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Cobyrinate a,c-diamide synthase

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Cobyrinate a,c-diamide synthase
Identifiers
EC no.6.3.5.11
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Cobyrinate a,c-diamide synthase (EC [1]), cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction[1]

2 ATP + cobyrinate + 2 L-glutamine + 2 H2O 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)
(1a) ATP + cobyrinate + L-glutamine + H2O ADP + phosphate + cobyrinate c-monamide + L-glutamate
(1b) ATP + cobyrinate c-monamide + L-glutamine + H2O ADP + phosphate + cobyrinate a,c-diamide + L-glutamate

This enzyme is a glutamine amidotransferase, part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

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References

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  1. ^ Fresquet V, Williams L, Raushel FM (August 2004). "Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2". Biochemistry. 43 (33): 10619–27. doi:10.1021/bi048972x. PMID 15311923.
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