Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.[5][6][7]

KRT23
Identifiers
AliasesKRT23, CK23, HAIK1, K23, keratin 23
External IDsOMIM: 606194; MGI: 2148866; HomoloGene: 9172; GeneCards: KRT23; OMA:KRT23 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282433
NM_015515
NM_173213

NM_033373

RefSeq (protein)

NP_001269362
NP_056330

NP_203537

Location (UCSC)Chr 17: 40.92 – 40.94 MbChr 11: 99.37 – 99.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.[7]

References

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  1. ^ a b c ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006777Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.
  6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. ^ a b "KRT23 keratin 23 [ Homo sapiens (human) ]".

Further reading

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