Javelin Biotech

Heading to the 2024 ISSX/JSSX Meeting next week? Don't miss Murat’s poster on on “Closing the Translational Gap: Human Multi-Tissue Chip Platform for Predictive and Mechanistic Preclinical Studies" Tuesday, September 17th from 12:30-1:30. Stop by poster #P153 to chat with Murat and learn more about how we’re humanizing drug discovery. If you would like to set up a meeting, send us a message or email [email protected]. We look forward to meeting you! #livertissuechip #drugdiscoveryhumanized #organonchip #ISSX2024 #MicrophysiologicalSystems

Our team is gearing up for the 2024 ISSX/JSSX Meeting next week. Our Sr. Director of Product, Shiny Amala Priya Rajan, Ph.D., MBA, will be presenting a poster on “Predicting Clinical ADME Parameters with a Multi-Tissue Chip Platform Using Primary Human Cells" Tuesday, September 17th from 1:30-2:30. Stop by poster #P166 to chat with Shiny and learn more about how we’re humanizing drug discovery. If you would like to set up a meeting, send us a message or email [email protected]. We look forward to meeting you! #livertissuechip #drugdiscoveryhumanized #organonchip #ISSX2024 #MicrophysiologicalSystems

Will we see you at the 2024 ISSX/JSSX conference in Honolulu from September 15th-18th? The theme of this year’s meeting is “The Future of Translational Xenobiotic Research”, and we can’t wait to share with you how we’re advancing the predictivity of Met ID, Clearance, and DDI studies with the Javelin Tissue Chip Platform. Make sure to visit us at Booth #4 to see our Liver Tissue Chip and learn how we’re humanizing drug discovery. If you would like to set up a meeting, send us a message or email [email protected]. We look forward to meeting you! #livertissuechip #drugdiscoveryhumanized #organonchip #ISSX2024 #MicrophysiologicalSystems

We're looking forward to seeing you next month at the ISSX/JSSX Meeting in Honolulu! Murat Cirit Kevin O'Handley Shiny Amala Priya Rajan, Ph.D., MBA James Ferritto #livertissuechip #drugdiscoveryhumanized #organonchip #ISSX2024 #MicrophysiologicalSystems

💊 Liver Tissue Chip for DDI Induction Studies 💊 Traditional in vitro models often fall short in assessing both perpetrator and victim drugs due to rapid loss of metabolic function or convolution from non-human cells. In our latest manuscript, we demonstrate the utility of the Javelin Liver Tissue Chip as a robust tool for pre-clinical DDI Induction Studies. Javelin’s unique all-human in vitro system with continuous recirculation maintains long-term functionality and metabolic activity for up to 4 weeks, enabling the study of perpetrator and victim drug pharmacokinetics, quantification of drug-induced CYP mRNA and activity levels, investigation of patient variability, and ultimately clinical predictions. Read more about our findings in the full article to explore how these advancements provide a translational experimental system for drug interaction assessments and learn how we’re humanizing drug discovery! bioRxiv preprint: https://lnkd.in/gJWm3KF7 #livertissuechip #drugdiscoveryhumanized #DDI #ADME Shivam Ohri, Paarth Parekh, Lauren Nichols, Shiny Amala Priya Rajan, Ph.D., MBA, Murat Cirit

⛳ Javelin Biotech Team Outing ⛳ Mini-golf, bumper boats, zip-lines, batting cages, and ice cream at Kimball Farm to celebrate 5 years of Javelin Biotech! It was such a fantastic day filled with laughter, camaraderie, and great memories. We are fortunate to have such an outstanding team, and we deeply appreciate the role each individual plays in making it so exceptional. Cheers to the Javelin team!

Looking forward to seeing our DMPK friends and colleagues next week at the Drug Metabolism Gordon Research Conference! Shiny Amala Priya Rajan, Ph.D., MBA will be presenting on “Closing the Translational Gap in Drug Development: Human Multi-Tissue Chip for Predictive and Mechanistic Preclinical Studies”. We hope to see you there! #livertissuechip #drugdiscoveryhumanized Gordon Research Conferences

This week, Javelin Biotech was showcased at the Massachusetts State House for an animal-free technology demonstration day held by The Humane Society of the United States in support of Bill H.850. This bill, sponsored by Rep. Jack Patrick Lewis, aims to reduce animal testing in cosmetics and household product development, promoting a more humane approach to scientific research. Murat Cirit and Kevin O'Handley demonstrated the Liver Tissue Chip platform and shared how we are humanizing research and product testing. Learn more about bill H850: https://lnkd.in/etayFyz7

Reflecting on an inspiring experience at the 2024 MPS World Summit: What a fantastic opportunity to connect with industry leaders and pioneers in the field of #microphysiologicalsystems and #organsonchips. The exchange of ideas and expertise was truly enriching, and we're excited about the possibilities that lie ahead. Thank you to everyone who visited our booth and engaged with us during the conference. Let's keep the conversation going! Feel free to reach out for more information on our tissue chip platform or to explore potential collaborations. Together, we can take steps to humanize drug discovery. email [email protected] to connect #MPSWorldSummit #livertissuechip #drugdiscoveryhumanized Murat Cirit Shiny Amala Priya Rajan, Ph.D., MBA James Ferritto Kevin O'Handley

Accurate clinical translation of preclinical research remains challenging, primarily due to species-specific differences and disease and patient heterogeneity. Given this, how do you know how relevant your model is? This study by Javelin Biotech describes the development of pathway-based similarity measurement (PBSM), which leverages RNA-seq data and pathway-based information to assess the human relevance of preclinical models for specific CoU. This figure shows PBSM-based scores for pre-clinical animal models of nonalcoholic fatty liver disease compared to reference human NAFL liver tissue samples for the KEGG NAFL pathway. There is a room for improvement - Stay tuned for more about Javelin’s human healthy and disease models! bioRxiv preprint: https://lnkd.in/dUZVAGCD