Search Results (6,278)

Background: Knee osteoarthritis (OA) is a prevalent condition that significantly impairs pain, mobility, and quality of life. Hydrokinesiotherapy, a water-based exercise therapy, is gaining traction as a potential alternative to traditional land-based rehabilitation for managing knee OA symptoms. Methods: This scoping review aimed to evaluate the effectiveness of hydrokinesiotherapy compared to standard land-based physical therapy and self-administered exercise regimens in improving pain, joint mobility, quality of life, and physical function in patients with knee OA. Five randomized controlled trials (RCTs) were included, assessing outcomes using measures such as the WOMAC score, Visual Analog Scale (VAS), and SF-12. The studies were critically appraised using the PEDro scale and the RoB-2 tool to determine the quality and risk of bias. Results: Hydrokinesiotherapy consistently demonstrated superior outcomes in pain reduction, joint mobility, and physical function across all studies. Patients in the hydrokinesiotherapy groups reported significant improvements in pain and mobility, which were strongly associated with enhanced quality of life. The review also highlighted the potential for hydrokinesiotherapy to serve as an effective alternative or complement to land-based exercises, particularly in populations experiencing severe symptoms. Conlusions: Hydrokinesiotherapy is an effective intervention for managing knee OA, offering significant improvements in key clinical outcomes. Given its benefits, hydrokinesiotherapy should be considered a valuable addition to knee OA treatment protocols. However, further research is needed to confirm long-term effects and to explore ways to improve accessibility to this therapeutic option. Full article

Oximeters have significantly evolved since their invention and are essential for monitoring chronic diseases in home care. However, commercial models can present an economic barrier. Therefore, we conducted a review of the use of low-cost pulse oximeters in the home care of patients with respiratory diseases. Our review included studies addressing oxygen saturation and heart rate monitoring in adults, focusing on the use of portable devices. Our search identified advances in vital signs monitoring that could provide accessible solutions for non-clinical settings. Although there are challenges related to clinical validation and accuracy, these oximeters may improve medical care, particularly in resource-limited areas. As a result, the accessibility of these devices opens up new possibilities for patients with chronic respiratory diseases in home care, enabling regular self-monitoring and increasing control over their health. Full article

Biospecimen imaging is essential across various fields. In particular, a considerable amount of research has focused on developing pretreatment techniques, ranging from freeze-drying to the use of highly conductive polymers, and on advancements in instrumentation, such as cryogenic electron microscopy. These specialized techniques and equipment have facilitated nanoscale and microscale bioimaging. However, user access to these environments remains limited. This study introduced a novel technique to achieve high conductivity in bioimaging by employing a magnetically controlled sputtering cathode to facilitate low-temperature deposition and low-electron bombardment. This approach allows for the convenient high-magnification observation of highly structured three-dimensional specimens, such as pill bugs and butterfly wings, and fragile specimens, such as single-cell protozoan parasites, using metal deposition only. Furthermore, it is easily accessible in the field of bioimaging because it does not require any pretreatment and enables surface analysis of biospecimens with an electron microscope using only a single pretreatment process. Protozoa, which are microorganisms, were successfully observed at high magnification without structural changes due to thermal denaturation. Furthermore, metallic film deposition and electrochemical signal measurements using these metallic films were achieved in pill bugs. Full article

Creating an adult-sized humanoid robot with stable walking capabilities is a major challenge in robotics. While many renowned research groups focus on robots for perilous work environments and precision tasks, our approach simplifies balance control, making it accessible to robotics research groups and educational institutes. This facilitates the development of complex functionalities such as vision and object manipulation for adult-sized humanoids. This research article introduces RoboMan II, an advanced version of RoboMan I, which won the most prestigious award in all humanoid robot leagues at RoboCup 2016 due to its exceptional performance in walking and playing soccer. RoboMan II features significant improvements in performance, inherent stability, recovery after falls, and balance control. To facilitate its development, RoboMan II is lighter and incorporates a modified foot and parallel structure for its leg to boost its inherent stability, along with a two-stage balance control system for Immediate Response and Gradual Adaptation, enhancing its adaptability in various environments. Our simulation results demonstrate that RoboMan II’s walking stability on flat surfaces improved significantly in the face of minor perturbations, with the number of steps within the stable region increasing from 24%, with only the immediate controller to 58% when both controllers were used. Similar improvements were observed on inclined surfaces. Additionally, the 3D CAD files for all of the robot parts are released as open source in conjunction with this paper to facilitate reproduction and further innovation. The forthcoming RoboMan III will incorporate custom servo motors for increased speed, torque, and enhanced fall recovery, preventing disengagement of the gear box after a fall. It promises to be an invaluable asset for research and practical applications in humanoid robotics. Full article

