephine Ojoo MBCHB FRCP CCST (Resp) Dip Hiv Med Senior Lecturer Maseno University
disorders
Dr Josephine Ojoo
MBChB FRCP CCST(Resp) Dip HIV Med
Senior Lecturer
Maseno University
Objectives
• by end of lecture you should:
• Relapsing Polychondritis
Systemic lupus erythematosus
(SLE)
• Chronic, multisystem, inflammatory autoimmune
disorder
• Antipsychotics - Chlorpromazine
• Environmental factors
• UV light
• viral infections
• Hormonal factors
• oestrogen or prolactin
• Damage results in cell apoptosis releasing nucleic antigens
• Hematologic cytopenias
Joint manifestations
• Range from intermittent arthralgias to acute polyarthritis
Acute
transverse
myelitis
• Mixed CTD can mimic SLE but also may involve features of
systemic sclerosis, rheumatoid-like polyarthritis, and
polymyositis
• Anticardiolipin antibodies
• lupus anticoagulant
Associated with:
• Hemolytic anemia
• ESR
Progression
• The course chronic, relapsing, and unpredictable.
• atherosclerosis
• malignancies
• osteoporosis
• skin
• joints
• Raynaud phenomenon
• Telangiectases
Internal organs
• Esophageal dysfunction most frequent visceral disturbance, occurs in
most patient
• muscle enzymes(CK)
• MRI
• electromyography
• Common findings
• Hand swelling
• Raynaud phenomenon
• polyarthralgia
• inflammatory myopathy
• esophageal hypo motility
• pulmonary dysfunction are common