Hepatic fibrosis is a reparative response of diffuse over deposition and abnormal distribution of extracellular matrix (collagen, glycoprotein and proteoglycans) after exposure to various kinds of liver injuries, and is a key step in the developmental process of various chronic liver diseases to cirrhosis. Recently, many advances in our understanding of hepatic fibrosis have been recognized through the basic and clinical research. Therefore, we have organized the relevant domestic experts of this field to form consensus on the diagnosis and evaluation, treatment, and clinical development and application of therapy in order to better guide the diagnosis and treatment, and drug research and development.
肝纤维化是肝脏受到各种损伤后细胞外基质(即胶原、糖蛋白和蛋白多糖等)弥漫性过度沉积与异常分布的修复反应,是各种慢性肝病向肝硬化发展过程中的关键步骤。近年来对肝纤维化基础和临床研究及其认识方面有不少进展,我们为此组织了国内本领域相关专家,就肝纤维化诊断和评估、肝纤维化治疗及肝纤维化治疗药物临床开发应用形成共识,以便更好地指导肝纤维化诊断和治疗及药物研发。.
Keywords: Consensus; Diagnosis; Hepatic fibrosis; Therapeutics.