Search Results (56,727)

Ziziphus jujuba has been used since ancient times in traditional Eastern medicine. It is widely cultivated in numerous countries between the tropical and temperate climatic zones due to its high ecological plasticity and resilience to adverse weather. The different classes of chemical compounds contained in the plant are the reason for its medicinal properties. Research shows that every part of Ziziphus jujuba, the leaves, fruits and seeds, demonstrate therapeutic properties. This review focuses on the chemical composition in order to establish the relationship between the plant and its clinical use. Various biological effects are summarized and discussed: anticancer, anti-inflammatory, immunostimulating, antioxidant, hepatoprotective, gastrointestinal, etc. Apart from medicinal uses, the fruits of Ziziphus jujuba are edible and used in fresh and dried form. This literature review reveals possible medical applications of Ziziphus jujuba and its great potential for improving the diet of people in areas where the plant is abundant. Full article

Although South Africa was the first country to register and roll out oral pre-exposure prophylaxis (PrEP) biomedical human immunodeficiency virus (HIV) prevention intervention in sub-Saharan Africa (SSA), its uptake remains low, particularly among adolescent girls and young women (AGYW). The uptake of PrEP may have worsened during the Coronavirus disease 2019 (COVID-19) pandemic. Some innovative interventions to improve PrEP uptake among AGYW have been implemented. This study aims to evaluate the effectiveness of PrEP innovative interventions implemented during COVID-19 towards reducing the risk of HIV infection among AGYW in South Africa. An exploratory, descriptive design will be conducted to carry out four study objectives. Firstly, to carry out a systematic review of innovative PrEP interventions implemented during COVID-19 in SSA countries. Secondly, to conduct a stakeholder analysis to identify PrEP stakeholders and interview them on their views on the implemented interventions. Thirdly, to assess the implementation outcomes of the innovative interventions using document reviews and Consolidated Framework for Implementation Research. Fourthly, to develop a framework for an improved PrEP service delivery among AGYW. Qualitative data will be captured in ATLAS.ti software (Technical University, Berlin, Germany) version 23 and analysed via thematic analysis. A statistical software package (STATA) version 18 (College Station, TX, USA) will be used to capture quantitative data and analyse them via descriptive analysis. The generated evidence will be used towards the development of framework, guidelines, and policies to strengthen the uptake of, scale-up, and adherence to PrEP among AGYW. Full article

This article presents a multifaceted portrait of immigrants to Germany from the post-Soviet states. The article traces the paths of two families over the course almost of a third of a century after immigration, focusing on language use and integration into the new environment. In-depth interviews conducted at various stages of the integration process and age-appropriate tests served as research material. The content, text, and lexical analyses, as well as a linguistic biography method, were used. The research included four generations of Russian Germans and Jews in each family. Russophones in Germany have not had an easy time integrating but, ultimately, have a positive attitude toward their adoptive country. The results show that the German language became the primary means of communication outside the family and partly within the family where Russian dominates among the second and third generations. The oldest generation (great-grandfathers and great-grandmothers) were fluent in German to some extent; those who moved at the age of 20–40 learned it sufficiently for their jobs; their children studied in German preschools and schools and became completely bilingual; and the great-grandchildren were born in Germany. The younger generations have fully integrated into German society, although strong connections with locals exist among the older generations too. Proficiency in the Russian language is still maintained even among the great-grandchildren’s generation, although not to the same extent as among the generation of young parents. Full article

Financial literacy plays a crucial role in individuals’ decision-making processes. The paper aims to thoroughly identify the financial literacy needs and challenges of adults with low financial literacy living in rural areas. The paper presents the results of a focus group study conducted among a target group (35 people) and interviews with financial experts (14 people) in the first quarter of 2023. The study allows us to identify common areas of financial knowledge crucial for adults with low financial literacy living in rural areas. The study was conducted in seven European countries as part of the Erasmus+ project “Learning by Experiencing Escape Rooms: Financial Literacy for Adults (FLER)”. Key findings from the study revealed that participants exhibited low awareness of financial fraud and expressed a need to protect personal information when using digital platforms. There was a clear demand for improved knowledge in certain areas, such as budgeting, emergency funds, balancing risk and reward, and planning for retirement or long-term savings. Participants consistently viewed gamification as a valuable tool for enhancing their understanding of financial topics. The contribution of our study is that we narrow the research gap on the needs and challenges related to financial literacy among rural residents. The results will help pinpoint specific areas of financial knowledge and competencies that are particularly important for adults with low financial literacy. Moreover, these insights are crucial for developing educational content integrated into a virtual escape room to improve financial literacy through engaging, scenario-based learning. Full article

Mexico has recently introduced the Nueva Escuela Mexicana (NEM) in Basic Education, which aims to create a more meaningful, contextualised, inclusive learning environment. This study examined stakeholder experiences and perspectives on the NEM in its first year of implementation. A total of 79 semi-structured individual and group interviews were conducted in 12 primary schools in three Mexican states. A total of 168 participants were interviewed: learners, teachers, head teachers, teacher trainers, and local and regional supervisors. This study found that stakeholders held a range of positive and negative views about the NEM reform. Participants reported several concerns, such as the lack of foundational knowledge developed through the new approach, doubts about certain curricular content (e.g., gender and sexuality), and a lack of explicit guidance and training. This paper offers policy recommendations, which may also be relevant to policymakers in other countries. Limitations of this study and recommendations for future studies are discussed. Full article

