Search Results (28,216)

Foodborne infections caused by microbes are a serious health risk. Regarding this, customer preferences for “ready-to-eat” or minimally processed (MP) deer meat are one of the main risk factors. Given the health dangers associated with food, essential oil (EO) is a practical substitute used to decrease pathogenic germs and extend the shelf-life of MP meals. Nonetheless, further data regarding EO use in MP meals are required. In order to evaluate new, safer alternatives to chemicals for disease control and food preservation, this research was carried out in the following areas to assess the antibacterial and antibiofilm characteristics of Thymus serpyllum (TSEO) essential oil, which is extracted from dried flowering stalks. Furthermore, this study applied an essential oil of wild thyme and inoculated the sous vide deer meat with Pseudomonas aeruginosa for seven days at 4 °C in an effort to prolong its shelf-life. Against P. aeruginosa, the essential oil exhibited potent antibacterial action. The findings of the minimal biofilm inhibition concentration (MBIC) crystal violet test demonstrated the substantial antibiofilm activity of the TSEO. The TSEO modified the protein profiles of bacteria on glass and plastic surfaces, according to data from MALDI-TOF MS analysis. Moreover, it was discovered that P. aeruginosa was positively affected by the antibacterial properties of TSEO. The anti-Pseudomonas activity of the TSEO was marginally higher in vacuum-packed sous vide red deer meat samples than in control samples. The most frequently isolated species from sous vide deer meat, if we do not consider the applied bacteria Pseudomonas aeruginosa, were P. fragi, P. lundensis, and P. taetrolens. These results highlight the antibacterial and antibiofilm qualities of TSEO, demonstrating its potential for food preservation and extending the shelf-life of deer meat. Full article

Background and Objectives: The significance of periodontal disease as a public health issue prompts the exploration of effective treatments, including the potential use of tocopherol (Vitamin E) due to its anti-inflammatory and antioxidant properties. Materials and Methods: The PICO statement (Population, Intervention, Comparator, Outcome) was as follows: In patients with periodontal disease, does tocopherol (Vitamin E) supplementation compared to no supplementation or insufficient Vitamin E intake improve clinical outcomes such as gingival inflammation, pocket depth, and clinical attachment levels? This study searched through PubMed, Scopus, and Web of Science up to June 2024 focused on studies involving human subjects with various forms of periodontal disease, analyzing the impact of tocopherol through dietary or supplementary intake. Primary outcomes evaluated included improvements in gingival inflammation, pocket depth, and clinical attachment levels, with data synthesis conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Quality assessment and risk of bias were meticulously performed for the included observational studies and randomized controlled trials. Results: The meta-analysis incorporated 8 studies that were used for data extraction, totaling 12,832 patients, revealing a heterogeneous response to tocopherol supplementation, with a pooled odds ratio for efficacy in reducing periodontal disease severity at about 0.97 (95% CI: 0.96–0.98). Noteworthy findings indicated a statistically significant increase in clinical attachment loss and pocket depth with odds ratios ranging from 1.15 to 9.33 when Vitamin E was insufficient. However, the considerable heterogeneity (I² = 88.35%) underscores variations in tocopherol’s effectiveness across different populations and study designs. Conclusions: While tocopherol supplementation shows a modest benefit in managing periodontal disease, particularly in reducing clinical attachment levels and pocket depth, the variability in outcomes emphasizes the necessity for more research to establish standardized treatment protocols and dosages. Full article

Using survey data from three dwelling types in Jakarta, we examine how dwelling type, socioeconomic identity, and commuting distance affect women’s travel-mode choices and motivations behind women’s choices for nearby and distant non-working trips. We compared the performance of the multinomial logit (MNL) model with two machine-learning classifiers, random forest (RF) and XGBoost, using Shapley additive explanations (SHAP) for interpretation. The models’ efficacy varies across different datasets, with XGBoost mostly outperforming other models. The women’s preferred commuting modes varied by dwelling type and trip purpose, but their motives for choosing the nearest activity were similar. Over half of the women rely on private motorized vehicles, with women living in the gated community heavily relying on private cars. For nearby shopping trips, low income and young age discourage women in urban villages (kampungs) and apartment complexes from walking. Women living in gated communities often choose private cars to fulfill household responsibilities, enabling them to access distant options. For nearby leisure, longer commutes discourage walking except for residents of apartment complexes. Car ownership and household responsibilities increase private car use for distant options. SHAP analysis offers practitioners insights into identifying key variables affecting travel-mode choice to design effective targeted interventions that address women’s mobility needs. Full article

