In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.9) is an enzyme that catalyzes the chemical reaction
N-acylglucosamine-6-phosphate 2-epimerase | |||||||||
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Identifiers | |||||||||
EC no. | 5.1.3.9 | ||||||||
CAS no. | 37318-35-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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- N-acyl-D-glucosamine 6-phosphate N-acyl-D-mannosamine 6-phosphate
Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.
Structural studies
editAs of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.
References
edit- Ghosh S, Roseman S (April 1965). "The Sialic Acids. Iv. N-Acyl--D-Glucosamine 6-Phosphate 2-Epimerase". The Journal of Biological Chemistry. 240: 1525–30. doi:10.1016/S0021-9258(18)97467-3. PMID 14285487.