Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. (Q55019535)

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Englisch	Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

1 reference

26 October 2022

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. (English)

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

1 reference

6 November 2020

RNA-directed DNA polymerase

1 reference

28 September 2019

reverse-transcriptase inhibitor

1 reference

2 October 2019

Hepatitis B virus

1 reference

3 November 2019

1 reference

6 November 2020

viral drug resistance

1 reference

PubMed publication ID

2

object named as

So-Young Lee

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

3

object named as

Bum-Joon Kim

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

1

object named as

Yu-Min Choi

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

language of work or name

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publication date

1 April 2018

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

28 April 2018

14 references

23 March 2019

21 March 2019

20 June 2019

22 June 2019

30 June 2019

14 September 2019

28 September 2019

2 October 2019

3 November 2019

23 December 2019

6 November 2020

24 October 2022

25 October 2022

26 October 2022

World Journal of Gastroenterology

15 references

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

23 March 2019

21 March 2019

20 June 2019

22 June 2019

30 June 2019

14 September 2019

28 September 2019

2 October 2019

3 November 2019

23 December 2019

6 November 2020

24 October 2022

25 October 2022

26 October 2022

24

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

16

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

1708-1724

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

14 references

Europe PubMed Central

23 March 2019

Europe PubMed Central

21 March 2019

Europe PubMed Central

20 June 2019

Europe PubMed Central

22 June 2019

Europe PubMed Central

30 June 2019

Europe PubMed Central

14 September 2019

Europe PubMed Central

28 September 2019

Europe PubMed Central

2 October 2019

Europe PubMed Central

3 November 2019

Europe PubMed Central

23 December 2019

Europe PubMed Central

6 November 2020

Europe PubMed Central

24 October 2022

Europe PubMed Central

25 October 2022

Europe PubMed Central

26 October 2022

on focus list of Wikimedia project

0 references

Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B.

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16 June 2018

Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2.

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16 June 2018

Identification of Novel A2/C2 Inter-Genotype Recombinants of Hepatitis B Virus from a Korean Chronic Patient Co-Infected with Both Genotype A2 and C2.

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16 June 2018

F221Y mutation in hepatitis B virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection

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16 June 2018

Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing

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16 June 2018

Different Variants in Reverse Transcriptase Domain Determined by Ultra-deep Sequencing in Treatment-naïve and Treated Indonesian Patients Infected with Hepatitis B Virus

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16 June 2018

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients

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16 June 2018

Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China

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16 June 2018

Overview of hepatitis B virus mutations and their implications in the management of infection

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16 June 2018

Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive Chinese patients with chronic hepatitis B

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16 June 2018

Molecular biology of the hepatitis B virus for clinicians

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16 June 2018

Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

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16 June 2018

Identification of hepatitis B virus intergenotype recombination in Chinese patients

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16 June 2018

Incidence of natural resistance mutations in naïve chronic hepatitis B patients: a systematic review and meta-analysis

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16 June 2018

Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection

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16 June 2018

Hepatitis B virus genotypes: global distribution and clinical importance

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Hepatitis B virus PreS/S gene variants: pathobiology and clinical implications

1 reference

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Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma

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The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene

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16 June 2018

Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method

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16 June 2018

Mutations in HBV DNA polymerase associated with nucleos(t)ide resistance are rare in treatment-naive patients

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Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and São Paulo, Brazil

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Mutation analysis of hepatitis B virus reverse transcriptase region among untreated chronically infected patients in Ahvaz city (South-West of Iran).

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Impact of genetic heterogeneity in polymerase of hepatitis B virus on dynamics of viral load and hepatitis B progression

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Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients.

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Characterization of the dynamics of hepatitis B virus resistance to adefovir by ultra-deep pyrosequencing.

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Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population

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Telbivudine plus adefovir therapy for chronic hepatitis B patients with virological breakthrough or genotypic resistance to telbivudine

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Characterization of HIV-HBV coinfection in a multinational HIV-infected cohort

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Genotyping and molecular characterization of hepatitis B virus from human immunodeficiency virus-infected individuals in southern Africa

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Subgenotype reclassification of genotype B hepatitis B virus.

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Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients

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Tracking the naturally occurring mutations across the full-length genome of hepatitis B virus of genotype D in different phases of chronic e-antigen-negative infection.

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Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing

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The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation

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Discrepancy of potential antiviral resistance mutation profiles within the HBV reverse transcriptase between nucleos(t)ide analogue-untreated and -treated patients with chronic hepatitis B in a hospital in China

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Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

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Hepatitis B therapy

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Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery

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Mutation pattern of lamivudine resistance in relation to hepatitis B genotypes: hepatitis B genotypes differ in their lamivudine resistance associated mutation pattern.

