A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

Affiliations

• ¹ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, the Netherlands.
• ² NORMENT Centre, University of Oslo, Oslo, Norway.
• ³ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
• ⁴ Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
• ⁵ Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
• ⁶ Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.
• ⁷ The University of Bergen, Institute of Clinical Medicine (K1), Bergen, Norway.
• ⁸ Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
• ⁹ K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• ¹⁰ Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
• ¹¹ Department of Neurology, Oslo University Hospital, Oslo, Norway.
• ¹² Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• ¹³ Division of Mental Health Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
• ¹⁴ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
• ¹⁵ Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
• ¹⁶ Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
• ¹⁷ Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
• ¹⁸ Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
• ¹⁹ Department of Psychiatry, Hospital Namsos, Nord-Trøndelag Health Trust, Namsos, Norway.
• ²⁰ Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
• ²¹ Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
• ²² Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
• ²³ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
• ²⁴ Institute of Psychiatry Psychology and Neurosciences, King's College London, London, UK.
• ²⁵ Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
• ²⁶ NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK.
• ²⁷ Health Data Research UK London, University College London, London, UK.
• ²⁸ Institute of Health Informatics, University College London, London, UK.
• ²⁹ NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust, London, UK.
• ³⁰ 23andMe Inc., Sunnyvale, CA, USA.
• ³¹ Division of Genetic Medicine, Department of Medicine Vanderbilt University Medical Center Nashville, Nashville, TN, USA.
• ³² Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
• ³³ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• ³⁴ Department of Psychology, University of California-Riverside, Riverside, CA, USA.
• ³⁵ Institute of Gerontology and Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.
• ³⁶ deCODE Genetics/Amgen, Reykjavik, Iceland.
• ³⁷ Department of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland.
• ³⁸ Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
• ³⁹ Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Gothenburg, Sweden.
• ⁴⁰ Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.
• ⁴¹ Region Västra Götaland, Sahlgrenska University Hospital, Psychosis Clinic, Gothenburg, Sweden.
• ⁴² Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
• ⁴³ UK Dementia Research Institute at UCL, London, UK.
• ⁴⁴ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
• ⁴⁵ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
• ⁴⁶ HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• ⁴⁷ Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
• ⁴⁸ Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
• ⁴⁹ Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
• ⁵⁰ NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
• ⁵¹ Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
• ⁵² Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
• ⁵³ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ⁵⁴ Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
• ⁵⁵ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, the Netherlands. [email protected].
• ⁵⁶ Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam University Medical Center, Amsterdam, the Netherlands. [email protected].