Chlamydia trachomatis (C. trachomatis) screening and treatment in pregnancy allows the opportunity to reduce adverse pregnancy and neonatal outcomes worldwide. Although C. trachomatis infection is easily treated and cured with antibiotics, only some countries have routine pregnancy screening and treatment programs. We therefore evaluated whether just one maternal screening for C. trachomatis is enough to prevent adverse pregnancy and negative neonatal outcomes. Among the 4087 first-time gynecological–obstetric consultations granted at the National Institute of Perinatology in 2018, we selected the study population according to a case–cohort design. Antenatal C. trachomatis screening and treatment interventions were performed on 628 pregnant women using COBAS^® TaqMan CT. C. trachomatis DNA was also detected in samples from 157 infants of these mothers. In the maternal cohort, incidence of C. trachomatis infection was 10.5%. The vertical transmission rate was 1.5% for the cohort of mothers who tested positive for C. trachomatis and received treatment, and 29.7% for those with a negative test. By evaluating symptomatic neonatal infection, the hazard rate of perinatal pneumonia was 3.6 times higher in C. trachomatis-positive babies than in C. trachomatis-negative babies. Despite the low rate of mother-to-child transmission in women positive for C. trachomatis, possible maternal infection that is not detected in pregnancy significantly increases the risk of neonatal infection with consequent perinatal pneumonia. Full article

Background: Intravenous thrombolysis is one of the most effective therapies for the treatment of acute ischemic stroke (AIS), with urokinase offering a cost-effective alternative to newer agents like alteplase and tenecteplase, especially in resource-limited settings. Methods: This review provides a comprehensive overview of the application of intravenous thrombolysis with urokinase for AIS in the clinical practice of stroke management, including the efficacy, safety, and cost-effectiveness of urokinase compared to other thrombolytic agents. Results: Urokinase, a first-generation thrombolytic drug, is a non-specific plasminogen activator that offers a cost-effective alternative. It has been used in clinical practice for over two decades to improve neurological outcomes in patients with AIS if administered within 6 h of ictus. Numerous studies have indicated that urokinase remains a viable option for patients who cannot access alteplase or tenecteplase because of economic constraints, time window limitations, availability, or other reasons. Conclusions: In low- and middle-income countries, urokinase is a cost-effective alternative thrombolytic drug. High-level evidence-based medical research is therefore urgently needed to confirm that urokinase is not inferior to new-generation thrombolytic drugs, and to assess whether it may even be superior in some patient populations. Full article

Avoiding downtime is one of the major concerns of manufacturing industries. In the era of connected industry, acquiring data has become cheaper than ever; however, turning that data into actionable insights for operators is not always straightforward. In this work, we present a manufacturing scenario involving a circular blade rubber cutting machine, where the goal is to minimize downtime. Historical cutting data are available, and the aim is to provide the machine operators with an intuitive tool that helps them reduce this downtime. This work demonstrates how, in an Industry 4.0 environment, data can be leveraged to minimize downtime. To achieve this, different survival model approaches are compared, a Health Index (HI) is developed, and the model deployment is analysed, highlighting the importance of understanding the model as a dynamic system in which the operator plays a key role. Full article

With the recent acceleration in urbanisation and industrialisation, industrial pollution has severely impacted inland water bodies and ecosystem services globally, causing significant restrains to freshwater availability and myriad damages to benthic species. The Kelani River Basin in Sri Lanka, covering only ~3.6% of the land but hosting over a quarter of its population and many industrial zones, is identified as the most polluted watershed in the country. This study used unsupervised learning (UL) and an indexing approach to identify potential industrial pollutant sources along the Kelani River. The UL results were compared with those obtained from a novel Industrial Pollution Index (IPI). Three latent variables related to industrial pollution were identified via Factor Analysis of monthly water quality data from 17 monitoring stations from 2016 to 2020. The developed IPI was validated using a Long Short-Term Memory Artificial Neural Network model (NSE = 0.98, RMSE = 0.81), identifying Cd, Zn, and Fe as the primary parameters influencing river pollution status. The UL method identified five stations with elevated concentrations for the developed latent variables, and the IPI confirmed four of them. Based on the findings from both methods, the industrial zones along the Kelani River have emerged as a likely source of pollution in the river’s water. The results suggest that the proposed method effectively identifies industrial pollution sources, offering a scalable methodology for other river basins to ensure sustainable water resource management. Full article

