Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.[5][6][7]

NPLOC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNPLOC4, NPL4, NPL4 homolog, ubiquitin recognition factor
External IDsOMIM: 606590; MGI: 2679787; HomoloGene: 5403; GeneCards: NPLOC4; OMA:NPLOC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017921
NM_001369698

NM_001195023
NM_199469

RefSeq (protein)

NP_060391
NP_001356627
NP_060391.2

NP_001181952
NP_955763

Location (UCSC)Chr 17: 81.56 – 81.65 MbChr 11: 120.27 – 120.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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NPLOC4 has been shown to interact with UFD1L.[5][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182446Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039703Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (Sep 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
  6. ^ Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G (Jun 2000). "A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways". EMBO J. 19 (10): 2181–92. doi:10.1093/emboj/19.10.2181. PMC 384367. PMID 10811609.
  7. ^ "Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)".
  8. ^ Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (Aug 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

Further reading

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