Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.[5]

PPBP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
External IDsOMIM: 121010; MGI: 1888712; HomoloGene: 136759; GeneCards: PPBP; OMA:PPBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002704

NM_023785

RefSeq (protein)

NP_002695

NP_076274

Location (UCSC)Chr 4: 73.99 – 73.99 MbChr 5: 90.92 – 90.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).[6]

It is a protein that is released in large amounts from platelets following their activation.[7] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163736Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029372Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)".
  6. ^ Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812.
  7. ^ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem. 266 (9): 5785–9. doi:10.1016/S0021-9258(19)67665-9. PMID 1826003.
  8. ^ Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA. 80 (3): 765–9. Bibcode:1983PNAS...80..765C. doi:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368.
  9. ^ Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry. 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.

Further reading

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