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Acetone carboxylase

From Wikipedia, the free encyclopedia
Acetone carboxylase
Identifiers
EC no.6.4.1.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an acetone carboxylase (EC 6.4.1.6) is an enzyme that catalyzes the chemical reaction

acetone + CO2 + ATP + 2 H2O acetoacetate + AMP + 2 phosphate

The 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is acetone:carbon-dioxide ligase (AMP-forming).

References

[edit]
  • Sluis MK, Ensign SA (1997). "Purification and characterization of acetone carboxylase from Xanthobacter strain Py2". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8456–61. doi:10.1073/pnas.94.16.8456. PMC 22955. PMID 9237998.