This paper reviews natural capital (NC) valuation approaches in the context of woodland, forest, and riparian ecosystems, emphasising the need for participatory methods to take priority over neoclassical economics approaches. Focusing on research carried out in Scotland, the study analyses findings according to a classification of natural capital initiatives that we have developed, building on ideas proposed by the UK ENCA initiative, a guideline proposed to help researchers and practitioners understand NC and take it into account in valuation, decision-making and policy. We have found that landscape-scale initiatives that address the relationships between people and place to inform value and decision-making beyond the economic (monetary) benefits generated by ecosystem services (ES) are becoming popular. For instance, recent methods employed to capture stakeholders’ non-utilitarian preferences include the use of participatory GIS mapping, scenario planning, and other participatory methods to identify, explore and quantify less tangible cultural ecosystem services (CES). The review shows that many studies provide information relevant to the formulation of a place-based NC approach, working towards the integration of contextual and relational values into land management decisions to help formulate management strategies that maximise ES delivery. Conversely, we have not found evidence of the integration of shared values arising from an eco-centric perspective of nature valuation into the more classical, instrumental value lens. Such an approach would help inform broader, overarching aspects of woodland and forest management that may foster more effective conservation and help to manage conflicts. Full article

This paper introduces a novel method for emotion classification within virtual reality (VR) environments, which integrates biosignal processing with advanced machine learning techniques. It focuses on the processing and analysis of electrocardiography (ECG) and galvanic skin response (GSR) signals, which are established indicators of emotional states. To develop a predictive model for emotion classification, we extracted key features, i.e., heart rate variability (HRV), morphological characteristics, and Hjorth parameters. We refined the dataset using a feature selection process based on statistical techniques to optimize it for machine learning applications. The model achieved an accuracy of 97.78% in classifying emotional states, demonstrating that by accurately identifying and responding to user emotions in real time, VR systems can become more immersive, personalized, and emotionally resonant. Ultimately, the potential applications of this method are extensive, spanning various fields. Emotion recognition in education would allow further implementation of adapted learning environments through responding to the current emotional states of students, thereby fostering improved engagement and learning outcomes. The capability for emotion recognition could be used by virtual systems in psychotherapy to provide more personalized and effective therapy through dynamic adjustments of the therapeutic content. Similarly, in the entertainment domain, this approach could be extended to provide the user with a choice regarding emotional preferences for experiences. These applications highlight the revolutionary potential of emotion recognition technology in improving the human-centric nature of digital experiences. Full article

A common retrofitting method for wind farms is the replacement of low-power turbines with high-power ones. The determination of the optimal replacement sequence for the purpose of maximizing revenue is a significant challenge. This paper employs a combination of FLORIS and a sequencing algorithm to simulate the power output resulting from the replacement of 1.5 MW small turbines with 5 MW large turbines. This study demonstrates that the optimal strategy for maximizing the overall power output is to replace the turbines in the first column. When the turbines situated in the first column have already undergone replacement or are unable to be replaced due to the characteristics of the terrain, it would be prudent to prioritize those in the final column. In the case of staggered arrangements, priority should be given to diagonal points that do not have turbines situated behind them. In the case of replacing the same number of large wind turbines, the preferred replacement option has a minimal impact on the power output of the existing small wind turbines, with an estimated reduction of 0.67%. This effectively enhances the economic efficiency of wind farm renovation. Full article