With the paradigm shift in minimally invasive surgery from the video-assisted thoracoscopic platform to the robotic platform, thoracic surgeons are applying the new technology through various commonly practiced thoracic surgeries, striving to improve patient outcomes and reduce morbidity and mortality. This review will discuss the updates in lung resections, lung transplantation, mediastinal surgeries with a focus on thymic resection, rib resection, tracheal resection, tracheobronchoplasty, diaphragm plication, esophagectomy, and paraesophageal hernia repair. The transition from open surgery to video-assisted thoracoscopic surgery (VATS) to now robotic video-assisted thoracic surgery (RVATS) allows complex surgeries to be completed through smaller and smaller incisions with better visualization through high-definition images and finer mobilization, accomplishing what might be unresectable before, permitting shorter hospital stay, minimizing healing time, and encompassing broader surgical candidacy. Moreover, better patient outcomes are not only achieved through what the lead surgeon could carry out during surgeries but also through the training of the next generation via accessible live video feedback and recordings. Though larger volume randomized controlled studies are pending to compare the outcomes of VATS to RVATS surgeries, published studies show non-inferiority data from RVATS performances. With progressive enhancement, such as overcoming the lack of haptic feedback, and future incorporation of artificial intelligence (AI), the robotic platform will likely be a cost-effective route once surgeons overcome the initial learning curve. Full article

Background/Objectives: Emotional intelligence may help nurses to cope with demanding work environments where the need to improve the quality and safety of the care provided, as well as the care of the chronically ill, prevails. Although it is well known that emotional intelligence is positively related to work performance, the literature on nurses is limited. The aim of our study was to examine the impact of emotional intelligence on work performance in a sample of nurses in Greece. Methods: We conducted a cross-sectional study with 318 nurses. We collected data from a convenience sample of nurses during January 2024. Since we conducted an online survey through social media, our sample could not be representative of all nurses in Greece. For instance, older nurses may be underrepresented in our study due to limited access on social media. We measured emotional intelligence with the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF) and work performance with the Individual Work Performance Questionnaire (IWPQ). We created multivariable linear regression models adjusted for sex, age, educational level, and work experience. We followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Results: We found that the four streams of emotional intelligence (i.e., well-being, self-control, emotionality, sociability) increased nurses’ work performance. In particular, we found a positive relationship between well-being and task performance (adjusted beta = 0.210, 95% CI = 0.140 to 0.281, p-value < 0.001) and contextual performance (adjusted beta = 0.135, 95% CI = 0.050 to 0.221, p-value = 0.002). Similarly, there was a positive relationship between self-control and task performance (adjusted beta = 0.136, 95% CI = 0.030 to 0.241, p-value = 0.012). Additionally, sociability increased task performance (adjusted beta = 0.223, 95% CI = 0.151 to 0.295, p-value < 0.001) and contextual performance (adjusted beta = 0.198, 95% CI = 0.111 to 0.286, p-value < 0.001). Moreover, emotionality (adjusted beta = −0.198, 95% CI = −0.319 to −0.076, p-value = 0.002) and sociability (adjusted beta = −0.133, 95% CI = −0.221 to −0.044, p-value = 0.003) reduced counterproductive work behavior. Conclusions: Our multivariable models identified a positive impact of emotional intelligence on nurses’ work performance. Nurse managers and healthcare organizations should adopt appropriate interventions to improve nurses’ emotional intelligence. Enhancing emotional intelligence among nurses can improve work performance and, thus, healthcare outcomes. Moreover, higher levels of emotional intelligence may empower nurses’ compassion and resilience, fostering a supportive work environment. In this context, the well-being of both nurses and patients may improve. Full article

Umbria is an Italian region characterized by a highly fragmented water supply and distribution system, with many small systems fed by local sources. Chlorination in these small systems faces several challenges, including strong fluctuating demand, low economic significance, and limited access to infrastructure. Due to Italian regulations, the resulting frequent noncompliance with water quality standards negatively impacts performance indicators and tariffs. This research explores the possibility of implementing a low-cost chlorination system designed to adapt to varying environmental conditions (e.g., water and environmental temperature fluctuations, changes in pH, etc.) and demands. A prototype of the device was developed and tested in the Water Engineering Laboratory of the University of Perugia, Italy, to assess its ability to apply a programmable chlorination model. The effects of electronic environmental noise, along with the reliability of water meters, thermometer measurements, dosing pump control, local logging, and remote data transmission, were tested under different conditions. The results demonstrated the instrument’s readiness for field applications in pilot studies under real-world conditions. Full article

