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DAZAP2

From Wikipedia, the free encyclopedia
DAZAP2
Identifiers
AliasesDAZAP2, PRTB, DAZ associated protein 2
External IDsOMIM: 607431; MGI: 1344344; HomoloGene: 8038; GeneCards: DAZAP2; OMA:DAZAP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_011873

RefSeq (protein)

NP_036003

Location (UCSC)Chr 12: 51.24 – 51.27 MbChr 15: 100.51 – 100.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene.[5][6][7]

Function

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In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.[7]

Interactions

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DAZAP2 has been shown to interact with DAZ1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183283Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000346Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (Aug 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
  6. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  7. ^ a b "Entrez Gene: DAZAP2 DAZ associated protein 2".
  8. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Further reading

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