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Nuclear receptors that bind to retinoids
Retinoid receptors are nuclear receptors (a class of proteins ) that bind to retinoids . When bound to a retinoid, they act as transcription factors , altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis .[1]
Subtypes include:
^ Dyall SC, Michael GJ, Michael-Titus AT (2010). "Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats". Journal of Neuroscience Research . 88 (10): 2091–2102. doi :10.1002/jnr.22390 . PMID 20336774 . S2CID 1620277 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
RAR Tooltip Retinoic acid receptor
Retinoic acid metabolism inhibitors: Liarozole
RXR Tooltip Retinoid X receptor