🎙️𝗠𝗶𝗰 𝗖𝗵𝗲𝗰𝗸 𝟭,𝟮,𝟭,𝟮 🎙️ We are very excited to share an insightful podcast featuring our incredible CKB team member Cara Statz ! Cara is a Senior Clinical Analyst at The Jackson Laboratory. She has her PhD in Genetics and Genomics from The University of Connecticut and has been in the field for just over 9 years! To hear from Cara directly tune into “Two Industry Leaders on Dealing with the Growing Complexity of Genomic Cancer Data.” She discusses with other field experts how innovations from The Jackson Laboratory’s CKB and Illumina are revolutionizing the landscape of oncology research. From navigating the influx of scientific data to providing practical advice for labs, this discussion has it all. Click the link below to listen now! https://lnkd.in/es4afRrG #GenomeWeb #PrecisionMedicine #ClinicalResearch #GenomeEra #GoHuskies
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💕 𝗖𝗲𝗿𝘃𝗶𝗰𝗮𝗹 𝗖𝗮𝗻𝗰𝗲𝗿 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗚𝗲𝗻𝗲 𝗦𝗽𝗼𝘁𝗹𝗶𝗴𝗵𝘁: Navigating CD274 💕 Greetings LinkedIn community! 🌟 In recognition of Cervical Cancer Awareness, let’s take a deeper look at the significance of CD274 in cervical cancer. Join us as we navigate the intricate details, brought to you by The Jackson Laboratory’s renowned CKB! 🔍𝗡𝗮𝘃𝗶𝗴𝗮𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗖𝗗𝟮𝟳𝟰 𝗚𝗲𝗻𝗲: CD274, also known as PD-L1, is a pivotal immune checkpoint molecule that plays a crucial role in regulating the immune response. It is involved in suppressing T-cell activity, thereby allowing cancer cells to evade the immune system. 🧬 𝗜𝗺𝗽𝗮𝗰𝘁 𝗼𝗻 𝗖𝗲𝗿𝘃𝗶𝗰𝗮𝗹 𝗖𝗮𝗻𝗰𝗲𝗿: In the context of cervical cancer, the overexpression of PD-L1 can contribute to immune evasion and disease progression. Studies have shown correlations between PD-L1 expression levels and clinical outcomes in cervical cancer patients. Understanding the molecular intricacies of CD274 can open doors to potential targeted therapies and immunotherapeutic approaches. 💡 𝗖𝗞𝗕 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀: While CD274/PD-L1 is a key player in cervical cancer, CKB’s wealth of knowledge goes beyond. Explore reports on various CD274 gene variants and delve into 127 molecular profiles related to CD274. CKB stands as a global force, arming researchers and clinicians with valuable insights that play a crucial role in refining patient care strategies for cervical cancer and related conditions. To explore more about CD274 and other gene variants, visit the JAX CKB Website: https://ckbhome.jax.org/. Together, let's deepen our understanding of the genetic landscape and work towards improved outcomes in the fight against cervical cancer. 🔬 💕
The Clinical Knowledgebase (CKB)
ckbhome.jax.org
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🎄✨ Wishing You Joy and Cheer! ✨🎄 As we gather with the spirit of the season, we're delighted to share in the joy and warmth of the holidays and the anticipation of a brand-new year. With the end of the year approaching, we reflect on the moments that made it special – moments of collaboration, growth, and shared success. Here's to the spirit of togetherness, the beauty of new beginnings, and the promise of a brighter future. Thank you for being a cherished part of our journey. 🎅 Merry Christmas and a Happy New Year to you and yours! 🎉
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🌟 𝗦𝗲𝗮𝘀𝗼𝗻'𝘀 𝗚𝗿𝗲𝗲𝘁𝗶𝗻𝗴𝘀 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗖𝗞𝗕 𝗧𝗲𝗮𝗺 🌟 As the temperatures are dropping and the holidays are fast approaching, we want to take a moment to extend our warmest wishes to you and your loved ones during this festive season. In the spirit of unity and gratitude, we extend our thanks to all of you for your continued support and engagement. May the coming days bring you peace, prosperity, and fulfillment!
