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NRN1

From Wikipedia, the free encyclopedia
NRN1
Identifiers
AliasesNRN1, NRN, dJ380B8.2, neuritin 1
External IDsOMIM: 607409; MGI: 1915654; HomoloGene: 9577; GeneCards: NRN1; OMA:NRN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278710
NM_001278711
NM_016588

NM_153529
NM_001374754

RefSeq (protein)

NP_001265639
NP_001265640
NP_057672

NP_705757
NP_001361683

Location (UCSC)Chr 6: 6 – 6.01 MbChr 13: 36.91 – 36.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuritin 1 is a protein that in humans is encoded by the NRN1 gene. [5]

Function

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This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124785Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039114Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Neuritin 1". Retrieved 2017-12-15.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.