Cucurbitacin D
Appearance
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Names | |
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IUPAC name
(23E)-2β,16α,20,25-Tetrahydroxy-9-methyl-19-nor-9β,10α-lanosta-5,23-diene-3,11,22-trione
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Systematic IUPAC name
(1R,2R,3aS,3bS,8S,9aR,9bR,11aR)-1-[(2R,4E)-2,6-Dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,8-dihydroxy-3a,6,6,9b,11a-pentamethyl-2,3,3a,3b,4,6,8,9,9a,9b,11,11a-dodecahydro-1H-cyclopenta[a]phenanthrene-7,10-dione | |
Other names
Elatericin A
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.211.825 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C30H44O7 | |
Molar mass | 516.675 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Cucurbitacin D is a plant triterpene first identified in plants in the family Cucurbitaceae.[1][2] In preliminary in vitro studies, it has shown inhibitory properties against endometrial and ovarian cancer cell lines.[3]
References
[edit]- ^ Enslin, P. R. (1954). "Bitter principles of the cucurbitaceae. I.—Observations on the chemistry of cucurbitacin A". Journal of the Science of Food and Agriculture. 5 (9): 410–416. doi:10.1002/jsfa.2740050904.
- ^ Lavie, David; Willner, David (1958). "The Constituents of Ecballium elaterium L. III. Elatericin a and B1,2". Journal of the American Chemical Society. 80 (3): 710–714. doi:10.1021/ja01536a047.
- ^ Ishii, Terukazu; Kira, Naoko; Yoshida, Toshie; Narahara, Hisashi (2013). "Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells". Tumor Biology. 34 (1): 285–291. doi:10.1007/s13277-012-0549-2. PMID 23150173. S2CID 16889635.