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𝗟𝘂𝗻𝗴 𝗖𝗮𝗻𝗰𝗲𝗿 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗚𝗲𝗻𝗲 𝗦𝗽𝗼𝘁𝗹𝗶𝗴𝗵𝘁: Decoding ALK Hello, LinkedIn community! 🌟 In honor of Lung Cancer Awareness Month, let's shine a light on the ALK gene and its significant role in lung cancer. Join us as we navigate the genetic landscape, with a focus on fusion EML4-ALK. All brought to you by @The Jackson Laboratory’s very own CKB CORE! 🔍 𝗨𝗻𝗿𝗮𝘃𝗲𝗹𝗶𝗻𝗴 𝘁𝗵𝗲 𝗔𝗟𝗞 𝗚𝗲𝗻𝗲: ALK, or Anaplastic Lymphoma Kinase, is a crucial regulator in the insulin receptor superfamily, impacting neuronal development and promoting cell proliferation through MAPK and PI3K signaling pathways. In the realm of cancer, ALK has been associated with various cancers, including the notorious EML4-ALK fusion in non-small cell lung cancer (NSCLC). 🧬 𝗘𝗠𝗟𝟰-𝗔𝗟𝗞 𝗙𝘂𝘀𝗶𝗼𝗻: EML4-ALK, resulting from the fusion of EML4 and ALK, sparks constitutive kinase activity, transforms cultured cells, and leads to tumor formation in mouse models. In the context of NSCLC, EML4-ALK fusions have been identified and typically have influence on targeted therapy efficacy. Understanding the nuances of genetic variants like EML4 is crucial for personalized treatment strategies. 🎯 💡 𝗖𝗞𝗕 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀: EML4 is just one of the many variants related to ALK. Dive into the CKB CORE’s wealth of knowledge where reports on 210 other ALK gene variants await exploration. CKB CORE allows you to search beyond variants, as CKB offers insights into 435 complex molecular profiles related to ALK gene as well! This invaluable resource empowers researchers and clinicians alike, advancing our understanding of the genetic intricacies influencing lung and many other cancer types. 🌐💪 To explore more about EML4 and other ALK gene variants visit the JAX CKB Website: https://ckbhome.jax.org/. Together, let's continue to unravel the mysteries of genetics and strive for improved outcomes in the fight against lung cancer. 🔬 🤍 #LungCancerAwareness #ALKGene #GenomicVariants #EML4 #CKBCORE #CancerResearch #GeneSpotlight #MolecularProfiles #JAXCKB
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📢 Breaking News from the CKB Team at AMP 2023! 🌟 We are thrilled to share that our very own Sarah Edie from the CKB team had the incredible opportunity to showcase her groundbreaking work at the 2023 AMP Meeting through a poster presentation. 🚀 Check out Sarah's poster at Booth #I028 to learn more about how The Jackson Laboratory's CKB can be leveraged alongside disease ontology to analyze therapeutic responses across cancer subtypes. The commitment and expertise Sarah has brought to this project are truly commendable. She navigated the complexities of cancer subtypes with precision, shedding light on new avenues for therapeutic exploration. 🌐💡 Join us in congratulating Sarah on this remarkable achievement! 🎉 Her dedication to advancing our understanding of cancer is paving the way for a brighter and healthier future. 👏🔬 #CKBTeam #AMPMeeting2023 #CancerResearch #Innovation #TherapeuticResponses #JAXCKB #DiseaseOntology #PosterPresentation
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🌟 Exciting News for #AMP2023 Attendees! Dive into the future of cancer genomics at the The Jackson Laboratory’s CKB Booth! 🚀🧬 Join us at Booth #1427 during the ongoing AMP meeting to explore how JAX-CKB is transforming the landscape and conversations surrounding complex cancer profiles. 🚀 Why Visit JAX CKB Booth? • Unlock Insights with Unparalleled Data • Boost Confidence in Patient Care • Stay ahead in your research • Engage with experts in the field 🌐 Connect with us and be part of the conversations that drive advancement in cancer diagnostics and treatment. Don't miss out on this opportunity to be at the forefront of precision medicine! #JAXCKB #AMPMeeting #PrecisionMedicine #CancerGenomics #Innovation #Collaboration #TumorProfiling #MolecularPathology See you there! 👋✨
