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VPS29

From Wikipedia, the free encyclopedia
VPS29
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVPS29, DC15, PEP11, DC7, VPS29 retromer complex component, retromer complex component
External IDsOMIM: 606932; MGI: 1928344; HomoloGene: 9433; GeneCards: VPS29; OMA:VPS29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282150
NM_001282151
NM_016226
NM_057180

NM_019780
NM_001347453
NM_001359226

RefSeq (protein)

NP_001269079
NP_001269080
NP_057310
NP_476528

NP_001334382
NP_062754
NP_001346155

Location (UCSC)Chr 12: 110.49 – 110.5 MbChr 5: 122.49 – 122.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.[5]

Yeast homolog

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The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae).[6]

Function

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VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases.[7] The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.[8] Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111237Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029462Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Edgar AJ, Polak JM (November 2000). "Human homologues of yeast vacuolar protein sorting 29 and 35". Biochem. Biophys. Res. Commun. 277 (3): 622–30. doi:10.1006/bbrc.2000.3727. PMID 11062004.
  6. ^ a b "Entrez Gene: VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae)".
  7. ^ Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (December 2000). "Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes". Mol. Biol. Cell. 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC 15060. PMID 11102511.
  8. ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259.

Further reading

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