Automatic milking systems (AMSs) are revolutionizing the dairy industry by boosting herd efficiency, primarily through an increased milk yield per cow and reduced labor costs. The performance of milking machines, whether traditional or automated, can be evaluated using advanced vacuum meters through dynamic testing. This process involves scrutinizing the system and milking routine to identify critical points, utilizing the VaDia™ logger (BioControl AS, Rakkestad, Norway). Vacuum recordings were downloaded and analyzed using the VaDia Suite™ software under the guidance of a milking specialist. Access to data from AMSs across various manufacturers and herds facilitated a retrospective study aimed at describing and comparing key milk emission parameters for different AMS brands while identifying potential mastitis risk factors. Using the proper statistical procedures of SPSS 29.1 (IBM Corp., Armonk, NY, USA), researchers analyzed data from 4878 individual quarter milkings from cows in 48 dairy herds. Results indicated a significant variability in milking parameters associated with quarter milk yield and AMS brand. Notably, despite AMSs standardizing teat preparation and stimulation, this study revealed a surprisingly high frequency of two major mastitis risk factors—bimodality and irregular vacuum fluctuations—occurring more frequently than in conventional milking systems. This study, one of the few comparing different AMS brands and their performance, highlights the crucial role of dynamic testing in evaluating AMS performance under real-world conditions. Full article

Biogeochemical redox cycling of iron (Fe) essentially governs various geochemical processes in nature. However, the mechanistic underpinnings of Fe-redox cycling in deep-sea sediments remain poorly understood, due to the limited access to the deep-sea environment. Here, abyssal sediment collected from a depth of 5800 m in the Pacific Ocean was characterized for its elemental, mineralogical, and biological properties. The sedimentary environment was determined to be oligotrophic with limited nutrition, yet contained a considerable amount of trace elements. Fe-redox reactions in sediment progressed through an initial lag phase, followed by a fast Fe(II) reduction and an extended period of Fe(III) oxidation before achieving equilibrium after 58 days. The presence of an external H₂ electron donor significantly increased the extent of Fe(III) bio-reduction by 7.73% relative to an amendment-free control under high pressure of 58 MPa. A similar enhancement of 11.20% was observed following lactate amendment under atmospheric pressure. Fe(II) bio-oxidation occurred after 16 days’ anaerobic culturing, coupled with nitrate reduction. During Fe bio-redox reactions, microbial community composition was significantly shaped by the presence/absence of an electron donor, while the hydrostatic pressure levels were the controlling factor. Shewanella spp. emerged as the primary Fe(III)-reducing microorganisms, and were stimulated by supplemented lactate. Marinobacter hydrocarbonoclasticus was the predominant Fe(II)-oxidizing microorganism across all conditions. Our findings illustrate continuous Fe-redox reactions occurring in the deep-sea environment, with coexisting Fe-redox microorganisms determining the oscillation of Fe valence states within the abyssal sediment. Full article

The recent COVID-19 pandemic has led to a reassessment of workplace necessities. It has resulted in the current shift from traditional workplace design to creating work experiences—a new paradigm in workplace management. Hence, while some conventional workplace factors remain important to the experiences of workers and, thus, to their well-being, comfort, and productivity, recent studies suggest other factors, not widely known, as important in creating the appropriate work experience. Our study explores these other factors in the workplace that contribute to or may be very important to, workers’ comfort, well-being and productivity. These include working mode; facilities; sustainability practices; and diversity, equity, and inclusion (DEI)—cultural connection. A sample of 149 occupants across offices in New Zealand was conveniently collected for the study and analysed using descriptive and content analysis in SPSS v24. The results show that the occupants prefer to have private offices in the workplace and separate meeting rooms for better concentration on work. In terms of working mode, a combined model of remote working and in-office working is preferred. Furthermore, occupants prefer to have access control and fire safety systems essentially in the workplace and for their offices to be cleaned daily. For sustainable measures in the workplace, the respondents choose the following as practical and convenient: turning off computers outside work hours, using more LED light bulbs in the office, opening windows and doors when required, and using a motion sensor lighting system. Interestingly, most of the respondents did not think having a cultural connection in their workplace was important. The study findings represent significant progress in identifying the needs of contemporary office workers. These findings assist facility managers and workplace designers in developing more proactive approaches to anticipated user issues in buildings. Full article

Fifth-generation (5G) sensor networks are critical enablers of Industry 4.0, facilitating real-time monitoring and control of industrial processes. However, significant challenges to their deployment in industrial settings remain, such as a lack of support for interoperability and manageability with existing industrial applications and the specialized technical expertise required for the management of private 5G sensor networks. This research proposes a solution to achieve interoperability between private 5G sensor networks and industrial applications by mapping Yet Another Next Generation (YANG) models to Open Platform Communication Unified Architecture (OPC UA) models. An OPC UA pyang plugin, developed to convert YANG models into OPC UA design model files, has been made available on GitHub for open access. The key finding of this research is that the proposed solution enables seamless interoperability without requiring modifications to the private 5G sensor network components, thus enhancing the efficiency and reliability of industrial automation systems. By leveraging existing industrial applications, the management and monitoring of private 5G networks are streamlined. Unlike prior studies that explored OPC UA’s integration with other protocols, this work is the first to focus on the YANG–OPC UA integration, filling a critical gap in Industry 4.0 enablement research. Full article

