Healthcare delivery for HIV-positive people with tuberculosis in Europe

HIV Med. 2021 Apr;22(4):283-293. doi: 10.1111/hiv.13016. Epub 2020 Nov 20.

Abstract

Background: In a 2013 survey, we reported distinct discrepancies in delivery of tuberculosis (TB) and HIV services in eastern Europe (EE) vs. western Europe (WE).

Objectives: To verify the differences in TB and HIV services in EE vs. WE.

Methods: Twenty-three sites completed a survey in 2018 (EE, 14; WE, nine; 88% response rate). Results were compared across as well as within the two regions. When possible, results were compared with the 2013 survey.

Results: Delivery of healthcare was significantly less integrated in EE: provision of TB and HIV services at one site (36% in EE vs. 89% in WE; P = 0.034), and continued TB follow-up in one location (42% vs. 100%; P = 0.007). Although access to TB diagnostics, standard TB and HIV drugs was generally good, fewer sites in EE reported unlimited access to rifabutin/multi-drug-resistant TB (MDR-TB) drugs, HIV integrase inhibitors and opioid substitution therapy (OST). Compared with 2013, routine usage of GeneXpert was more common in EE in 2018 (54% vs. 92%; P = 0.073), as was access to moxifloxacin (46% vs. 91%; P = 0.033), linezolid (31% vs. 64%; P = 0.217), and bedaquiline (0% vs. 25%; P = 0.217). Integration of TB and HIV services (46% vs. 39%; P = 1.000) and provision of OST to patients with opioid dependency (54% vs. 46%; P = 0.695) remained unchanged.

Conclusion: Delivery of TB and HIV healthcare, including integration of TB and HIV care and access to MDR-TB drugs, still differs between WE and EE, as well as between individual EE sites.

Keywords: HIV; clinical management; coinfection; eastern Europe; tuberculosis; western Europe.

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Delivery of Health Care
  • Europe / epidemiology
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Humans
  • Tuberculosis* / diagnosis
  • Tuberculosis* / drug therapy

Substances

  • Antitubercular Agents