Cullin 4A (Q21112920)

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mammalian protein found in Homo sapiens
  • CUL-4A
  • CUL4A
  • cullin-4A
  • CUL4A protein, human
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Language Label Description Also known as
English
Cullin 4A
mammalian protein found in Homo sapiens
  • CUL-4A
  • CUL4A
  • cullin-4A
  • CUL4A protein, human

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
1 January 2018
stated in
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
TIP120A associates with cullins and modulates ubiquitin ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
retrieved
1 January 2018
stated in
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
GOA
curator
Developmental FunctionaL Annotation at Tufts
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IPI
cell component
Cul4A-RING E3 ubiquitin ligase complex
determination method
IDA
6 references
retrieved
24 April 2018
stated in
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
24 April 2018
stated in
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
24 April 2018
stated in
Identification of a primary target of thalidomide teratogenicity
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
24 April 2018
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
24 April 2018
stated in
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
24 April 2018
stated in
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13619&geneProductId=UniProtKB:Q13619
determination method
IDA
Cul4A-RING E3 ubiquitin ligase complex
determination method
IBA
IDA
7 references
retrieved
1 January 2018
stated in
Identification of a primary target of thalidomide teratogenicity
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
1 January 2018
stated in
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
1 January 2018
stated in
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
1 January 2018
stated in
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
1 January 2018
stated in
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
1 January 2018
stated in
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
GOA
curator
UniProt
UniProt protein ID
Q13619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13619
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
C114234
subject named as
CUL4A protein, human
0 references
 
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