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Tenofovir for the treatment of hepatitis B virus

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Molecular characteristics and stages of chronic hepatitis B virus infection

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Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.

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Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy

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Hepatitis B virus genotypes and lamivudine resistance mutations in Jordan

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Use of massively parallel ultradeep pyrosequencing to characterize the genetic diversity of hepatitis B virus in drug-resistant and drug-naive patients and to detect minor variants in reverse transcriptase and hepatitis B S antigen

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Hepatitis B virus escape mutants induced by antiviral therapy

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Telbivudine for the management of chronic hepatitis B virus infection

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Hepatitis B virus genotype distribution and its lamivudine-resistant mutants in HIV-coinfected patients with chronic and occult hepatitis B.

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Entecavir: a new nucleoside analogue for the treatment of chronic hepatitis B.

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Hepatitis B virus taxonomy and hepatitis B virus genotypes

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Mutations affecting the replication capacity of the hepatitis B virus

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YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines

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Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma.

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Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B

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1 reference

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Hepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene

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Comparison of sequence analysis and the INNO-LiPA HBV DR line probe assay for detection of lamivudine-resistant hepatitis B virus strains in patients under various clinical conditions

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Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

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Viral dynamics in hepatitis B virus infection

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Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine

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Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients

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13 August 2018

Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study

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13 August 2018

Accumulation of mutations in reverse transcriptase of hepatitis B virus is associated with liver disease severity in treatment-naïve Chinese patients with chronic hepatitis B.

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13 August 2018

Novel HBV recombinants between genotypes B and C in 3'-terminal reverse transcriptase (RT) sequences are associated with enhanced viral DNA load, higher RT point mutation rates and place of birth among Chinese patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Comparing Efficacy of Lamivudine, Adefovir Dipivoxil, Telbivudine, and Entecavir in Treating Nucleoside Analogues Naïve for HBeAg-Negative Hepatitis B with Medium Hepatitis B Virus (HBV) DNA Levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Profile of Mutations in the Reverse Transcriptase and Overlapping Surface Genes of Hepatitis B Virus (HBV) in Treatment-Naïve Indonesian HBV Carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Nucleotide analogue-resistant mutations in hepatitis B viral genomes found in hepatitis B patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Hepatitis B virus reverse transcriptase mutations in treatment Naïve chronic hepatitis B patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Identification of novel inter-genotypic recombinants of human hepatitis B viruses by large-scale phylogenetic analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Characterization of drug-resistance mutations in HBV D-genotype chronically infected patients, naïve to antiviral drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Antiviral resistance mutations and genotype-associated amino acid substitutions in treatment-naïve hepatitis B virus-infected individuals from the Indian subcontinent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naïve patients with chronic hepatitis B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Variability of reverse transcriptase and overlapping S gene in hepatitis B virus isolates from untreated and lamivudine-resistant chronic hepatitis B patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Lamivudine resistance in untreated chronic hepatitis B patients in Turkey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment-naive patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Mutations associated with lamivudine-resistance in therapy-naïve hepatitis B virus (HBV) infected patients with and without HIV co-infection: implications for antiretroviral therapy in HBV and HIV co-infected South African patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Hepatitis B virus (HBV) genotype and YMDD motif mutation profile among patients infected with HBV and untreated with lamivudine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis B virus polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

YMDD motif variants in inactive hepatitis B carriers detected by Inno-Lipa HBV DR assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Identification of Hepatitis B virus putative intergenotype recombinants by using fragment typing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Variant of hepatitis B virus with primary resistance to adefovir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Frequency of hepatitis B virus 'a' determinant variants in unselected Spanish chronic carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Identification of HBV DNA sequences that are predictive of response to lamivudine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Prevalence of HBV precore/core promoter variants in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Detection of YMDD mutant using a novel sensitive method in chronic liver disease type B patients before and during lamivudine treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Detection of YMDD motif mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Hepatitis B virus genotypes and hepatocellular carcinoma in Japan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Role of additional mutations outside the YMDD motif of hepatitis B virus polymerase in L(-)SddC (3TC) resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

13 August 2018

Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5922991

2 November 2018

Lamivudine therapy for chronic hepatitis B: a six-month randomized dose-ranging study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29713126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B

1 reference

https://pubmed.ncbi.nlm.nih.gov/29713126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Entecavir resistance is rare in nucleoside naïve patients with hepatitis B

1 reference

https://pubmed.ncbi.nlm.nih.gov/29713126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B

1 reference

https://pubmed.ncbi.nlm.nih.gov/29713126

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3748/WJG.V24.I16.1708

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5922991

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