Jump to content

ABLIM1

From Wikipedia, the free encyclopedia
ABLIM1
Identifiers
AliasesABLIM1, ABLIM, LIMAB1, LIMATIN, abLIM-1, actin binding LIM protein 1
External IDsOMIM: 602330; MGI: 1194500; HomoloGene: 40994; GeneCards: ABLIM1; OMA:ABLIM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 114.43 – 114.77 MbChr 19: 57.02 – 57.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene.[5][6]

Function

[edit]

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

Interactions

[edit]

ABLIM1 has been shown to interact with LDOC1.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099204Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025085Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ABLIM1 actin binding LIM protein 1".
  6. ^ Roof DJ, Hayes A, Adamian M, Chishti AH, Li T (August 1997). "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein". The Journal of Cell Biology. 138 (3): 575–88. doi:10.1083/jcb.138.3.575. PMC 2141644. PMID 9245787.
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
[edit]

Further reading

[edit]