<a href="/wg_a52b03be97db00a8b00fb8f33a293d141/en/de/iopscience.iop.org/journal/1478-3975" itemprop="url"="">Physical Biology</a>

The effect of interactions on the cellular uptake of nanoparticles

<span itemtype="http://schema.org/Person" itemprop="author" class="nowrap"=""><span itemprop="name"="">Abhishek Chaudhuri</span><sup="">1,2</sup></span>, <span itemtype="http://schema.org/Person" itemprop="author" class="nowrap"=""><span itemprop="name"="">Giuseppe Battaglia</span><sup="">1</sup></span> and <span itemtype="http://schema.org/Person" itemprop="author" class="nowrap"=""><span itemprop="name"="">Ramin Golestanian</span><sup="">2</sup></span>

Published 20 April 2011 • 2011 IOP Publishing Ltd
, , <strong="">Citation</strong> Abhishek Chaudhuri <em="">et al</em> 2011 <em="">Phys. Biol.</em> <b="">8</b> 046002 <strong="">DOI</strong> 10.1088/1478-3975/8/4/046002

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<sup="">1</sup> Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK

<sup="">2</sup> The Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford OX1 3NP, UK

Dates

  1. Received <span itemprop="dateReceived"="">13 January 2011 </span>
  2. Accepted <span itemprop="dateAccepted"="">28 March 2011 </span>
  3. Published <span itemprop="datePublished"="">20 April 2011 </span>

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1478-3975/8/4/046002

Abstract

We present a simple two-state model to understand the size-dependent endocytosis of nanoparticles. Using this model, we elucidate the relevant energy terms required to understand the size-dependent uptake mechanism and verify it by correctly predicting the behavior at large and small particle sizes. In the absence of interactions between the nanoparticles, we observe an asymmetric distribution of sizes with maximum uptake at intermediate sizes and a minimum size cut-off below which there can be no endocytosis. Including the effect of interactions in our model has remarkable effects on the uptake characteristics. Attractive interactions shift the minimum size cut-off and increase the optimal uptake while repulsive interactions make the distribution more symmetric lowering the optimal uptake.

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10.1088/1478-3975/8/4/046002