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CYP20A1

From Wikipedia, the free encyclopedia
CYP20A1
Identifiers
AliasesCYP20A1, CYP-M, cytochrome P450 family 20 subfamily A member 1
External IDsMGI: 1925201; HomoloGene: 18584; GeneCards: CYP20A1; OMA:CYP20A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020674
NM_177538

NM_030013
NM_001313721

RefSeq (protein)

NP_001300650
NP_084289

Location (UCSC)Chr 2: 203.24 – 203.31 MbChr 1: 60.38 – 60.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein which in humans is encoded by the CYP20A1 gene.[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in pollutant and drug metabolism and the synthesis of cholesterol, steroids, and other lipids. CYP20A1 lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen.[6]

CYP20A1 has no identified substrate or biological role and is considered an "orphan" P450.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119004Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049439Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  6. ^ Public Domain This article incorporates public domain material from "Entrez Gene: CY20A1". Reference Sequence collection. National Center for Biotechnology Information.
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.