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JAX Clinical Genomics reposted this
Dr. Jens Rueter was invited to speak as part of the translational medicine plenary during the 2023 SWOG Cancer Research Network Fall Meeting held last month. He spoke on both the Maine Cancer Genomics Initiative (MCGI) Study and the S2108CD Genomic Tumor Board Study, with a focus on how to achieve more evidence-based genome-informed therapies in the community setting. 👉 Learn more about the MCGI Study here: www.jax.org/mcgi 👉 Learn more about the S2108CD Genomic Tumor Board Study here: https://lnkd.in/gPrvgtfS In addition, Dr. Jens Rueter and Dr. Meghna Trivedi were featured on the cover of the Hope Foundation's Generation of Hope Magazine, celebrating 30 years of supporting SWOG. #PersonalizedMedicine #S2108CD #SWOG2023 The Jackson Laboratory
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JAX Clinical Genomics reposted this
Team members representing our Teaching the Genome Generation™ program at The Jackson Laboratory gathered in Maryland last week at the National Association of Biology Teachers conference to showcase our genetics learning resources and host an interactive workshop for teachers. #STEM educators who attended the workshop had the opportunity to engage with our new genetic ancestry curriculum and learn how to incorporate data analysis and quantitative skills into their classrooms. We are so excited by all the learning and engagement at #NABT2023! Learn more about TtGG™ at www.jax.org/ttgg.
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𝑩𝒓𝒆𝒂𝒔𝒕 𝑪𝒂𝒏𝒄𝒆𝒓 𝑨𝒘𝒂𝒓𝒆𝒏𝒆𝒔𝒔 𝑮𝒆𝒏𝒆 𝑺𝒑𝒐𝒕𝒍𝒊𝒈𝒉𝒕: 𝑼𝒏𝒎𝒂𝒔𝒌𝒊𝒏𝒈 𝑨𝑻𝑴🔮 Greetings, from the CKB witches and wizards 🧙🧙♀️! This Halloween, we're unwrapping a gene spotlight that's more treat than trick. Let's delve into the mysterious world of gene variants and shed light on ATM. No need to be spooked, we're your trusty guides through this genetic maze. So, grab your metaphorical trick-or-treat bags as we fill them with enlightening facts! 🍬 ATM, or Ataxia Telangiectasia Mutated belongs to the serine-threonine kinase family. ATM plays a key role in DNA repair by sensing DNA damage and activating to recruit repair proteins that restore integrity of the DNA. But beware👻, not all variants play nice with ATM. Take, for instance, ATM S707P, a missense mutation that results in decreased Atm protein expression. S707P is associated with a modest increased risk of breast cancer. ATM S707P is one of 393 variants currently housed in JAX CKB CORE. You can unlock the secrets of all ATM variants for free at our portal of genetic knowledge: https://ckbhome.jax.org/. And the treats keep coming! Our gene grid has been freshly updated this month, so you can explore not only ATM but also 49 other publicly available genes. Pay a visit to our site to unravel the mysteries of tumor suppressor genes. Be sure to join us next month for another gene spotlight. Together, we'll continue to demystify the complex world of genetics. Happy Halloween and happy learning! 🎃🔬 #BreastCancerAwareness #GeneSpotlight #halloweenfun #CKBSpotlight #TheJacksonLaboratory The Jackson Laboratory
The Clinical Knowledgebase (CKB)
ckbhome.jax.org