In Mexico, marine acoustics research still faces technical and scientific challenges. For the past decade, the country has made a sustained effort to implement acoustic techniques to generate time series of standardized information; however, these data have been underutilized. Marine acoustics research has been used mainly for small pelagic species and has contributed to improving fishery management and to advising stakeholders. The Mexican scientific community has perceived marine acoustic techniques as expensive tools that are only used for industrial fishing purposes. Marine acoustics can provide information on the variability and interactions between species, their physical environment, and other communities of species, but this approach has not yet been integrated into interdisciplinary research programs or ecosystem models. Additionally, acoustic data provide estimates of biomass and indices of relative abundance, and they have suitable statistical properties for use in integrated catch-at-age models. In summary, to consolidate marine acoustic techniques in Mexico, it is necessary, at a minimum, to maintain the current infrastructure for acoustic studies, to increase the budget for the development of monitoring programs that collect ecosystem indicator data, to promote the training of human resources, and to encourage peer review of the information generated and reported in gray literature. Full article

Risk management exerts a significant influence on the competitiveness of an organization and its operational processes. It presents opportunities for expansion, foresight, and the need to promote sustainability. Many organizations have executed comprehensive risk management processes. Moreover, internal audit has increasingly attracted managers’ attention, forming the basis of modern governance methods. The aim of this study is to examine, from the viewpoint of the agency, the impact of the role of internal auditors, training in risk management, and management support on risk management. Following this, the work examines risk management in terms of the risk-based auditing implementation that is performed by Saudi public organizations. This study encompassed 234 completed and therefore valid questionnaires from the manager and assistance of the internal audit department, internal auditors, accountants, and managers employed in Saudi public organizations. The data collected have been analyzed utilizing Smart Partial Least Squares (SmartPLS). This study’s findings confirmed that there is a significant association between the role of internal auditors in risk management, training in risk management, and between management support and risk management. There is also a significant association between risk management and the implementation of risk-based internal auditing. This study’s findings have significant ramifications for those in charge of public-sector organizations, and sustainability, aiming to enhance the dependability and trustworthiness of the internal audit process and other aspects of financial reports and audits in general. Currently, there is a dearth of published research on the factors that influence risk management and also on risk-based internal auditing. This study contributes to the emerging literature on this subject by examining Saudi public organizations; it also establishes empirical variables through a thorough review of relevant research. Conducted here is an empirical investigation that identifies the factors that affect risk management and then its influence on risk-based internal auditing implementation in the economic system of Saudi Arabia. By focusing on Saudi public organizations, this article highlights other countries that have similar systems of governance rules and procedures in their government-operated entities. Full article

This paper considers the articles presented in this Special Issue and argues that, in most developed education systems in Western countries, there have been four major shifts in how school education is understood and delivered over the course of human history, from a time when only the wealthy and privileged received an education to the present day. It tracks changes in school leadership since the 1980s, when a combination of efforts to improve the effectiveness of schools and efforts to decentralise schools led to self-managing schools and changed responsibilities for school leaders. It reflects on whether the recent impact of the COVID-19 pandemic on school communities may lead to a fifth major shift in school education. This article discusses four different school leadership approaches that have emerged in Western education since the 1980s, instructional leadership, transformational leadership, distributed leadership, and leadership for learning, and argues that of these four, leadership for learning would be the most appropriate leadership approach in a post-COVID-19 future. Full article

This paper systematically reviews the behavior of numerical indicators in predicting future bankruptcy of companies through statistical analysis models. Following the PRISMA standard, ten primary studies were included in the review. The obtained results underline (1) the ability of numerical indicators, through simple statistical analysis models, to forecast the bankruptcy of businesses and companies and (2) the reliability of cash flows in predicting financial distress through statistical analysis, and (3) models are built with indicators from a specific economy; it is impossible to consider them stable and unchanging, as changes in a country’s economic conditions can potentially impact their predictive accuracy. Full article

The Hepatitis C Virus (HCV) is a significant public health challenge in European countries. Historically, healthcare-related procedures were the primary source of HCV infection in Europe. However, with the implementation of blood safety programs, injection drug use has become the main transmission route. The infection’s distribution and genotype prevalence vary widely across the continent. Even with the availability of highly effective direct-acting antiviral (DAA) therapies, HCV infection is far from being controlled. A significant proportion of patients remain undiagnosed, contributing to the ongoing transmission of the virus. Additionally, several barriers hinder the widespread use of DAAs, including high treatment costs, stigma, poor linkage to care, and considerable geographical variations in prevalence and transmission routes. The World Health Organization has set ambitious targets to reduce liver-related deaths, decrease new viral hepatitis infections, and ensure that 90% of infected individuals are diagnosed by 2030. However, most European countries face challenges, highlighting the need for screening programs, funding mechanisms, and public health strategies to effectively control HCV infection in Europe. Full article

Religious tourism is a growing phenomenon that is increasingly intertwined with cultural tourism, particularly in countries like Bulgaria, which possesses a wealthy heritage of religious interest. The Ancient City of Nessebar, a UNESCO World Heritage site with a rich religious history, provides a unique case study for examining this dynamic. This study employed a mixed-methods approach, including documentary analysis and case study methodology, to investigate the current state of religious tourism in Nessebar. The research revealed the underutilization of Nessebar’s religious sites for tourism purposes, despite their potential value. A complex interplay between mass tourism, cultural preservation, and the decline of traditional religious practices was identified. Full article