Jump to content

MYO1E

From Wikipedia, the free encyclopedia
MYO1E
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYO1E, FSGS6, HuncM-IC, MYO1C, myosin IE
External IDsOMIM: 601479; MGI: 106621; HomoloGene: 55864; GeneCards: MYO1E; OMA:MYO1E - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004998

NM_181072
NM_025612

RefSeq (protein)

NP_004989

NP_851417

Location (UCSC)Chr 15: 59.13 – 59.37 MbChr 9: 70.11 – 70.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.[5][6]

Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. [7]

The MYO1E gene was included in several genetic signatures for cancer prognosis.[8]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157483Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032220Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–439. doi:10.1006/geno.1996.0488. PMID 8884266.
  6. ^ "Entrez Gene: MYO1E myosin IE".
  7. ^ McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology. 20 (7): 418–426. doi:10.1016/j.tcb.2010.04.004. PMC 2897960. PMID 20471271.
  8. ^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.

Further reading

[edit]
[edit]
  • Overview of all the structural information available in the PDB for UniProt: E9Q634 (Mouse Unconventional myosin-Ie) at the PDBe-KB.