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Cycloartenol synthase

From Wikipedia, the free encyclopedia
cycloartenol synthase
Identifiers
EC no.5.4.99.8
CAS no.9075-25-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a cycloartenol synthase (EC 5.4.99.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3-epoxysqualene cycloartenol

Hence, this enzyme has one substrate, (S)-2,3-epoxysqualene, and one product, cycloartenol.

This enzyme is an oxidosqualene cyclase and belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. This enzyme participates in biosynthesis of steroids.

Nomenclature

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The systematic name of this enzyme class is:

  • (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming).

Other names in common use include:

  • 2,3-epoxysqualene cycloartenol-cyclase
  • squalene-2,3-epoxide-cycloartenol cyclase
  • 2,3-epoxysqualene cycloartenol-cyclase
  • 2,3-epoxysqualene-cycloartenol cyclase
  • 2,3-oxidosqualene-cycloartenol cyclase

References

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  • Rees HH, Goad LJ, Goodwin TW (1969). "2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis". Biochim. Biophys. Acta. 176 (4): 892–4. doi:10.1016/0005-2760(69)90274-4. PMID 5797101.