multichaperone
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English
[edit]Etymology
[edit]Noun
[edit]multichaperone (plural multichaperones)
- (biochemistry) A chaperone consisting of multiple proteins
- 2015 September 29, “The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein”, in PLOS ONE[1], :
- The complex containing Cdc37 and p23 is thought to be the primary stable form, and the HSP70- and HOP-associated complex is another proteasome-targeting form that induces ubiquitin-proteasome degradation [45, 46 ]. 17-AAG is an ansamycin antibiotic that binds to HSP90 and inhibits the formation of the stabilized HSP90-client protein complex, resulting in the accumulation of the proteasome-targeting HSP90-based multichaperone.