Jump to content

KLHDC3

From Wikipedia, the free encyclopedia
KLHDC3
Identifiers
AliasesKLHDC3, PEAS, dJ20C7.3, kelch domain containing 3
External IDsOMIM: 611248; MGI: 2651568; HomoloGene: 14290; GeneCards: KLHDC3; OMA:KLHDC3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242872
NM_057161

NM_001163729
NM_027910

RefSeq (protein)

NP_476502

NP_001157201
NP_082186

Location (UCSC)Chr 6: 43.01 – 43.02 MbChr 17: 46.99 – 46.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.[5][6]

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124702Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063576Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y (Nov 2002). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis". Biol Reprod. 67 (6): 1824–31. doi:10.1095/biolreprod.101.002550. PMID 12444059.
  6. ^ a b "Entrez Gene: KLHDC3 kelch domain containing 3".

Further reading

[edit]