���F�̕��z�̌�������Aurora B������(CPC)�̃��j�[�N�ȕ��q�\���𔭌�
�`�N���}�`�����qHP�P�����N���[�g����CPC��INCENP�T�u���j�b�g������
�u��A�����̈�SSH�h���C���v�̔����Ƃ��̏d�v���ɂ‚��ā`

���񌤋��������a�����̔����C���C�������A���V��������A�L�c�������́A�Ð숟��q�y����(���s��w�_�w������ ���p�����Ȋw��U���p�����w�u��)�A�I�c������C����(���l�s����w������Ȋw������ �v���W�F�N�g������)�A�����P�����_�����i���������j��Ƃ̋��������ɂ��A�ȉ��̌������ʂ𓾂܂����B

1. INCENP�́A�ۑ����̍���HP1�������`�[�t(PVI-motif)�݂̂Ȃ炸�A���̉����̃A�~�m�_�z�񂪊֗^����HP1�ƌ�������B
2. ���̌������ʂ�INCENP�̓V�R�ϐ��̈撆�Ɉʒu���Ă���AHP1�������ɂ̂݃�-strand (PVI-motif)�ƃ�-helix (�����z��)�ɍ\�����ω�����B
3. ���̌����̈���uSSH �h���C�� (Structure composed of Strand and Helix)�v�Ɩ��t�����B
4. SSH �h���C���́AINCENP��HP1�����\�͂�啝�ɑ������A������ɂ�����Aurora B�̃L�i�[�[�����Ɛ��F�̕��z�̍P�퐫�ێ��ɕK�{�ł���B

�Ȃ��A����זE�ɂ����Ă�HP1�����ቺ�ɔ���CPC�̋@�\�ቺ���N�����Ă���(Abe et al., 2016)�A���̕��q�@�\��S�������\����Ղ����񖾂炩�ɂȂ������Ƃ���A�����CPC�̕��q����̂���Ȃ闝����n�򌤋��ɂ��q����Ɗ��҂���܂��B�{�������ʂ́A2024�N5��23���t��Journal of Cell Biology���ɃI�����C���f�ڂ���܂����B

�ڍ�

• Sasaki, N., Asano, Y., Sorayama, Y., Kamimura, C., Kitano, S., Irie, S., Katayama, R., Shimoda, H. and Matsusaki, M.
  Promoting Biological Similarity by Collagen Microfibers in 3D Colorectal Cancer-Stromal Tissue: Replicating Mechanical Properties and Cancer Stem Cell Markers.
  Acta biomaterialia, in press (2024)
• Yoshida, R., Kaneyasu, T., Ueki, A., Yamauchi, H., Ohsumi, S., Ohno, S., Aoki, D., Baba, S., Kawano, J., Matsumoto, N., Nagasaki, M., Ueno, T., Inari, H., Kobayashi, Y., Takei, J., Gotoh, O., Nishi, M., Okamura, M., Kaneko, K., Okawa, M., Suzuki, M., Amino, S., Inuzuka, M., Noda, T., Mori, S. and Nakamura, S.
  High-risk pathogenic germline variants in blood relatives of BRCA1/2 negative probands.
  Breast Cancer, in press (2024)
• Nagasaka, M., Miyajima, C., Inoue, Y., Hashiguchi, S., Suzuki, Y., Morishita, D., Aoki, H., Toriuchi, K., Katayama, R., Aoyama, M. and Hayashi, H.
  ID3 is a novel target gene of p53 and modulates lung cancer cell metastasis.
  Biochem. Biophys. Res. Commun., 708, in press (2024)
• Otomo, K., Omura, T., Nozawa, Y., Edwards, S. J., Sato, Y., Saito, Y., Yagishita, S., Uchida, H., Watakabe, Y., Naitou, K., Yanai, R., Sahara, N., Takagi, S., Katayama, R., Iwata, Y., Shiokawa, T., Hayakawa, Y., Otsuka, K., Watanabe-Takano, H., Haneda, Y., Fukuhara, S., Fujiwara, M., Nii, T., Meno, C., Takeshita, N., Yashiro, K., Rosales Rocabado, J. M., Kaku, M., Yamada, T., Oishi, Y., Koike, H., Cheng, Y., Sekine, K., Koga, J. I., Sugiyama, K., Kimura, K., Karube, F., Kim, H., Manabe, I., Nemoto, T., Tainaka, K., Hamada, A., Brismar, H. and Susaki, E. A.
  descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques.
  Nat. Commun., 15, 4941 (2024)
• Takahashi, Y., Morimura, R., Tsukamoto, K., Gomi, S., Kato, A., Mizukami, M., Naito, Y., Irie, S., Nagayama, S., Shinozaki, E., Yamaguchi, K., Fujita, N., Kitano, S., Katayama, R. and Matsusaki, M.
  In vitro throughput screening of anticancer drugs using patient-derived cell lines cultured on vascularized three-dimensional stromal tissues.
  Acta biomaterialia, in press (2024)

more