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Hsp90 cis-regulatory element

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Hsp90 cis-regulatory element
Predicted secondary structure and sequence conservation of Hsp90_CRE
Identifiers
SymbolHsp90_CRE
RfamRF00433
Other data
RNA typeCis-reg; thermoregulator
Domain(s)Eukaryota
SOSO:0000233
PDB structuresPDBe

The Hsp90 cis regulatory element is an RNA element (RNA thermometer) found in the 5' UTR of the Drosophila hsp90 mRNA. It is required for increased translational efficiency during the heat shock response.

The hsp90 gene product is involved in the Drosophila heat shock response. Translation of the hsp90 mRNA is very inefficient under normal growth temperatures; when heat shock occurs, translation becomes more efficient. This is mediated via this regulatory element.[1]

See also

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References

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  1. ^ Ahmed R, Duncan RF (November 2004). "Translational regulation of Hsp90 mRNA. AUG-proximal 5'-untranslated region elements essential for preferential heat shock translation". The Journal of Biological Chemistry. 279 (48): 49919–49930. doi:10.1074/jbc.M404681200. PMID 15347681.
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