Chimeric antigen receptor (CAR) T-cell therapy has achieved notable success in treating hematological cancers but faces significant challenges in solid-tumor treatment and overall efficacy. Key limitations include T-cell exhaustion, tumor relapse, immunosuppressive tumor microenvironments (TME), immunogenicity, and antigen heterogeneity. To address these issues, various genetic engineering strategies have been proposed. Approaches such as overexpression of transcription factors or metabolic armoring and dynamic CAR regulation are being explored to improve CAR T-cell function and safety. Other efforts to improve CAR T-cell efficacy in solid tumors include targeting novel antigens or developing alternative strategies to address antigen diversity. Despite the promising preclinical results of these solutions, challenges remain in translating CAR T-cell therapies to the clinic to enable economically viable access to these transformative medicines. The efficiency and scalability of autologous CAR T-cell therapy production are hindered by traditional, manual processes which are costly, time-consuming, and prone to variability and contamination. These high-cost, time-intensive processes have complex quality-control requirements. Recent advancements suggest that smaller, decentralized solutions such as microbioreactors and automated point-of-care systems could improve production efficiency, reduce costs, and shorten manufacturing timelines, especially when coupled with innovative manufacturing methods such as transposons and lipid nanoparticles. Future advancements may include harmonized consumables and AI-enabled technologies, which promise to streamline manufacturing, reduce costs, and enhance production quality. Full article

Considering human influence and its negative impact on the environment, the world will have to transform the current energy system into a cleaner and more sustainable one. In residential as well as office buildings, there is a demand to minimize electricity consumption, improve the automation of electrical appliances and optimize electricity utilization. This paper describes the implementation of a smart switch with extended facilities compared to traditional switches, such as visual indication of evacuation routes in case of fire and acoustic alerts for emergencies. The proposed embedded system implements Modbus RTU serial communication to receive information from a fire alarm-control panel. An extension to the Modbus communication protocol, called Modbus Extended (ModbusE), is also proposed for smart switches and emergency switchboards. The embedded smart switch described in this paper as a scientific and practical contribution in this field, based on a performant microcontroller system, is integrated into the Building Internet of Things (BIoT) concept and uses the innovative ModbusE protocol. The proposed smart lighting system integrates building lighting access control for smart switches and sockets and can be extended to incorporate functionality for smart thermostats, access control and smart sensor-based information acquisition. Full article

To guarantee the reliability of Tactile Internet (TI) applications such as telesurgery, which demand extremely high reliability and are experiencing rapid expansion, we propose a novel smart resilience mechanism for Next-Generation Ethernet Passive Optical Networks (NG-EPONs). Our architecture integrates Artificial Intelligence (AI) and Software-Defined Networking (SDN)-Enabled Broadband Access (SEBA) platform to proactively enhance network reliability and performance. By harnessing the AI’s capabilities, our system automatically detects and localizes fiber faults, establishing backup communication links using Radio Frequency over Glass (RFoG) to prevent service disruptions. This empowers NG-EPONs to maintain uninterrupted, high-quality network service even in the face of unexpected failures, meeting the stringent Quality-of-Service (QoS) requirements of critical TI applications. Our AI model, rigorously validated through 5-fold cross-validation, boasts an average accuracy of 81.49%, with a precision of 84.33%, recall of 78.18%, and F1-score of 81.00%, demonstrating its robust performance in fault detection and prediction. The AI model triggers immediate corrective actions through the SDN controller. Simulation results confirm the efficacy of our proposed mechanism in terms of delay, system throughputs and packet drop rate, and bandwidth waste, ultimately ensuring the delivery of high-quality network services. Full article

Women undergoing breast surgery with axillary lymph node dissection continue to experience complications in the ipsilateral upper limb, impacting their daily lives and quality of life. This study aims to evaluate the relationship between quality of life (overall and specific) and the functional capacity of patients undergoing breast surgery with lymph node clearance before and after implementing a rehabilitation program. This short-term quasi-experimental study included 48 women, and the design did not include control groups. Data collection involved a sociodemographic and clinical characterization questionnaire, the Disabilities of the Arm, Shoulder and Hand questionnaire, and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and Breast Cancer questionnaires. The study revealed a significant negative association between all general functional subscales and the functionality of the ipsilateral upper limb, except for emotional (p 0.941) and cognitive (p 0.927) functional scales. The functional capacity of the ipsilateral upper limb following surgery influences the quality of life of women undergoing breast surgery. The study concluded that monitoring the quality of life is essential to underscore the importance of providing access to rehabilitation to minimize or eliminate these changes, thus contributing to a better quality of life for these women. Full article