The 2008 melamine crisis led to widespread consumer distrust of Chinese domestic infant milk formula (IMF), which was substituted through a surge of imported products. Recent studies, however, suggest a revival in consumer confidence in Chinese domestic products and regulatory supervision. This coincides with a rise in consumer ethnocentrism and increased concern about foreign IMF, which arose during the COVID-19 pandemic. This study aims to investigate the multifaceted factors that influence consumers’ intention to purchase domestic IMF, using a structural equation model based on a survey of 563 online consumers. Our findings challenge conventional thinking that food safety governance, consumer ethnocentrism, and COVID-19 have no significant direct impact on IMF purchase decisions. Instead, consumer purchase intentions are driven more indirectly by mediating factors of perceived product quality and perceived behavioural control. The findings have significant implications for Chinese policymakers and industry stakeholders seeking to rebuild trust and strengthen the market position of domestic IMF in the post-melamine and post-pandemic era. By understanding the nuanced dynamics and consumer preferences in this market, international stakeholders can also develop more effective strategies to navigate and compete in the ever-evolving landscape of the Chinese IMF industry. Full article

Purpose: Pulmonary sequestration is a rare pulmonary malformation that often necessitates surgical intervention due to potential complications such as recurrent infections or hemoptysis. This case series presents the clinical trajectory of four patients diagnosed with pulmonary sequestration, from initial diagnosis through postoperative care, with a specific focus on the limited arterial supply in two of the cases. Materials and Methods: We conducted a retrospective descriptive analysis of four patients diagnosed with pulmonary sequestration who underwent surgical treatment at our institution between January 2013 and November 2022. The affected lung segments were excised via either thoracoscopy or thoracotomy. We evaluated perioperative and postoperative complications, hospital stay duration, histological findings, and the vascular supply of the affected areas. Results: Thoracoscopic surgery was initially preferred for all patients, though one required conversion to an open procedure due to technical challenges. Perioperative complications included increased pain and atelectasis. Two patients developed pleural empyema postoperatively, necessitating additional surgical intervention. The overall outcomes were favorable, with appropriate management addressing the complications effectively. Conclusions: Pulmonary sequestration, despite its rarity, often requires surgical treatment. Both thoracoscopic and open surgical methods are effective, though thoracoscopic surgery is generally preferred when feasible. The findings underscore the importance of meticulous preoperative planning and vigilant postoperative care to manage and mitigate potential complications. Full article

Introduction: Professional certification programs play a crucial role in helping pharmacists develop specialized skills and establish their expertise in the field. This study explores how pharmacists in Saudi Arabia engage with these programs by examining their levels of awareness, attitudes, and participation. It also identifies the key barriers and motivators that influence their decision to pursue certification. Methods: An online survey was conducted among pharmacists in Saudi Arabia to assess participants’ knowledge of certification programs, their perceived benefits, the actual participation rates, and their preferences regarding certification areas and assessment methods. Results: Out of 394 participating pharmacists, around 47% had never participated in a professional certification program, and about 27% of our sample were unaware of such programs in Saudi Arabia. Financial constraints and a lack of awareness were noted as the primary barriers to participation. Almost 55% showed an interest in Clinical Pharmacy Specialties certification, while 54% were inclined toward Pharmacy Management and Leadership certifications. A preference for practical assessments in certification programs was suggested by 55% of participants. Conclusions: This study highlights a significant need for increased awareness and accessibility to professional certification programs among pharmacists in Saudi Arabia. Addressing participation barriers is vital to foster professional development and meet the healthcare sector’s evolving demands in Saudi Arabia. Full article

