HIV drug resistance report 2012

Übersicht

This report assesses the general levels of transmitted and acquired drug resistance in select geographical areas of low- and middle-income countries. It is based on two distinct data sources: surveys performed to assess transmitted and acquired drug resistance using standardized WHO methods (WHO surveys) and a broad systematic review of the published literature on transmitted and acquired drug resistance. Findings from the monitoring of early warning indicators of HIV drug resistance are also presented and discussed. This report is organized as follows.

• Chapter 1 outlines the objectives of the report, discusses the determinants of HIV drug resistance, and describes the WHO global HIV drug resistance surveillance and monitoring strategy.
• Chapter 2 provides an overview of HIV drug resistance in high-income countries.
• Chapter 3 discusses a systematic review and meta-analysis of the published literature on levels and trends of transmitted drug resistance in select areas of low- and middle-income countries and presents data from surveys of transmitted drug resistance conducted according to standardized WHO methods.
• Chapter 4 discusses a systematic review of levels of acquired drug resistance in patients failing first-line antiretroviral therapy in select low- and middle-income countries, and presents data from surveys of acquired drug resistance conducted according to standardized WHO methods.
• Chapter 5 presents findings from the monitoring of early warning indicators of HIV drug resistance.
• Chapter 6 discusses overall conclusions.