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All-trans-retinyl-palmitate hydrolase

From Wikipedia, the free encyclopedia
retinoid isomerohydrolase
Identifiers
EC no.3.1.1.64
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme retinoid isomerohydrolase (EC 3.1.1.64, all-trans-retinyl-palmitate hydrolase) catalyzes the reaction

an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is all-trans-retinyl ester acylhydrolase, 11-cis retinol-forming. This enzyme participates in retinol metabolism.

References

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  • Blaner WS, Das SR, Gouras P, Flood MT (1987). "Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells". J. Biol. Chem. 262 (1): 53–8. PMID 3793734.