Background/Objectives: Proximal humeral fractures (PHFs) are common, especially in the elderly, and account for 4% to 10% of all fractures, with women more often affected than men. Treatments include conservative methods, internal fixation and arthroplasty, with surgical approaches increasingly being used due to technological advancements. This study analyzes the evolution of PHF treatments in Italy from 2001 to 2022, using data from the Italian Hospital Discharge Records (HDRs) Database, and includes a stratified analysis by age and sex. Methods: Using HDR data from 2001 to 2022, records with ICD9-CM codes for proximal humeral fractures (812.0 and 812.1) among diagnoses were selected and categorized into three treatment groups: arthroplasty, fixation and conservative. Time series were analyzed with stratification by sex and age. Results: The extracted data included 486,368 records of PHFs, with 223,742 cases treated surgically (arthroplasty or internal fixation) and 262,626 treated conservatively; the average patient age was 66.6 years, with a higher proportion of women, especially among arthroplasty patients. Over time, the use of fixation and arthroplasty increased from 20% of treatments in 2001 to over 60% in 2022, with fixation becoming the most common treatment method by 2014 and arthroplasty significantly increasing among women, particularly in the 65–74 and 75–84 age groups. Conclusions: The study shows that in Italy, over the past two decades, treatment for PHFs has shifted from conservative methods to a preference for internal fixation and increasingly for arthroplasty, particularly among women and patients aged 65–84, reflecting evolving trends and technological improvements. Full article

Based on the project portfolio selection and scheduling problem (PPSS), the development of a systematic and scientific project scheduling plan necessitates comprehensive consideration of individual preferences and multiple realistic constraints, rendering it an NP-hard problem. Simultaneously, accurately and swiftly evaluating the value of projects as a complex entity poses a challenging issue that requires urgent attention. This paper introduces a novel qualitative evaluation-based project value assessment process that significantly reduces the cost and complexity of project value assessment, upon which a preference-based deep reinforcement learning method is presented for computing and solving project subsets and time scheduling plans. This paper first determines the key parameter values of the algorithm through specific examples. Then, using the method of controlling variables, it explores the sensitivity of the algorithm to changes in problem size and dimensionality. Finally, the proposed algorithm is compared with two classical algorithms and two heuristic algorithms across different instances. The experimental results demonstrate that the proposed algorithm exhibits higher effectiveness and accuracy. Full article

Introduction: Acute necrotizing pancreatitis (ANP) is the acute inflammation of pancreatic parenchyma, most commonly due to alcohol abuse or cholelithiasis. The treatment can be either conservative or invasive, including a variety of techniques; however, it has not yet been established if the intervention should be early or if it should be delayed. The aim of this review is to investigate the optimal time for intervention in ANP. Methods: A literature search was conducted in PubMed and Scopus from inception until September 2024 for studies reporting the comparison between early and late intervention. Results: Early intervention, within 4 weeks of symptom onset, often involves drainage via percutaneous, endoscopic, or combined methods. Delayed intervention occurs after 4 weeks of symptom onset. This can be conducted either surgically or via minimally invasive means. The results of this review reveal that the time of intervention for ANP plays an important role in the prognosis and the course of the disease. In particular, early intervention is associated with higher mortality, which is also the primary clinical outcome. Delayed intervention is also superior regarding secondary clinical outcomes, specifically the complications associated with the intervention. Thus, it is accompanied by fewer episodes of new-onset organ failure, bleeding, gastrointestinal fistula, pancreatic fistula, wound infection, endocrine pancreatic insufficiency, and other complications. Finally, delayed intervention results in shorter stays, both in hospitals and the ICU. Conclusions: Delayed intervention is clearly more effective than early intervention and should be preferred. However, early intervention appears to be both safe and effective, and it is feasible. Full article

Goal 4 of the United Nations Sustainable Development Goals emphasizes ensuring inclusive and equitable quality education to achieve sustainability. It is well known that gifted mathematics education is crucial, but teachers for gifted mathematics education are extremely scarce. The promotion of sustainability in gifted mathematics education on a large scale is an important issue to ensure equity and quality in education. Mathematical competitions have always been an important method for gifted education and have received widespread attention from students and parents. Many high school students prepare for these competitions through extracurricular gifted mathematics tutoring. With the advancement of science and technology and the outbreak of the COVID-19 pandemic in 2020, many tutoring courses have gradually turned to online courses. Online gifted mathematics education has become a model for developing gifted education. In this study, we conducted an in-depth analysis of the learning patterns, grades, and family backgrounds of students participating in mathematics competitions in 10 key high schools in Liaoning Province from 2018 to 2024. The research results are as follows: (1) Before the COVID-19 pandemic, extracurricular gifted mathematics education primarily consisted of offline courses. During the COVID-19 pandemic, online learning resources developed rapidly and became prevalent, while offline education decreased. (2) Students from high-income families preferred offline courses when participating in extracurricular gifted education tutoring for mathematics. In contrast, students from middle- and low-income families were more inclined to choose online courses. Household registration and the place of residence had a weak correlation with the time spent participating in online gifted mathematics education. Among the influencing factors, material resources such as computers, smartphones, and broadband internet had a significant mediating effect. (3) With the advent of online education, the correlation between mathematics competition achievements and family income significantly decreased. However, students from rural families face challenges in accessing online education due to a lack of material resources consequent to the COVID-19 pandemic, resulting in lower mathematics competition achievements. The results show that online gifted education in mathematics breaks through the limitations of time, space, and resources; solves the problem of scarce teaching staff; and helps promote a comprehensive strategy for sustainable development in gifted education. At the same time, issues such as the digital divide, insufficient hardware, and limited internet access still need to be addressed. Full article

