Jump to content

DBN1

From Wikipedia, the free encyclopedia
DBN1
Identifiers
AliasesDBN1, D0S117E, drebrin 1
External IDsOMIM: 126660; MGI: 1931838; HomoloGene: 3236; GeneCards: DBN1; OMA:DBN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177371
NM_001177372
NM_019813

RefSeq (protein)

NP_004386
NP_543157
NP_001350470
NP_001351080
NP_001351081

NP_001170842
NP_001170843
NP_062787

Location (UCSC)Chr 5: 177.46 – 177.47 MbChr 13: 55.62 – 55.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Drebrin is a protein that in humans is encoded by the DBN1 gene.[5][6]

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113758Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034675Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Toda M, Shirao T, Minoshima S, Shimizu N, Toya S, Uyemura K (Nov 1993). "Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene". Biochem Biophys Res Commun. 196 (1): 468–72. doi:10.1006/bbrc.1993.2273. PMID 8216329.
  6. ^ a b "Entrez Gene: DBN1 drebrin 1".

Further reading

[edit]