Our study aimed to analyse socio-economic sustainability and the drivers of land abandonment in the Kras region of Slovenia, a representative eastern Mediterranean farmland area. We also sought to provide policy recommendations for supporting biodiversity conservation and facilitating the sustainable transition of similar High Nature Value (HNV) farming systems across Europe. The Slovenian Typical Farm Model (SiTFarm) was used to assess the economic performance of representative livestock and wine-growing farm types. Additionally, in-depth interviews with farmers were conducted to understand their perspectives on these farming systems and their preferences for alternative management strategies and policy instruments. Our findings indicate that, due to the introduction of basic income support for sustainability and complementary voluntary coupled payments, budgetary support for the livestock sector in the region is projected to increase by 27–55% in estimated gross margins during the 2023–2027 Common Agricultural Policy (CAP) period, depending on the farm type. Furthermore, farms can enhance their economic performance by converting to organic farming and enrolling in agri-environmental schemes that promote extensive grasslands management, which is crucial for biodiversity conservation. This suggests that Slovenia’s current CAP strategic plan adequately addresses the maintenance of the existing farming systems. However, the region faces significant challenges, particularly in restructuring small farms and adding value to primary farm products. These issues appear to be insufficiently addressed by the current CAP strategic plan, implying that limited progress is expected in mitigating land abandonment in the long term. Comprehensive strategies for the development of feasible HNV farming systems, aligned with biodiversity conservation recommendations, and a well-managed system of supporting institutions and policy instruments is needed to facilitate more market-oriented and sustainable development of agriculture at the local level. Full article

Background: Varicella zoster virus (VZV) is the causative agent for chickenpox and herpes zoster (HZ, shingles). HZ is a debilitating disease affecting elderly and immunocompromised populations. Glycoprotein E (gE) is indispensable for viral replication and cell-to-cell spread and is the primary target for anti-VZV antibodies. Importantly, gE is the sole antigen in Shingrix, a highly efficacious, AS01_B-adjuvanted vaccine approved in multiple countries for the prevention of HZ, yet the three-dimensional (3D) structure of gE remains elusive. Objectives: We sought to determine the structure of VZV gE and to understand in detail its interactions with neutralizing antibodies. Methods: We used X-ray crystallography and cryo-electron microscopy to elucidate structures of gE bound by recombinant Fabs of antibodies previously elicited through vaccination with Zostavax, a live, attenuated vaccine. Results: The 3D structures resolve distinct central and C-terminal antigenic domains, presenting an array of diverse conformational epitopes. The central domain has two beta-sheets and two alpha helices, including an IgG-like fold. The C-terminal domain exhibits 3 beta-sheets and an Ig-like fold and high structural similarity to HSV1 gE. Conclusions: gE from VZV-infected cells elicits a human antibody response with a preference for the gI binding domain of gE. These results yield insights to VZV gE structure and immunogenicity, provide a framework for future studies, and may guide the design of additional herpesvirus vaccine antigens. Teaser: Structures of varicella zoster virus glycoprotein E reveal distinct antigenic domains and define epitopes for vaccine-elicited human antibodies. Full article